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The map label for this gene is pepB [H]

Identifier: 119773919

GI number: 119773919

Start: 964251

End: 965534

Strand: Direct

Name: pepB [H]

Synonym: Sama_0782

Alternate gene names: 119773919

Gene position: 964251-965534 (Clockwise)

Preceding gene: 119773910

Following gene: 119773926

Centisome position: 22.39

GC content: 61.45

Gene sequence:

>1284_bases
ATGACACAAGCCATGCGTGTAACCCTCACCCAGGAAGCCCCGGCAGCCCATTGGGGCAAGGCCGACATCACATTCGAAGG
CAATCTGGCCCGTATCCATCTGCAGGGCTCCGATGCCTTGCGTCAAATTCAGATGGCCGCTCGCAAACTGCGCAGTCAGG
GCATTGCCAGCGCCGCGCTGGAAGGCGAGGGCTGGGATCTTAATCGCCAGTGGGTGTTTGCCCAGGGCTTTGTCACCGCC
AAGGCTGGTTGGGACATCAGCTGGACCGGCGATGAGGCCACCCTGCGCGAACTGGCCTCTCGTATGGAAGCCGCTCGCTT
TGTGCGCCAGCTCACTAATGAGACCCCGGAAAACCTGTCACCGGTGAAACTGGCCACTCAGGCCGGTCACTGGATTAAAG
AGCTCGGGGGCGACAAGGTGAGCTTTCGTATCATCGAAGGTGAGCAGCTACTGGAGGAGCAGTGGATTGGTATCCACGCC
GTTGGCCGTGGCAGCGAGCGTCCACCTGCGATGCTGGAGCTGGACTACAACCCGCTGGGCGCCGATGCCCCTGTGTCAGT
GGCGCTGGTAGGTAAGGGTATTACTTTCGATTCGGGCGGCTACAGCCTCAAAGCCAGTGAAGGCATGCTCAATATGAAGT
GTGACATGGGCGGCGCCGCTACTATCACGGGTGCCCTGGGACTGGCCATTAAAAACGGTCTTAACAAGCGGGTGAAGCTG
TTTTTGTGCTGCGCCGAAAACCTGGTCAGCGGCCGCGCCTATAAGCTTGGCGATATCCTCACTTACAAAAACGGCGTCAC
CGTGGAAGTGGTCAACACTGACGCCGAAGGCCGTCTGGTGCTGGCCGACGGCCTGCAGGCCGCCTCTGCCACAGGCGCAC
CGCTGATTATTGACGCCGCGACCCTCACGGGCGCCGCCGTGATGGCGGTGGGCGGTAACTACAACGCTATCTTCTCCCCC
GACGAAGCCGTGATTGAGCTGACCCGTGAAAAGGCCCGCAGCGTGGCCGAGCGGGTGTGGCCACTGCCGCTGGACCCCTG
GCACAAAGACATGTGCCCATCGGCCTATGCCGATACCGCCAACAGCCGTCCGGTAAAAGGCGGCGGCGCCGGTGGTGCCT
CCAATGCCGCGGGTTTCCTGTGGCGCTTTGTACGGGACGATGCCAAGTGGCTGCACATGGACCTTGCTGGCTCCTTTGAA
GACAGCGCAGGCGCGCTATGGGCTGCTGGCGCTACCACCCACGGTGTGCTTACCCTGGCCGAGCTGATTAAAGACGCCGA
CTAA

Upstream 100 bases:

>100_bases
TGGCCTTCTGGGGTACACTCGTGGCATATCGCCAGCTTCAAGCGCAATGCTTCGGGCACAGTGTTTCGAGCCGGCGCCAA
TAAACAGAAAAGGAAGCAAG

Downstream 100 bases:

>100_bases
CGGCGGATTTGACGGTTAAACGTCCGCAAAAAAGGCCGCATTGCGGCCTTTTTCTTTGGGTGACTCCGTGTGACAGGGGG
CTCTCAAGCCGGTTTCAGCG

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTQAMRVTLTQEAPAAHWGKADITFEGNLARIHLQGSDALRQIQMAARKLRSQGIASAALEGEGWDLNRQWVFAQGFVTA
KAGWDISWTGDEATLRELASRMEAARFVRQLTNETPENLSPVKLATQAGHWIKELGGDKVSFRIIEGEQLLEEQWIGIHA
VGRGSERPPAMLELDYNPLGADAPVSVALVGKGITFDSGGYSLKASEGMLNMKCDMGGAATITGALGLAIKNGLNKRVKL
FLCCAENLVSGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPLIIDAATLTGAAVMAVGGNYNAIFSP
DEAVIELTREKARSVAERVWPLPLDPWHKDMCPSAYADTANSRPVKGGGAGGASNAAGFLWRFVRDDAKWLHMDLAGSFE
DSAGALWAAGATTHGVLTLAELIKDAD

Sequences:

>Translated_427_residues
MTQAMRVTLTQEAPAAHWGKADITFEGNLARIHLQGSDALRQIQMAARKLRSQGIASAALEGEGWDLNRQWVFAQGFVTA
KAGWDISWTGDEATLRELASRMEAARFVRQLTNETPENLSPVKLATQAGHWIKELGGDKVSFRIIEGEQLLEEQWIGIHA
VGRGSERPPAMLELDYNPLGADAPVSVALVGKGITFDSGGYSLKASEGMLNMKCDMGGAATITGALGLAIKNGLNKRVKL
FLCCAENLVSGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPLIIDAATLTGAAVMAVGGNYNAIFSP
DEAVIELTREKARSVAERVWPLPLDPWHKDMCPSAYADTANSRPVKGGGAGGASNAAGFLWRFVRDDAKWLHMDLAGSFE
DSAGALWAAGATTHGVLTLAELIKDAD
>Mature_426_residues
TQAMRVTLTQEAPAAHWGKADITFEGNLARIHLQGSDALRQIQMAARKLRSQGIASAALEGEGWDLNRQWVFAQGFVTAK
AGWDISWTGDEATLRELASRMEAARFVRQLTNETPENLSPVKLATQAGHWIKELGGDKVSFRIIEGEQLLEEQWIGIHAV
GRGSERPPAMLELDYNPLGADAPVSVALVGKGITFDSGGYSLKASEGMLNMKCDMGGAATITGALGLAIKNGLNKRVKLF
LCCAENLVSGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPLIIDAATLTGAAVMAVGGNYNAIFSPD
EAVIELTREKARSVAERVWPLPLDPWHKDMCPSAYADTANSRPVKGGGAGGASNAAGFLWRFVRDDAKWLHMDLAGSFED
SAGALWAAGATTHGVLTLAELIKDAD

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=373, Percent_Identity=35.1206434316354, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI47155554, Length=313, Percent_Identity=37.0607028753994, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI87082123, Length=429, Percent_Identity=50.1165501165501, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1790710, Length=316, Percent_Identity=38.6075949367089, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=317, Percent_Identity=35.3312302839117, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=344, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357381, Length=275, Percent_Identity=38.9090909090909, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI221379063, Length=275, Percent_Identity=38.9090909090909, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI221379062, Length=275, Percent_Identity=38.9090909090909, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21355725, Length=297, Percent_Identity=32.3232323232323, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24661038, Length=239, Percent_Identity=32.6359832635983, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI161077148, Length=301, Percent_Identity=30.2325581395349, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI20130057, Length=301, Percent_Identity=30.2325581395349, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24662227, Length=303, Percent_Identity=28.0528052805281, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20129969, Length=300, Percent_Identity=27, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21355645, Length=301, Percent_Identity=27.2425249169435, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24662223, Length=301, Percent_Identity=27.2425249169435, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129963, Length=298, Percent_Identity=27.5167785234899, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24646701, Length=232, Percent_Identity=32.3275862068966, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24646703, Length=232, Percent_Identity=32.3275862068966, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21358201, Length=232, Percent_Identity=32.3275862068966, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19922386, Length=300, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 45430; Mature: 45299

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAMRVTLTQEAPAAHWGKADITFEGNLARIHLQGSDALRQIQMAARKLRSQGIASAAL
CCCEEEEEEECCCCCCCCCCEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHCCCHHEEE
EGEGWDLNRQWVFAQGFVTAKAGWDISWTGDEATLRELASRMEAARFVRQLTNETPENLS
CCCCCCCCCEEEEEECEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PVKLATQAGHWIKELGGDKVSFRIIEGEQLLEEQWIGIHAVGRGSERPPAMLELDYNPLG
CEEEHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCEEEEECCCCCCCCEEEEECCCCCC
ADAPVSVALVGKGITFDSGGYSLKASEGMLNMKCDMGGAATITGALGLAIKNGLNKRVKL
CCCCEEEEEEECCEEECCCCCEEEECCCEEEEEECCCCCEEHHHHHHHHHHCCCCCEEEE
FLCCAENLVSGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPLIIDAA
EEEEHHHHHCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEH
TLTGAAVMAVGGNYNAIFSPDEAVIELTREKARSVAERVWPLPLDPWHKDMCPSAYADTA
HHCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHCCC
NSRPVKGGGAGGASNAAGFLWRFVRDDAKWLHMDLAGSFEDSAGALWAAGATTHGVLTLA
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHHH
ELIKDAD
HHHHCCC
>Mature Secondary Structure 
TQAMRVTLTQEAPAAHWGKADITFEGNLARIHLQGSDALRQIQMAARKLRSQGIASAAL
CCEEEEEEECCCCCCCCCCEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHCCCHHEEE
EGEGWDLNRQWVFAQGFVTAKAGWDISWTGDEATLRELASRMEAARFVRQLTNETPENLS
CCCCCCCCCEEEEEECEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PVKLATQAGHWIKELGGDKVSFRIIEGEQLLEEQWIGIHAVGRGSERPPAMLELDYNPLG
CEEEHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCEEEEECCCCCCCCEEEEECCCCCC
ADAPVSVALVGKGITFDSGGYSLKASEGMLNMKCDMGGAATITGALGLAIKNGLNKRVKL
CCCCEEEEEEECCEEECCCCCEEEECCCEEEEEECCCCCEEHHHHHHHHHHCCCCCEEEE
FLCCAENLVSGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPLIIDAA
EEEEHHHHHCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEH
TLTGAAVMAVGGNYNAIFSPDEAVIELTREKARSVAERVWPLPLDPWHKDMCPSAYADTA
HHCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHCCC
NSRPVKGGGAGGASNAAGFLWRFVRDDAKWLHMDLAGSFEDSAGALWAAGATTHGVLTLA
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHHH
ELIKDAD
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]