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The map label for this gene is gltP [H]

Identifier: 119773733

GI number: 119773733

Start: 745648

End: 746892

Strand: Direct

Name: gltP [H]

Synonym: Sama_0595

Alternate gene names: 119773733

Gene position: 745648-746892 (Clockwise)

Preceding gene: 119773732

Following gene: 119773734

Centisome position: 17.32

GC content: 55.82

Gene sequence:

>1245_bases
ATGTTCAAATCTCTGTCGGCCAGGATTTTCCTTGGCCTTGCTATCGGACTCCTGTCCGGCACTCTGGTGCAGTATGTGCT
GCACGATATCAATTTCTTCTCCGGCACCCTGGTCGAAATCGCCTCTGGCCTTGGCACCATGTTCGTCAACATGATCATGA
TGCTGGTGGTGCCACTGGTGTTTGTCAGCATCGTTTGCGGCGTGTGTGAGCTTAAAGATCTCTCCAGCTTCGGTCGCCTC
GGTGGCAAGACCTTTGGTTTTTACATCATCAATACCCTGGTCGCTATATTCGCGGCCCTGACGGTTGCGCTGTTGCTGGA
ACCCGGCAAGGGCGTGGACATGACCGGCGGCGGAGAGCTCGCCATTACCGCCACCGAGCTGCCGAGCCTGATGGCGCTGG
TGGTAGACATAGTGCCCCGTAATCCGGTGGCAGCCTTTATGTCGGGCAATATGCTGCAGGTCATCTTTATGGCCTTGCTG
CTTGGCGGCGTCATCAAGTCTCTGGGCGAGCATGTGACCGGCGCCGTATCTGCCTTCCAAACCGCCAATAAAATCATGAT
GAAGCTGATTTCGGTGGTGATGCATCTGGCGCCCATTGGTGTTGGCGCACTGATGTTCAAACTGGGTGCTACCCTGGAAG
CCGGGGTGTTTCTCAGTGTGATGGAATATCTGGTGCTGATTCTTGGCTTGCTGCTGCTGTGGATTTTCGTGGTTTACCCT
TATGCGGTGCAGCTGTTCACCCCGGTGAAAGCCAGCGTGTTTCGTGAGAAAACCCAGGAGCAAATCCTGTTTTCCCTCTC
TACCGCCAGCTCCAATGCCACCATTCCGGTGACCATGCGAACCCTCACCGAAAAGCTCAAGGTGAACCGCGCCGTGGCCG
GTTTTGGGGTGCCTCTGGGCGCGACCATGAACATGGGCGGTGTGTCCATTTACATTACTGTGGCGATTTTCTTTATCGCC
AACGCCTTTGGTATGCCTATCACCATGGAGCAATTGCCGGCGCTTATCTTCAGTATCTTCCTGCTTTCTGTGGGCGCCGG
TGGCGTACCCGGCGGCGGCATGGTGATGATTGGCGTGCTTATCCACCAGATGGGCTTGCCGGTGGAAGCCTTTGCGCTGG
TGGCCGCGCTGGATAGGCTTATCGATATGGTACTGACTTCCTGTAACGTGGTGGGTGACACCGCGGTGCTGACGATTGTC
GACCAAACAGAGCGCCCTCATCAGGTTGCCAGTGATGATGACTGA

Upstream 100 bases:

>100_bases
TCCATACATTTTCGTTGAAATTGCCGCTGGCATGTTTCACTATCCGGGAGCGAACGGGGCAGCAGACCCCAGACACAATA
ACAACACAGGCATGCAATCT

Downstream 100 bases:

>100_bases
GCTGTGATGGAGACAGTGAGCCGACGTTAAGTCGGCTTTTTGTTGTCACTCTAAAACCACCTCCTATGGAGGTGGTGATC
GTTCTAGTGGGGCTTTGCCC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MFKSLSARIFLGLAIGLLSGTLVQYVLHDINFFSGTLVEIASGLGTMFVNMIMMLVVPLVFVSIVCGVCELKDLSSFGRL
GGKTFGFYIINTLVAIFAALTVALLLEPGKGVDMTGGGELAITATELPSLMALVVDIVPRNPVAAFMSGNMLQVIFMALL
LGGVIKSLGEHVTGAVSAFQTANKIMMKLISVVMHLAPIGVGALMFKLGATLEAGVFLSVMEYLVLILGLLLLWIFVVYP
YAVQLFTPVKASVFREKTQEQILFSLSTASSNATIPVTMRTLTEKLKVNRAVAGFGVPLGATMNMGGVSIYITVAIFFIA
NAFGMPITMEQLPALIFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPVEAFALVAALDRLIDMVLTSCNVVGDTAVLTIV
DQTERPHQVASDDD

Sequences:

>Translated_414_residues
MFKSLSARIFLGLAIGLLSGTLVQYVLHDINFFSGTLVEIASGLGTMFVNMIMMLVVPLVFVSIVCGVCELKDLSSFGRL
GGKTFGFYIINTLVAIFAALTVALLLEPGKGVDMTGGGELAITATELPSLMALVVDIVPRNPVAAFMSGNMLQVIFMALL
LGGVIKSLGEHVTGAVSAFQTANKIMMKLISVVMHLAPIGVGALMFKLGATLEAGVFLSVMEYLVLILGLLLLWIFVVYP
YAVQLFTPVKASVFREKTQEQILFSLSTASSNATIPVTMRTLTEKLKVNRAVAGFGVPLGATMNMGGVSIYITVAIFFIA
NAFGMPITMEQLPALIFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPVEAFALVAALDRLIDMVLTSCNVVGDTAVLTIV
DQTERPHQVASDDD
>Mature_414_residues
MFKSLSARIFLGLAIGLLSGTLVQYVLHDINFFSGTLVEIASGLGTMFVNMIMMLVVPLVFVSIVCGVCELKDLSSFGRL
GGKTFGFYIINTLVAIFAALTVALLLEPGKGVDMTGGGELAITATELPSLMALVVDIVPRNPVAAFMSGNMLQVIFMALL
LGGVIKSLGEHVTGAVSAFQTANKIMMKLISVVMHLAPIGVGALMFKLGATLEAGVFLSVMEYLVLILGLLLLWIFVVYP
YAVQLFTPVKASVFREKTQEQILFSLSTASSNATIPVTMRTLTEKLKVNRAVAGFGVPLGATMNMGGVSIYITVAIFFIA
NAFGMPITMEQLPALIFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPVEAFALVAALDRLIDMVLTSCNVVGDTAVLTIV
DQTERPHQVASDDD

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=396, Percent_Identity=28.030303030303, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI40254478, Length=440, Percent_Identity=25.6818181818182, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI169790839, Length=425, Percent_Identity=25.6470588235294, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI5032093, Length=389, Percent_Identity=27.7634961439589, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI194239697, Length=249, Percent_Identity=30.1204819277108, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI66773030, Length=261, Percent_Identity=30.2681992337165, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI4827012, Length=241, Percent_Identity=31.5352697095436, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI223468566, Length=279, Percent_Identity=29.0322580645161, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI223468564, Length=270, Percent_Identity=28.8888888888889, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI262359914, Length=365, Percent_Identity=25.2054794520548, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI301601644, Length=122, Percent_Identity=35.2459016393443, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1790514, Length=414, Percent_Identity=28.5024154589372, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1789947, Length=426, Percent_Identity=27.4647887323944, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1788024, Length=433, Percent_Identity=29.0993071593533, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789473, Length=279, Percent_Identity=29.7491039426523, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71983106, Length=432, Percent_Identity=28.2407407407407, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71983099, Length=432, Percent_Identity=28.2407407407407, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17537407, Length=387, Percent_Identity=27.390180878553, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71996953, Length=427, Percent_Identity=26.6978922716628, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=457, Percent_Identity=24.945295404814, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=414, Percent_Identity=26.0869565217391, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=424, Percent_Identity=25, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24583025, Length=440, Percent_Identity=25.6818181818182, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137668, Length=440, Percent_Identity=25.6818181818182, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24583023, Length=440, Percent_Identity=25.6818181818182, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281360481, Length=305, Percent_Identity=27.5409836065574, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281360483, Length=305, Percent_Identity=27.5409836065574, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17137666, Length=305, Percent_Identity=27.5409836065574, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43795; Mature: 43795

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure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HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]