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The map label for this gene is 119773637

Identifier: 119773637

GI number: 119773637

Start: 611362

End: 612816

Strand: Direct

Name: 119773637

Synonym: Sama_0497

Alternate gene names: NA

Gene position: 611362-612816 (Clockwise)

Preceding gene: 119773636

Following gene: 119773638

Centisome position: 14.2

GC content: 55.95

Gene sequence:

>1455_bases
ATGAGTATGACCCTGACGTTTTGGGGAGCCACAGAGGAAGTCACAGGCTCCTGTCACTTGCTGGAACTCAACGGTAAACG
CCTGCTGCTGGATTGCGGCCTCCTGCAGGGAGGCAAGCAGCAGGAAGCCCGAAATCGCGAGCCCTTCCCCTTCGACCCCG
CAAGCCTGGATGCCGTGGTCTTATCCCATGCCCACATTGACCATTCAGGACGATTGCCTCTGCTGGTAAAGCAGGGTTTC
AGTGGTCCCATTTATACCCACAGCGCCACCCTCGACCTTTGCGCTATTCTCCTCAAAGATGCCGCCATGTTGCAGGGCCG
GGACACAGAGCGGCAAAACAAAAAGCGGTTGAAACAAGGTTTGGAACCCCTCGAAGCTCTCTTCGATGAGCAGGATGTGG
ATATTGCCATGACCCGCTTTATACCGCTGGAATACGGTATGCGGCTGGACCCTGTTCCGGGGGTGACCATCACCCTCAGG
GATGCCGGGCATATTTTGGGCTCGGCGCTGCTGGAGTTGGAGTTGGATGATGGCCAGCGGCAGAAGCGTCTGGTGTTTTC
AGGCGATCTGGGGCGAGCCGGAATGCCCATACTGAGGGATCCTGATTTGGTGGAGGCGGCCGATCTGGTGCTCATGGAAT
CCACCTATGGCAACCGTCTGCACCGCAGCTGGGAAGCGACACTGGAAGAGCTTAAAGGGATTTTTGCCAAGGCCATCAGC
GACAGCCGTGGCAATATCCTTATCCCGGCATTCTCGGTTGGCCGTGCGCAGGAGCTGCTGTATCTGTTTCATTTGAATGC
CAAAGACTGGGATCTGTCGCGCTGGACCATTTGCCTGGATAGCCCCATGGCCATTGAGGCTACCAAGGTGTATATACGCC
ACTTTCCCTTGATGGATGATGATTTCAAACGCTTTGTTCGCCAACACCCAGGAAAACACCCCTTGCTCACTGACGTGGCG
TTTATTCAAAGCACTGACGAATCCATTGCACTGAATGAAGTACATCAGGGGCTCATCATTATTGCAGGCAGTGGTATGTG
TAACGGCGGGCGTATTCGTTGCCATCTGGAACACAACCTCTACCGACCCGAATGCGACGTGATTATTTGCGGCTATCAGG
CCGAAGGCACACCGGGCAGGGCGCTGGTGGATGGGGTAGATAAGTTGACCATCAACGGACAATCCATTGATGTGCGTGCC
CGTATTCATACCGTGGGCGGTCTGTCGGCCCACGCGGATCAGGCCGAGCTGCTGCGCTGGTATCATCACTTCGAGGGACG
GCCGCCGCTGGTGCTGGTGCATGGTGAAAAAGAAGCCCAGGAAATTTTAATGGCCACCCTTGAGAATGAGCCCGAACCGC
CCAAGGCAATCAGCGCGGCCAGTTATGGCGATCATCTGGATCTGGCTGCTTTACCACGGCTCAGCTGGTTGTATCAGGGC
AAAACCCCCGGCTGA

Upstream 100 bases:

>100_bases
AGTACCACTTCATATCTTTAAACATAAAACTTTTTGAGTTTTATACGCTTTTTCGGCAATCTGCTTATGTACTTACAGCG
TGATTGCAGGAGGCAATGCC

Downstream 100 bases:

>100_bases
TAGTGCTGGAGTTGTCTCTGTGCTTGCTGCATCATTGGCGCTTTCCTCCGTGGAGAGCGTGAAGTGGATGCAGCATCGTT
CCGGGCCGGTTTTATTTATG

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSMTLTFWGATEEVTGSCHLLELNGKRLLLDCGLLQGGKQQEARNREPFPFDPASLDAVVLSHAHIDHSGRLPLLVKQGF
SGPIYTHSATLDLCAILLKDAAMLQGRDTERQNKKRLKQGLEPLEALFDEQDVDIAMTRFIPLEYGMRLDPVPGVTITLR
DAGHILGSALLELELDDGQRQKRLVFSGDLGRAGMPILRDPDLVEAADLVLMESTYGNRLHRSWEATLEELKGIFAKAIS
DSRGNILIPAFSVGRAQELLYLFHLNAKDWDLSRWTICLDSPMAIEATKVYIRHFPLMDDDFKRFVRQHPGKHPLLTDVA
FIQSTDESIALNEVHQGLIIIAGSGMCNGGRIRCHLEHNLYRPECDVIICGYQAEGTPGRALVDGVDKLTINGQSIDVRA
RIHTVGGLSAHADQAELLRWYHHFEGRPPLVLVHGEKEAQEILMATLENEPEPPKAISAASYGDHLDLAALPRLSWLYQG
KTPG

Sequences:

>Translated_484_residues
MSMTLTFWGATEEVTGSCHLLELNGKRLLLDCGLLQGGKQQEARNREPFPFDPASLDAVVLSHAHIDHSGRLPLLVKQGF
SGPIYTHSATLDLCAILLKDAAMLQGRDTERQNKKRLKQGLEPLEALFDEQDVDIAMTRFIPLEYGMRLDPVPGVTITLR
DAGHILGSALLELELDDGQRQKRLVFSGDLGRAGMPILRDPDLVEAADLVLMESTYGNRLHRSWEATLEELKGIFAKAIS
DSRGNILIPAFSVGRAQELLYLFHLNAKDWDLSRWTICLDSPMAIEATKVYIRHFPLMDDDFKRFVRQHPGKHPLLTDVA
FIQSTDESIALNEVHQGLIIIAGSGMCNGGRIRCHLEHNLYRPECDVIICGYQAEGTPGRALVDGVDKLTINGQSIDVRA
RIHTVGGLSAHADQAELLRWYHHFEGRPPLVLVHGEKEAQEILMATLENEPEPPKAISAASYGDHLDLAALPRLSWLYQG
KTPG
>Mature_483_residues
SMTLTFWGATEEVTGSCHLLELNGKRLLLDCGLLQGGKQQEARNREPFPFDPASLDAVVLSHAHIDHSGRLPLLVKQGFS
GPIYTHSATLDLCAILLKDAAMLQGRDTERQNKKRLKQGLEPLEALFDEQDVDIAMTRFIPLEYGMRLDPVPGVTITLRD
AGHILGSALLELELDDGQRQKRLVFSGDLGRAGMPILRDPDLVEAADLVLMESTYGNRLHRSWEATLEELKGIFAKAISD
SRGNILIPAFSVGRAQELLYLFHLNAKDWDLSRWTICLDSPMAIEATKVYIRHFPLMDDDFKRFVRQHPGKHPLLTDVAF
IQSTDESIALNEVHQGLIIIAGSGMCNGGRIRCHLEHNLYRPECDVIICGYQAEGTPGRALVDGVDKLTINGQSIDVRAR
IHTVGGLSAHADQAELLRWYHHFEGRPPLVLVHGEKEAQEILMATLENEPEPPKAISAASYGDHLDLAALPRLSWLYQGK
TPG

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=462, Percent_Identity=27.0562770562771, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33300633, Length=466, Percent_Identity=25.5364806866953, Blast_Score=124, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32566029, Length=464, Percent_Identity=26.9396551724138, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI32564696, Length=483, Percent_Identity=24.8447204968944, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323307, Length=453, Percent_Identity=24.7240618101545, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24648013, Length=473, Percent_Identity=27.4841437632135, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21358523, Length=466, Percent_Identity=25.5364806866953, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 53737; Mature: 53606

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMTLTFWGATEEVTGSCHLLELNGKRLLLDCGLLQGGKQQEARNREPFPFDPASLDAVV
CCEEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCHHHEE
LSHAHIDHSGRLPLLVKQGFSGPIYTHSATLDLCAILLKDAAMLQGRDTERQNKKRLKQG
EEHHCCCCCCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
LEPLEALFDEQDVDIAMTRFIPLEYGMRLDPVPGVTITLRDAGHILGSALLELELDDGQR
CHHHHHHHCCCCCCEEEEEEEEHHCCCEECCCCCCEEEECCCHHHHEEEEEEEEECCCCC
QKRLVFSGDLGRAGMPILRDPDLVEAADLVLMESTYGNRLHRSWEATLEELKGIFAKAIS
CEEEEEECCCCCCCCCCCCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
DSRGNILIPAFSVGRAQELLYLFHLNAKDWDLSRWTICLDSPMAIEATKVYIRHFPLMDD
CCCCCEEEEECCCCCHHEEEEEEEECCCCCCCCEEEEEECCCCEEHHEEEEEEECCCCCH
DFKRFVRQHPGKHPLLTDVAFIQSTDESIALNEVHQGLIIIAGSGMCNGGRIRCHLEHNL
HHHHHHHHCCCCCCCHHHHHHHCCCCCCEEHHHHCCCEEEEECCCCCCCCEEEEEEECCC
YRPECDVIICGYQAEGTPGRALVDGVDKLTINGQSIDVRARIHTVGGLSAHADQAELLRW
CCCCCCEEEEEEECCCCCCCHHHCCCEEEEECCCEEEEEEEEEEECCCCCCCCHHHHHHH
YHHFEGRPPLVLVHGEKEAQEILMATLENEPEPPKAISAASYGDHLDLAALPRLSWLYQG
HHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHCCCCCEEECC
KTPG
CCCC
>Mature Secondary Structure 
SMTLTFWGATEEVTGSCHLLELNGKRLLLDCGLLQGGKQQEARNREPFPFDPASLDAVV
CEEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCHHHEE
LSHAHIDHSGRLPLLVKQGFSGPIYTHSATLDLCAILLKDAAMLQGRDTERQNKKRLKQG
EEHHCCCCCCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
LEPLEALFDEQDVDIAMTRFIPLEYGMRLDPVPGVTITLRDAGHILGSALLELELDDGQR
CHHHHHHHCCCCCCEEEEEEEEHHCCCEECCCCCCEEEECCCHHHHEEEEEEEEECCCCC
QKRLVFSGDLGRAGMPILRDPDLVEAADLVLMESTYGNRLHRSWEATLEELKGIFAKAIS
CEEEEEECCCCCCCCCCCCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
DSRGNILIPAFSVGRAQELLYLFHLNAKDWDLSRWTICLDSPMAIEATKVYIRHFPLMDD
CCCCCEEEEECCCCCHHEEEEEEEECCCCCCCCEEEEEECCCCEEHHEEEEEEECCCCCH
DFKRFVRQHPGKHPLLTDVAFIQSTDESIALNEVHQGLIIIAGSGMCNGGRIRCHLEHNL
HHHHHHHHCCCCCCCHHHHHHHCCCCCCEEHHHHCCCEEEEECCCCCCCCEEEEEEECCC
YRPECDVIICGYQAEGTPGRALVDGVDKLTINGQSIDVRARIHTVGGLSAHADQAELLRW
CCCCCCEEEEEEECCCCCCCHHHCCCEEEEECCCEEEEEEEEEEECCCCCCCCHHHHHHH
YHHFEGRPPLVLVHGEKEAQEILMATLENEPEPPKAISAASYGDHLDLAALPRLSWLYQG
HHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHCCCCCEEECC
KTPG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA