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The map label for this gene is coaBC [H]

Identifier: 119773467

GI number: 119773467

Start: 393131

End: 394384

Strand: Reverse

Name: coaBC [H]

Synonym: Sama_0326

Alternate gene names: 119773467

Gene position: 394384-393131 (Counterclockwise)

Preceding gene: 119773473

Following gene: 119773466

Centisome position: 9.16

GC content: 55.5

Gene sequence:

>1254_bases
ATGGTATGGTTAGCGCCAGTTAATTTTAGTCGGGATCTGCGTGTGAGCCTGAATAATCGAAAAATCCTGCTGGGGATTGG
TGGCGGCATTGCTGCCTACAAGAGCGCCGATTTGGTGCGCCGTCTGAAAGAACAAGGGGCCGATGTGCGCGTGGTGATGA
GCCAGAGCGCCTGCGAATTTATCACCCCACTGACACTGCAGGCCCTCAGCGGTTATCCGGTCAGCATGGATTTGCTCGAC
CCCGCTGCCGAAGCCGCCATGGGGCACATTGAATTGGCCCGCTGGGCAGAACTGATTATTCTGGCTCCGGCCACTGCCAA
TCTGATTGCCCGCATGAGCATAGGGATGGCGGATGAACTTATTACCACCACCTGCCTTGCCACCTCGGCGCCCATCGCCA
TTTGCCCGGCAATGAATCAGCAGATGTATGCCAACCCTGCAACCCAGGCCAATTTAAGCACACTGCAGCAACGTGGCATG
CTGATTTGGGGCCCGGGCAGCGGTAGTCAGGCCTGCGGCGAAGTCGGTGCAGGCCGTATGTTGGAGCCGCTGGAAATCCG
CACTCTGGCAGAACAATTTTTTGCTCAAAAGGCTCAGGCAAGCAGCGCGCTGCAGGGCGTCAAACTCATGCTGACCGCTG
GCCCCACCCGCGAAGCCATAGATCCTGTGCGTTATATTTCCAACCACAGCTCCGGCAAAATGGGCTTTGCCCTTGCCGAG
GCCGCTGTGGCCATGGGCGCAGAAGTGACTCTGGTATCAGGTCCTGTGACCCTGGCCACGCCAAGAGGCGTGAGCCGCAT
CAATGTGGACTCGGCCGAACAAATGTTGACCGCTGTAATGCAACATATTGACCAGCAAGATATCTTCATTGGCTGTGCTG
CCGTGGCTGATTATCGGGTTGCCGATGTCGCTGCCGGTAAAATTAAAAAGAGCAGCGAAACCATGCAGCTTGCGCTGGTG
CGCAATCCTGATATCTTAGCCACGGTTGCCGCCCTAGAGGCGCGACCTTTTACGGTGGGATTTGCCGCCGAAACCCACGA
CGTAGAAACCTACGCCCGAGATAAACTCAAACGCAAAAATCTCGATATGATCGCGGCCAATGATGTGTCTGTGCCGGGTC
AGGGGTTTAATTCGGATACCAATGCTCTGCGCGTCTTTTGGCCTCAGGGCAACCAGGATTTGCCGGCAACCGACAAGTTG
TCACTGGCATACCAACTGCTTTCGCTGATATCGACAAAAATAACCAAAAAATGA

Upstream 100 bases:

>100_bases
CAGTCCCGAATTGCCATCCCTTGCCTCCCGTGTCCCGTCTTTAGGTACCGCTTGCATGTTAAGATTTTGACTTTGGCCGC
TCACTCTTGGGGCGGCGTCT

Downstream 100 bases:

>100_bases
AGACACCGATCGAACTGAAAATTCTCGACTCCCGCATAGGCTCGGAATTCCCACTGCCGGCCTATGCCACGCCTGGCAGT
GCCGGCATGGACCTTAGAGC

Product: phosphopantothenoylcysteine decarboxylase., phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MVWLAPVNFSRDLRVSLNNRKILLGIGGGIAAYKSADLVRRLKEQGADVRVVMSQSACEFITPLTLQALSGYPVSMDLLD
PAAEAAMGHIELARWAELIILAPATANLIARMSIGMADELITTTCLATSAPIAICPAMNQQMYANPATQANLSTLQQRGM
LIWGPGSGSQACGEVGAGRMLEPLEIRTLAEQFFAQKAQASSALQGVKLMLTAGPTREAIDPVRYISNHSSGKMGFALAE
AAVAMGAEVTLVSGPVTLATPRGVSRINVDSAEQMLTAVMQHIDQQDIFIGCAAVADYRVADVAAGKIKKSSETMQLALV
RNPDILATVAALEARPFTVGFAAETHDVETYARDKLKRKNLDMIAANDVSVPGQGFNSDTNALRVFWPQGNQDLPATDKL
SLAYQLLSLISTKITKK

Sequences:

>Translated_417_residues
MVWLAPVNFSRDLRVSLNNRKILLGIGGGIAAYKSADLVRRLKEQGADVRVVMSQSACEFITPLTLQALSGYPVSMDLLD
PAAEAAMGHIELARWAELIILAPATANLIARMSIGMADELITTTCLATSAPIAICPAMNQQMYANPATQANLSTLQQRGM
LIWGPGSGSQACGEVGAGRMLEPLEIRTLAEQFFAQKAQASSALQGVKLMLTAGPTREAIDPVRYISNHSSGKMGFALAE
AAVAMGAEVTLVSGPVTLATPRGVSRINVDSAEQMLTAVMQHIDQQDIFIGCAAVADYRVADVAAGKIKKSSETMQLALV
RNPDILATVAALEARPFTVGFAAETHDVETYARDKLKRKNLDMIAANDVSVPGQGFNSDTNALRVFWPQGNQDLPATDKL
SLAYQLLSLISTKITKK
>Mature_417_residues
MVWLAPVNFSRDLRVSLNNRKILLGIGGGIAAYKSADLVRRLKEQGADVRVVMSQSACEFITPLTLQALSGYPVSMDLLD
PAAEAAMGHIELARWAELIILAPATANLIARMSIGMADELITTTCLATSAPIAICPAMNQQMYANPATQANLSTLQQRGM
LIWGPGSGSQACGEVGAGRMLEPLEIRTLAEQFFAQKAQASSALQGVKLMLTAGPTREAIDPVRYISNHSSGKMGFALAE
AAVAMGAEVTLVSGPVTLATPRGVSRINVDSAEQMLTAVMQHIDQQDIFIGCAAVADYRVADVAAGKIKKSSETMQLALV
RNPDILATVAALEARPFTVGFAAETHDVETYARDKLKRKNLDMIAANDVSVPGQGFNSDTNALRVFWPQGNQDLPATDKL
SLAYQLLSLISTKITKK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=176, Percent_Identity=32.3863636363636, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87082301, Length=407, Percent_Identity=60.6879606879607, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322762, Length=102, Percent_Identity=36.2745098039216, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24657262, Length=173, Percent_Identity=26.5895953757225, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44471; Mature: 44471

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWLAPVNFSRDLRVSLNNRKILLGIGGGIAAYKSADLVRRLKEQGADVRVVMSQSACEF
CEEEEECCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHH
ITPLTLQALSGYPVSMDLLDPAAEAAMGHIELARWAELIILAPATANLIARMSIGMADEL
HCHHHHHHHCCCCEEEHHCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCHHHH
ITTTCLATSAPIAICPAMNQQMYANPATQANLSTLQQRGMLIWGPGSGSQACGEVGAGRM
HHHHHHHCCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCEEEEECCCCCHHHHHCCCCCC
LEPLEIRTLAEQFFAQKAQASSALQGVKLMLTAGPTREAIDPVRYISNHSSGKMGFALAE
CCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHH
AAVAMGAEVTLVSGPVTLATPRGVSRINVDSAEQMLTAVMQHIDQQDIFIGCAAVADYRV
HHHHCCCEEEEEECCEEEECCCCCCEECCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCHH
ADVAAGKIKKSSETMQLALVRNPDILATVAALEARPFTVGFAAETHDVETYARDKLKRKN
HHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCC
LDMIAANDVSVPGQGFNSDTNALRVFWPQGNQDLPATDKLSLAYQLLSLISTKITKK
CCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVWLAPVNFSRDLRVSLNNRKILLGIGGGIAAYKSADLVRRLKEQGADVRVVMSQSACEF
CEEEEECCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHH
ITPLTLQALSGYPVSMDLLDPAAEAAMGHIELARWAELIILAPATANLIARMSIGMADEL
HCHHHHHHHCCCCEEEHHCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCHHHH
ITTTCLATSAPIAICPAMNQQMYANPATQANLSTLQQRGMLIWGPGSGSQACGEVGAGRM
HHHHHHHCCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCEEEEECCCCCHHHHHCCCCCC
LEPLEIRTLAEQFFAQKAQASSALQGVKLMLTAGPTREAIDPVRYISNHSSGKMGFALAE
CCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHH
AAVAMGAEVTLVSGPVTLATPRGVSRINVDSAEQMLTAVMQHIDQQDIFIGCAAVADYRV
HHHHCCCEEEEEECCEEEECCCCCCEECCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCHH
ADVAAGKIKKSSETMQLALVRNPDILATVAALEARPFTVGFAAETHDVETYARDKLKRKN
HHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCC
LDMIAANDVSVPGQGFNSDTNALRVFWPQGNQDLPATDKLSLAYQLLSLISTKITKK
CCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA