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The map label for this gene is aroE [H]

Identifier: 119773194

GI number: 119773194

Start: 54060

End: 54896

Strand: Direct

Name: aroE [H]

Synonym: Sama_0052

Alternate gene names: 119773194

Gene position: 54060-54896 (Clockwise)

Preceding gene: 119773192

Following gene: 119773195

Centisome position: 1.26

GC content: 52.45

Gene sequence:

>837_bases
ATGATTTGTTTATCCATGACAGACAGATTCGCCGTATTTGGTAATCCCATAAGCCACAGTAAGTCGCCACAAATTCATGC
CATGTTTGCCAAAGAAACAGGGCAGACCCTCACTTATGAGGCAATTCTGGCGCCACTGGATGGCTTTGCCGAAGCCGTGA
CTGCGTTTATGGCAGCAGGCGGATGTGGGGCGAATGTGACCGTGCCTTTTAAAGAGCAGGCCTTTACTCTGTGCGATGAG
CTCAGTGATGACGCCCGCATTGCAGGTGCGGTCAATACCTTGATAAAGCTGCCGGATGGACGCCTTCGGGGTGACAACAC
CGACGGCATGGGGCTGGTGGCGGATTTAATCCGGCATGGTGTTGAGTTAAATAATAAGCGAGTGCTTTTGGTGGGTGCCG
GTGGTGCTGCCCGCGGTGCGTTATTGCCGCTCGTTCGTGCGGGTGCCAAGCTGACCATCAGCAACCGCACCTTGAGCAAA
GCTGAGGCCCTGGCAGCATTGTGTCCTAAGGTTAATGTCGAGGTTATTTCAGGCAGTCATATCCGTAGCCCCTTTGATGT
GATTATTAATTCAACATCTGCGAGCCTCAGCGGTGACCTGCCAGTAATAGCTGCTAACGCCATCGACAATCAGACCGTGT
GCTATGACATGATGTATGGTGCCAAACCGACAGTCTTTAATGAGTGGGCCCGGTCTTTAGGTGCCAAAATCTGTATCGAT
GGCTTGGGTATGTTGGTTGGCCAGGCTGCAGAAAGCTTTTATTTGTGGCGCAGGGTAAGACCCAATGCAGCGCCCGTGCT
GCAAACCCTGCGGCAGAGTCTTATTTCAGGAGTGTGA

Upstream 100 bases:

>100_bases
TACATCAGCGCTGCTTTTTATTGTGCGCCTGAAAATTCCTGCGCATGGCGCCATTGCCGTAACCAAAAGGGCGAGGGTAG
ACTGAAGCCAACCCTCTTAG

Downstream 100 bases:

>100_bases
CTATGAACCAAAGCGTTATCTTTGCCGATGCGATTTCCATCGATGGCAAGAAGCAGCAGCTGATGCTGGTGGCCCATCAG
CAGGGGATGCGTATCGAATG

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MICLSMTDRFAVFGNPISHSKSPQIHAMFAKETGQTLTYEAILAPLDGFAEAVTAFMAAGGCGANVTVPFKEQAFTLCDE
LSDDARIAGAVNTLIKLPDGRLRGDNTDGMGLVADLIRHGVELNNKRVLLVGAGGAARGALLPLVRAGAKLTISNRTLSK
AEALAALCPKVNVEVISGSHIRSPFDVIINSTSASLSGDLPVIAANAIDNQTVCYDMMYGAKPTVFNEWARSLGAKICID
GLGMLVGQAAESFYLWRRVRPNAAPVLQTLRQSLISGV

Sequences:

>Translated_278_residues
MICLSMTDRFAVFGNPISHSKSPQIHAMFAKETGQTLTYEAILAPLDGFAEAVTAFMAAGGCGANVTVPFKEQAFTLCDE
LSDDARIAGAVNTLIKLPDGRLRGDNTDGMGLVADLIRHGVELNNKRVLLVGAGGAARGALLPLVRAGAKLTISNRTLSK
AEALAALCPKVNVEVISGSHIRSPFDVIINSTSASLSGDLPVIAANAIDNQTVCYDMMYGAKPTVFNEWARSLGAKICID
GLGMLVGQAAESFYLWRRVRPNAAPVLQTLRQSLISGV
>Mature_278_residues
MICLSMTDRFAVFGNPISHSKSPQIHAMFAKETGQTLTYEAILAPLDGFAEAVTAFMAAGGCGANVTVPFKEQAFTLCDE
LSDDARIAGAVNTLIKLPDGRLRGDNTDGMGLVADLIRHGVELNNKRVLLVGAGGAARGALLPLVRAGAKLTISNRTLSK
AEALAALCPKVNVEVISGSHIRSPFDVIINSTSASLSGDLPVIAANAIDNQTVCYDMMYGAKPTVFNEWARSLGAKICID
GLGMLVGQAAESFYLWRRVRPNAAPVLQTLRQSLISGV

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=269, Percent_Identity=49.4423791821561, Blast_Score=258, Evalue=3e-70,
Organism=Escherichia coli, GI1787983, Length=279, Percent_Identity=28.3154121863799, Blast_Score=94, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320332, Length=170, Percent_Identity=38.8235294117647, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29345; Mature: 29345

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICLSMTDRFAVFGNPISHSKSPQIHAMFAKETGQTLTYEAILAPLDGFAEAVTAFMAAG
CEEEEECCCEEEECCCCCCCCCCCEEEEEECCCCCEEEHHHHHHCHHHHHHHHHHHHHCC
GCGANVTVPFKEQAFTLCDELSDDARIAGAVNTLIKLPDGRLRGDNTDGMGLVADLIRHG
CCCCCEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCC
VELNNKRVLLVGAGGAARGALLPLVRAGAKLTISNRTLSKAEALAALCPKVNVEVISGSH
CCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCEEEEECCCC
IRSPFDVIINSTSASLSGDLPVIAANAIDNQTVCYDMMYGAKPTVFNEWARSLGAKICID
CCCCHHEEEECCCCCCCCCCCEEEECCCCCCEEEEEHHHCCCCHHHHHHHHHCCCEEHHH
GLGMLVGQAAESFYLWRRVRPNAAPVLQTLRQSLISGV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MICLSMTDRFAVFGNPISHSKSPQIHAMFAKETGQTLTYEAILAPLDGFAEAVTAFMAAG
CEEEEECCCEEEECCCCCCCCCCCEEEEEECCCCCEEEHHHHHHCHHHHHHHHHHHHHCC
GCGANVTVPFKEQAFTLCDELSDDARIAGAVNTLIKLPDGRLRGDNTDGMGLVADLIRHG
CCCCCEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCC
VELNNKRVLLVGAGGAARGALLPLVRAGAKLTISNRTLSKAEALAALCPKVNVEVISGSH
CCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCEEEEECCCC
IRSPFDVIINSTSASLSGDLPVIAANAIDNQTVCYDMMYGAKPTVFNEWARSLGAKICID
CCCCHHEEEECCCCCCCCCCCEEEECCCCCCEEEEEHHHCCCCHHHHHHHHHCCCEEHHH
GLGMLVGQAAESFYLWRRVRPNAAPVLQTLRQSLISGV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA