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The map label for this gene is hemF

Identifier: 119773192

GI number: 119773192

Start: 52537

End: 53451

Strand: Direct

Name: hemF

Synonym: Sama_0050

Alternate gene names: 119773192

Gene position: 52537-53451 (Clockwise)

Preceding gene: 119773191

Following gene: 119773194

Centisome position: 1.22

GC content: 55.52

Gene sequence:

>915_bases
ATGGGACTTCCCAACGCCGAAGAGGTAAAAGCGTTTTTAATGCAGCTGCAGGCTAACATCTGCGCTGGCCTGGAAAGGCT
GGATGGTCAGGCGAGCTTTGCCACCGACAGCTGGCAGCGTGCCGAAGGCGGCGGTGGTATCAGTCGTGTGCTGACCGATG
GCGCTGTATTTGAACAGGCCGGGGTGAACTTCTCCCATGTGATGGGCGCCTCCATGCCCGCATCTGCCACGGCACACAGA
CCCGAACTGGCGGGCCGCAGCTTTGAGGCGATGGGGGTTTCTTTGGTAATCCACCCCAAAAACCCTTATATCCCAACCAC
CCACGCCAACGTCCGCTTCTTTATTGCCCGTAAAGAAGGTGCCGACCCTGTGTGGTGGTTCGGCGGTGGCTTCGATTTAA
CCCCTTACTATCCGTTCGAGTCAGACGTTAAAGAGTGGCACCAGAGTGCCAAGGATCTCTGTGCGCCTTTCGGTAATGAG
GTTTACCCCAAGTACAAAGAATGGTGCGACAAATACTTCTTCCTGCCGCATCGCGGTGAAACCCGAGGTGTGGGTGGTCT
GTTCTTCGATGATCTCAATCATTGGGAATTTGATAAGTGCTTTGACTATATGCAAGCGGTGGGGAATGGCTTCCTCACGG
CCTATGCACCTATCGTTGAGCGTCGTAAAGACACGGCGTATGGCGAGCGTGAGCGTGATTTCCAGCTTTATCGCCGCGGC
CGCTATGTGGAATTTAACCTGGTGTATGACCGTGGCACCTTGTTCGGCCTGCAAACCGGTGGTCGCACTGAATCAATTCT
GATGTCGATGCCACCGCTGGTGCGTTGGCAGTATGCCTATAGTCCTGAAGCCGGGACGCCTGAGGCTGAGCTGTACGAGC
GTTTCCTCAAGCCCCAGGACTGGCTGGCTGATTAA

Upstream 100 bases:

>100_bases
GCCGTGGTGTTGGGAGCGCTGGGGCAATCTTGTCAGCCATCCACCATTATCGATATTCAAACCGGACATATTTTCAGACA
AGGATAAGAAGGAAAACAGC

Downstream 100 bases:

>100_bases
TGATCAAGGGCCATTTAATAATGGCCTATTGATTACGCATGTGGTCTGCCAGGGTGGCAATAGCCTGGTAGATCACCTCG
CGGTGCTGTTCATTTGCTAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MGLPNAEEVKAFLMQLQANICAGLERLDGQASFATDSWQRAEGGGGISRVLTDGAVFEQAGVNFSHVMGASMPASATAHR
PELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIARKEGADPVWWFGGGFDLTPYYPFESDVKEWHQSAKDLCAPFGNE
VYPKYKEWCDKYFFLPHRGETRGVGGLFFDDLNHWEFDKCFDYMQAVGNGFLTAYAPIVERRKDTAYGERERDFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYSPEAGTPEAELYERFLKPQDWLAD

Sequences:

>Translated_304_residues
MGLPNAEEVKAFLMQLQANICAGLERLDGQASFATDSWQRAEGGGGISRVLTDGAVFEQAGVNFSHVMGASMPASATAHR
PELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIARKEGADPVWWFGGGFDLTPYYPFESDVKEWHQSAKDLCAPFGNE
VYPKYKEWCDKYFFLPHRGETRGVGGLFFDDLNHWEFDKCFDYMQAVGNGFLTAYAPIVERRKDTAYGERERDFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYSPEAGTPEAELYERFLKPQDWLAD
>Mature_303_residues
GLPNAEEVKAFLMQLQANICAGLERLDGQASFATDSWQRAEGGGGISRVLTDGAVFEQAGVNFSHVMGASMPASATAHRP
ELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIARKEGADPVWWFGGGFDLTPYYPFESDVKEWHQSAKDLCAPFGNEV
YPKYKEWCDKYFFLPHRGETRGVGGLFFDDLNHWEFDKCFDYMQAVGNGFLTAYAPIVERRKDTAYGERERDFQLYRRGR
YVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYSPEAGTPEAELYERFLKPQDWLAD

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Homo sapiens, GI41393599, Length=303, Percent_Identity=45.5445544554455, Blast_Score=287, Evalue=9e-78,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=73.2441471571906, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=44.0625, Blast_Score=270, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17864388, Length=303, Percent_Identity=45.8745874587459, Blast_Score=282, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM6_SHEAM (A1S1K6)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_925932.1
- STRING:   A1S1K6
- GeneID:   4602307
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0050
- NMPDR:   fig|326297.7.peg.46
- eggNOG:   COG0408
- HOGENOM:   HBG631180
- OMA:   HMNTRFV
- PhylomeDB:   A1S1K6
- ProtClustDB:   PRK05330
- GO:   GO:0005737
- HAMAP:   MF_00333
- InterPro:   IPR001260
- InterPro:   IPR018375
- Gene3D:   G3DSA:3.40.1500.10
- PANTHER:   PTHR10755
- PIRSF:   PIRSF000166
- PRINTS:   PR00073

Pfam domain/function: PF01218 Coprogen_oxidas; SSF102886 Coprogen_oxidas

EC number: =1.3.3.3

Molecular weight: Translated: 34488; Mature: 34357

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: ACT_SITE 108-108 BINDING 94-94

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLPNAEEVKAFLMQLQANICAGLERLDGQASFATDSWQRAEGGGGISRVLTDGAVFEQA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHCCHHHHHH
GVNFSHVMGASMPASATAHRPELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIARKEG
CCCHHHHHCCCCCCCCCCCCCHHCCCCEECCCEEEEEECCCCCCCCCCCCEEEEEEECCC
ADPVWWFGGGFDLTPYYPFESDVKEWHQSAKDLCAPFGNEVYPKYKEWCDKYFFLPHRGE
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCC
TRGVGGLFFDDLNHWEFDKCFDYMQAVGNGFLTAYAPIVERRKDTAYGERERDFQLYRRG
CCCCCCHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYSPEAGTPEAELYERFLKPQD
CEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCH
WLAD
HCCC
>Mature Secondary Structure 
GLPNAEEVKAFLMQLQANICAGLERLDGQASFATDSWQRAEGGGGISRVLTDGAVFEQA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHCCHHHHHH
GVNFSHVMGASMPASATAHRPELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIARKEG
CCCHHHHHCCCCCCCCCCCCCHHCCCCEECCCEEEEEECCCCCCCCCCCCEEEEEEECCC
ADPVWWFGGGFDLTPYYPFESDVKEWHQSAKDLCAPFGNEVYPKYKEWCDKYFFLPHRGE
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCC
TRGVGGLFFDDLNHWEFDKCFDYMQAVGNGFLTAYAPIVERRKDTAYGERERDFQLYRRG
CCCCCCHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYSPEAGTPEAELYERFLKPQD
CEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCH
WLAD
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA