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The map label for this gene is fmt

Identifier: 119773184

GI number: 119773184

Start: 46088

End: 47050

Strand: Reverse

Name: fmt

Synonym: Sama_0042

Alternate gene names: 119773184

Gene position: 47050-46088 (Counterclockwise)

Preceding gene: 119773185

Following gene: 119773183

Centisome position: 1.09

GC content: 58.15

Gene sequence:

>963_bases
TTGAAGCCACTGAAAATCATCTTTGCTGGCACGCCGGATTTTGCTGCCCGCCACCTGCAGGCCCTGCTGACATCTGAGCA
TGAAGTCATAGCCGTCTACACCCAACCCGACCGTCCCGCCGGACGGGGGCAAAAACTCACACCCAGCCCGGTGAAGTCAC
TGGCGCTTGAACACCAGATCCCTGTTTATCAGCCTAAATCTCTTCGCAAAGAAGAAGCGCAGCAGGAACTGGCGGCCCTC
GGTGCCGACATCATGGTGGTGGTGGCCTATGGCCTGATCCTGCCCAAGGTGGTGCTGGATACTCCACGCCTCGGCTGCAT
CAATGTTCACGGCTCCATTCTGCCGCGCTGGCGCGGCGCGGCACCAATTCAACGCGCCCTGTGGGCCGGTGACACCGAGA
CCGGAGTCACCATCATGCAAATGGATGTGGGTCTGGATACCGGCGATATGCTGCTGAAAACCCATCTACCCATCGAAGAT
GACGACACCTCCGCCAGCCTGTATGAAAAACTGGCCGGTCAAGGCCCGGCGGCACTGTTGGACGCCCTCGCCGCCCTCAG
TGAAGGCACCTTGAGCGCCGAAAAGCAGGACGAAGCACTGGCCAACTATGCTGAGAAGCTCAGCAAAGAAGAGGCACGTC
TCGATTTTGCCAAGCCCGCCAAAAATCTGTGGCAGGAAGTACGTGCCTTTAACCCCTGGCCGGTGAGCTATTTTGAGCAT
CAGGGACAGACCATCAAGGTATGGCAGACAAGTGTGCTGGCTGAACCCAGCACCAAGGCGTCCGGCACCATAGTTGCCGC
AGGTAAACAAGGCATAGACATCGCTACTGCCGATGGCATGCTGCGCATTCATAAAATGCAGCTGCCCGGTAAAAAGCCGA
TGGACGTGGCCGACATCCTCAATAGCCGTGGTGACTGGTTCACTCCCGGCACCCTGCTGGCAAGCCCAGAGGCAAGTGAG
TAA

Upstream 100 bases:

>100_bases
CAAGCTCTTTGTTGACTATCTTTCTCCCCTGAAGCGTCAGCGTATTCGCCAAAAGCTGGAAAAAGCCGCCCGTAACGACA
AATAAGATTCAGGAATCGTT

Downstream 100 bases:

>100_bases
TGAATATCCGAGCCCTCGCCGCCAAGGCGATTTTCGATGTGCTGGAGCGTGGCGTGTCTCTGTCGGTGGCTTTGCCTACC
CAGCAACTTTGGCTTCGTGA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKPLKIIFAGTPDFAARHLQALLTSEHEVIAVYTQPDRPAGRGQKLTPSPVKSLALEHQIPVYQPKSLRKEEAQQELAAL
GADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGAAPIQRALWAGDTETGVTIMQMDVGLDTGDMLLKTHLPIED
DDTSASLYEKLAGQGPAALLDALAALSEGTLSAEKQDEALANYAEKLSKEEARLDFAKPAKNLWQEVRAFNPWPVSYFEH
QGQTIKVWQTSVLAEPSTKASGTIVAAGKQGIDIATADGMLRIHKMQLPGKKPMDVADILNSRGDWFTPGTLLASPEASE

Sequences:

>Translated_320_residues
MKPLKIIFAGTPDFAARHLQALLTSEHEVIAVYTQPDRPAGRGQKLTPSPVKSLALEHQIPVYQPKSLRKEEAQQELAAL
GADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGAAPIQRALWAGDTETGVTIMQMDVGLDTGDMLLKTHLPIED
DDTSASLYEKLAGQGPAALLDALAALSEGTLSAEKQDEALANYAEKLSKEEARLDFAKPAKNLWQEVRAFNPWPVSYFEH
QGQTIKVWQTSVLAEPSTKASGTIVAAGKQGIDIATADGMLRIHKMQLPGKKPMDVADILNSRGDWFTPGTLLASPEASE
>Mature_320_residues
MKPLKIIFAGTPDFAARHLQALLTSEHEVIAVYTQPDRPAGRGQKLTPSPVKSLALEHQIPVYQPKSLRKEEAQQELAAL
GADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGAAPIQRALWAGDTETGVTIMQMDVGLDTGDMLLKTHLPIED
DDTSASLYEKLAGQGPAALLDALAALSEGTLSAEKQDEALANYAEKLSKEEARLDFAKPAKNLWQEVRAFNPWPVSYFEH
QGQTIKVWQTSVLAEPSTKASGTIVAAGKQGIDIATADGMLRIHKMQLPGKKPMDVADILNSRGDWFTPGTLLASPEASE

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=306, Percent_Identity=27.7777777777778, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI238814322, Length=251, Percent_Identity=28.6852589641434, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI164663775, Length=319, Percent_Identity=29.7805642633229, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=64.1935483870968, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1788589, Length=281, Percent_Identity=29.8932384341637, Blast_Score=128, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI133930964, Length=285, Percent_Identity=27.3684210526316, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319458, Length=303, Percent_Identity=26.0726072607261, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45550868, Length=312, Percent_Identity=27.2435897435897, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585660, Length=239, Percent_Identity=30.1255230125523, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28571984, Length=232, Percent_Identity=28.0172413793103, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_SHEAM (A1S1J8)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_925924.1
- ProteinModelPortal:   A1S1J8
- SMR:   A1S1J8
- STRING:   A1S1J8
- GeneID:   4602299
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0042
- NMPDR:   fig|326297.7.peg.37
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   A1S1J8
- ProtClustDB:   CLSK905552
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34654; Mature: 34654

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLKIIFAGTPDFAARHLQALLTSEHEVIAVYTQPDRPAGRGQKLTPSPVKSLALEHQI
CCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
PVYQPKSLRKEEAQQELAALGADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGA
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
APIQRALWAGDTETGVTIMQMDVGLDTGDMLLKTHLPIEDDDTSASLYEKLAGQGPAALL
CHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCHHHHH
DALAALSEGTLSAEKQDEALANYAEKLSKEEARLDFAKPAKNLWQEVRAFNPWPVSYFEH
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHC
QGQTIKVWQTSVLAEPSTKASGTIVAAGKQGIDIATADGMLRIHKMQLPGKKPMDVADIL
CCCEEEEEEHHHHCCCCCCCCCEEEECCCCCCEEEECCCEEEEEEEECCCCCCCCHHHHH
NSRGDWFTPGTLLASPEASE
CCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure
MKPLKIIFAGTPDFAARHLQALLTSEHEVIAVYTQPDRPAGRGQKLTPSPVKSLALEHQI
CCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
PVYQPKSLRKEEAQQELAALGADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGA
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
APIQRALWAGDTETGVTIMQMDVGLDTGDMLLKTHLPIEDDDTSASLYEKLAGQGPAALL
CHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCHHHHH
DALAALSEGTLSAEKQDEALANYAEKLSKEEARLDFAKPAKNLWQEVRAFNPWPVSYFEH
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHC
QGQTIKVWQTSVLAEPSTKASGTIVAAGKQGIDIATADGMLRIHKMQLPGKKPMDVADIL
CCCEEEEEEHHHHCCCCCCCCCEEEECCCCCCEEEECCCEEEEEEEECCCCCCCCHHHHH
NSRGDWFTPGTLLASPEASE
CCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA