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The map label for this gene is purL

Identifier: 119718545

GI number: 119718545

Start: 4574768

End: 4577023

Strand: Reverse

Name: purL

Synonym: Noca_4326

Alternate gene names: 119718545

Gene position: 4577023-4574768 (Counterclockwise)

Preceding gene: 119718546

Following gene: 119718544

Centisome position: 91.8

GC content: 73.01

Gene sequence:

>2256_bases
GTGCTCGACACCGTCGCCGTCGCCGCCGAGGACCCCCACCACGACCAGCCGTGGGCCGACCTCGGCCTCAAGGCCGACGA
GTACGCCCGGATCCGCGAGATCCTCGGCCGCCGGCCCACGAGCTCCGAGCTCGCGATGTACTCGGTGATGTGGAGCGAGC
ACTGCTCCTACAAGAGCTCCAAGGTGCACCTCAAGCAGTTCTCCGAGCTCGCCGAGGTGCTCGCTCAGCGCCAGCCCGAC
GCCGGGCGCCTGCTCGCCGGCATCGGCGAGAACGCCGGCGTGGTCGACATCGGCCAGGGCTATGCGGTCACCTTCAAGGT
CGAGTCGCACAACCACCCGTCGTACGTCGAGCCCTACCAGGGCGCGGCCACCGGCGTCGGCGGCATCGTCCGCGACATTC
TGGCCATGGGGGCCCGCCCCGTCGCCGTGATGGATCCGCTGCGGTTCGGGCCGCTCGACGCGGACGACACGCACCGGGTG
CTGCCCGGGATCGTCGCGGGGGTGGGTGGCTACGGCAACTGTCTGGGCCTGCCGAACATCGGCGGCGAGGCGGTCTTCGA
CGCGACGTATCTCGGCAACCCGCTGGTCAACGCGCTGTGCGTGGGTGTGCTCCGCCACGAGGACCTGCACCTCGCCAAGG
CGTCCGGCGTCGGCAACCAGGTGATCCTGTACGGCGCCCGCACCGGCGGCGACGGCATCGGCGGCGTCAGCGTGCTCGCC
AGCGAGACCTTCGACGCCGACGGCCCCGCCAAGCGGCCGAGCGTCCAGGTCGGCGACCCCTTCATGGAGAAGCTGCTCAT
CGAGTGCACGCTCGAGATCTTCGCCGCCGGCCTGGTCGCCGGCATCCAGGACCTCGGCGGCGCCGGCCTGTCCTGCGCCA
CCTCGGAGCTCGCGTCCGCCGGCGACGGCGGCATGCACGTCGAGCTCGACCGGGTCCCCCTGCGCGACTCCACGCTCGCG
CCGGAGGAGATCTTGATGAGCGAGTCGCAGGAGCGGATGATGGCGGTCGTCGAGCCCGACGACGTCGCGGCGTTCCTCGC
GATCTGCGCGAAGTGGGACGTCGAGGCCGTCGTGGTCGGCGAGGTCACCGACACCGGGCGGCTCCAGATCGACTGGCACG
GCGAGCGCGTGGTCGACGTCCCGCCGCGGAGCGTCGCGCACGACGGGCCGACGTACCACCGCCCCTTCGCCCGGCCCGCC
TGGCAGGACGACCTGCAGGCCGACGCCGCGGAGTCGCTGCCGCGCCCGGGCTCGGGCGACGAGCTGCGCAAGACCCTGCT
GACCCTGGTCGCCAGCCCCAACCTGTGCGACAAGTCGTGGATCACCGACCAGTACGACCGTTACGTGCGCGGCAACACCG
TGCTCGCGCAGCCCAGCGACAGCGGCATGGTCCGCGTCGACGAGGAGACCGACCTCGGCGTCGCGCTCGCGACCGACTGC
AACGGCCGGTTCGCGCTCCTCGACCCGTACGCAGGCGCCCAGCTCGCCCTCGCGGAGGCCTACCGCAACGTGGCCACCGG
CGGCGCGACGCCGCTGGCGATCTCCGACTGCCTCAACTTCGGCTCACCCGAGGACCCGGCCGTGATGTGGCAGTTCGCCG
AGGCGTGCCGCGGCCTGAAGGACGGCTGCCTCGAGCTCGGCATCCCGGTCACCGGCGGCAACGTCAGCCTCTACAACCAG
ACGGGCGAGACCGCGATCCTCCCGACCCCGGTGGTCGCCGTGCTCGGCGTGATCGAGGACGTCACCCGCCGTACGCCGTC
GGCCTGGTCGACCGGGGGTGAGCGGGTCTTCCTGCTGGGCGAGACCCGCGAGGAGCTCTCGGGGTCGGAGTGGGCGCACG
TCGTCCACGGCCATCTCGGCGGGCTCCCGCCGCAGCTCGACCTGGAGGCCGAGCGCACCCTCGCCGAGCTGCTCCACGAC
GCCGTCGGCCTGGTCAGCTCCGCCCACGACCTCTCCGACGGCGGGCTCGCGCAGGCGCTCGTCGAGGGCGCCCTGCGCCA
CGGCGTGGGCGTGTCCGTCGAGGTCCCCGACGACGCGTTCGTCGGGCTCTTCAGCGAGTCGCCGGGCCGGGTCGTCGTGA
CCGTCCCCGACGGTGCCGCCGAGCGGCTGGTCGAGCTCGCCGAGCGCCACGGGGTCGAGCTGACCGCGCTCGGCGTCACC
GGTGGCGACGCCCTGGTGGTCGAGGGCCAGTTCGAGATCCCGCTCGACGAGCTGCGCGACGCCTGGACCACCACCCTGCC
CGCGGCGCTCGGCTGA

Upstream 100 bases:

>100_bases
GACCCCCGGCGACCCGGCTGCCGACCCCACCCGCGGTCCCGCCATGGTCCGGCCTGCGGGCGGATGTGGTGGCGCTGTCG
CGCGCCGGTAGATTGGCGTC

Downstream 100 bases:

>100_bases
CGGTGCGCGGGCTTGCCGGCGGCGGTTTCCCCGGTTGGCCGGGGAAACCGGAACCTGTCGGCCGAAACTTCGCCCGCGAA
GTTCCGGTATTGCCCGTCCG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 751; Mature: 751

Protein sequence:

>751_residues
MLDTVAVAAEDPHHDQPWADLGLKADEYARIREILGRRPTSSELAMYSVMWSEHCSYKSSKVHLKQFSELAEVLAQRQPD
AGRLLAGIGENAGVVDIGQGYAVTFKVESHNHPSYVEPYQGAATGVGGIVRDILAMGARPVAVMDPLRFGPLDADDTHRV
LPGIVAGVGGYGNCLGLPNIGGEAVFDATYLGNPLVNALCVGVLRHEDLHLAKASGVGNQVILYGARTGGDGIGGVSVLA
SETFDADGPAKRPSVQVGDPFMEKLLIECTLEIFAAGLVAGIQDLGGAGLSCATSELASAGDGGMHVELDRVPLRDSTLA
PEEILMSESQERMMAVVEPDDVAAFLAICAKWDVEAVVVGEVTDTGRLQIDWHGERVVDVPPRSVAHDGPTYHRPFARPA
WQDDLQADAAESLPRPGSGDELRKTLLTLVASPNLCDKSWITDQYDRYVRGNTVLAQPSDSGMVRVDEETDLGVALATDC
NGRFALLDPYAGAQLALAEAYRNVATGGATPLAISDCLNFGSPEDPAVMWQFAEACRGLKDGCLELGIPVTGGNVSLYNQ
TGETAILPTPVVAVLGVIEDVTRRTPSAWSTGGERVFLLGETREELSGSEWAHVVHGHLGGLPPQLDLEAERTLAELLHD
AVGLVSSAHDLSDGGLAQALVEGALRHGVGVSVEVPDDAFVGLFSESPGRVVVTVPDGAAERLVELAERHGVELTALGVT
GGDALVVEGQFEIPLDELRDAWTTTLPAALG

Sequences:

>Translated_751_residues
MLDTVAVAAEDPHHDQPWADLGLKADEYARIREILGRRPTSSELAMYSVMWSEHCSYKSSKVHLKQFSELAEVLAQRQPD
AGRLLAGIGENAGVVDIGQGYAVTFKVESHNHPSYVEPYQGAATGVGGIVRDILAMGARPVAVMDPLRFGPLDADDTHRV
LPGIVAGVGGYGNCLGLPNIGGEAVFDATYLGNPLVNALCVGVLRHEDLHLAKASGVGNQVILYGARTGGDGIGGVSVLA
SETFDADGPAKRPSVQVGDPFMEKLLIECTLEIFAAGLVAGIQDLGGAGLSCATSELASAGDGGMHVELDRVPLRDSTLA
PEEILMSESQERMMAVVEPDDVAAFLAICAKWDVEAVVVGEVTDTGRLQIDWHGERVVDVPPRSVAHDGPTYHRPFARPA
WQDDLQADAAESLPRPGSGDELRKTLLTLVASPNLCDKSWITDQYDRYVRGNTVLAQPSDSGMVRVDEETDLGVALATDC
NGRFALLDPYAGAQLALAEAYRNVATGGATPLAISDCLNFGSPEDPAVMWQFAEACRGLKDGCLELGIPVTGGNVSLYNQ
TGETAILPTPVVAVLGVIEDVTRRTPSAWSTGGERVFLLGETREELSGSEWAHVVHGHLGGLPPQLDLEAERTLAELLHD
AVGLVSSAHDLSDGGLAQALVEGALRHGVGVSVEVPDDAFVGLFSESPGRVVVTVPDGAAERLVELAERHGVELTALGVT
GGDALVVEGQFEIPLDELRDAWTTTLPAALG
>Mature_751_residues
MLDTVAVAAEDPHHDQPWADLGLKADEYARIREILGRRPTSSELAMYSVMWSEHCSYKSSKVHLKQFSELAEVLAQRQPD
AGRLLAGIGENAGVVDIGQGYAVTFKVESHNHPSYVEPYQGAATGVGGIVRDILAMGARPVAVMDPLRFGPLDADDTHRV
LPGIVAGVGGYGNCLGLPNIGGEAVFDATYLGNPLVNALCVGVLRHEDLHLAKASGVGNQVILYGARTGGDGIGGVSVLA
SETFDADGPAKRPSVQVGDPFMEKLLIECTLEIFAAGLVAGIQDLGGAGLSCATSELASAGDGGMHVELDRVPLRDSTLA
PEEILMSESQERMMAVVEPDDVAAFLAICAKWDVEAVVVGEVTDTGRLQIDWHGERVVDVPPRSVAHDGPTYHRPFARPA
WQDDLQADAAESLPRPGSGDELRKTLLTLVASPNLCDKSWITDQYDRYVRGNTVLAQPSDSGMVRVDEETDLGVALATDC
NGRFALLDPYAGAQLALAEAYRNVATGGATPLAISDCLNFGSPEDPAVMWQFAEACRGLKDGCLELGIPVTGGNVSLYNQ
TGETAILPTPVVAVLGVIEDVTRRTPSAWSTGGERVFLLGETREELSGSEWAHVVHGHLGGLPPQLDLEAERTLAELLHD
AVGLVSSAHDLSDGGLAQALVEGALRHGVGVSVEVPDDAFVGLFSESPGRVVVTVPDGAAERLVELAERHGVELTALGVT
GGDALVVEGQFEIPLDELRDAWTTTLPAALG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=731, Percent_Identity=27.906976744186, Blast_Score=110, Evalue=6e-24,
Organism=Escherichia coli, GI48994899, Length=775, Percent_Identity=26.1935483870968, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321498, Length=782, Percent_Identity=22.8900255754476, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_NOCSJ (A1SPT8)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_925510.1
- ProteinModelPortal:   A1SPT8
- SMR:   A1SPT8
- STRING:   A1SPT8
- GeneID:   4596844
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_4326
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- PhylomeDB:   A1SPT8
- ProtClustDB:   PRK01213
- BioCyc:   NSP35761:NOCA_4326-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79177; Mature: 79177

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTVAVAAEDPHHDQPWADLGLKADEYARIREILGRRPTSSELAMYSVMWSEHCSYKSS
CCCCEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
KVHLKQFSELAEVLAQRQPDAGRLLAGIGENAGVVDIGQGYAVTFKVESHNHPSYVEPYQ
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCCEEEEEEEECCCCCCCCCCCC
GAATGVGGIVRDILAMGARPVAVMDPLRFGPLDADDTHRVLPGIVAGVGGYGNCLGLPNI
CCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
GGEAVFDATYLGNPLVNALCVGVLRHEDLHLAKASGVGNQVILYGARTGGDGIGGVSVLA
CCCCEEEHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCCCCCHHHEE
SETFDADGPAKRPSVQVGDPFMEKLLIECTLEIFAAGLVAGIQDLGGAGLSCATSELASA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GDGGMHVELDRVPLRDSTLAPEEILMSESQERMMAVVEPDDVAAFLAICAKWDVEAVVVG
CCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHEEEEECCHHHHHHHHHHHCCCCCEEEEE
EVTDTGRLQIDWHGERVVDVPPRSVAHDGPTYHRPFARPAWQDDLQADAAESLPRPGSGD
ECCCCCEEEEEECCCEEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHH
ELRKTLLTLVASPNLCDKSWITDQYDRYVRGNTVLAQPSDSGMVRVDEETDLGVALATDC
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCEEECCCCCCCEEEEECC
NGRFALLDPYAGAQLALAEAYRNVATGGATPLAISDCLNFGSPEDPAVMWQFAEACRGLK
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHCCHH
DGCLELGIPVTGGNVSLYNQTGETAILPTPVVAVLGVIEDVTRRTPSAWSTGGERVFLLG
HCHHHCCCEEECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
ETREELSGSEWAHVVHGHLGGLPPQLDLEAERTLAELLHDAVGLVSSAHDLSDGGLAQAL
CCHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VEGALRHGVGVSVEVPDDAFVGLFSESPGRVVVTVPDGAAERLVELAERHGVELTALGVT
HHHHHHHCCCCEEECCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEEC
GGDALVVEGQFEIPLDELRDAWTTTLPAALG
CCCEEEEECCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDTVAVAAEDPHHDQPWADLGLKADEYARIREILGRRPTSSELAMYSVMWSEHCSYKSS
CCCCEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
KVHLKQFSELAEVLAQRQPDAGRLLAGIGENAGVVDIGQGYAVTFKVESHNHPSYVEPYQ
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCCEEEEEEEECCCCCCCCCCCC
GAATGVGGIVRDILAMGARPVAVMDPLRFGPLDADDTHRVLPGIVAGVGGYGNCLGLPNI
CCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
GGEAVFDATYLGNPLVNALCVGVLRHEDLHLAKASGVGNQVILYGARTGGDGIGGVSVLA
CCCCEEEHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCCCCCHHHEE
SETFDADGPAKRPSVQVGDPFMEKLLIECTLEIFAAGLVAGIQDLGGAGLSCATSELASA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GDGGMHVELDRVPLRDSTLAPEEILMSESQERMMAVVEPDDVAAFLAICAKWDVEAVVVG
CCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHEEEEECCHHHHHHHHHHHCCCCCEEEEE
EVTDTGRLQIDWHGERVVDVPPRSVAHDGPTYHRPFARPAWQDDLQADAAESLPRPGSGD
ECCCCCEEEEEECCCEEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHH
ELRKTLLTLVASPNLCDKSWITDQYDRYVRGNTVLAQPSDSGMVRVDEETDLGVALATDC
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCEEECCCCCCCEEEEECC
NGRFALLDPYAGAQLALAEAYRNVATGGATPLAISDCLNFGSPEDPAVMWQFAEACRGLK
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHCCHH
DGCLELGIPVTGGNVSLYNQTGETAILPTPVVAVLGVIEDVTRRTPSAWSTGGERVFLLG
HCHHHCCCEEECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
ETREELSGSEWAHVVHGHLGGLPPQLDLEAERTLAELLHDAVGLVSSAHDLSDGGLAQAL
CCHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VEGALRHGVGVSVEVPDDAFVGLFSESPGRVVVTVPDGAAERLVELAERHGVELTALGVT
HHHHHHHCCCCEEECCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEEC
GGDALVVEGQFEIPLDELRDAWTTTLPAALG
CCCEEEEECCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA