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The map label for this gene is celR [H]

Identifier: 119718203

GI number: 119718203

Start: 4203696

End: 4204715

Strand: Reverse

Name: celR [H]

Synonym: Noca_3984

Alternate gene names: 119718203

Gene position: 4204715-4203696 (Counterclockwise)

Preceding gene: 119718204

Following gene: 119718202

Centisome position: 84.33

GC content: 76.47

Gene sequence:

>1020_bases
ATGGCCCGCCGCCCCCGCACCCGCCCCACCCTGGAGGAGGTCGCCGCGCTCGCGGGCGTCGGCCGCGGCACCGCCTCGCG
CGTGATCAACGGTGGGGCGAAGGTCTCCGACCGCGCGCGCCAGGCGGTCGAGGACGCGATCGCCGAGCTCGGCTACGTGC
CGAACGCCGCCGCCCGCGCCCTGGTCACCCGGCGCACCGACGCGGTCGCGCTGGTCATCGCCGAGTCCGAGGAGCGGGTG
TTCGGCGAACCGTTCTTCGCAGGGATCGTGCGCGGCATCGGGGCGGCGCTCGCGACTGCCGATCGCCAGCTCGTGCTGAT
CCTGGCCGATGCCCGCCGCCGCGGCGGCCTCGAGCACTACCTCACCCGCCAGCACGTCGACGGGGTGCTGCTGCTCTCGC
TGCACGGCGACGACACGCTGCCCGACCGGATCCGCGGCCACGGGCTGCCGGTGGTCGTGGGTGGCCGCCCGCGGCCCGAC
GTCGCGACCGGCTTCGTCGACGTCGACAACGTGCAGGGCGCCGGCCTCGCCGTGGCCCACCTCGTCGACCGCGGCCGCAC
CCGGATCGCCACGATCGCCGGCCCGGCGGACATGGTCGCCGGCAGCTCCCGCTTCGAGGGGTACGTCGCCGGCCTCACCG
CCGCCGACCGGCCCATCGACGAGCGACTGGTGGCGCGCGGCGACTTCAGCCAGGAGAGCGGCACCCGCGCGATGCGGGCG
CTCCTGGACCGGGAGCCGGGCGTGGACGGCGTCTTCTGCGCCAACGACCTGATGGCGGTCGGCGCGCTCCAGGCCCTGCG
CGAGCACGGCCGCCGGGTCCCCGAGGACGTCTCCGTCGTGGGCTTCGAGGACGCTCCGATCGCCCGGGCGACGGTGCCCC
CGCTGACGACCGTGCACCAGTCACCCGGGGCGATGGGGGGCGAGATGGTCGCGCTCCTGCTGGAGACGATGGCCGGCACC
GACCCCGCGCCGCCCGGCCGGATGCTGCCCACCCGCCTGGTCGTGCGCCAGAGCAGCTGA

Upstream 100 bases:

>100_bases
CGGACCCGCCGCTCGCTCCGCGCCGGTGCGCCGCCCGTGCCGCACCGTGCCGCGCCGCGATGTCCGCGGCCGCCCGCCCG
CGCGACGGCATACTGACGCC

Downstream 100 bases:

>100_bases
ACCGGAGCAGCGGGGCAGCCGGCCCAACCGGTCTGAACCCGCTCCGCGCCCGGGCTCCGGTTGTCCTAATCTTCCCCCGT
GGACCAGCAGCCGACGAAAC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MARRPRTRPTLEEVAALAGVGRGTASRVINGGAKVSDRARQAVEDAIAELGYVPNAAARALVTRRTDAVALVIAESEERV
FGEPFFAGIVRGIGAALATADRQLVLILADARRRGGLEHYLTRQHVDGVLLLSLHGDDTLPDRIRGHGLPVVVGGRPRPD
VATGFVDVDNVQGAGLAVAHLVDRGRTRIATIAGPADMVAGSSRFEGYVAGLTAADRPIDERLVARGDFSQESGTRAMRA
LLDREPGVDGVFCANDLMAVGALQALREHGRRVPEDVSVVGFEDAPIARATVPPLTTVHQSPGAMGGEMVALLLETMAGT
DPAPPGRMLPTRLVVRQSS

Sequences:

>Translated_339_residues
MARRPRTRPTLEEVAALAGVGRGTASRVINGGAKVSDRARQAVEDAIAELGYVPNAAARALVTRRTDAVALVIAESEERV
FGEPFFAGIVRGIGAALATADRQLVLILADARRRGGLEHYLTRQHVDGVLLLSLHGDDTLPDRIRGHGLPVVVGGRPRPD
VATGFVDVDNVQGAGLAVAHLVDRGRTRIATIAGPADMVAGSSRFEGYVAGLTAADRPIDERLVARGDFSQESGTRAMRA
LLDREPGVDGVFCANDLMAVGALQALREHGRRVPEDVSVVGFEDAPIARATVPPLTTVHQSPGAMGGEMVALLLETMAGT
DPAPPGRMLPTRLVVRQSS
>Mature_338_residues
ARRPRTRPTLEEVAALAGVGRGTASRVINGGAKVSDRARQAVEDAIAELGYVPNAAARALVTRRTDAVALVIAESEERVF
GEPFFAGIVRGIGAALATADRQLVLILADARRRGGLEHYLTRQHVDGVLLLSLHGDDTLPDRIRGHGLPVVVGGRPRPDV
ATGFVDVDNVQGAGLAVAHLVDRGRTRIATIAGPADMVAGSSRFEGYVAGLTAADRPIDERLVARGDFSQESGTRAMRAL
LDREPGVDGVFCANDLMAVGALQALREHGRRVPEDVSVVGFEDAPIARATVPPLTTVHQSPGAMGGEMVALLLETMAGTD
PAPPGRMLPTRLVVRQSS

Specific function: Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA- 3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=350, Percent_Identity=32.8571428571429, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1790194, Length=311, Percent_Identity=35.048231511254, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=31.4705882352941, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1789068, Length=334, Percent_Identity=31.7365269461078, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788474, Length=338, Percent_Identity=32.8402366863905, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1787580, Length=332, Percent_Identity=26.8072289156627, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789202, Length=294, Percent_Identity=32.312925170068, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786540, Length=340, Percent_Identity=31.7647058823529, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790715, Length=322, Percent_Identity=28.8819875776398, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1787906, Length=341, Percent_Identity=28.4457478005865, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1789456, Length=333, Percent_Identity=26.4264264264264, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI48994940, Length=313, Percent_Identity=28.7539936102236, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790689, Length=300, Percent_Identity=24.3333333333333, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786268, Length=328, Percent_Identity=25, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35662; Mature: 35531

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRPRTRPTLEEVAALAGVGRGTASRVINGGAKVSDRARQAVEDAIAELGYVPNAAARA
CCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
LVTRRTDAVALVIAESEERVFGEPFFAGIVRGIGAALATADRQLVLILADARRRGGLEHY
HHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHCCCHHHH
LTRQHVDGVLLLSLHGDDTLPDRIRGHGLPVVVGGRPRPDVATGFVDVDNVQGAGLAVAH
HHHHCCCEEEEEEECCCCCCCHHHCCCCCEEEECCCCCCCHHCCCEECCCCCCCCHHHHH
LVDRGRTRIATIAGPADMVAGSSRFEGYVAGLTAADRPIDERLVARGDFSQESGTRAMRA
HHHCCCCEEEEEECCHHHHCCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHH
LLDREPGVDGVFCANDLMAVGALQALREHGRRVPEDVSVVGFEDAPIARATVPPLTTVHQ
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHCCC
SPGAMGGEMVALLLETMAGTDPAPPGRMLPTRLVVRQSS
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
ARRPRTRPTLEEVAALAGVGRGTASRVINGGAKVSDRARQAVEDAIAELGYVPNAAARA
CCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
LVTRRTDAVALVIAESEERVFGEPFFAGIVRGIGAALATADRQLVLILADARRRGGLEHY
HHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHCCCHHHH
LTRQHVDGVLLLSLHGDDTLPDRIRGHGLPVVVGGRPRPDVATGFVDVDNVQGAGLAVAH
HHHHCCCEEEEEEECCCCCCCHHHCCCCCEEEECCCCCCCHHCCCEECCCCCCCCHHHHH
LVDRGRTRIATIAGPADMVAGSSRFEGYVAGLTAADRPIDERLVARGDFSQESGTRAMRA
HHHCCCCEEEEEECCHHHHCCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHH
LLDREPGVDGVFCANDLMAVGALQALREHGRRVPEDVSVVGFEDAPIARATVPPLTTVHQ
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHCCC
SPGAMGGEMVALLLETMAGTDPAPPGRMLPTRLVVRQSS
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224066 [H]