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The map label for this gene is adk

Identifier: 119718104

GI number: 119718104

Start: 4099531

End: 4100106

Strand: Reverse

Name: adk

Synonym: Noca_3884

Alternate gene names: 119718104

Gene position: 4100106-4099531 (Counterclockwise)

Preceding gene: 119718105

Following gene: 119718103

Centisome position: 82.23

GC content: 68.4

Gene sequence:

>576_bases
ATGCGCCTGATCATCATGGGCCCCCCGGGGGCCGGCAAGGGAACCCAAGCGAAGTACATCGCCGAGCACTTCAAGATCCC
CGCGATCTCGACCGGTGACATCTTCCGCGCCAACGTCACCGAGGGCACGCCGCTCGGTGTCGAGGCGAAGCGCTACATGG
ACGCCGGCGAGTACGTCCCCGACGAGGTCACCAACCGGATGGTCCGCAACCGGATCGACGAGCCCGACGCCGTCGGCGGG
TTCCTGCTCGACGGCTACCCGCGCACGGTCGCCCAGGTCGAGGAGCTCGACGGGATGATCCGGTTCACCGGGCACCGGCT
CGACGCGGTCGTGTGCCTCACCGTCGACCAGGACGAGATCGTCGGCCGGCTGCTCCAGCGGGCCCAGGTCGAGGGTCGTG
CGGACGACACCGAGGACGTGATCCGGCGCCGTCAGGACCTCTACCTCGAGCAGACCGCGCCGCTCATCGAGATCTACAAG
CAGCGCGACCTCGTGCACGAGGTCGACGGCATCGGCGAGGTCGACGAGGTCACCGCCCGGATCTTCCAGGCGCTGGACGT
CATCCCTGAGTCGTGA

Upstream 100 bases:

>100_bases
CCAGCTCCAGCAGCGCAACTACGAAGGATTCCTGCGCTGATATGCGATTGATCACCAACGACTGCGGCGCCGCGACGCGC
TCTGCGACAATGCCGCTGCC

Downstream 100 bases:

>100_bases
CTCTCGACTGATGGGCTTCCTCGACCGCGGGATCGAGATCAAGACACCCGAGCAGATCGCCGGGATGCGCAAGGCCGGCC
TGGTGGTGGGCCGGACCTTG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MRLIIMGPPGAGKGTQAKYIAEHFKIPAISTGDIFRANVTEGTPLGVEAKRYMDAGEYVPDEVTNRMVRNRIDEPDAVGG
FLLDGYPRTVAQVEELDGMIRFTGHRLDAVVCLTVDQDEIVGRLLQRAQVEGRADDTEDVIRRRQDLYLEQTAPLIEIYK
QRDLVHEVDGIGEVDEVTARIFQALDVIPES

Sequences:

>Translated_191_residues
MRLIIMGPPGAGKGTQAKYIAEHFKIPAISTGDIFRANVTEGTPLGVEAKRYMDAGEYVPDEVTNRMVRNRIDEPDAVGG
FLLDGYPRTVAQVEELDGMIRFTGHRLDAVVCLTVDQDEIVGRLLQRAQVEGRADDTEDVIRRRQDLYLEQTAPLIEIYK
QRDLVHEVDGIGEVDEVTARIFQALDVIPES
>Mature_191_residues
MRLIIMGPPGAGKGTQAKYIAEHFKIPAISTGDIFRANVTEGTPLGVEAKRYMDAGEYVPDEVTNRMVRNRIDEPDAVGG
FLLDGYPRTVAQVEELDGMIRFTGHRLDAVVCLTVDQDEIVGRLLQRAQVEGRADDTEDVIRRRQDLYLEQTAPLIEIYK
QRDLVHEVDGIGEVDEVTARIFQALDVIPES

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=35.2112676056338, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=35.2112676056338, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI4502011, Length=189, Percent_Identity=34.9206349206349, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=29.7169811320755, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI310110345, Length=209, Percent_Identity=28.2296650717703, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI53832003, Length=209, Percent_Identity=28.2296650717703, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI8051579, Length=209, Percent_Identity=28.2296650717703, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI53832001, Length=209, Percent_Identity=28.2296650717703, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI7706497, Length=191, Percent_Identity=29.3193717277487, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI28144897, Length=190, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI28144899, Length=190, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=23.6263736263736, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=38.2488479262673, Blast_Score=124, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=33.9622641509434, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=186, Percent_Identity=34.9462365591398, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17533833, Length=191, Percent_Identity=31.9371727748691, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=190, Percent_Identity=30, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=34.7417840375587, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=30.4568527918782, Blast_Score=88, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322828, Length=171, Percent_Identity=30.9941520467836, Blast_Score=86, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026816, Length=205, Percent_Identity=36.5853658536585, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=33.1658291457286, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=33.1658291457286, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221459597, Length=183, Percent_Identity=31.6939890710383, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356893, Length=183, Percent_Identity=31.6939890710383, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663208, Length=189, Percent_Identity=29.1005291005291, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=189, Percent_Identity=29.1005291005291, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_NOCSJ (A1SNJ7)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_925069.1
- ProteinModelPortal:   A1SNJ7
- SMR:   A1SNJ7
- STRING:   A1SNJ7
- GeneID:   4598019
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3884
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- BioCyc:   NSP35761:NOCA_3884-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21323; Mature: 21323

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIIMGPPGAGKGTQAKYIAEHFKIPAISTGDIFRANVTEGTPLGVEAKRYMDAGEYVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCC
DEVTNRMVRNRIDEPDAVGGFLLDGYPRTVAQVEELDGMIRFTGHRLDAVVCLTVDQDEI
HHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHCCCEEECCCCEEEEEEEEECHHHH
VGRLLQRAQVEGRADDTEDVIRRRQDLYLEQTAPLIEIYKQRDLVHEVDGIGEVDEVTAR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
IFQALDVIPES
HHHHHHHCCCC
>Mature Secondary Structure
MRLIIMGPPGAGKGTQAKYIAEHFKIPAISTGDIFRANVTEGTPLGVEAKRYMDAGEYVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCC
DEVTNRMVRNRIDEPDAVGGFLLDGYPRTVAQVEELDGMIRFTGHRLDAVVCLTVDQDEI
HHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHCCCEEECCCCEEEEEEEEECHHHH
VGRLLQRAQVEGRADDTEDVIRRRQDLYLEQTAPLIEIYKQRDLVHEVDGIGEVDEVTAR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
IFQALDVIPES
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA