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The map label for this gene is deoA [H]

Identifier: 119717757

GI number: 119717757

Start: 3745401

End: 3746687

Strand: Reverse

Name: deoA [H]

Synonym: Noca_3535

Alternate gene names: 119717757

Gene position: 3746687-3745401 (Counterclockwise)

Preceding gene: 119717758

Following gene: 119717755

Centisome position: 75.15

GC content: 73.35

Gene sequence:

>1287_bases
ATGCCTGACCATGACGCCGTCGAGGTGATCGCCGCCAAGCGCGACCGCCACGAGCTGACCGACAGCCAGATCGACTGGGT
GGTCGACGCCTACACCAGGGGTGCGGTCGCCGACGAGCAGATGTCGTCGCTCGCGATGGCCATCCTGCTCAACGGGATGA
ACCGGCGCGAGATCGCCCGCTGGACCGCCGCGATGATCGCGTCGGGGGAGCGGATGGACTTCTCCTCGCTCTCGCGGCCG
ACCGCCGACAAGCACTCCACCGGCGGGGTCGGCGACAAGATCACGCTGCCGCTCGCGCCGCTGGTCGCCGCCTGCGGGGT
CGCCGTCCCGCAGCTCTCCGGGCGCGGCCTGGGCCACACGGGTGGCACCCTCGACAAGCTCGAGGCCATCCCCGGCTGGC
GGGCGGCCCTGTCGAACGACGAGATGATGGCGCAGCTCGAGTCGGTGGGTGCGGTGATCTGCGCGGCCGGCGATGGGCTG
GCGCCCGCGGACAAGAAGCTCTACGCGCTGCGCGACGTGACCGGCACCGTCGAGGCGATCCCGCTGATCGCCTCCTCGAT
CATGTCCAAGAAGATCGCCGAGGGCACCGGCTCACTGGTGCTCGACGTCAAGGTCGGCACCGGCGCGTTCATGAAGGACA
TCGACTCCGCGCGCGAGCTCGCCGAGACGATGGTCGCGCTCGGCACGGACGCGGGCGTCCACACGGTCGCGCTCCTGACC
GACATGTCTACCCCCCTGGGGCGCACCGCCGGCAACGCGATCGAGGTCGCCGAGTCGGTGGAGGTGCTCGCCGGCGGCGG
CCCGGCCGACGTCGTGGAGCTGACCCTGGCGCTGGCCCGCGAGATGCTGGCCGGCGCGGGTCGCGACGACGTCGACCCGG
CCGACAAGCTGGCCGACGGCTCCGCGATGGACGCCTGGAAGGCGATGATCCGGGCCCAGGGCGGCGACCCCGACGCCGCG
CTCCCGCAGGCGCGGGAGAGCCATGTCGTCAGTGCTCCCGCGTCCGGCGTGCTGACCCGGCTGGACGCGATGGCCGTCGG
GCTGGCCGCCTGGCGGCTGGGCGCCGGCCGGGCCCGCAAGGAGGACCCGGTGCAGGCCGGCGCCGGCGTCGTCTGGCACG
CCCGCCCCGGGGACGCCGTCACCGAGGGGCAGCCGCTGTTCACGCTGCTCACCGACGACGAGCACCGGTTCGAGCGGGCC
CTGGACTCACTCGGGGGCGGCTACGACATCGCGCCCGCGGACTCGCCGTACACCCCGACGCCGCTGGTGATCGACCGGAT
CGCCTGA

Upstream 100 bases:

>100_bases
CTGTTCGAGACGTTCCCCGACCTGGCCCTCACCGGAGCGCCGGAGAGCCGCGGGACGTTCGTGTTGAGAGGGTTCCGTAG
CGTGCCCGTGGGAGGAACAC

Downstream 100 bases:

>100_bases
CCCGGGGTCAGGGGAGGAGCAGGACGACGGTCTCGGCGACGCAGGCGGGCTTGGCCTCGCCCTCGATCTCGACGGTGTAG
CGCAGCGTGAGCTGCTGGCC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MPDHDAVEVIAAKRDRHELTDSQIDWVVDAYTRGAVADEQMSSLAMAILLNGMNRREIARWTAAMIASGERMDFSSLSRP
TADKHSTGGVGDKITLPLAPLVAACGVAVPQLSGRGLGHTGGTLDKLEAIPGWRAALSNDEMMAQLESVGAVICAAGDGL
APADKKLYALRDVTGTVEAIPLIASSIMSKKIAEGTGSLVLDVKVGTGAFMKDIDSARELAETMVALGTDAGVHTVALLT
DMSTPLGRTAGNAIEVAESVEVLAGGGPADVVELTLALAREMLAGAGRDDVDPADKLADGSAMDAWKAMIRAQGGDPDAA
LPQARESHVVSAPASGVLTRLDAMAVGLAAWRLGAGRARKEDPVQAGAGVVWHARPGDAVTEGQPLFTLLTDDEHRFERA
LDSLGGGYDIAPADSPYTPTPLVIDRIA

Sequences:

>Translated_428_residues
MPDHDAVEVIAAKRDRHELTDSQIDWVVDAYTRGAVADEQMSSLAMAILLNGMNRREIARWTAAMIASGERMDFSSLSRP
TADKHSTGGVGDKITLPLAPLVAACGVAVPQLSGRGLGHTGGTLDKLEAIPGWRAALSNDEMMAQLESVGAVICAAGDGL
APADKKLYALRDVTGTVEAIPLIASSIMSKKIAEGTGSLVLDVKVGTGAFMKDIDSARELAETMVALGTDAGVHTVALLT
DMSTPLGRTAGNAIEVAESVEVLAGGGPADVVELTLALAREMLAGAGRDDVDPADKLADGSAMDAWKAMIRAQGGDPDAA
LPQARESHVVSAPASGVLTRLDAMAVGLAAWRLGAGRARKEDPVQAGAGVVWHARPGDAVTEGQPLFTLLTDDEHRFERA
LDSLGGGYDIAPADSPYTPTPLVIDRIA
>Mature_427_residues
PDHDAVEVIAAKRDRHELTDSQIDWVVDAYTRGAVADEQMSSLAMAILLNGMNRREIARWTAAMIASGERMDFSSLSRPT
ADKHSTGGVGDKITLPLAPLVAACGVAVPQLSGRGLGHTGGTLDKLEAIPGWRAALSNDEMMAQLESVGAVICAAGDGLA
PADKKLYALRDVTGTVEAIPLIASSIMSKKIAEGTGSLVLDVKVGTGAFMKDIDSARELAETMVALGTDAGVHTVALLTD
MSTPLGRTAGNAIEVAESVEVLAGGGPADVVELTLALAREMLAGAGRDDVDPADKLADGSAMDAWKAMIRAQGGDPDAAL
PQARESHVVSAPASGVLTRLDAMAVGLAAWRLGAGRARKEDPVQAGAGVVWHARPGDAVTEGQPLFTLLTDDEHRFERAL
DSLGGGYDIAPADSPYTPTPLVIDRIA

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=406, Percent_Identity=40.64039408867, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4503445, Length=406, Percent_Identity=40.64039408867, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI166158922, Length=406, Percent_Identity=40.64039408867, Blast_Score=267, Evalue=1e-71,
Organism=Escherichia coli, GI1790842, Length=409, Percent_Identity=41.320293398533, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 44349; Mature: 44218

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDHDAVEVIAAKRDRHELTDSQIDWVVDAYTRGAVADEQMSSLAMAILLNGMNRREIAR
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHH
WTAAMIASGERMDFSSLSRPTADKHSTGGVGDKITLPLAPLVAACGVAVPQLSGRGLGHT
HHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCC
GGTLDKLEAIPGWRAALSNDEMMAQLESVGAVICAAGDGLAPADKKLYALRDVTGTVEAI
CCCHHHHHCCCCHHHHCCCHHHHHHHHHCCEEEEECCCCCCCCCHHEEEHHHCCCHHHHH
PLIASSIMSKKIAEGTGSLVLDVKVGTGAFMKDIDSARELAETMVALGTDAGVHTVALLT
HHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DMSTPLGRTAGNAIEVAESVEVLAGGGPADVVELTLALAREMLAGAGRDDVDPADKLADG
HCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
SAMDAWKAMIRAQGGDPDAALPQARESHVVSAPASGVLTRLDAMAVGLAAWRLGAGRARK
CHHHHHHHHHHCCCCCCCCCCCCHHHCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EDPVQAGAGVVWHARPGDAVTEGQPLFTLLTDDEHRFERALDSLGGGYDIAPADSPYTPT
CCCHHHCCCEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEECCCCCCCCCCC
PLVIDRIA
CCEEECCC
>Mature Secondary Structure 
PDHDAVEVIAAKRDRHELTDSQIDWVVDAYTRGAVADEQMSSLAMAILLNGMNRREIAR
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHH
WTAAMIASGERMDFSSLSRPTADKHSTGGVGDKITLPLAPLVAACGVAVPQLSGRGLGHT
HHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCC
GGTLDKLEAIPGWRAALSNDEMMAQLESVGAVICAAGDGLAPADKKLYALRDVTGTVEAI
CCCHHHHHCCCCHHHHCCCHHHHHHHHHCCEEEEECCCCCCCCCHHEEEHHHCCCHHHHH
PLIASSIMSKKIAEGTGSLVLDVKVGTGAFMKDIDSARELAETMVALGTDAGVHTVALLT
HHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DMSTPLGRTAGNAIEVAESVEVLAGGGPADVVELTLALAREMLAGAGRDDVDPADKLADG
HCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
SAMDAWKAMIRAQGGDPDAALPQARESHVVSAPASGVLTRLDAMAVGLAAWRLGAGRARK
CHHHHHHHHHHCCCCCCCCCCCCHHHCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EDPVQAGAGVVWHARPGDAVTEGQPLFTLLTDDEHRFERALDSLGGGYDIAPADSPYTPT
CCCHHHCCCEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEECCCCCCCCCCC
PLVIDRIA
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]