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The map label for this gene is lpd [H]

Identifier: 119717740

GI number: 119717740

Start: 3729951

End: 3731345

Strand: Reverse

Name: lpd [H]

Synonym: Noca_3518

Alternate gene names: 119717740

Gene position: 3731345-3729951 (Counterclockwise)

Preceding gene: 119717742

Following gene: 119717739

Centisome position: 74.84

GC content: 67.89

Gene sequence:

>1395_bases
GTGACCCACTTCAACGTCCTCGTCCTCGGTGCCGGCCCCGGTGGGTACGTCGCCGCCATCCGCGCCGCCCAGCTGGGCCA
GACCGTCGCCGTCATCGAGGAGAAGTACTGGGGCGGCGTGTGCCTCAACGTCGGGTGCATCCCCTCGAAGGCGCTGCTGC
GCAACGCCGAGATCGCCCACATCATCACGAAGGAGAAGGACACCTTCGGGATCAGCGGCGAGGCGACGATGGACTTCGGT
GCCACTCACAAGCGCAGCCGCGGTGTGGCGGAGGCGAGCGCCAAGGGCGTGCACTACCTGATGAAGAAGAACAAGATCAC
CGAGCTCGACGGCTGGGGCACGATCAAGAGCCCGCGCGAGGTCGAGGTCGACAAGGACGGCCAGAAGCAGACCTACACCT
GTGACAACCTGATCATCGCCACCGGCGCACGGGTCCGGATGCTGCCGGGCATGAGCGTGAGCCAGAACGTCGTCACCTAC
GAGGAGCAGATCCTCACCGACCAGCTCCCGAAGTCGATCATCATCGGCGGCTCCGGCGCGATCGGCGTGGAGTTCGCCTA
CGTGCTCACCAACTTCGGCGTCGACGTCACGATCGTGGAGTTCCTCGACCGGATGGTCCCGACCGAGGACGCGGACGTCT
CCAAGGAGCTGCTCAAGCAGTACAAGAAGCTCGGCGTGAAGGTGCTGCTCTCGACCAAGGTCGACCAGGTCGAGGACACC
GGCTCCGGCGTCCGGGTCACCGTCAGCCCGGCGGCCGGCGGCGACGCGCAGGTCCTCGAGGCCGACAAGATGCTCGCGGC
GTTCGGCTTCGCGCCGCGGATCGAGGGCTACGGCCTCGAGAACGCCGGGGTCGAGGTCAGCGACCGCGGCGCGATCGAGG
TGGACGCCCGCGGCCGCACCAGCGTCGAGAACGTCTACGCGATCGGCGACGTCACCGGCAAGCTGATGCTGGCCCACACC
GCGGAGGCGATGGGGGTCGTGGCCGCGGAGACGATCGCCGGCGCCGAGACCCACGAGATCGACTTCGACATGATCCCGCG
CGCGACGTTCTGCCAGCCGCAGATCGCCTCGTTCGGCTACTCCGAGGCCCAGGCCAAGGAGAAGGGGTACGACGTCAAGG
TCGCGACGTTCCCGTTCAGCGCCAACGGCAAGGCCCGCGGCATGGCCGAGGGCGTCGGCTTCGTGAAGATCGTCGCGGAC
GCGACGTACAACGAGATCGTCGGCGCGCACATGATCGGCCCGGAGGTCACCGAGCTGCTGCCCGCCCTGACGCTGGCCCA
GCAGTGGGACCTGACCGCCGACGAGGTCGCCCGCAACGTCTTCGCCCACCCGACGCTCTCGGAGGCGATGAAGGAGGCCG
TCGAGGGCATCGCCGGCCACATGATCAACCTGTGA

Upstream 100 bases:

>100_bases
CGGGATCCAGATTGGTCCCGTAGGCGGCGTAAAGCGTCACGCGTGCAGAGTAGTGGAGCGGCGTGGAGCCGGTCCCGGTC
ACGTCAGTAGGCTGGCGACC

Downstream 100 bases:

>100_bases
CCGACAGTCGGATGACCAGCCAGCGCGTCGTCATCATCGGCGGTGGCCCCGGCGGCTACGAGGCGGCCCACGTCGCGGCC
CAGCTCGGTGCCGAGGTCAC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTHFNVLVLGAGPGGYVAAIRAAQLGQTVAVIEEKYWGGVCLNVGCIPSKALLRNAEIAHIITKEKDTFGISGEATMDFG
ATHKRSRGVAEASAKGVHYLMKKNKITELDGWGTIKSPREVEVDKDGQKQTYTCDNLIIATGARVRMLPGMSVSQNVVTY
EEQILTDQLPKSIIIGGSGAIGVEFAYVLTNFGVDVTIVEFLDRMVPTEDADVSKELLKQYKKLGVKVLLSTKVDQVEDT
GSGVRVTVSPAAGGDAQVLEADKMLAAFGFAPRIEGYGLENAGVEVSDRGAIEVDARGRTSVENVYAIGDVTGKLMLAHT
AEAMGVVAAETIAGAETHEIDFDMIPRATFCQPQIASFGYSEAQAKEKGYDVKVATFPFSANGKARGMAEGVGFVKIVAD
ATYNEIVGAHMIGPEVTELLPALTLAQQWDLTADEVARNVFAHPTLSEAMKEAVEGIAGHMINL

Sequences:

>Translated_464_residues
MTHFNVLVLGAGPGGYVAAIRAAQLGQTVAVIEEKYWGGVCLNVGCIPSKALLRNAEIAHIITKEKDTFGISGEATMDFG
ATHKRSRGVAEASAKGVHYLMKKNKITELDGWGTIKSPREVEVDKDGQKQTYTCDNLIIATGARVRMLPGMSVSQNVVTY
EEQILTDQLPKSIIIGGSGAIGVEFAYVLTNFGVDVTIVEFLDRMVPTEDADVSKELLKQYKKLGVKVLLSTKVDQVEDT
GSGVRVTVSPAAGGDAQVLEADKMLAAFGFAPRIEGYGLENAGVEVSDRGAIEVDARGRTSVENVYAIGDVTGKLMLAHT
AEAMGVVAAETIAGAETHEIDFDMIPRATFCQPQIASFGYSEAQAKEKGYDVKVATFPFSANGKARGMAEGVGFVKIVAD
ATYNEIVGAHMIGPEVTELLPALTLAQQWDLTADEVARNVFAHPTLSEAMKEAVEGIAGHMINL
>Mature_463_residues
THFNVLVLGAGPGGYVAAIRAAQLGQTVAVIEEKYWGGVCLNVGCIPSKALLRNAEIAHIITKEKDTFGISGEATMDFGA
THKRSRGVAEASAKGVHYLMKKNKITELDGWGTIKSPREVEVDKDGQKQTYTCDNLIIATGARVRMLPGMSVSQNVVTYE
EQILTDQLPKSIIIGGSGAIGVEFAYVLTNFGVDVTIVEFLDRMVPTEDADVSKELLKQYKKLGVKVLLSTKVDQVEDTG
SGVRVTVSPAAGGDAQVLEADKMLAAFGFAPRIEGYGLENAGVEVSDRGAIEVDARGRTSVENVYAIGDVTGKLMLAHTA
EAMGVVAAETIAGAETHEIDFDMIPRATFCQPQIASFGYSEAQAKEKGYDVKVATFPFSANGKARGMAEGVGFVKIVADA
TYNEIVGAHMIGPEVTELLPALTLAQQWDLTADEVARNVFAHPTLSEAMKEAVEGIAGHMINL

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=38.1578947368421, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=29.1304347826087, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI22035672, Length=464, Percent_Identity=27.1551724137931, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI148277065, Length=460, Percent_Identity=23.4782608695652, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI33519430, Length=460, Percent_Identity=23.4782608695652, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI33519428, Length=460, Percent_Identity=23.4782608695652, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI33519426, Length=460, Percent_Identity=23.4782608695652, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI148277071, Length=464, Percent_Identity=23.4913793103448, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI291045266, Length=455, Percent_Identity=23.956043956044, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI291045268, Length=452, Percent_Identity=22.5663716814159, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=34.8484848484849, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=28.0087527352298, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=27.3913043478261, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1789915, Length=438, Percent_Identity=27.8538812785388, Blast_Score=135, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=38.3620689655172, Blast_Score=315, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=27.2340425531915, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71983429, Length=369, Percent_Identity=28.4552845528455, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=369, Percent_Identity=28.4552845528455, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71982272, Length=459, Percent_Identity=23.9651416122004, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559934, Length=235, Percent_Identity=29.7872340425532, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=462, Percent_Identity=37.2294372294372, Blast_Score=274, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=27.4468085106383, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=26.5524625267666, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=41.3186813186813, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24640549, Length=473, Percent_Identity=25.5813953488372, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640553, Length=473, Percent_Identity=25.5813953488372, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640551, Length=475, Percent_Identity=25.6842105263158, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737741, Length=482, Percent_Identity=26.1410788381743, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49417; Mature: 49286

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHFNVLVLGAGPGGYVAAIRAAQLGQTVAVIEEKYWGGVCLNVGCIPSKALLRNAEIAH
CCEEEEEEEECCCCCHHHHHHHHHHCCEEEEEHHHCCCCEEEEECCCCCHHHHCCCCEEE
IITKEKDTFGISGEATMDFGATHKRSRGVAEASAKGVHYLMKKNKITELDGWGTIKSPRE
EEECCCCCCCCCCCCEECCCCCCHHHCCCHHHHHCCHHHHHHCCCEEECCCCCCCCCCCE
VEVDKDGQKQTYTCDNLIIATGARVRMLPGMSVSQNVVTYEEQILTDQLPKSIIIGGSGA
EECCCCCCCCEEEECCEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
IGVEFAYVLTNFGVDVTIVEFLDRMVPTEDADVSKELLKQYKKLGVKVLLSTKVDQVEDT
CHHHHEEHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHCC
GSGVRVTVSPAAGGDAQVLEADKMLAAFGFAPRIEGYGLENAGVEVSDRGAIEVDARGRT
CCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCEEECCCCCC
SVENVYAIGDVTGKLMLAHTAEAMGVVAAETIAGAETHEIDFDMIPRATFCQPQIASFGY
CCCCEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCC
SEAQAKEKGYDVKVATFPFSANGKARGMAEGVGFVKIVADATYNEIVGAHMIGPEVTELL
HHHHHHHCCCEEEEEEEEECCCCCCCCHHCCCCEEEEEECCCHHHHHHHHCCCHHHHHHH
PALTLAQQWDLTADEVARNVFAHPTLSEAMKEAVEGIAGHMINL
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
THFNVLVLGAGPGGYVAAIRAAQLGQTVAVIEEKYWGGVCLNVGCIPSKALLRNAEIAH
CEEEEEEEECCCCCHHHHHHHHHHCCEEEEEHHHCCCCEEEEECCCCCHHHHCCCCEEE
IITKEKDTFGISGEATMDFGATHKRSRGVAEASAKGVHYLMKKNKITELDGWGTIKSPRE
EEECCCCCCCCCCCCEECCCCCCHHHCCCHHHHHCCHHHHHHCCCEEECCCCCCCCCCCE
VEVDKDGQKQTYTCDNLIIATGARVRMLPGMSVSQNVVTYEEQILTDQLPKSIIIGGSGA
EECCCCCCCCEEEECCEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
IGVEFAYVLTNFGVDVTIVEFLDRMVPTEDADVSKELLKQYKKLGVKVLLSTKVDQVEDT
CHHHHEEHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHCC
GSGVRVTVSPAAGGDAQVLEADKMLAAFGFAPRIEGYGLENAGVEVSDRGAIEVDARGRT
CCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCEEECCCCCC
SVENVYAIGDVTGKLMLAHTAEAMGVVAAETIAGAETHEIDFDMIPRATFCQPQIASFGY
CCCCEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCC
SEAQAKEKGYDVKVATFPFSANGKARGMAEGVGFVKIVADATYNEIVGAHMIGPEVTELL
HHHHHHHCCCEEEEEEEEECCCCCCCCHHCCCCEEEEEECCCHHHHHHHHCCCHHHHHHH
PALTLAQQWDLTADEVARNVFAHPTLSEAMKEAVEGIAGHMINL
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]