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The map label for this gene is lpdA [H]

Identifier: 119717739

GI number: 119717739

Start: 3728542

End: 3729939

Strand: Reverse

Name: lpdA [H]

Synonym: Noca_3517

Alternate gene names: 119717739

Gene position: 3729939-3728542 (Counterclockwise)

Preceding gene: 119717740

Following gene: 119717738

Centisome position: 74.81

GC content: 72.96

Gene sequence:

>1398_bases
ATGACCAGCCAGCGCGTCGTCATCATCGGCGGTGGCCCCGGCGGCTACGAGGCGGCCCACGTCGCGGCCCAGCTCGGTGC
CGAGGTCACGATCGTCGACACCGACGGGGTCGGTGGCTCTGCGGTGCTCACCGACTGCGTGCCGAGCAAGACCCTGATCG
CGACGGCGGAGGTGATGAGCGACCTCGCCGACGCGGCCGAGCTCGGCGTGACGTTCGCCGACGCCGAGGGCGACGTGGCC
ACGTCGATCCGGGTCGACCTCGCGACGGTCAACGCGCGGGTCAAGCGGCTCGCCGCCGCCCAGTCCGCCGACATCGGCCG
GCGGCTGGACCGCGACGGCGTCACCGTGCTCCGCGGCCGCGGCAGCCTGGTCGGTCCCGACCGGGTGCTGGCCCGGCTCG
CCGACGGCACCGAGCAGGTGCTCGAGGCCGACGCGATCCTGCTCGCCACCGGCGCCGCCCCGCGCACGCTGCCCACCGCG
CAGCCGGACGGCGAGCGGATCCTCACCTGGGAGCAGGTCTACGACCTCACCGAGGTCCCCACCGAGCTGATCGTCGTCGG
CTCCGGCGTCACCGGCGCCGAGTTCGCGAGCGCCTACCTCAACCTCGGGATCCCCGTCACCCTCGTCTCCTCCCGCGATC
ACGTCCTGCCCGGCGAGGATGCCGACGCCGCGAAGGTCCTCGAGGACGTCCTGACCCGCCGCGGCATGACGGTCCTGGCC
CGCTCGCGCATGGAGTCGGTGTCGCGCGATGGCGACCGGGTCACGGTCACGCTGACCGACGGGCGCACCGTCGAGGGTTC
GCACTGCATCCTCGCGCTCGGGTCGGTGCCCAACACCGCGGGCCTGGGCCTGGAGGAGGCGGGCGTGGTCCTCGATGACG
GCGGCTTCGTCAACGTCGACCGGGTCTCCCGTACGTCGGCCCGCGGAATCTATGCCGCCGGCGACTGCACCGGCGTGCTG
ATGCTGGCCAGCGTCGCCGCCATGCAGGGCCGGATCGCGATGTGGCACTTCCTCGGCGACGCCGTGCAGCCCCTGGACCT
GAAGACCGTGTCCTCGAACGTGTTCACGGCGCCCGAGATCGCCACCGTGGGCTGGTCGCAGCGCGCCATGGAGGAAGGGG
AGATCCTGGCCGAGGTCGTCATGCTGCCGATGTCGGGCAACCCCCGCGCGAAGATGCAGGGCGTCCGGGACGGCTTCGTC
AAGCTGCTCTGCCGGCCCGGCACCCGCACCATCGTCGGCGGCGTGGTCGTCGGCCCGCGGGCCAGCGAGCTGATCCACCC
GGTGGCGATCGCGGTCGCCGAGTCGCTGACCGCCGACCAGCTTGCCCAGGCCTTTACGGTGTATCCATCGATGAGCGGCT
CGATCGCCGAGGCCGCTCGCCGCCTGCACCGCGCCTAG

Upstream 100 bases:

>100_bases
TCGCCCGCAACGTCTTCGCCCACCCGACGCTCTCGGAGGCGATGAAGGAGGCCGTCGAGGGCATCGCCGGCCACATGATC
AACCTGTGACCGACAGTCGG

Downstream 100 bases:

>100_bases
GCCGACGACCCTCGGCCGACGACTCTCGGAGGACCCATGATCCGACGGCTCGCCGTCCTGCTGACGGCCGCCGCCCTCGC
CGCGCCGGTCGCTCCGGCCT

Product: flavoprotein disulfide reductase

Products: NA

Alternate protein names: NAD(P)H quinone reductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTSQRVVIIGGGPGGYEAAHVAAQLGAEVTIVDTDGVGGSAVLTDCVPSKTLIATAEVMSDLADAAELGVTFADAEGDVA
TSIRVDLATVNARVKRLAAAQSADIGRRLDRDGVTVLRGRGSLVGPDRVLARLADGTEQVLEADAILLATGAAPRTLPTA
QPDGERILTWEQVYDLTEVPTELIVVGSGVTGAEFASAYLNLGIPVTLVSSRDHVLPGEDADAAKVLEDVLTRRGMTVLA
RSRMESVSRDGDRVTVTLTDGRTVEGSHCILALGSVPNTAGLGLEEAGVVLDDGGFVNVDRVSRTSARGIYAAGDCTGVL
MLASVAAMQGRIAMWHFLGDAVQPLDLKTVSSNVFTAPEIATVGWSQRAMEEGEILAEVVMLPMSGNPRAKMQGVRDGFV
KLLCRPGTRTIVGGVVVGPRASELIHPVAIAVAESLTADQLAQAFTVYPSMSGSIAEAARRLHRA

Sequences:

>Translated_465_residues
MTSQRVVIIGGGPGGYEAAHVAAQLGAEVTIVDTDGVGGSAVLTDCVPSKTLIATAEVMSDLADAAELGVTFADAEGDVA
TSIRVDLATVNARVKRLAAAQSADIGRRLDRDGVTVLRGRGSLVGPDRVLARLADGTEQVLEADAILLATGAAPRTLPTA
QPDGERILTWEQVYDLTEVPTELIVVGSGVTGAEFASAYLNLGIPVTLVSSRDHVLPGEDADAAKVLEDVLTRRGMTVLA
RSRMESVSRDGDRVTVTLTDGRTVEGSHCILALGSVPNTAGLGLEEAGVVLDDGGFVNVDRVSRTSARGIYAAGDCTGVL
MLASVAAMQGRIAMWHFLGDAVQPLDLKTVSSNVFTAPEIATVGWSQRAMEEGEILAEVVMLPMSGNPRAKMQGVRDGFV
KLLCRPGTRTIVGGVVVGPRASELIHPVAIAVAESLTADQLAQAFTVYPSMSGSIAEAARRLHRA
>Mature_464_residues
TSQRVVIIGGGPGGYEAAHVAAQLGAEVTIVDTDGVGGSAVLTDCVPSKTLIATAEVMSDLADAAELGVTFADAEGDVAT
SIRVDLATVNARVKRLAAAQSADIGRRLDRDGVTVLRGRGSLVGPDRVLARLADGTEQVLEADAILLATGAAPRTLPTAQ
PDGERILTWEQVYDLTEVPTELIVVGSGVTGAEFASAYLNLGIPVTLVSSRDHVLPGEDADAAKVLEDVLTRRGMTVLAR
SRMESVSRDGDRVTVTLTDGRTVEGSHCILALGSVPNTAGLGLEEAGVVLDDGGFVNVDRVSRTSARGIYAAGDCTGVLM
LASVAAMQGRIAMWHFLGDAVQPLDLKTVSSNVFTAPEIATVGWSQRAMEEGEILAEVVMLPMSGNPRAKMQGVRDGFVK
LLCRPGTRTIVGGVVVGPRASELIHPVAIAVAESLTADQLAQAFTVYPSMSGSIAEAARRLHRA

Specific function: May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NAD(P)H is the physiological reductant rather than NADH [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=30.6695464362851, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI50301238, Length=448, Percent_Identity=28.125, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI291045266, Length=462, Percent_Identity=24.2424242424242, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI22035672, Length=461, Percent_Identity=26.6811279826464, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI148277071, Length=460, Percent_Identity=25.4347826086956, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI148277065, Length=454, Percent_Identity=25.5506607929515, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI33519430, Length=454, Percent_Identity=25.5506607929515, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI33519428, Length=454, Percent_Identity=25.5506607929515, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI33519426, Length=454, Percent_Identity=25.5506607929515, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI291045268, Length=453, Percent_Identity=22.7373068432671, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=29.2207792207792, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=25.4347826086956, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87081717, Length=466, Percent_Identity=26.3948497854077, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1789915, Length=437, Percent_Identity=24.9427917620137, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1789065, Length=196, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=30.2375809935205, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=27.2916666666667, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=446, Percent_Identity=27.8026905829596, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983429, Length=446, Percent_Identity=27.8026905829596, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=467, Percent_Identity=23.5546038543897, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=29.0870488322718, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=26.271186440678, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325166, Length=447, Percent_Identity=22.8187919463087, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=32.3913043478261, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24640549, Length=468, Percent_Identity=27.7777777777778, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=27.8723404255319, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24640551, Length=468, Percent_Identity=27.7777777777778, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17737741, Length=469, Percent_Identity=26.6524520255864, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.5.2 [H]

Molecular weight: Translated: 48280; Mature: 48148

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50006 FHA_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQRVVIIGGGPGGYEAAHVAAQLGAEVTIVDTDGVGGSAVLTDCVPSKTLIATAEVMS
CCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHH
DLADAAELGVTFADAEGDVATSIRVDLATVNARVKRLAAAQSADIGRRLDRDGVTVLRGR
HHHHHHHHCEEEECCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
GSLVGPDRVLARLADGTEQVLEADAILLATGAAPRTLPTAQPDGERILTWEQVYDLTEVP
CCCCCHHHHHHHHHCCHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCC
TELIVVGSGVTGAEFASAYLNLGIPVTLVSSRDHVLPGEDADAAKVLEDVLTRRGMTVLA
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHH
RSRMESVSRDGDRVTVTLTDGRTVEGSHCILALGSVPNTAGLGLEEAGVVLDDGGFVNVD
HHHHHHHHCCCCEEEEEEECCCEECCCEEEEEECCCCCCCCCCCCCCCEEEECCCEEEHH
RVSRTSARGIYAAGDCTGVLMLASVAAMQGRIAMWHFLGDAVQPLDLKTVSSNVFTAPEI
HCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCEEEEECCCCCCCCCE
ATVGWSQRAMEEGEILAEVVMLPMSGNPRAKMQGVRDGFVKLLCRPGTRTIVGGVVVGPR
EECCCHHHHHHHHHHEEEHEEECCCCCCHHHHHHHHHHHHHEEECCCCCEEEEEEEECCC
ASELIHPVAIAVAESLTADQLAQAFTVYPSMSGSIAEAARRLHRA
HHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TSQRVVIIGGGPGGYEAAHVAAQLGAEVTIVDTDGVGGSAVLTDCVPSKTLIATAEVMS
CCCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHH
DLADAAELGVTFADAEGDVATSIRVDLATVNARVKRLAAAQSADIGRRLDRDGVTVLRGR
HHHHHHHHCEEEECCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
GSLVGPDRVLARLADGTEQVLEADAILLATGAAPRTLPTAQPDGERILTWEQVYDLTEVP
CCCCCHHHHHHHHHCCHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCC
TELIVVGSGVTGAEFASAYLNLGIPVTLVSSRDHVLPGEDADAAKVLEDVLTRRGMTVLA
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHH
RSRMESVSRDGDRVTVTLTDGRTVEGSHCILALGSVPNTAGLGLEEAGVVLDDGGFVNVD
HHHHHHHHCCCCEEEEEEECCCEECCCEEEEEECCCCCCCCCCCCCCCEEEECCCEEEHH
RVSRTSARGIYAAGDCTGVLMLASVAAMQGRIAMWHFLGDAVQPLDLKTVSSNVFTAPEI
HCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCEEEEECCCCCCCCCE
ATVGWSQRAMEEGEILAEVVMLPMSGNPRAKMQGVRDGFVKLLCRPGTRTIVGGVVVGPR
EECCCHHHHHHHHHHEEEHEEECCCCCCHHHHHHHHHHHHHEEECCCCCEEEEEEEECCC
ASELIHPVAIAVAESLTADQLAQAFTVYPSMSGSIAEAARRLHRA
HHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]