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The map label for this gene is serA [H]

Identifier: 119717608

GI number: 119717608

Start: 3588017

End: 3589627

Strand: Reverse

Name: serA [H]

Synonym: Noca_3385

Alternate gene names: 119717608

Gene position: 3589627-3588017 (Counterclockwise)

Preceding gene: 119717610

Following gene: 119717607

Centisome position: 72.0

GC content: 72.07

Gene sequence:

>1611_bases
GTGACCATGCCCGCCGCCACGCCCGCCGACCGGCCCGTCGTACTCATCGCCGAGGAGCTCAGTCCGGCGACCGTCGAGGC
ACTCGGACCGGACTTCGAGATCCGGTACTGCGACGGCGCGGATCGCGGCGAGCTGCTGGCCGCGCTCCCCGAGGCGGACG
CGATCCTGGTGCGGTCCGCGACCAAGGTCGACGCCGAGGCGCTCGCCGCGGCCCGCCGGCTCAAGGTCATCGCCCGGGCC
GGTGTGGGCCTGGACAACGTCGACGTGCGCGCGGCGACCCAGGCGGGCGTGATGGTCGTCAACGCCCCGACCTCCAACAT
CGTCTCCGCCGCCGAGCTCGCGGTCGCGCTGATGCTCGCCGCCGCCCGGCACATCTCGCCGGCCCACGCCGCGCTGAAGA
ACGGCGAGTGGAAGCGGGCCCGCTACACCGGCACCGAGCTCTACGAGAAGACCGTCGGCATCGTCGGCCTGGGTCGGATC
GGCGTCCTGGTCGCGCAGCGGCTGAGCGCCTTCGGCATGAAGATCGTGGCGTACGACCCGTACGTGCAGGCTGGCCGGGC
CGCGCAGATGGGCGTGCGGCTGGTCGACCTCGACACGCTGCTGGCCGAGGCCGACTTCATGTCCGTGCACCTGCCCAAGA
CCCCCGAGACCGTCGGCCTGATCGGCGCCGACCAGCTCGCGAAGGTCAAGCCCTCGCTGGTGCTGGTCAACGCCGCGCGC
GGCGGCATCGTCGAGGAGGCCGCCCTCTATGCCGCCCTCAAGGAGGGCCGGGTCGCGGCGGCCGGGCTCGACGTGTTCGC
GCAGGAGCCGTGCACCGACAGCCCGCTGTTCGAGCTCGAGAACGTCGTCGCCACGCCGCACCTCGGCGCCTCCACCGACG
AGGCGCAGGAGAAGGCCGGCATCGCGGTCGCGAAGTCGGTGCGGCTCGCGCTGTCCGGCGAGCTGGTCCCCGACGCGGTC
AACGTGCAGGGCGGTGTGATCGCCGAGGACGTGCGCCCTGGCATCCCGCTCACCGAGAAGCTCGGCCGGGTGTTCACCGC
CGTGGCCGGCGAGGTCGCGCTGTCGATCGACGTCGAGGTGCGCGGCGAGATCACCGACTACGACGTCAAGGTGCTCGAGC
TGGCGGCCCTCAAGGGGATCTTCACCGACATCGTCGAGGACCAGGTCTCCTACGTGAACGCGCCGCTGCTCGCCGCCGAG
CGCGGCACCGCCGTACGCCTGGTCGCCGACCCGGAGAGCCCCGACCACCGCAACCTGATCACGATCCGCGGCACCCTCGC
CGACGGCGAGCAGGTCTCGGTCAGCGGCACCCTGATCGGGATCAACCAGAAGGAGCGGCTGGTCGAGGTCAACGGCTTCG
ACGTCGACCTCGAGCCCACCGAGCACCTCGCGTTCCTCACCTACGAGGACCGGCCCGGCATGGTCGGCACCGTCGGCGTG
ATCATCGGGGACGCCGGCATCAACATCGCCGGCATGCAGGTCGCCCGCGACGCCAAGGGCGGCCGGGCCCTGGTCGCGCT
GTCGGTCGACACCGCCATCCCCGCCGAGGTGCTCGCCGAGATGCAGCACGCGATCGATGCGATCTCGGTGCGCGCGGTCG
ACCTGGTCTGA

Upstream 100 bases:

>100_bases
CGCGACCGAATACTTCGGCGCGGTCGGGTAGAGTGCGAGATGCAGCACAGCGTCGTGCGCCGATCGAGACACCACCCCTC
TTCCGCGAGGACTCCACGCT

Downstream 100 bases:

>100_bases
CTTCGCGCCACGCCGGGCCGGACTGCTTGGTCGGCGCACCCGATTCGAGCCCGCGGCCCGCGTTCTCGCGTTAGCGTCGC
CCCCATGCCAGCCCGGCCGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MTMPAATPADRPVVLIAEELSPATVEALGPDFEIRYCDGADRGELLAALPEADAILVRSATKVDAEALAAARRLKVIARA
GVGLDNVDVRAATQAGVMVVNAPTSNIVSAAELAVALMLAAARHISPAHAALKNGEWKRARYTGTELYEKTVGIVGLGRI
GVLVAQRLSAFGMKIVAYDPYVQAGRAAQMGVRLVDLDTLLAEADFMSVHLPKTPETVGLIGADQLAKVKPSLVLVNAAR
GGIVEEAALYAALKEGRVAAAGLDVFAQEPCTDSPLFELENVVATPHLGASTDEAQEKAGIAVAKSVRLALSGELVPDAV
NVQGGVIAEDVRPGIPLTEKLGRVFTAVAGEVALSIDVEVRGEITDYDVKVLELAALKGIFTDIVEDQVSYVNAPLLAAE
RGTAVRLVADPESPDHRNLITIRGTLADGEQVSVSGTLIGINQKERLVEVNGFDVDLEPTEHLAFLTYEDRPGMVGTVGV
IIGDAGINIAGMQVARDAKGGRALVALSVDTAIPAEVLAEMQHAIDAISVRAVDLV

Sequences:

>Translated_536_residues
MTMPAATPADRPVVLIAEELSPATVEALGPDFEIRYCDGADRGELLAALPEADAILVRSATKVDAEALAAARRLKVIARA
GVGLDNVDVRAATQAGVMVVNAPTSNIVSAAELAVALMLAAARHISPAHAALKNGEWKRARYTGTELYEKTVGIVGLGRI
GVLVAQRLSAFGMKIVAYDPYVQAGRAAQMGVRLVDLDTLLAEADFMSVHLPKTPETVGLIGADQLAKVKPSLVLVNAAR
GGIVEEAALYAALKEGRVAAAGLDVFAQEPCTDSPLFELENVVATPHLGASTDEAQEKAGIAVAKSVRLALSGELVPDAV
NVQGGVIAEDVRPGIPLTEKLGRVFTAVAGEVALSIDVEVRGEITDYDVKVLELAALKGIFTDIVEDQVSYVNAPLLAAE
RGTAVRLVADPESPDHRNLITIRGTLADGEQVSVSGTLIGINQKERLVEVNGFDVDLEPTEHLAFLTYEDRPGMVGTVGV
IIGDAGINIAGMQVARDAKGGRALVALSVDTAIPAEVLAEMQHAIDAISVRAVDLV
>Mature_535_residues
TMPAATPADRPVVLIAEELSPATVEALGPDFEIRYCDGADRGELLAALPEADAILVRSATKVDAEALAAARRLKVIARAG
VGLDNVDVRAATQAGVMVVNAPTSNIVSAAELAVALMLAAARHISPAHAALKNGEWKRARYTGTELYEKTVGIVGLGRIG
VLVAQRLSAFGMKIVAYDPYVQAGRAAQMGVRLVDLDTLLAEADFMSVHLPKTPETVGLIGADQLAKVKPSLVLVNAARG
GIVEEAALYAALKEGRVAAAGLDVFAQEPCTDSPLFELENVVATPHLGASTDEAQEKAGIAVAKSVRLALSGELVPDAVN
VQGGVIAEDVRPGIPLTEKLGRVFTAVAGEVALSIDVEVRGEITDYDVKVLELAALKGIFTDIVEDQVSYVNAPLLAAER
GTAVRLVADPESPDHRNLITIRGTLADGEQVSVSGTLIGINQKERLVEVNGFDVDLEPTEHLAFLTYEDRPGMVGTVGVI
IGDAGINIAGMQVARDAKGGRALVALSVDTAIPAEVLAEMQHAIDAISVRAVDLV

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=410, Percent_Identity=39.0243902439024, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI6912396, Length=282, Percent_Identity=35.8156028368794, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI145580578, Length=296, Percent_Identity=33.445945945946, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI4557499, Length=296, Percent_Identity=33.445945945946, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI61743967, Length=297, Percent_Identity=32.6599326599327, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4557497, Length=297, Percent_Identity=32.6599326599327, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI145580575, Length=291, Percent_Identity=33.6769759450172, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=39.7058823529412, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789279, Length=332, Percent_Identity=34.6385542168675, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=35.7142857142857, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788660, Length=262, Percent_Identity=31.6793893129771, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=29.2372881355932, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=296, Percent_Identity=42.9054054054054, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI25147481, Length=300, Percent_Identity=33, Blast_Score=152, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=34.7826086956522, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6322116, Length=276, Percent_Identity=34.4202898550725, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324055, Length=275, Percent_Identity=31.6363636363636, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=287, Percent_Identity=29.616724738676, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=181, Percent_Identity=34.8066298342541, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=216, Percent_Identity=26.3888888888889, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=274, Percent_Identity=45.2554744525547, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI28574286, Length=315, Percent_Identity=34.9206349206349, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24585514, Length=281, Percent_Identity=35.5871886120996, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574282, Length=281, Percent_Identity=35.5871886120996, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574284, Length=281, Percent_Identity=35.5871886120996, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45552429, Length=281, Percent_Identity=35.5871886120996, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45551003, Length=281, Percent_Identity=35.5871886120996, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=37.2759856630824, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24646446, Length=300, Percent_Identity=32, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646448, Length=300, Percent_Identity=32, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646452, Length=300, Percent_Identity=32, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646450, Length=300, Percent_Identity=32, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62472511, Length=302, Percent_Identity=31.7880794701987, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24585516, Length=278, Percent_Identity=30.5755395683453, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55952; Mature: 55821

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS01095 CHITINASE_18

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPAATPADRPVVLIAEELSPATVEALGPDFEIRYCDGADRGELLAALPEADAILVRSA
CCCCCCCCCCCCEEEEECCCCCCCHHHCCCCEEEEECCCCCCCCEEEECCCCCEEEEECC
TKVDAEALAAARRLKVIARAGVGLDNVDVRAATQAGVMVVNAPTSNIVSAAELAVALMLA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHH
AARHISPAHAALKNGEWKRARYTGTELYEKTVGIVGLGRIGVLVAQRLSAFGMKIVAYDP
HHHCCCHHHHHHCCCCCCEEECCCHHHHHHHCCEEEEHHHHHHHHHHHHHCCEEEEEECC
YVQAGRAAQMGVRLVDLDTLLAEADFMSVHLPKTPETVGLIGADQLAKVKPSLVLVNAAR
HHHCCCHHHHCEEEEEHHHHHHCCCEEEEECCCCCCCEEEECCCHHHHCCCCEEEEECCC
GGIVEEAALYAALKEGRVAAAGLDVFAQEPCTDSPLFELENVVATPHLGASTDEAQEKAG
CCCHHHHHHHHHHHCCCEEEECCHHHCCCCCCCCCHHHHHHHEECCCCCCCCCHHHHHCC
IAVAKSVRLALSGELVPDAVNVQGGVIAEDVRPGIPLTEKLGRVFTAVAGEVALSIDVEV
EEEEEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEE
RGEITDYDVKVLELAALKGIFTDIVEDQVSYVNAPLLAAERGTAVRLVADPESPDHRNLI
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCEE
TIRGTLADGEQVSVSGTLIGINQKERLVEVNGFDVDLEPTEHLAFLTYEDRPGMVGTVGV
EEEEEECCCCEEEEEEEEEECCCCCEEEEECCEEEECCCCCCEEEEEECCCCCCEEEEEE
IIGDAGINIAGMQVARDAKGGRALVALSVDTAIPAEVLAEMQHAIDAISVRAVDLV
EEECCCCCEEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHEEEEEECC
>Mature Secondary Structure 
TMPAATPADRPVVLIAEELSPATVEALGPDFEIRYCDGADRGELLAALPEADAILVRSA
CCCCCCCCCCCEEEEECCCCCCCHHHCCCCEEEEECCCCCCCCEEEECCCCCEEEEECC
TKVDAEALAAARRLKVIARAGVGLDNVDVRAATQAGVMVVNAPTSNIVSAAELAVALMLA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHH
AARHISPAHAALKNGEWKRARYTGTELYEKTVGIVGLGRIGVLVAQRLSAFGMKIVAYDP
HHHCCCHHHHHHCCCCCCEEECCCHHHHHHHCCEEEEHHHHHHHHHHHHHCCEEEEEECC
YVQAGRAAQMGVRLVDLDTLLAEADFMSVHLPKTPETVGLIGADQLAKVKPSLVLVNAAR
HHHCCCHHHHCEEEEEHHHHHHCCCEEEEECCCCCCCEEEECCCHHHHCCCCEEEEECCC
GGIVEEAALYAALKEGRVAAAGLDVFAQEPCTDSPLFELENVVATPHLGASTDEAQEKAG
CCCHHHHHHHHHHHCCCEEEECCHHHCCCCCCCCCHHHHHHHEECCCCCCCCCHHHHHCC
IAVAKSVRLALSGELVPDAVNVQGGVIAEDVRPGIPLTEKLGRVFTAVAGEVALSIDVEV
EEEEEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEE
RGEITDYDVKVLELAALKGIFTDIVEDQVSYVNAPLLAAERGTAVRLVADPESPDHRNLI
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCEE
TIRGTLADGEQVSVSGTLIGINQKERLVEVNGFDVDLEPTEHLAFLTYEDRPGMVGTVGV
EEEEEECCCCEEEEEEEEEECCCCCEEEEECCEEEECCCCCCEEEEEECCCCCCEEEEEE
IIGDAGINIAGMQVARDAKGGRALVALSVDTAIPAEVLAEMQHAIDAISVRAVDLV
EEECCCCCEEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]