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The map label for this gene is ilvE [H]

Identifier: 119717590

GI number: 119717590

Start: 3567527

End: 3568600

Strand: Reverse

Name: ilvE [H]

Synonym: Noca_3367

Alternate gene names: 119717590

Gene position: 3568600-3567527 (Counterclockwise)

Preceding gene: 119717591

Following gene: 119717589

Centisome position: 71.57

GC content: 71.51

Gene sequence:

>1074_bases
ATGGAGATCAGCACCACCCCGTCGAGCGCCGCGGTCTCCGACGAGCGCCTCGCCGAGATCCTCGCCAACCCCGGCTTCGG
CCTGCACTTCACCGACCACATGCTCACGGTCGAGTGGGCCCCGGACGCCGGCTGGCACGCCGGGCGCATCGAGCCGTACG
GGCCGCTCACGCTCGACCCCGCGACCGCGGTCCTGCACTACGCGCAGGAGATCTTCGAGGGCATGAAGGCCTACCGGCAC
GCGGACGGGTCGATCTGGTCGTTCCGGCCCGAGGAGAACGCCGCGCGCATGATGCGCTCGAGCCGGCGGCTCGCGCTGCC
CGAGCTCGACGTCGCCGACTACGTCCAGGCGGTCGACGCGCTCGTGACCGCCGACCAGCGCTGGGTCCCCGACCCGGCGG
GGGAGAAGAGCCTCTACGTGCGCCCGTTCATGTTCGCCTCGGAGGCGTTCTTGGGCGTGCGGCCGGCCCAGCACGTCACG
TTCATGGTGATCGCGAGCCCGGCCGGCGCCTACTTCAAGGGCGGCGTCAAGCCGGTCACGCTGTGGCTGACCGACGAGTA
CACCCGCGCCGGCCGCGGCGGCATGGGCGCGGCGAAGACCGGCGGCAACTACGCCAGCTCGCTGGTCGCGCAGCAGCAGG
CGAGCGCCCAGGGCTGCGACCAGGTCGTGTTCCTCGATGCCCAGGAGGGGCAGTACGTCGAGGAGCTCGGCGGCATGAAC
ATGTACTTCGTCCACGACGACGGCACCATCGTCACCCCCGAGACCGGCACCATCCTCGAGGGGATCACCCGCTCCAGCAT
CATCGAGCTGGCCGGCAAGCTCGGCCACCAGGTCGAGGAGCGCCGGTTCTCCATCGACGAGTGGCGCGAGGGCGTGCGCA
GCGGCCGGATCGTGGAGATCTTCGCCTGCGGCACCGCCGCCGTCGTCACCCCGGTCGGCGAGCTGAAGTGGGACGGCGGG
TCGGCGCCCGCCCCCGCGAGCACCGACCTCACCATGCGGGTCCGGCAGGCCCTGGTCGACATCCAGTACGGCCGCGCCGA
GGACACGTTCGGCTGGATGCACCGGATCGTCTGA

Upstream 100 bases:

>100_bases
GCGTGTCGTGCGGGGATGGGCTGCCAGCAGCCGAACCCGGCGCATCTCCGAGGCCTCCCGCCCCGCCCATTTCGTTGGAA
GGCCTACTAAGTTGTCCCCC

Downstream 100 bases:

>100_bases
TCAGGCCTTCGCCGCGGGCGGCTCCGTGGACGGGTCGCCGTCGGCGGCCGCGACGAGCTGGGGCACGTACCGGTCCAGCA
GGTACGGGATGCTCAGCGGC

Product: branched chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MEISTTPSSAAVSDERLAEILANPGFGLHFTDHMLTVEWAPDAGWHAGRIEPYGPLTLDPATAVLHYAQEIFEGMKAYRH
ADGSIWSFRPEENAARMMRSSRRLALPELDVADYVQAVDALVTADQRWVPDPAGEKSLYVRPFMFASEAFLGVRPAQHVT
FMVIASPAGAYFKGGVKPVTLWLTDEYTRAGRGGMGAAKTGGNYASSLVAQQQASAQGCDQVVFLDAQEGQYVEELGGMN
MYFVHDDGTIVTPETGTILEGITRSSIIELAGKLGHQVEERRFSIDEWREGVRSGRIVEIFACGTAAVVTPVGELKWDGG
SAPAPASTDLTMRVRQALVDIQYGRAEDTFGWMHRIV

Sequences:

>Translated_357_residues
MEISTTPSSAAVSDERLAEILANPGFGLHFTDHMLTVEWAPDAGWHAGRIEPYGPLTLDPATAVLHYAQEIFEGMKAYRH
ADGSIWSFRPEENAARMMRSSRRLALPELDVADYVQAVDALVTADQRWVPDPAGEKSLYVRPFMFASEAFLGVRPAQHVT
FMVIASPAGAYFKGGVKPVTLWLTDEYTRAGRGGMGAAKTGGNYASSLVAQQQASAQGCDQVVFLDAQEGQYVEELGGMN
MYFVHDDGTIVTPETGTILEGITRSSIIELAGKLGHQVEERRFSIDEWREGVRSGRIVEIFACGTAAVVTPVGELKWDGG
SAPAPASTDLTMRVRQALVDIQYGRAEDTFGWMHRIV
>Mature_357_residues
MEISTTPSSAAVSDERLAEILANPGFGLHFTDHMLTVEWAPDAGWHAGRIEPYGPLTLDPATAVLHYAQEIFEGMKAYRH
ADGSIWSFRPEENAARMMRSSRRLALPELDVADYVQAVDALVTADQRWVPDPAGEKSLYVRPFMFASEAFLGVRPAQHVT
FMVIASPAGAYFKGGVKPVTLWLTDEYTRAGRGGMGAAKTGGNYASSLVAQQQASAQGCDQVVFLDAQEGQYVEELGGMN
MYFVHDDGTIVTPETGTILEGITRSSIIELAGKLGHQVEERRFSIDEWREGVRSGRIVEIFACGTAAVVTPVGELKWDGG
SAPAPASTDLTMRVRQALVDIQYGRAEDTFGWMHRIV

Specific function: Acts on leucine, isoleucine and valine [H]

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI296010904, Length=335, Percent_Identity=41.1940298507463, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI38176287, Length=335, Percent_Identity=41.1940298507463, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI296010906, Length=335, Percent_Identity=41.1940298507463, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI50658084, Length=339, Percent_Identity=40.4129793510324, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI296010902, Length=335, Percent_Identity=36.1194029850746, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI296010900, Length=335, Percent_Identity=36.1194029850746, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI258614015, Length=295, Percent_Identity=37.9661016949153, Blast_Score=192, Evalue=6e-49,
Organism=Escherichia coli, GI48994963, Length=319, Percent_Identity=31.0344827586207, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17568601, Length=347, Percent_Identity=38.0403458213257, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17565728, Length=360, Percent_Identity=36.3888888888889, Blast_Score=208, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6322002, Length=337, Percent_Identity=40.6528189910979, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322608, Length=337, Percent_Identity=40.3560830860534, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24641779, Length=334, Percent_Identity=38.9221556886228, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 38945; Mature: 38945

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEISTTPSSAAVSDERLAEILANPGFGLHFTDHMLTVEWAPDAGWHAGRIEPYGPLTLDP
CCCCCCCCCHHCCHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCEEECH
ATAVLHYAQEIFEGMKAYRHADGSIWSFRPEENAARMMRSSRRLALPELDVADYVQAVDA
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LVTADQRWVPDPAGEKSLYVRPFMFASEAFLGVRPAQHVTFMVIASPAGAYFKGGVKPVT
HHHCCCCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCEEEEEEECCCCHHHCCCCEEEE
LWLTDEYTRAGRGGMGAAKTGGNYASSLVAQQQASAQGCDQVVFLDAQEGQYVEELGGMN
EEEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCE
MYFVHDDGTIVTPETGTILEGITRSSIIELAGKLGHQVEERRFSIDEWREGVRSGRIVEI
EEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEE
FACGTAAVVTPVGELKWDGGSAPAPASTDLTMRVRQALVDIQYGRAEDTFGWMHRIV
EECCCCCEECCCHHEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MEISTTPSSAAVSDERLAEILANPGFGLHFTDHMLTVEWAPDAGWHAGRIEPYGPLTLDP
CCCCCCCCCHHCCHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCEEECH
ATAVLHYAQEIFEGMKAYRHADGSIWSFRPEENAARMMRSSRRLALPELDVADYVQAVDA
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LVTADQRWVPDPAGEKSLYVRPFMFASEAFLGVRPAQHVTFMVIASPAGAYFKGGVKPVT
HHHCCCCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCEEEEEEECCCCHHHCCCCEEEE
LWLTDEYTRAGRGGMGAAKTGGNYASSLVAQQQASAQGCDQVVFLDAQEGQYVEELGGMN
EEEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCE
MYFVHDDGTIVTPETGTILEGITRSSIIELAGKLGHQVEERRFSIDEWREGVRSGRIVEI
EEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEE
FACGTAAVVTPVGELKWDGGSAPAPASTDLTMRVRQALVDIQYGRAEDTFGWMHRIV
EECCCCCEECCCHHEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]