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The map label for this gene is tetR [H]

Identifier: 119717572

GI number: 119717572

Start: 3550987

End: 3551544

Strand: Reverse

Name: tetR [H]

Synonym: Noca_3348

Alternate gene names: 119717572

Gene position: 3551544-3550987 (Counterclockwise)

Preceding gene: 119717576

Following gene: 119717565

Centisome position: 71.23

GC content: 75.45

Gene sequence:

>558_bases
ATGCGCTACCACCGCGCGGACGTCGTCGACCGGGCGGTCGGGGTCCTGGACGCCTACGGGCTCGCGGACCTGACCATGCG
GCGGCTCGGCGCGGAGCTCGGCGTGCAGCCGAGCGCGCTCTACCACCACTTCGCGAACAAGCAGACCCTGCTGGCCGCGG
TCGCCGACGAGGTGCTGGCGCGCGGGCCGAGCGGGCCCCGGCCGGACGCATGGGACGACCGGGTCGCCGCGGTCTGCGGC
GAGCTGCGCGACGCGATGCTGGCCTACCGCGACGGCGCCGAGCTGGTGGCCACGGCGTACTCCTTCGGGCTGGGCGCGGC
GGCGCCGTACGACGAGCTGGTCGTGGCCCTTCGCGAGGGTGGGCTGGACCCGGTGCTGGTGCCGACGGCCGCGCGCACGC
TGCTGCACTTCGTCTTCGGCCACGCGACCGACGAGCAGACCCACCTGCAGGCCGGGTCCGCGGGCGCCATCGACGACCAG
CCGCGCGAGACCTCCGACTTCGCGCTCGGGCTCGGGCTCGTGCTGGACGGGATCAGGTTGCGCCAGCGCGTGGGCTGA

Upstream 100 bases:

>100_bases
ACGTACCTGAACGGTGGTCAGGTGAACGGTGTTCAGGTTAGGGTTCGTGACAGGGGCGGTCAACGGGTGTTCGCCTCCAG
GAGACCAGGAGAGGTGTGAC

Downstream 100 bases:

>100_bases
CCGGCCGGGCTACGGCTCGACGAGCGCGCCGTGCTGCTCGGCGAGCTGGACGGCGCCGGCGAGGTCCAGCCTGGTGCCGC
GCAGGGTGGCGACCCTGAGG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MRYHRADVVDRAVGVLDAYGLADLTMRRLGAELGVQPSALYHHFANKQTLLAAVADEVLARGPSGPRPDAWDDRVAAVCG
ELRDAMLAYRDGAELVATAYSFGLGAAAPYDELVVALREGGLDPVLVPTAARTLLHFVFGHATDEQTHLQAGSAGAIDDQ
PRETSDFALGLGLVLDGIRLRQRVG

Sequences:

>Translated_185_residues
MRYHRADVVDRAVGVLDAYGLADLTMRRLGAELGVQPSALYHHFANKQTLLAAVADEVLARGPSGPRPDAWDDRVAAVCG
ELRDAMLAYRDGAELVATAYSFGLGAAAPYDELVVALREGGLDPVLVPTAARTLLHFVFGHATDEQTHLQAGSAGAIDDQ
PRETSDFALGLGLVLDGIRLRQRVG
>Mature_185_residues
MRYHRADVVDRAVGVLDAYGLADLTMRRLGAELGVQPSALYHHFANKQTLLAAVADEVLARGPSGPRPDAWDDRVAAVCG
ELRDAMLAYRDGAELVATAYSFGLGAAAPYDELVVALREGGLDPVLVPTAARTLLHFVFGHATDEQTHLQAGSAGAIDDQ
PRETSDFALGLGLVLDGIRLRQRVG

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 19717; Mature: 19717

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYHRADVVDRAVGVLDAYGLADLTMRRLGAELGVQPSALYHHFANKQTLLAAVADEVLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHH
RGPSGPRPDAWDDRVAAVCGELRDAMLAYRDGAELVATAYSFGLGAAAPYDELVVALREG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHC
GLDPVLVPTAARTLLHFVFGHATDEQTHLQAGSAGAIDDQPRETSDFALGLGLVLDGIRL
CCCCEEHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RQRVG
HHHCC
>Mature Secondary Structure
MRYHRADVVDRAVGVLDAYGLADLTMRRLGAELGVQPSALYHHFANKQTLLAAVADEVLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHH
RGPSGPRPDAWDDRVAAVCGELRDAMLAYRDGAELVATAYSFGLGAAAPYDELVVALREG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHC
GLDPVLVPTAARTLLHFVFGHATDEQTHLQAGSAGAIDDQPRETSDFALGLGLVLDGIRL
CCCCEEHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RQRVG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527; 3208760 [H]