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The map label for this gene is uvrB [H]

Identifier: 119717061

GI number: 119717061

Start: 3005648

End: 3007768

Strand: Reverse

Name: uvrB [H]

Synonym: Noca_2837

Alternate gene names: 119717061

Gene position: 3007768-3005648 (Counterclockwise)

Preceding gene: 119717063

Following gene: 119717060

Centisome position: 60.33

GC content: 67.89

Gene sequence:

>2121_bases
ATGCGACCAGTCACGGATCTCGAGCGCCGGGTGGCCCCGTTCAAGGTGGTCTCGGACTACCAGCCGTCCGGCGACCAGCC
GGCGGCGATCAAGGAGATCACCCAGCGGCTCCGGGCGGGCGTCCAGGACGTCGTGCTGCTGGGCGCCACCGGGACCGGCA
AGACCGCGACCGTGGCCTGGGTCGCCGAGCAGGTGCAGCGGCCGATGCTGGTCATGCAGCCGAACAAGACGCTGGCCGCG
CAGTTCGCCAACGAGCTGCGCCAGCTCTTCCCCGACAACGCGATCGAGTACTTCGTCTCCTACTACGACTACTACCAGCC
CGAGGCGTACGTCCCCCAGACCGACACCTACATCGAGAAGGACTCCTCGATCAACGAGGAGGTGGAGCGGCTGCGCCACT
CCGCGACCAACAGCCTGCTCACCCGGCGGGACGTGATCGTGGTCAGCACGGTCTCCTGCATCTACGGCCTCGGCACCCCG
CAGGAGTACGTCGACCGGATGGTCCGGCTCAAGGTGGGGGAGGAGCACGACCGCGACTCGATCCTGCGCCGCCTGGTCGA
GATCCAGTACACCCGCAACGACATGACGTTCACCCGCGGCACCTTCCGGGTCCGCGGTGACACCCTCGAGATCTTCCCGG
TCTACGAGGAGATGGCGATCCGGATCGAGTTCTTCGGCGACGAGATCGAGCGGATGATGACGCTGCACCCGGTGACCGGC
GAGGTCGTCACCGAGGACGAGGAGCTCTACATCTTCCCCGCCACCCACTACGTCGCCGGGCCCGAGCGGATGGAGCGCGC
GATCCGCGGCATCGAGCTCGAGCTGGAGGACCAGCTCGCGACGTTCGAGCGGCAGGGCAAGCTGCTCGAGGCGCAGCGGC
TGCGGATGCGCACGACGTACGACGTCGAGATGATGCGCCAGGTCGGCTCGTGCTCGGGGATCGAGAACTACTCGATGCAC
ATCGACGGCCGCACCCGCGGCTCGGCGCCCAACTGCCTGCTCGACTACTTCCCCGAGGACTTCGTGCTGGTGATCGACGA
GTCGCATGTCGCGGTCCCCCAGATCGGCGGCATGTACGAAGGCGACATGTCCCGCAAGCGCAACCTGGTCGACCACGGCT
TCCGGCTGCCGAGTGCGATGGACAACCGGCCGCTGCGCTGGGAGGAGTTCCTCGACCGGATCGGCCAGACCATCTACCTC
TCCGCGACCCCCGGCGACTACGAGCTCGACAAGGTCGGCGGTGACACCGTGGAGCAGATCATCCGCCCCACCGGCCTGGT
CGACCCCGAGGTCGTCGTCAAGCCGACCAAGGGTCAGATCGACGACCTGATCCACGAGATCAACCTGCGCGTGGAGAAGA
ACGAGCGGGTGCTGGTCACCACCCTGACCAAGAAGATGTCCGAGGACCTCACCGACTACCTCCTCGACGCCGGCGTGCGG
ACCCGGTACCTCCACTCCGAGGTGGACACCCTCAAGCGGATCGAGCTGCTGCGTGACCTGCGACTGGGGCAGTACGACGT
GCTGGTCGGCATCAACCTGCTGCGCGAGGGCCTGGACCTGCCCGAGGTGTCCCTGGTGGCGATCCTGGACGCCGACAAGG
AGGGCTTCCTGCGCTCGGACAAGTCGCTGATCCAGACGATCGGCCGCGCGGCCCGCAACGTGTCCGGCCAGGTGCACATG
TACGCCGACCGGATCACGCCGTCGATGGAGGCGGCGATCGACGAGACCAACCGGCGCCGCGCCAAGCAGGTCGCCTACAA
CACTGCCCACGGCATCGACCCGACCCCGCTGCGCAAGAAGATCGCCGACATCACCGACATGCTCGCCCGCGAGGAGGAGA
GCACCCAGGAGCTGCTCGACACCTGGCAGCACCTCGACCCCAAGCACCGCAAGGCCCCGGTGCCCGGCCTCTCGCGGATC
GCCGGCGGCGAGGCGGGCCAGCACACCGCCGACCTCGCGGGGCTGCCGAGCGCCGAGCTCGCCCAGCTGATCCAGGAGCT
GACCGACCAGATGAAGGGCGCGGCCGCCGAGCTGCACTTCGAGGTCGCCGCCCGGCTCCGCGACGAGATCGGCGACCTCA
AGAAGGAGCTGCGGCAGATGATGTCGGCAGGTGCGAAGTGA

Upstream 100 bases:

>100_bases
GCATGACCCGGATCACCCGCTCGGCGGCGATCGACAGGCGGCTCACGCGCTCACCCTAGCGAGCGGCCCGCTGTCGGTGT
CCCGGTCTACGCTCGAAGCC

Downstream 100 bases:

>100_bases
CCGCCGCCAAGCAGGTGCAGGTGACCTTCGACTGCGCCGATCCACGGGCGCTGTCGCTGTTCTGGAACGAGGTGCTCGGC
TACGAGCTCCCGCCGCCACC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 706; Mature: 706

Protein sequence:

>706_residues
MRPVTDLERRVAPFKVVSDYQPSGDQPAAIKEITQRLRAGVQDVVLLGATGTGKTATVAWVAEQVQRPMLVMQPNKTLAA
QFANELRQLFPDNAIEYFVSYYDYYQPEAYVPQTDTYIEKDSSINEEVERLRHSATNSLLTRRDVIVVSTVSCIYGLGTP
QEYVDRMVRLKVGEEHDRDSILRRLVEIQYTRNDMTFTRGTFRVRGDTLEIFPVYEEMAIRIEFFGDEIERMMTLHPVTG
EVVTEDEELYIFPATHYVAGPERMERAIRGIELELEDQLATFERQGKLLEAQRLRMRTTYDVEMMRQVGSCSGIENYSMH
IDGRTRGSAPNCLLDYFPEDFVLVIDESHVAVPQIGGMYEGDMSRKRNLVDHGFRLPSAMDNRPLRWEEFLDRIGQTIYL
SATPGDYELDKVGGDTVEQIIRPTGLVDPEVVVKPTKGQIDDLIHEINLRVEKNERVLVTTLTKKMSEDLTDYLLDAGVR
TRYLHSEVDTLKRIELLRDLRLGQYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSDKSLIQTIGRAARNVSGQVHM
YADRITPSMEAAIDETNRRRAKQVAYNTAHGIDPTPLRKKIADITDMLAREEESTQELLDTWQHLDPKHRKAPVPGLSRI
AGGEAGQHTADLAGLPSAELAQLIQELTDQMKGAAAELHFEVAARLRDEIGDLKKELRQMMSAGAK

Sequences:

>Translated_706_residues
MRPVTDLERRVAPFKVVSDYQPSGDQPAAIKEITQRLRAGVQDVVLLGATGTGKTATVAWVAEQVQRPMLVMQPNKTLAA
QFANELRQLFPDNAIEYFVSYYDYYQPEAYVPQTDTYIEKDSSINEEVERLRHSATNSLLTRRDVIVVSTVSCIYGLGTP
QEYVDRMVRLKVGEEHDRDSILRRLVEIQYTRNDMTFTRGTFRVRGDTLEIFPVYEEMAIRIEFFGDEIERMMTLHPVTG
EVVTEDEELYIFPATHYVAGPERMERAIRGIELELEDQLATFERQGKLLEAQRLRMRTTYDVEMMRQVGSCSGIENYSMH
IDGRTRGSAPNCLLDYFPEDFVLVIDESHVAVPQIGGMYEGDMSRKRNLVDHGFRLPSAMDNRPLRWEEFLDRIGQTIYL
SATPGDYELDKVGGDTVEQIIRPTGLVDPEVVVKPTKGQIDDLIHEINLRVEKNERVLVTTLTKKMSEDLTDYLLDAGVR
TRYLHSEVDTLKRIELLRDLRLGQYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSDKSLIQTIGRAARNVSGQVHM
YADRITPSMEAAIDETNRRRAKQVAYNTAHGIDPTPLRKKIADITDMLAREEESTQELLDTWQHLDPKHRKAPVPGLSRI
AGGEAGQHTADLAGLPSAELAQLIQELTDQMKGAAAELHFEVAARLRDEIGDLKKELRQMMSAGAK
>Mature_706_residues
MRPVTDLERRVAPFKVVSDYQPSGDQPAAIKEITQRLRAGVQDVVLLGATGTGKTATVAWVAEQVQRPMLVMQPNKTLAA
QFANELRQLFPDNAIEYFVSYYDYYQPEAYVPQTDTYIEKDSSINEEVERLRHSATNSLLTRRDVIVVSTVSCIYGLGTP
QEYVDRMVRLKVGEEHDRDSILRRLVEIQYTRNDMTFTRGTFRVRGDTLEIFPVYEEMAIRIEFFGDEIERMMTLHPVTG
EVVTEDEELYIFPATHYVAGPERMERAIRGIELELEDQLATFERQGKLLEAQRLRMRTTYDVEMMRQVGSCSGIENYSMH
IDGRTRGSAPNCLLDYFPEDFVLVIDESHVAVPQIGGMYEGDMSRKRNLVDHGFRLPSAMDNRPLRWEEFLDRIGQTIYL
SATPGDYELDKVGGDTVEQIIRPTGLVDPEVVVKPTKGQIDDLIHEINLRVEKNERVLVTTLTKKMSEDLTDYLLDAGVR
TRYLHSEVDTLKRIELLRDLRLGQYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSDKSLIQTIGRAARNVSGQVHM
YADRITPSMEAAIDETNRRRAKQVAYNTAHGIDPTPLRKKIADITDMLAREEESTQELLDTWQHLDPKHRKAPVPGLSRI
AGGEAGQHTADLAGLPSAELAQLIQELTDQMKGAAAELHFEVAARLRDEIGDLKKELRQMMSAGAK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=684, Percent_Identity=54.8245614035088, Blast_Score=721, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 80056; Mature: 80056

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPVTDLERRVAPFKVVSDYQPSGDQPAAIKEITQRLRAGVQDVVLLGATGTGKTATVAW
CCCHHHHHHHCCCHHEECCCCCCCCCCHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHH
VAEQVQRPMLVMQPNKTLAAQFANELRQLFPDNAIEYFVSYYDYYQPEAYVPQTDTYIEK
HHHHHHCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DSSINEEVERLRHSATNSLLTRRDVIVVSTVSCIYGLGTPQEYVDRMVRLKVGEEHDRDS
CCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHH
ILRRLVEIQYTRNDMTFTRGTFRVRGDTLEIFPVYEEMAIRIEFFGDEIERMMTLHPVTG
HHHHHHHHHCCCCCCEEECCEEEEECCEEEEEEEHHHHEEEEEEHHHHHHHHHHHCCCCC
EVVTEDEELYIFPATHYVAGPERMERAIRGIELELEDQLATFERQGKLLEAQRLRMRTTY
CEEECCCEEEEEECHHHCCCHHHHHHHHHCCCEEEHHHHHHHHHCCCHHHHHHHHHHCHH
DVEMMRQVGSCSGIENYSMHIDGRTRGSAPNCLLDYFPEDFVLVIDESHVAVPQIGGMYE
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCC
GDMSRKRNLVDHGFRLPSAMDNRPLRWEEFLDRIGQTIYLSATPGDYELDKVGGDTVEQI
CCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHCCCHHHHHH
IRPTGLVDPEVVVKPTKGQIDDLIHEINLRVEKNERVLVTTLTKKMSEDLTDYLLDAGVR
HCCCCCCCCCEEEECCCCHHHHHHHHHCCEEECCCEEEEHHHHHHHHHHHHHHHHHCCHH
TRYLHSEVDTLKRIELLRDLRLGQYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCC
KSLIQTIGRAARNVSGQVHMYADRITPSMEAAIDETNRRRAKQVAYNTAHGIDPTPLRKK
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IADITDMLAREEESTQELLDTWQHLDPKHRKAPVPGLSRIAGGEAGQHTADLAGLPSAEL
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHCCCCCHHH
AQLIQELTDQMKGAAAELHFEVAARLRDEIGDLKKELRQMMSAGAK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRPVTDLERRVAPFKVVSDYQPSGDQPAAIKEITQRLRAGVQDVVLLGATGTGKTATVAW
CCCHHHHHHHCCCHHEECCCCCCCCCCHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHH
VAEQVQRPMLVMQPNKTLAAQFANELRQLFPDNAIEYFVSYYDYYQPEAYVPQTDTYIEK
HHHHHHCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DSSINEEVERLRHSATNSLLTRRDVIVVSTVSCIYGLGTPQEYVDRMVRLKVGEEHDRDS
CCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHH
ILRRLVEIQYTRNDMTFTRGTFRVRGDTLEIFPVYEEMAIRIEFFGDEIERMMTLHPVTG
HHHHHHHHHCCCCCCEEECCEEEEECCEEEEEEEHHHHEEEEEEHHHHHHHHHHHCCCCC
EVVTEDEELYIFPATHYVAGPERMERAIRGIELELEDQLATFERQGKLLEAQRLRMRTTY
CEEECCCEEEEEECHHHCCCHHHHHHHHHCCCEEEHHHHHHHHHCCCHHHHHHHHHHCHH
DVEMMRQVGSCSGIENYSMHIDGRTRGSAPNCLLDYFPEDFVLVIDESHVAVPQIGGMYE
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCC
GDMSRKRNLVDHGFRLPSAMDNRPLRWEEFLDRIGQTIYLSATPGDYELDKVGGDTVEQI
CCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHCCCHHHHHH
IRPTGLVDPEVVVKPTKGQIDDLIHEINLRVEKNERVLVTTLTKKMSEDLTDYLLDAGVR
HCCCCCCCCCEEEECCCCHHHHHHHHHCCEEECCCEEEEHHHHHHHHHHHHHHHHHCCHH
TRYLHSEVDTLKRIELLRDLRLGQYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCC
KSLIQTIGRAARNVSGQVHMYADRITPSMEAAIDETNRRRAKQVAYNTAHGIDPTPLRKK
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IADITDMLAREEESTQELLDTWQHLDPKHRKAPVPGLSRIAGGEAGQHTADLAGLPSAEL
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHCCCCCHHH
AQLIQELTDQMKGAAAELHFEVAARLRDEIGDLKKELRQMMSAGAK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA