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The map label for this gene is hsaA [H]

Identifier: 119717000

GI number: 119717000

Start: 2946819

End: 2947985

Strand: Reverse

Name: hsaA [H]

Synonym: Noca_2776

Alternate gene names: 119717000

Gene position: 2947985-2946819 (Counterclockwise)

Preceding gene: 119717001

Following gene: 119716999

Centisome position: 59.13

GC content: 70.44

Gene sequence:

>1167_bases
ATGTCCCAGGCTGTTCTCGATGGCGTCCGTGACCTGCTGCCCGGGATCCGGGAGCGGGCCGACGAGGCCGAGCGTCTTCG
CGTCGTCCCCGATGCCTCGATCAAGGAGCTCGAGGAGGTCGGGTTCTTCCGGCTGCTCCAGCCCCGGAGGTTCGACGGCC
ACGAGGCCGACCCCGTCGACTTCTACACCGCGGTGCGCGACATCGCCGGCGCGTGCGGCTCCACCGGCTGGGTCTCCAGC
GTGGTCGGCGTCCACCCGTGGCAGATCGCGCTGTTCCCCGACCGGGCCCAGCAGGCCGTGTGGGGCGCGGACACCGCGAC
CCGGGTGAGCTCGTCGTACGCCCCGACCGGCAAGGCGCTGGTCGCTGACGGCGGCTACACCCTGTCCGGCAAGTGGAGCT
TCTCCTCCGGGTGCGACCACTGCAGCTGGGTGCTGCTCGGCGGCCTGGTGTTCAACGACGAGGGCCAGGTCGTGGACTTC
AAGACCTTCCTGGTGCCGCGCGAGAACTACACGATCAACGACGTCTGGAACGTCGTCGGCCTGTCCGGCACCGGCTCCAA
CGACATCGTGGTGGAGGACGTGTTCGTCCCCGAGGAGTTCACGCTCTCGATGGGGGACACCGGCCGCTGCTTCGGCCCGG
GCCAGGAGCAGAACCCCTCCGACCTCTACAAGCTGCCCTTCCACTCGATCTTCACCGGCACGATCACCACGCCGATCATC
GGCATGGCGCTGGGCGCGTACGCCGAGCACGTCGAGATGCAGCAGAAGCGGGTGCGCGCGGCGTACCTCGGTGAGAAGGC
CTCGCTCGACCCGTTCGCGGCCGTCCGGATCGCGAAGGCCTCCTCCGACATCGACGCCGCGTGGGCGCTGCTGGTCAACA
ACATCCGCGAGGAGCAGGCCTGCGTCGCGCGCGGGGAGAAGATCCCGCTCGGCCTGCGGCTCAAGGTGCGCCGCGACCAG
GTGCTCGGCACCCAGCGCGCGATCGACGCGATCGACTCGCTGTTCGAGGCCTCCGGCGGCCGCGCGCTCGCGACCGGCAC
CTACCTGCAGCGCGCCTGGCGCGACGCCCACGCCGGCCGGGTGCACGCCGCCAACGACCCCGAGCGGGCGCTGCAGATGT
ACGGCGCGCACGAGTTCGGGCACAAGATCGACCCGGGGATGTACTGA

Upstream 100 bases:

>100_bases
TGCGCCCGGCCTGCACTCGACCGGTGCGGGCGCGCGCCGTCTCGACCAAAACAAGAACGTGTTCTAGTATTGCTCCTGTC
CGACCACGACAGGAGCTGCG

Downstream 100 bases:

>100_bases
GTTGGCTCTCACGAAGGAGAGCGCGCAGCGCTCCGCCAAGGCGAAGGACATCACGCTCAGCTACTACGAGGCCGGGACCG
CGGCGACCTCCGCGACCGGG

Product: acyl-CoA dehydrogenase type 2

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSQAVLDGVRDLLPGIRERADEAERLRVVPDASIKELEEVGFFRLLQPRRFDGHEADPVDFYTAVRDIAGACGSTGWVSS
VVGVHPWQIALFPDRAQQAVWGADTATRVSSSYAPTGKALVADGGYTLSGKWSFSSGCDHCSWVLLGGLVFNDEGQVVDF
KTFLVPRENYTINDVWNVVGLSGTGSNDIVVEDVFVPEEFTLSMGDTGRCFGPGQEQNPSDLYKLPFHSIFTGTITTPII
GMALGAYAEHVEMQQKRVRAAYLGEKASLDPFAAVRIAKASSDIDAAWALLVNNIREEQACVARGEKIPLGLRLKVRRDQ
VLGTQRAIDAIDSLFEASGGRALATGTYLQRAWRDAHAGRVHAANDPERALQMYGAHEFGHKIDPGMY

Sequences:

>Translated_388_residues
MSQAVLDGVRDLLPGIRERADEAERLRVVPDASIKELEEVGFFRLLQPRRFDGHEADPVDFYTAVRDIAGACGSTGWVSS
VVGVHPWQIALFPDRAQQAVWGADTATRVSSSYAPTGKALVADGGYTLSGKWSFSSGCDHCSWVLLGGLVFNDEGQVVDF
KTFLVPRENYTINDVWNVVGLSGTGSNDIVVEDVFVPEEFTLSMGDTGRCFGPGQEQNPSDLYKLPFHSIFTGTITTPII
GMALGAYAEHVEMQQKRVRAAYLGEKASLDPFAAVRIAKASSDIDAAWALLVNNIREEQACVARGEKIPLGLRLKVRRDQ
VLGTQRAIDAIDSLFEASGGRALATGTYLQRAWRDAHAGRVHAANDPERALQMYGAHEFGHKIDPGMY
>Mature_387_residues
SQAVLDGVRDLLPGIRERADEAERLRVVPDASIKELEEVGFFRLLQPRRFDGHEADPVDFYTAVRDIAGACGSTGWVSSV
VGVHPWQIALFPDRAQQAVWGADTATRVSSSYAPTGKALVADGGYTLSGKWSFSSGCDHCSWVLLGGLVFNDEGQVVDFK
TFLVPRENYTINDVWNVVGLSGTGSNDIVVEDVFVPEEFTLSMGDTGRCFGPGQEQNPSDLYKLPFHSIFTGTITTPIIG
MALGAYAEHVEMQQKRVRAAYLGEKASLDPFAAVRIAKASSDIDAAWALLVNNIREEQACVARGEKIPLGLRLKVRRDQV
LGTQRAIDAIDSLFEASGGRALATGTYLQRAWRDAHAGRVHAANDPERALQMYGAHEFGHKIDPGMY

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 42318; Mature: 42187

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAVLDGVRDLLPGIRERADEAERLRVVPDASIKELEEVGFFRLLQPRRFDGHEADPVD
CCHHHHHHHHHHHHHHHHHCCHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHH
FYTAVRDIAGACGSTGWVSSVVGVHPWQIALFPDRAQQAVWGADTATRVSSSYAPTGKAL
HHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHHCCCCCCCCEE
VADGGYTLSGKWSFSSGCDHCSWVLLGGLVFNDEGQVVDFKTFLVPRENYTINDVWNVVG
EECCCEEEEEECCCCCCCCHHHHHHHCCEEECCCCCEEEEEEEEECCCCCCHHHHHHEEE
LSGTGSNDIVVEDVFVPEEFTLSMGDTGRCFGPGQEQNPSDLYKLPFHSIFTGTITTPII
ECCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHH
GMALGAYAEHVEMQQKRVRAAYLGEKASLDPFAAVRIAKASSDIDAAWALLVNNIREEQA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHH
CVARGEKIPLGLRLKVRRDQVLGTQRAIDAIDSLFEASGGRALATGTYLQRAWRDAHAGR
HHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCE
VHAANDPERALQMYGAHEFGHKIDPGMY
EECCCCHHHHHHHHCCHHCCCCCCCCCC
>Mature Secondary Structure 
SQAVLDGVRDLLPGIRERADEAERLRVVPDASIKELEEVGFFRLLQPRRFDGHEADPVD
CHHHHHHHHHHHHHHHHHCCHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHH
FYTAVRDIAGACGSTGWVSSVVGVHPWQIALFPDRAQQAVWGADTATRVSSSYAPTGKAL
HHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHHCCCCCCCCEE
VADGGYTLSGKWSFSSGCDHCSWVLLGGLVFNDEGQVVDFKTFLVPRENYTINDVWNVVG
EECCCEEEEEECCCCCCCCHHHHHHHCCEEECCCCCEEEEEEEEECCCCCCHHHHHHEEE
LSGTGSNDIVVEDVFVPEEFTLSMGDTGRCFGPGQEQNPSDLYKLPFHSIFTGTITTPII
ECCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHH
GMALGAYAEHVEMQQKRVRAAYLGEKASLDPFAAVRIAKASSDIDAAWALLVNNIREEQA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHH
CVARGEKIPLGLRLKVRRDQVLGTQRAIDAIDSLFEASGGRALATGTYLQRAWRDAHAGR
HHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCE
VHAANDPERALQMYGAHEFGHKIDPGMY
EECCCCHHHHHHHHCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA