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The map label for this gene is hsaC [H]

Identifier: 119716998

GI number: 119716998

Start: 2945010

End: 2945912

Strand: Reverse

Name: hsaC [H]

Synonym: Noca_2774

Alternate gene names: 119716998

Gene position: 2945912-2945010 (Counterclockwise)

Preceding gene: 119716999

Following gene: 119716997

Centisome position: 59.09

GC content: 70.54

Gene sequence:

>903_bases
GTGACCATCGACATCAAGTCCATGGGCTACGTCCGCGTGGCCAGCACCGACCTGTCCCGGTGGGAGACCTTCGCGGGCAA
GGTCCTCGGGCTCGCCGCCGGCCGTGGGCCCGACCCTGAGCACCAGTACTGGCGCATCGACGAGGTCTCCGCGCGGCTGG
TCGTGTTCCCGGCCGACGTCGACCAGCTCGCCTGCGTGGGCTGGGAGGTCGCCGACCACCGCGCGCTGCAGGAGGCCCGC
GAGCACCTGCAGAAGGCGGGGGTCGACTTCGAGGAGGGCACCCGTGAGGAGCTCGACGAGCGCCGGGTGCAGGAGCTGGT
CCGGTTCAGCGACCCGTGGGACAACGTCTTCGAGCTGTTCCACGGCATCAGCTACGAGTCCCGCCCCGTGGTGACGCCGT
ACGCCGCGAAGTTCGTGACCGGCGACCAGGGGATGGGCCACATCGTGCTGCCGGTGCTCGACGACGTCGAGGCGCTGCGG
TTCTACACCGACGTGCTCGGGTTCCGGCTGCGCGACTCGATGAGCATGCCGGGGGAGTTCGTCGGCAAGGAGCCGGGGTC
GAAGGTGTGGCTGCGGTTCCTCGGGGTGAACCCGCGCCACCACTCGTTGGCGTTCCTGCCGATGCCCAACCCGGCCAAGT
GCGTCCACATCATGCTGGAGGTCGACGAGCTGGACCACGTCGGCCGCGCGCTCGAGCGGGTGCGCAAGCACCGGGCGCCG
CTGTCGGCGACGCTCGGGCGGCACATGAACGACGAGATGATCTCCTTCTACGTGAGGTCGCCGGGCGGCTTCGACGTCGA
GTTCGGCACCGACGGGCTCACCGTCGACGACGCGCGCTGGGTGGCGCGGGAGTCGACCGCGGTGTCGTACTGGGGCCACG
ACTTCGGCGCGGCGGCCGGGTGA

Upstream 100 bases:

>100_bases
CGAACTGCGGGCACTGGGCGCAGGTCGAGGCCGCCGACGAGTTCGCCGAGGTCTCCATCGCGTTCCTGGCCCGGCACGTC
GAGCGCCCCGAGGGGGAGTC

Downstream 100 bases:

>100_bases
GCGATGCCCAGCGATTTCGGGAGCAGTGAGAAACTCGACCACATGACCTCCGAGCCGAGCCGTGAGATCCCGGAGGGCAT
GAGCCCGGACGCGCGCGAGA

Product: glyoxalase/bleomycin resistance protein/dioxygenase

Products: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate; H2O

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTIDIKSMGYVRVASTDLSRWETFAGKVLGLAAGRGPDPEHQYWRIDEVSARLVVFPADVDQLACVGWEVADHRALQEAR
EHLQKAGVDFEEGTREELDERRVQELVRFSDPWDNVFELFHGISYESRPVVTPYAAKFVTGDQGMGHIVLPVLDDVEALR
FYTDVLGFRLRDSMSMPGEFVGKEPGSKVWLRFLGVNPRHHSLAFLPMPNPAKCVHIMLEVDELDHVGRALERVRKHRAP
LSATLGRHMNDEMISFYVRSPGGFDVEFGTDGLTVDDARWVARESTAVSYWGHDFGAAAG

Sequences:

>Translated_300_residues
MTIDIKSMGYVRVASTDLSRWETFAGKVLGLAAGRGPDPEHQYWRIDEVSARLVVFPADVDQLACVGWEVADHRALQEAR
EHLQKAGVDFEEGTREELDERRVQELVRFSDPWDNVFELFHGISYESRPVVTPYAAKFVTGDQGMGHIVLPVLDDVEALR
FYTDVLGFRLRDSMSMPGEFVGKEPGSKVWLRFLGVNPRHHSLAFLPMPNPAKCVHIMLEVDELDHVGRALERVRKHRAP
LSATLGRHMNDEMISFYVRSPGGFDVEFGTDGLTVDDARWVARESTAVSYWGHDFGAAAG
>Mature_299_residues
TIDIKSMGYVRVASTDLSRWETFAGKVLGLAAGRGPDPEHQYWRIDEVSARLVVFPADVDQLACVGWEVADHRALQEARE
HLQKAGVDFEEGTREELDERRVQELVRFSDPWDNVFELFHGISYESRPVVTPYAAKFVTGDQGMGHIVLPVLDDVEALRF
YTDVLGFRLRDSMSMPGEFVGKEPGSKVWLRFLGVNPRHHSLAFLPMPNPAKCVHIMLEVDELDHVGRALERVRKHRAPL
SATLGRHMNDEMISFYVRSPGGFDVEFGTDGLTVDDARWVARESTAVSYWGHDFGAAAG

Specific function: Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4- oic acid (4,9-DSHA). Also involved in biphenyl and polychlorinated biphenyls

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the extradiol ring-cleavage dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR000486 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.39

Molecular weight: Translated: 33755; Mature: 33623

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDIKSMGYVRVASTDLSRWETFAGKVLGLAAGRGPDPEHQYWRIDEVSARLVVFPADV
CEEEECCCCEEEEECCCHHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCEEEEEEECCC
DQLACVGWEVADHRALQEAREHLQKAGVDFEEGTREELDERRVQELVRFSDPWDNVFELF
HHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
HGISYESRPVVTPYAAKFVTGDQGMGHIVLPVLDDVEALRFYTDVLGFRLRDSMSMPGEF
HCCCCCCCCCCCHHHHEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
VGKEPGSKVWLRFLGVNPRHHSLAFLPMPNPAKCVHIMLEVDELDHVGRALERVRKHRAP
CCCCCCCEEEEEEECCCCCCCCEEEEECCCCHHEEEEEEEHHHHHHHHHHHHHHHHHCCC
LSATLGRHMNDEMISFYVRSPGGFDVEFGTDGLTVDDARWVARESTAVSYWGHDFGAAAG
HHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCEECCHHHHHHCCCEEEECCCCCCCCCC
>Mature Secondary Structure 
TIDIKSMGYVRVASTDLSRWETFAGKVLGLAAGRGPDPEHQYWRIDEVSARLVVFPADV
EEEECCCCEEEEECCCHHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCEEEEEEECCC
DQLACVGWEVADHRALQEAREHLQKAGVDFEEGTREELDERRVQELVRFSDPWDNVFELF
HHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
HGISYESRPVVTPYAAKFVTGDQGMGHIVLPVLDDVEALRFYTDVLGFRLRDSMSMPGEF
HCCCCCCCCCCCHHHHEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
VGKEPGSKVWLRFLGVNPRHHSLAFLPMPNPAKCVHIMLEVDELDHVGRALERVRKHRAP
CCCCCCCEEEEEEECCCCCCCCEEEEECCCCHHEEEEEEEHHHHHHHHHHHHHHHHHCCC
LSATLGRHMNDEMISFYVRSPGGFDVEFGTDGLTVDDARWVARESTAVSYWGHDFGAAAG
HHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCEECCHHHHHHCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: biphenyl-2,3-diol; O2

Specific reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA