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The map label for this gene is fadA [H]

Identifier: 119716988

GI number: 119716988

Start: 2935358

End: 2936521

Strand: Reverse

Name: fadA [H]

Synonym: Noca_2764

Alternate gene names: 119716988

Gene position: 2936521-2935358 (Counterclockwise)

Preceding gene: 119716989

Following gene: 119716984

Centisome position: 58.9

GC content: 72.51

Gene sequence:

>1164_bases
GTGCCTGAGGCCTACATCGTCGACGCCGTCCGCACGCCGGTCGGCAAGCGCGGGGGAGCGCTGGCTGGCGTCCACTCCGC
CGACCTCGGCGCGCACTCGATCGCCGCCCTGATGCGGCGTACCGGCGTGGACCCGGGCGCCGTGGACGACGTGATCCTCG
GCTGCTGCGACACGATCGGCTCGCAGGCCGGAGACGTGGCCCGCACGGCGTGGCTGGTCGCGGGGCTGCCCGACCACGTG
CCGGGCGTGACCATCGACCGCCAGTGCGGCTCGGCCCAGCAGGCGGTGCACTTCGCCGCCCAGGGCGTGCTCTCCGGCAC
CCAGGACCTCGTGGTCGCCGGAGGCGTGCAGAACATGAGCGCGATCCCGATCTCGTCCGCGATGCTCGTCGGCCAGCAGT
ACGGGTTCTCCACGCCGTTCGCCGAGTCGCCGGGCTGGCTCGCGAGGTACGGCGACCAGGAGGTCAGCCAGTTCCGCGCC
GCGGAGCTGATCGCGGAGAAGTGGGGTCTCTCGCGCGAGGAGATGGAGTCGTTCGCGCTGGTCTCCCACGAGCGCGCGCG
GGCGGCGATCGCGGAGGGGCGGTTCAAGGACGAGATCGAGCCGGTCACGCTGCCCGACGGGACCGTCGTCGACACGGACC
AGTGCCCGCGCGACACGTCGCTCTCGAAGATGGCGGCGCTGTCGCCGCTGATCCCGGACGGGCGGATCACCGCCGCCGTG
GCCTCCCAGATCTCCGACGCGTCGGTGGCGATGCTGATCGCGTCGGAGGCCGCCGTACGCGATCACGGGCTGACGCCGCG
GGCGCGGATCCACCATCTCTCAGTGCGCGGGGACGACCCGGTCTGGATGCTCACCGGCCCGATCCGGGCGACCAGGCACG
CGCTGGAGCGCAGCGGCCTGGCGATCGAGGACATCGACCTGTTCGAGTGCAACGAGGCCTTCGCGCCCGTGGTGCTGGCC
TGGATGAAGGAGACCGGGGCCCCCCACCAGCGGGTCAACGTCAACGGCGGCGCGATCGCCCTGGGCCATCCGATCGGCGC
CACCGGGGCGCGCCTGATGACGACGCTCCTCGGCGAACTGGAGCGCACCGGTGGCCGCTACGGGCTGCAGACCATGTGCG
AGGGCGGCGGCCAGGCCAACGTCACGATCATCGAGCGACTCTGA

Upstream 100 bases:

>100_bases
ACCGTCTGGGTCGCCGTGTCCTGGTACCGGCCCGGCGGCCGGCGCACGCACACCGAGATCGCGCGGCAGTACCTGTCCAT
CCTGCTCGAAGGGATCGCCC

Downstream 100 bases:

>100_bases
CGGGAGCGCCGTCCGGTGCCGCCGGGCGGCGGTGGCGCGGAAGACGGCCCAGCCGGCGGCGGTCGCGATCACGGCCGCCA
GGAGGATGCCGACGACCGCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MPEAYIVDAVRTPVGKRGGALAGVHSADLGAHSIAALMRRTGVDPGAVDDVILGCCDTIGSQAGDVARTAWLVAGLPDHV
PGVTIDRQCGSAQQAVHFAAQGVLSGTQDLVVAGGVQNMSAIPISSAMLVGQQYGFSTPFAESPGWLARYGDQEVSQFRA
AELIAEKWGLSREEMESFALVSHERARAAIAEGRFKDEIEPVTLPDGTVVDTDQCPRDTSLSKMAALSPLIPDGRITAAV
ASQISDASVAMLIASEAAVRDHGLTPRARIHHLSVRGDDPVWMLTGPIRATRHALERSGLAIEDIDLFECNEAFAPVVLA
WMKETGAPHQRVNVNGGAIALGHPIGATGARLMTTLLGELERTGGRYGLQTMCEGGGQANVTIIERL

Sequences:

>Translated_387_residues
MPEAYIVDAVRTPVGKRGGALAGVHSADLGAHSIAALMRRTGVDPGAVDDVILGCCDTIGSQAGDVARTAWLVAGLPDHV
PGVTIDRQCGSAQQAVHFAAQGVLSGTQDLVVAGGVQNMSAIPISSAMLVGQQYGFSTPFAESPGWLARYGDQEVSQFRA
AELIAEKWGLSREEMESFALVSHERARAAIAEGRFKDEIEPVTLPDGTVVDTDQCPRDTSLSKMAALSPLIPDGRITAAV
ASQISDASVAMLIASEAAVRDHGLTPRARIHHLSVRGDDPVWMLTGPIRATRHALERSGLAIEDIDLFECNEAFAPVVLA
WMKETGAPHQRVNVNGGAIALGHPIGATGARLMTTLLGELERTGGRYGLQTMCEGGGQANVTIIERL
>Mature_386_residues
PEAYIVDAVRTPVGKRGGALAGVHSADLGAHSIAALMRRTGVDPGAVDDVILGCCDTIGSQAGDVARTAWLVAGLPDHVP
GVTIDRQCGSAQQAVHFAAQGVLSGTQDLVVAGGVQNMSAIPISSAMLVGQQYGFSTPFAESPGWLARYGDQEVSQFRAA
ELIAEKWGLSREEMESFALVSHERARAAIAEGRFKDEIEPVTLPDGTVVDTDQCPRDTSLSKMAALSPLIPDGRITAAVA
SQISDASVAMLIASEAAVRDHGLTPRARIHHLSVRGDDPVWMLTGPIRATRHALERSGLAIEDIDLFECNEAFAPVVLAW
MKETGAPHQRVNVNGGAIALGHPIGATGARLMTTLLGELERTGGRYGLQTMCEGGGQANVTIIERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=38.0462724935733, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=38.0710659898477, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4557237, Length=400, Percent_Identity=34, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4504327, Length=419, Percent_Identity=33.4128878281623, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4501853, Length=402, Percent_Identity=33.3333333333333, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=27.5510204081633, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1787663, Length=405, Percent_Identity=42.4691358024691, Blast_Score=270, Evalue=8e-74,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=39.5989974937343, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI87082165, Length=395, Percent_Identity=43.0379746835443, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI1788554, Length=411, Percent_Identity=39.1727493917275, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1788683, Length=407, Percent_Identity=28.7469287469287, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=37, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=402, Percent_Identity=31.8407960199005, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=32.6478149100257, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=30.6976744186047, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=28.7531806615776, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=33.4170854271357, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=32.4808184143223, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=38.0710659898477, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=36.4795918367347, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24640423, Length=395, Percent_Identity=33.1645569620253, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17137578, Length=421, Percent_Identity=29.4536817102138, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40679; Mature: 40547

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAYIVDAVRTPVGKRGGALAGVHSADLGAHSIAALMRRTGVDPGAVDDVILGCCDTIG
CCCCEEEHHHHCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
SQAGDVARTAWLVAGLPDHVPGVTIDRQCGSAQQAVHFAAQGVLSGTQDLVVAGGVQNMS
CCCCHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCC
AIPISSAMLVGQQYGFSTPFAESPGWLARYGDQEVSQFRAAELIAEKWGLSREEMESFAL
CCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VSHERARAAIAEGRFKDEIEPVTLPDGTVVDTDQCPRDTSLSKMAALSPLIPDGRITAAV
HHHHHHHHHHHCCCCCCCCCCEECCCCCEECCCCCCCCCCHHHHHHHCCCCCCCCHHHHH
ASQISDASVAMLIASEAAVRDHGLTPRARIHHLSVRGDDPVWMLTGPIRATRHALERSGL
HHHCCCCCEEEEHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHCCC
AIEDIDLFECNEAFAPVVLAWMKETGAPHQRVNVNGGAIALGHPIGATGARLMTTLLGEL
EEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHH
ERTGGRYGLQTMCEGGGQANVTIIERL
HHCCCCCCHHHHHCCCCCCCEEEEECC
>Mature Secondary Structure 
PEAYIVDAVRTPVGKRGGALAGVHSADLGAHSIAALMRRTGVDPGAVDDVILGCCDTIG
CCCEEEHHHHCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
SQAGDVARTAWLVAGLPDHVPGVTIDRQCGSAQQAVHFAAQGVLSGTQDLVVAGGVQNMS
CCCCHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCC
AIPISSAMLVGQQYGFSTPFAESPGWLARYGDQEVSQFRAAELIAEKWGLSREEMESFAL
CCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VSHERARAAIAEGRFKDEIEPVTLPDGTVVDTDQCPRDTSLSKMAALSPLIPDGRITAAV
HHHHHHHHHHHCCCCCCCCCCEECCCCCEECCCCCCCCCCHHHHHHHCCCCCCCCHHHHH
ASQISDASVAMLIASEAAVRDHGLTPRARIHHLSVRGDDPVWMLTGPIRATRHALERSGL
HHHCCCCCEEEEHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHCCC
AIEDIDLFECNEAFAPVVLAWMKETGAPHQRVNVNGGAIALGHPIGATGARLMTTLLGEL
EEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHH
ERTGGRYGLQTMCEGGGQANVTIIERL
HHCCCCCCHHHHHCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA