| Definition | Nocardioides sp. JS614 chromosome, complete genome. |
|---|---|
| Accession | NC_008699 |
| Length | 4,985,871 |
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The map label for this gene is coaBC [H]
Identifier: 119716665
GI number: 119716665
Start: 2598781
End: 2600091
Strand: Direct
Name: coaBC [H]
Synonym: Noca_2438
Alternate gene names: 119716665
Gene position: 2598781-2600091 (Clockwise)
Preceding gene: 119716664
Following gene: 119716666
Centisome position: 52.12
GC content: 73.61
Gene sequence:
>1311_bases ATGCGGGCAGCTCGTTCAGCGAGTGATCCGCTGACCACCAGCAGCACCCACGAGGCCGCCTCCCCGTCAGGGGGGCGGCC CGCTGCTCGTCCCGAGCAGGCTCCGCGGGTGGTGCTCGGGGTCTCCGGCGGCATCGCGGCCTACAAGGTCTGCGAGCTGC TGCGCCGCTTCACCGAGTCAGGTCATGACGTGACCGTCGTGCCGACCGTCGCCGCGCTGGAGTTCGTCGGAGCCCCGACC TGGGCAGCGCTGTCCGGCAAGCCCGTGTCGACCGAGGTGTGGAACGACGTCCACCAGGTGCCGCACGTGCGGATCGGCCA GTGGGCGGACCTCCTCGTGCTCGCGCCCGCGACCGCCGACCTGATCGCGAAGGCCGCCCACGGGCTGGCGGACGACCTGC TCACCAACACGCTGCTGACCGCCCGCTGTCCGGTGGTCCTCGCCCCGGCGATGCACACCGAGATGTGGGAGCACCCGGCG ACCCAGGCGAACGTGGCCACCCTTCGGGAGCGGGGCGTCGTGGTCATCGAGCCCGCCGAGGGCCGGCTCACCGGCAAGGA CACCGGCAAGGGCCGGCTGCCCGAGCCGGACGCGATCTTCGACCTGTGCCGGGAGCTGCTGACCCGGGGGAGCGGTGCTC CCGACCTGGCCGGGCGGCAGGTCCTGGTCACCGCCGGCGGCACCCGCGAGTACCTCGACCCGGTCCGGTTCCTCGGCAAC AGGTCCTCGGGCCTGCAGGGCTACGCCCTGGCCCGCGCGGCTGCCGCGCGTGGCGCCGAGGTCACCCTCGTCGCCGCGAA CGTCAGCCTCCCCGACCCCGCGGGGGTGAAGATCGTGCGGGTCGGCAGCACCGCCGAGCTGCGCGACGCGGTGCTGGCCG GCGCTGCGTCGGCCGACGCGGTGGTGATGGCAGCCGCGCCCGCGGACTTCCGGCCCGTCGACGTGAGCGAGGCGAAGATC AAGAAGGACGTCGACGGCTCCGCGCCGACCGTGACCCTCGCGCAGAACCCCGACATCCTCCACGAGATCAGCACCCATCG GGCCCGCCCGGGCGCCGTGATCGTCGGCTTCGCCGCCGAGACCGGCGACGAGACCGGAACCGTGCTCGACCTGGCCCGCG CCAAGCTCGCCCGCAAGGGCTGCGACCTGCTGGTGGTCAACGACGTCAGCGGCGGCGCGGTCTTCGGCAGCCCGGAGAAC CAGGCGGTGATCCTCGCGGCGGACGGCGCCGAGGTGGAGGTGCCGCGGGGCCCGAAGAACGCGCTGGCCCACATCATCTG GGACCAGGTGGCGAGCAGGCTGCAGGATTGA
Upstream 100 bases:
>100_bases ATCGCGCTGCGCGAGATCAACGAAGACCTGCTGACCTGCGAGGACGTCGACCCCGCCGAGCTCGCCGCCGAGGAGGCCGC CGCGCAGGCCGCCGCCGCGG
Downstream 100 bases:
>100_bases GACCGCCGTCCCGTGATCCGGGACGCTCGATATCGTTGGCAATCGTTGGCAGACCGCCAACCAGGACACAGGAGCGCAGA AGTGACCGGACGCCTCTTCA
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 436; Mature: 436
Protein sequence:
>436_residues MRAARSASDPLTTSSTHEAASPSGGRPAARPEQAPRVVLGVSGGIAAYKVCELLRRFTESGHDVTVVPTVAALEFVGAPT WAALSGKPVSTEVWNDVHQVPHVRIGQWADLLVLAPATADLIAKAAHGLADDLLTNTLLTARCPVVLAPAMHTEMWEHPA TQANVATLRERGVVVIEPAEGRLTGKDTGKGRLPEPDAIFDLCRELLTRGSGAPDLAGRQVLVTAGGTREYLDPVRFLGN RSSGLQGYALARAAAARGAEVTLVAANVSLPDPAGVKIVRVGSTAELRDAVLAGAASADAVVMAAAPADFRPVDVSEAKI KKDVDGSAPTVTLAQNPDILHEISTHRARPGAVIVGFAAETGDETGTVLDLARAKLARKGCDLLVVNDVSGGAVFGSPEN QAVILAADGAEVEVPRGPKNALAHIIWDQVASRLQD
Sequences:
>Translated_436_residues MRAARSASDPLTTSSTHEAASPSGGRPAARPEQAPRVVLGVSGGIAAYKVCELLRRFTESGHDVTVVPTVAALEFVGAPT WAALSGKPVSTEVWNDVHQVPHVRIGQWADLLVLAPATADLIAKAAHGLADDLLTNTLLTARCPVVLAPAMHTEMWEHPA TQANVATLRERGVVVIEPAEGRLTGKDTGKGRLPEPDAIFDLCRELLTRGSGAPDLAGRQVLVTAGGTREYLDPVRFLGN RSSGLQGYALARAAAARGAEVTLVAANVSLPDPAGVKIVRVGSTAELRDAVLAGAASADAVVMAAAPADFRPVDVSEAKI KKDVDGSAPTVTLAQNPDILHEISTHRARPGAVIVGFAAETGDETGTVLDLARAKLARKGCDLLVVNDVSGGAVFGSPEN QAVILAADGAEVEVPRGPKNALAHIIWDQVASRLQD >Mature_436_residues MRAARSASDPLTTSSTHEAASPSGGRPAARPEQAPRVVLGVSGGIAAYKVCELLRRFTESGHDVTVVPTVAALEFVGAPT WAALSGKPVSTEVWNDVHQVPHVRIGQWADLLVLAPATADLIAKAAHGLADDLLTNTLLTARCPVVLAPAMHTEMWEHPA TQANVATLRERGVVVIEPAEGRLTGKDTGKGRLPEPDAIFDLCRELLTRGSGAPDLAGRQVLVTAGGTREYLDPVRFLGN RSSGLQGYALARAAAARGAEVTLVAANVSLPDPAGVKIVRVGSTAELRDAVLAGAASADAVVMAAAPADFRPVDVSEAKI KKDVDGSAPTVTLAQNPDILHEISTHRARPGAVIVGFAAETGDETGTVLDLARAKLARKGCDLLVVNDVSGGAVFGSPEN QAVILAADGAEVEVPRGPKNALAHIIWDQVASRLQD
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=198, Percent_Identity=34.3434343434343, Blast_Score=93, Evalue=5e-19, Organism=Escherichia coli, GI87082301, Length=406, Percent_Identity=40.8866995073892, Blast_Score=243, Evalue=1e-65, Organism=Drosophila melanogaster, GI24657262, Length=182, Percent_Identity=27.4725274725275, Blast_Score=71, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 45192; Mature: 45192
Theoretical pI: Translated: 6.02; Mature: 6.02
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 0.9 %Met (Translated Protein) 1.8 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 0.9 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRAARSASDPLTTSSTHEAASPSGGRPAARPEQAPRVVLGVSGGIAAYKVCELLRRFTES CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHC GHDVTVVPTVAALEFVGAPTWAALSGKPVSTEVWNDVHQVPHVRIGQWADLLVLAPATAD CCCEEEEEHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCEECCCCCCEEEECCCHHH LIAKAAHGLADDLLTNTLLTARCPVVLAPAMHTEMWEHPATQANVATLRERGVVVIEPAE HHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCHHHHHHHHCCEEEEECCC GRLTGKDTGKGRLPEPDAIFDLCRELLTRGSGAPDLAGRQVLVTAGGTREYLDPVRFLGN CEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCC RSSGLQGYALARAAAARGAEVTLVAANVSLPDPAGVKIVRVGSTAELRDAVLAGAASADA CCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCE VVMAAAPADFRPVDVSEAKIKKDVDGSAPTVTLAQNPDILHEISTHRARPGAVIVGFAAE EEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCCCEEEEEEECC TGDETGTVLDLARAKLARKGCDLLVVNDVSGGAVFGSPENQAVILAADGAEVEVPRGPKN CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCCEEEEEECCCEEECCCCCHH ALAHIIWDQVASRLQD HHHHHHHHHHHHHHCC >Mature Secondary Structure MRAARSASDPLTTSSTHEAASPSGGRPAARPEQAPRVVLGVSGGIAAYKVCELLRRFTES CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHC GHDVTVVPTVAALEFVGAPTWAALSGKPVSTEVWNDVHQVPHVRIGQWADLLVLAPATAD CCCEEEEEHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCEECCCCCCEEEECCCHHH LIAKAAHGLADDLLTNTLLTARCPVVLAPAMHTEMWEHPATQANVATLRERGVVVIEPAE HHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCHHHHHHHHCCEEEEECCC GRLTGKDTGKGRLPEPDAIFDLCRELLTRGSGAPDLAGRQVLVTAGGTREYLDPVRFLGN CEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCC RSSGLQGYALARAAAARGAEVTLVAANVSLPDPAGVKIVRVGSTAELRDAVLAGAASADA CCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCE VVMAAAPADFRPVDVSEAKIKKDVDGSAPTVTLAQNPDILHEISTHRARPGAVIVGFAAE EEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCCCEEEEEEECC TGDETGTVLDLARAKLARKGCDLLVVNDVSGGAVFGSPENQAVILAADGAEVEVPRGPKN CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCCEEEEEECCCEEECCCCCHH ALAHIIWDQVASRLQD HHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]