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The map label for this gene is dapA1 [H]

Identifier: 119716542

GI number: 119716542

Start: 2464225

End: 2465121

Strand: Direct

Name: dapA1 [H]

Synonym: Noca_2315

Alternate gene names: 119716542

Gene position: 2464225-2465121 (Clockwise)

Preceding gene: 119716540

Following gene: 119716543

Centisome position: 49.42

GC content: 72.13

Gene sequence:

>897_bases
ATGACCTCCGCGCCCGCCGCTCCCTTCGGTCGTGTGCTCACGGCGATGGCCACCGCCTTCCACGACGACGGGTCGGTGGA
CCTCGAGGGCACCGCCCGGATCGCCGCCTACCTCGTCGACCACGGCCACGACGGGGTCGTGGTCTCCGGCACCACCGGCG
AGTCGCCGACGACCACCACCGCGGAGGACGGCGCGATCCTGGCCGCGGTCAAGGACGCGGTCGGTGGCCGCGCGGTCGTC
GTGGCCGGCGTCGGCACCAACTCCACGGCACACTCGGTCGAGCTGGCCGAGCAGGCCGCCAAGCTGGGCGCCGACGGGCT
GCTGCTGGTCACGCCCTACTACAACAAGCCCGGCCAGGCGGGCGTCCTGCACCACTTCACGGCCGTTGCCGAGGCCAGCG
ACGTCCCGGTCATGCTCTACGACGTCCCCGGCCGCACCGGCACCCAGATCGCGCTCGAGACCTATGAGGCGGCGATCCGG
CTGGAGACCGTCGTCGCGGTCAAGGACGCCGTCGGCGACTTCACCCGCGGCGTCAAGATCATGCAGCTGGGCTACGCCCT
CTACTCCGGCGACGACGCGAACAACCTCGGCTGGCTCGCGCACGGCGCCGCCGGCTTCGTCTCCGTCGTCGGGCACGCCG
CCGGCGAGCAGTTCAAGGCGATGGCCGACACCTTCCAGGCCGGCGACCACGCCGGCGCGCTCGAGATCTTCACGCGGCTG
CTCCCCGCGATCGACGCCGTCATGGGCGTCCCCAACTACGGAGCGACCACCGCCAAAGCAGCGCTCCAGCTGCTCGGCGT
CCTCGACAACCGCAACGTCCGGGCACCGCTGGTGCCGTTGGACGACGACGAGGTGGCCGCGCTGCGAGCAGGGCTCGCCG
CATCCGGCCTCCTGTAA

Upstream 100 bases:

>100_bases
GCTCTCACCCTGCCGGGGGACGGCGGAGCCGGCACAGGGAACAAGGCCCCGCGGCGACGGGTCCGAAGGACCCGGCGCGC
GGAGCGATAGCCTGTAGGAC

Downstream 100 bases:

>100_bases
GGAACCAGATGAGTCATCCCCATCCCGAGCTCTCCGCACCGGCCGCACTTCCGACGGGGGGCCTGCGGGTCATCCCGCTG
GGCGGGCTGGGCGAGGTCGG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 1 [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTSAPAAPFGRVLTAMATAFHDDGSVDLEGTARIAAYLVDHGHDGVVVSGTTGESPTTTTAEDGAILAAVKDAVGGRAVV
VAGVGTNSTAHSVELAEQAAKLGADGLLLVTPYYNKPGQAGVLHHFTAVAEASDVPVMLYDVPGRTGTQIALETYEAAIR
LETVVAVKDAVGDFTRGVKIMQLGYALYSGDDANNLGWLAHGAAGFVSVVGHAAGEQFKAMADTFQAGDHAGALEIFTRL
LPAIDAVMGVPNYGATTAKAALQLLGVLDNRNVRAPLVPLDDDEVAALRAGLAASGLL

Sequences:

>Translated_298_residues
MTSAPAAPFGRVLTAMATAFHDDGSVDLEGTARIAAYLVDHGHDGVVVSGTTGESPTTTTAEDGAILAAVKDAVGGRAVV
VAGVGTNSTAHSVELAEQAAKLGADGLLLVTPYYNKPGQAGVLHHFTAVAEASDVPVMLYDVPGRTGTQIALETYEAAIR
LETVVAVKDAVGDFTRGVKIMQLGYALYSGDDANNLGWLAHGAAGFVSVVGHAAGEQFKAMADTFQAGDHAGALEIFTRL
LPAIDAVMGVPNYGATTAKAALQLLGVLDNRNVRAPLVPLDDDEVAALRAGLAASGLL
>Mature_297_residues
TSAPAAPFGRVLTAMATAFHDDGSVDLEGTARIAAYLVDHGHDGVVVSGTTGESPTTTTAEDGAILAAVKDAVGGRAVVV
AGVGTNSTAHSVELAEQAAKLGADGLLLVTPYYNKPGQAGVLHHFTAVAEASDVPVMLYDVPGRTGTQIALETYEAAIRL
ETVVAVKDAVGDFTRGVKIMQLGYALYSGDDANNLGWLAHGAAGFVSVVGHAAGEQFKAMADTFQAGDHAGALEIFTRLL
PAIDAVMGVPNYGATTAKAALQLLGVLDNRNVRAPLVPLDDDEVAALRAGLAASGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=260, Percent_Identity=30, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI13540533, Length=286, Percent_Identity=26.5734265734266, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=33.7883959044369, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI87082415, Length=297, Percent_Identity=26.2626262626263, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789620, Length=282, Percent_Identity=25.886524822695, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786463, Length=289, Percent_Identity=28.3737024221453, Blast_Score=94, Evalue=9e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 30330; Mature: 30199

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAPAAPFGRVLTAMATAFHDDGSVDLEGTARIAAYLVDHGHDGVVVSGTTGESPTTTT
CCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHEEEEEEECCCCCEEEECCCCCCCCCCC
AEDGAILAAVKDAVGGRAVVVAGVGTNSTAHSVELAEQAAKLGADGLLLVTPYYNKPGQA
CCCCEEEEEEHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
GVLHHFTAVAEASDVPVMLYDVPGRTGTQIALETYEAAIRLETVVAVKDAVGDFTRGVKI
CHHHHHHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
MQLGYALYSGDDANNLGWLAHGAAGFVSVVGHAAGEQFKAMADTFQAGDHAGALEIFTRL
EEEEEHEECCCCCCCCCEECCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHH
LPAIDAVMGVPNYGATTAKAALQLLGVLDNRNVRAPLVPLDDDEVAALRAGLAASGLL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHCCHHCCCC
>Mature Secondary Structure 
TSAPAAPFGRVLTAMATAFHDDGSVDLEGTARIAAYLVDHGHDGVVVSGTTGESPTTTT
CCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHEEEEEEECCCCCEEEECCCCCCCCCCC
AEDGAILAAVKDAVGGRAVVVAGVGTNSTAHSVELAEQAAKLGADGLLLVTPYYNKPGQA
CCCCEEEEEEHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
GVLHHFTAVAEASDVPVMLYDVPGRTGTQIALETYEAAIRLETVVAVKDAVGDFTRGVKI
CHHHHHHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
MQLGYALYSGDDANNLGWLAHGAAGFVSVVGHAAGEQFKAMADTFQAGDHAGALEIFTRL
EEEEEHEECCCCCCCCCEECCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHH
LPAIDAVMGVPNYGATTAKAALQLLGVLDNRNVRAPLVPLDDDEVAALRAGLAASGLL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]