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The map label for this gene is merA [H]

Identifier: 119716319

GI number: 119716319

Start: 2231905

End: 2233359

Strand: Reverse

Name: merA [H]

Synonym: Noca_2088

Alternate gene names: 119716319

Gene position: 2233359-2231905 (Counterclockwise)

Preceding gene: 119716320

Following gene: 119716317

Centisome position: 44.79

GC content: 74.09

Gene sequence:

>1455_bases
ATGAGCGCCGGACACCCCAGGGGAGACGGCCCCTGGGACCTGGTGATCATCGGGGGCGGCACCGCCGGCATCGTGGGTGC
CAAGACCGCGGCCCGCTTCGGGGCGCGGGTTCTCCTGATCGAACGCGACCGTACCGGTGGCGACTGTCTGTGGACCGGCT
GCGTGCCGTCAAAGGCGCTCCTCGCGGCCGCGGACGTGGCGGCCACCGCGCGCTCCGGTCATCGGCTCGGGGTTGAGGCC
TACGGTGTCTCGGTCGACTTCCACGCCGTGCTGGGCCATGTCCGCGGAGCCATCGACCACATCGCGCCGATCGACTCACC
CCAGGCGCTCGAGGCCGAGGGTGTCACCGTGTGGCGCGGCGACGCGAAGTTCACGGGTCGCGACCAGGTCGCCGTCGGCG
ATCGACGCGCCACCTTCACCCAAGCGCTCCTGGCGACCGGGGCTGCCCCGGCCGTCCCGCGCATCCCGGGTCTGGCGCAG
ACGCCACACCTGACGAGCGACTCAGTCTGGCAACTCGACCGGCTCCCCGAGGACCTGGTCGTGCTCGGTGGCGGCAGCAT
CGGTTGCGAGCTGGGGCAGGCGTTCGCCCGGCTCGGCTCCCGGGTGACCGTCGTCGAGGGTGCGCCCCGGCTGCTCCCCC
GCGAGGACGCAGACGCTGCCACCGCCGTCACCACCGGCCTGCGCACTGACGGCGTCGACGTCATCACCGGCGTGGCGGTC
ACCCGGGTCGGACAAGGCGGCGGGCGGCCCCGCCTGGAACTGGCCGACGGCCGCGCCCTGGCGTTCAGCCAGCTGCTGGT
AGCGGTGGGCCGGTCGCCGCGGACCCACGGCATGGGACTCGAGCTGGCGGGGGTCGAGGTCACCGACCACGGGTTCGTGC
GCACTGACAGCCACCTCCGCACCACGAACCCGCGGATCTGGGCTGCCGGCGATCTCACCGGCCACCCCCAGTTCACCCAC
ACCGCCGGCGTCCACGGCAGCCTGGCCGCCAGCAACGCGGTCCTCGGCGTCCGCCGCAAGGTCGATCTCAGCGCGATCCC
GCGGGTGACCTACACCCAGCCCGAGGTGGCCGCGGTCGGGGTGGGGACCGAGTCGCCGCCGGACGGGTTGCGGCGGCTGA
CGTGGCAGCACACCCGCGTGGACCGGGCGGTGACCGAGCTGGCCACCGGCGGGTTCACCCGGCTGACGGTCGATCGACGT
GGCCGCCTGGTCGGCGCGACGGTCGTCGGCCCGCGGGCCGGCGAGAGCATCGGCGAGCTGACGCTGGCCATCAGCCAGGG
CCTACGCACCCGGGACCTCGCCGGCGTCACCCATGCCTACCCGACCTGGAACGACGGGCTCTGGCAGGCAGCAATCGCGG
ACCTGCGCGATCAGCTCGCGCGCCCGGGCACCAGACGGGCCCTCGGCATGCTGGCCCGCAGCCGCCGGTGGTGGCTCAAC
CGCGCCAGCAGCTGA

Upstream 100 bases:

>100_bases
ACCAGGCCCTGTCGCTGTGGTCGAGCCGCGCCTACGTCGACCCGTCGGCGGTGGACCGGGTCCGGCACTTCCTCGACGAC
ATCACCGAGGGACGGACCGG

Downstream 100 bases:

>100_bases
CCGATCGCGACCGTGCGACCGTGGGAGGATCGACGGCACACCAGTCCCGCCGTGAGGATCGGACAACCGTGACGCACCTT
CCCTCGCTGCCCGAGGACGC

Product: FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSAGHPRGDGPWDLVIIGGGTAGIVGAKTAARFGARVLLIERDRTGGDCLWTGCVPSKALLAAADVAATARSGHRLGVEA
YGVSVDFHAVLGHVRGAIDHIAPIDSPQALEAEGVTVWRGDAKFTGRDQVAVGDRRATFTQALLATGAAPAVPRIPGLAQ
TPHLTSDSVWQLDRLPEDLVVLGGGSIGCELGQAFARLGSRVTVVEGAPRLLPREDADAATAVTTGLRTDGVDVITGVAV
TRVGQGGGRPRLELADGRALAFSQLLVAVGRSPRTHGMGLELAGVEVTDHGFVRTDSHLRTTNPRIWAAGDLTGHPQFTH
TAGVHGSLAASNAVLGVRRKVDLSAIPRVTYTQPEVAAVGVGTESPPDGLRRLTWQHTRVDRAVTELATGGFTRLTVDRR
GRLVGATVVGPRAGESIGELTLAISQGLRTRDLAGVTHAYPTWNDGLWQAAIADLRDQLARPGTRRALGMLARSRRWWLN
RASS

Sequences:

>Translated_484_residues
MSAGHPRGDGPWDLVIIGGGTAGIVGAKTAARFGARVLLIERDRTGGDCLWTGCVPSKALLAAADVAATARSGHRLGVEA
YGVSVDFHAVLGHVRGAIDHIAPIDSPQALEAEGVTVWRGDAKFTGRDQVAVGDRRATFTQALLATGAAPAVPRIPGLAQ
TPHLTSDSVWQLDRLPEDLVVLGGGSIGCELGQAFARLGSRVTVVEGAPRLLPREDADAATAVTTGLRTDGVDVITGVAV
TRVGQGGGRPRLELADGRALAFSQLLVAVGRSPRTHGMGLELAGVEVTDHGFVRTDSHLRTTNPRIWAAGDLTGHPQFTH
TAGVHGSLAASNAVLGVRRKVDLSAIPRVTYTQPEVAAVGVGTESPPDGLRRLTWQHTRVDRAVTELATGGFTRLTVDRR
GRLVGATVVGPRAGESIGELTLAISQGLRTRDLAGVTHAYPTWNDGLWQAAIADLRDQLARPGTRRALGMLARSRRWWLN
RASS
>Mature_483_residues
SAGHPRGDGPWDLVIIGGGTAGIVGAKTAARFGARVLLIERDRTGGDCLWTGCVPSKALLAAADVAATARSGHRLGVEAY
GVSVDFHAVLGHVRGAIDHIAPIDSPQALEAEGVTVWRGDAKFTGRDQVAVGDRRATFTQALLATGAAPAVPRIPGLAQT
PHLTSDSVWQLDRLPEDLVVLGGGSIGCELGQAFARLGSRVTVVEGAPRLLPREDADAATAVTTGLRTDGVDVITGVAVT
RVGQGGGRPRLELADGRALAFSQLLVAVGRSPRTHGMGLELAGVEVTDHGFVRTDSHLRTTNPRIWAAGDLTGHPQFTHT
AGVHGSLAASNAVLGVRRKVDLSAIPRVTYTQPEVAAVGVGTESPPDGLRRLTWQHTRVDRAVTELATGGFTRLTVDRRG
RLVGATVVGPRAGESIGELTLAISQGLRTRDLAGVTHAYPTWNDGLWQAAIADLRDQLARPGTRRALGMLARSRRWWLNR
ASS

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=473, Percent_Identity=29.5983086680761, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI50301238, Length=457, Percent_Identity=25.164113785558, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=23.6323851203501, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=23.6323851203501, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=23.6323851203501, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=23.6323851203501, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI148277071, Length=457, Percent_Identity=23.6323851203501, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=22.7571115973742, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI22035672, Length=465, Percent_Identity=23.6559139784946, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786307, Length=478, Percent_Identity=32.0083682008368, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=30.4824561403509, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=25.8741258741259, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=24.5652173913043, Blast_Score=119, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI32565766, Length=481, Percent_Identity=30.5613305613306, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=24.5283018867925, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983429, Length=336, Percent_Identity=26.7857142857143, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71983419, Length=336, Percent_Identity=26.7857142857143, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=477, Percent_Identity=24.1090146750524, Blast_Score=92, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=30.8823529411765, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=460, Percent_Identity=26.304347826087, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=25, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=30.2173913043478, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI17737741, Length=490, Percent_Identity=25.5102040816327, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640549, Length=486, Percent_Identity=25.9259259259259, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24640551, Length=485, Percent_Identity=25.979381443299, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640553, Length=486, Percent_Identity=25.9259259259259, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 50762; Mature: 50631

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGHPRGDGPWDLVIIGGGTAGIVGAKTAARFGARVLLIERDRTGGDCLWTGCVPSKAL
CCCCCCCCCCCEEEEEECCCCCCEECCHHHHHCCCEEEEEEECCCCCCEEEECCCCCHHH
LAAADVAATARSGHRLGVEAYGVSVDFHAVLGHVRGAIDHIAPIDSPQALEAEGVTVWRG
HHHHHHHHHHCCCCEECEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
DAKFTGRDQVAVGDRRATFTQALLATGAAPAVPRIPGLAQTPHLTSDSVWQLDRLPEDLV
CCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEE
VLGGGSIGCELGQAFARLGSRVTVVEGAPRLLPREDADAATAVTTGLRTDGVDVITGVAV
EECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHH
TRVGQGGGRPRLELADGRALAFSQLLVAVGRSPRTHGMGLELAGVEVTDHGFVRTDSHLR
EEECCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCEEECCCEE
TTNPRIWAAGDLTGHPQFTHTAGVHGSLAASNAVLGVRRKVDLSAIPRVTYTQPEVAAVG
CCCCCEEEECCCCCCCCCCCCCCCCCCHHHCCCEEEEEEECCHHHCCCEEECCCCEEEEE
VGTESPPDGLRRLTWQHTRVDRAVTELATGGFTRLTVDRRGRLVGATVVGPRAGESIGEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCHHHH
TLAISQGLRTRDLAGVTHAYPTWNDGLWQAAIADLRDQLARPGTRRALGMLARSRRWWLN
HHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
RASS
CCCC
>Mature Secondary Structure 
SAGHPRGDGPWDLVIIGGGTAGIVGAKTAARFGARVLLIERDRTGGDCLWTGCVPSKAL
CCCCCCCCCCEEEEEECCCCCCEECCHHHHHCCCEEEEEEECCCCCCEEEECCCCCHHH
LAAADVAATARSGHRLGVEAYGVSVDFHAVLGHVRGAIDHIAPIDSPQALEAEGVTVWRG
HHHHHHHHHHCCCCEECEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
DAKFTGRDQVAVGDRRATFTQALLATGAAPAVPRIPGLAQTPHLTSDSVWQLDRLPEDLV
CCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEE
VLGGGSIGCELGQAFARLGSRVTVVEGAPRLLPREDADAATAVTTGLRTDGVDVITGVAV
EECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHH
TRVGQGGGRPRLELADGRALAFSQLLVAVGRSPRTHGMGLELAGVEVTDHGFVRTDSHLR
EEECCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCEEECCCEE
TTNPRIWAAGDLTGHPQFTHTAGVHGSLAASNAVLGVRRKVDLSAIPRVTYTQPEVAAVG
CCCCCEEEECCCCCCCCCCCCCCCCCCHHHCCCEEEEEEECCHHHCCCEEECCCCEEEEE
VGTESPPDGLRRLTWQHTRVDRAVTELATGGFTRLTVDRRGRLVGATVVGPRAGESIGEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCHHHH
TLAISQGLRTRDLAGVTHAYPTWNDGLWQAAIADLRDQLARPGTRRALGMLARSRRWWLN
HHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
RASS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2067577 [H]