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The map label for this gene is mprB [H]

Identifier: 119716239

GI number: 119716239

Start: 2148713

End: 2150239

Strand: Reverse

Name: mprB [H]

Synonym: Noca_2007

Alternate gene names: 119716239

Gene position: 2150239-2148713 (Counterclockwise)

Preceding gene: 119716240

Following gene: 119716238

Centisome position: 43.13

GC content: 73.48

Gene sequence:

>1527_bases
ATGACCACAGCGGCAGCGGCAGCGACGACAGCGGCCACGGGAGCAGCGACGACTGACCCGACGACGGAGGGGACGGACCC
CCGACGCAGCGCCCGGCCGACGTCCCGGCCGGGCGTCTCCGTCCGGGTCCGCATCACCGCCGCGGTCGCGCTCCTCGGCG
CCCTGGCGCTGACCGGCGCGGGCGCGATCGTCTACGCCGTCGAGGGGCAGCGGGTCGAGGAGCAACAGCTCGCCGAGATC
GACCAGGAGCTCGCGGAGCTGGGCAAGCTGCACAAGCGGGGGCTGAACCCCGACACCGGCCGGCCGTTCGACAGCGTCGG
CACCATGCTGGACACCTTCCTGGTCCGCAACGTCCCGGACGAGAACGAGATCCTCGTCAGCTGGTTCGACGGCCGCCCCC
AGAAGGCCTCCCCCACGGCCGCGTTCGCGGAGACCCAGCTGTTCCGCGACACCGCCGGCGCGCTGGTCGACGACGGCGGC
GGCTCCGCACGGGTGGACGTGCCCGGGTACGGCGAGGCGCTGATCACCGTGCAGCCGGTGCGCAGCACGCGGGAGGCCGG
GGCCCTGGTGATCGTGACCTACCTGACCGAGGCCCGCGCCGAGCTGCGCGACACGATGCGCACCTACGCGACCGTCGCGC
TGCTCTCGCTGTTGCTCGTCACCGCAGCCGCGGCCTGGCTGTCCGGTCGGTTGCTCGCGCCGCTGCGCACGCTCCGCGAG
ACCGCGGACGACATCTCCGGGTCCGACCTCTCCCGCCGGCTGCCCGTCACCGGGCACGACGACATCACGGCCCTCACCCG
TACCGTGAACGGGATGCTCGACCGGCTCGAGGCCGCGTTCGTCGGCCAGCGGGAGTTCCTCGACGACGCCGGGCACGAGC
TGCGGACCCCGCTGACCGTGCTCCGGGGGCACCTCGAGCTGCTCGACACCGGCGACCCCGCCGAGGTCGCCGAGACCAAG
GAGCTGCTGCTCGACGAGGTGGACCGGATGTCCCGGTTGGTCGGCGACCTGATCCTGCTGGCGAAGAGCGACCGGCCCGA
CTTCCTCCAGCTCCGGCCGGTCGACCTGGCCGGCCTGACCGCCGACGTGCTCGCCAAGGCCCGTGGTCTCGGCGACCGGG
ACTGGCAGCTCGACGCGGCCGCCGACGTGGTGGTCGTCGGGGACGAGCAGCGGCTGACCCAGGCCCTGCTCCAGCTCGCC
GACAACGCGGTCAAGCACACCGGCCCCGGAGACACGGTCGCGATCGGGTCGTCGTACGACGACGGCCGCGCGCGGCTGTG
GGTCCGCGACACCGGACCCGGCGTACCGCCCGAACAGCGCGGGCTGATCTTTGAACGATTCGGCCGCGGCGCCGTAATGC
CTGGTGACGAGGGCTTCGGCCTCGGCCTGTCGATCGTGTCCGCCATCGCGCGGTCGCACGGCGGCGGCGTCGAGGTCGAG
GACGCCGAGGAGACCGCCCCCCGCGGTGCTCGGTTCGTCATGACGCTGCCCGCGCCACCGAAGGAGGACCCGTGGCCAGG
ATCCTGA

Upstream 100 bases:

>100_bases
GACGACGACAGCGACGACTTCGGGCGCGACGACGACCGGTTCGACGACCACGGCGACGACCACGGCGACGACGACCACTC
CGGGCCCGGCGGAGGCGGCG

Downstream 100 bases:

>100_bases
TCGTCGAGGACGAGGAGCGGATCGCGTCGTTCCTGGCCAAGGGGCTGCGCGCCGACGGCCACGTGACGACCTGCGTGGCG
GACGGCCGTGAGGGGCTCGA

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MTTAAAAATTAATGAATTDPTTEGTDPRRSARPTSRPGVSVRVRITAAVALLGALALTGAGAIVYAVEGQRVEEQQLAEI
DQELAELGKLHKRGLNPDTGRPFDSVGTMLDTFLVRNVPDENEILVSWFDGRPQKASPTAAFAETQLFRDTAGALVDDGG
GSARVDVPGYGEALITVQPVRSTREAGALVIVTYLTEARAELRDTMRTYATVALLSLLLVTAAAAWLSGRLLAPLRTLRE
TADDISGSDLSRRLPVTGHDDITALTRTVNGMLDRLEAAFVGQREFLDDAGHELRTPLTVLRGHLELLDTGDPAEVAETK
ELLLDEVDRMSRLVGDLILLAKSDRPDFLQLRPVDLAGLTADVLAKARGLGDRDWQLDAAADVVVVGDEQRLTQALLQLA
DNAVKHTGPGDTVAIGSSYDDGRARLWVRDTGPGVPPEQRGLIFERFGRGAVMPGDEGFGLGLSIVSAIARSHGGGVEVE
DAEETAPRGARFVMTLPAPPKEDPWPGS

Sequences:

>Translated_508_residues
MTTAAAAATTAATGAATTDPTTEGTDPRRSARPTSRPGVSVRVRITAAVALLGALALTGAGAIVYAVEGQRVEEQQLAEI
DQELAELGKLHKRGLNPDTGRPFDSVGTMLDTFLVRNVPDENEILVSWFDGRPQKASPTAAFAETQLFRDTAGALVDDGG
GSARVDVPGYGEALITVQPVRSTREAGALVIVTYLTEARAELRDTMRTYATVALLSLLLVTAAAAWLSGRLLAPLRTLRE
TADDISGSDLSRRLPVTGHDDITALTRTVNGMLDRLEAAFVGQREFLDDAGHELRTPLTVLRGHLELLDTGDPAEVAETK
ELLLDEVDRMSRLVGDLILLAKSDRPDFLQLRPVDLAGLTADVLAKARGLGDRDWQLDAAADVVVVGDEQRLTQALLQLA
DNAVKHTGPGDTVAIGSSYDDGRARLWVRDTGPGVPPEQRGLIFERFGRGAVMPGDEGFGLGLSIVSAIARSHGGGVEVE
DAEETAPRGARFVMTLPAPPKEDPWPGS
>Mature_507_residues
TTAAAAATTAATGAATTDPTTEGTDPRRSARPTSRPGVSVRVRITAAVALLGALALTGAGAIVYAVEGQRVEEQQLAEID
QELAELGKLHKRGLNPDTGRPFDSVGTMLDTFLVRNVPDENEILVSWFDGRPQKASPTAAFAETQLFRDTAGALVDDGGG
SARVDVPGYGEALITVQPVRSTREAGALVIVTYLTEARAELRDTMRTYATVALLSLLLVTAAAAWLSGRLLAPLRTLRET
ADDISGSDLSRRLPVTGHDDITALTRTVNGMLDRLEAAFVGQREFLDDAGHELRTPLTVLRGHLELLDTGDPAEVAETKE
LLLDEVDRMSRLVGDLILLAKSDRPDFLQLRPVDLAGLTADVLAKARGLGDRDWQLDAAADVVVVGDEQRLTQALLQLAD
NAVKHTGPGDTVAIGSSYDDGRARLWVRDTGPGVPPEQRGLIFERFGRGAVMPGDEGFGLGLSIVSAIARSHGGGVEVED
AEETAPRGARFVMTLPAPPKEDPWPGS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=322, Percent_Identity=31.055900621118, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=33.984375, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789403, Length=287, Percent_Identity=33.7979094076655, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786600, Length=260, Percent_Identity=31.9230769230769, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=30.2491103202847, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=30.4545454545455, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787894, Length=295, Percent_Identity=29.1525423728814, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790346, Length=297, Percent_Identity=28.956228956229, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788279, Length=320, Percent_Identity=25.9375, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=257, Percent_Identity=29.5719844357977, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787374, Length=270, Percent_Identity=27.4074074074074, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788549, Length=254, Percent_Identity=27.5590551181102, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789808, Length=283, Percent_Identity=26.8551236749117, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082128, Length=278, Percent_Identity=26.2589928057554, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=29.5833333333333, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53919; Mature: 53788

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAAAAATTAATGAATTDPTTEGTDPRRSARPTSRPGVSVRVRITAAVALLGALALTGA
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCC
GAIVYAVEGQRVEEQQLAEIDQELAELGKLHKRGLNPDTGRPFDSVGTMLDTFLVRNVPD
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
ENEILVSWFDGRPQKASPTAAFAETQLFRDTAGALVDDGGGSARVDVPGYGEALITVQPV
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCEEEEEECC
RSTREAGALVIVTYLTEARAELRDTMRTYATVALLSLLLVTAAAAWLSGRLLAPLRTLRE
HHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TADDISGSDLSRRLPVTGHDDITALTRTVNGMLDRLEAAFVGQREFLDDAGHELRTPLTV
HHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHCHHHH
LRGHLELLDTGDPAEVAETKELLLDEVDRMSRLVGDLILLAKSDRPDFLQLRPVDLAGLT
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEECCHHHCCH
ADVLAKARGLGDRDWQLDAAADVVVVGDEQRLTQALLQLADNAVKHTGPGDTVAIGSSYD
HHHHHHHCCCCCCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
DGRARLWVRDTGPGVPPEQRGLIFERFGRGAVMPGDEGFGLGLSIVSAIARSHGGGVEVE
CCCEEEEEEECCCCCCCHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEC
DAEETAPRGARFVMTLPAPPKEDPWPGS
CCHHCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TTAAAAATTAATGAATTDPTTEGTDPRRSARPTSRPGVSVRVRITAAVALLGALALTGA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCC
GAIVYAVEGQRVEEQQLAEIDQELAELGKLHKRGLNPDTGRPFDSVGTMLDTFLVRNVPD
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
ENEILVSWFDGRPQKASPTAAFAETQLFRDTAGALVDDGGGSARVDVPGYGEALITVQPV
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCEEEEEECC
RSTREAGALVIVTYLTEARAELRDTMRTYATVALLSLLLVTAAAAWLSGRLLAPLRTLRE
HHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TADDISGSDLSRRLPVTGHDDITALTRTVNGMLDRLEAAFVGQREFLDDAGHELRTPLTV
HHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHCHHHH
LRGHLELLDTGDPAEVAETKELLLDEVDRMSRLVGDLILLAKSDRPDFLQLRPVDLAGLT
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEECCHHHCCH
ADVLAKARGLGDRDWQLDAAADVVVVGDEQRLTQALLQLADNAVKHTGPGDTVAIGSSYD
HHHHHHHCCCCCCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
DGRARLWVRDTGPGVPPEQRGLIFERFGRGAVMPGDEGFGLGLSIVSAIARSHGGGVEVE
CCCEEEEEEECCCCCCCHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEC
DAEETAPRGARFVMTLPAPPKEDPWPGS
CCHHCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA