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The map label for this gene is lldD2 [H]

Identifier: 119716212

GI number: 119716212

Start: 2111905

End: 2112975

Strand: Direct

Name: lldD2 [H]

Synonym: Noca_1980

Alternate gene names: 119716212

Gene position: 2111905-2112975 (Clockwise)

Preceding gene: 119716211

Following gene: 119716213

Centisome position: 42.36

GC content: 76.47

Gene sequence:

>1071_bases
GTGGCGCCGGCGGCCGAGCGGGATCCGCGCTGGCTCGACACGCTGGCCGAGCGGGCCCGCGACCGGCTGCCGGCGTCCGT
CCTGGAGTACGTGCTGCAGGGCGCGCGCGACTCGCTCACCGCCGGGGAGGCCGTGGCCGCGTGGCGCGCCGTGCGGCTGC
TGCCCCGCGTGCTGCACGACGTCACCCAGGTGGAGACGTCGGTCAGCCTGCTGGGCCACCCGGCTCAGGTGCCCTGGGGG
GTCGCGCCCAGCACGCTGCAGCGTGCCGTCCACCCCGACGGGGAGCTCGCGATGGCGCGGGCCTGTGCCGCGGCGGGGTC
GGTCATGGTGGTCTCGAGCAACGCCGGCACGGCCTTCTCCGAGATCGGCGGCACAGGGGTGCACTGGTGGCTCCAGGCCT
ACCTGCCGGCGGACCGGACGCTCGCCGGGCCGATGCTCGACCGCGCCGTGGCCGCCGGGGCCCGGGCCGTGGTGCTGACC
GTCGACACCCCGGTCGTCGGCACCAAGTACGCCAGTCCGGGCACGGCGTTGGTCTGGGAGACGGTCGACCCGGCGCTGCT
GCGGGTGAACTTCGAGCCGGGGTACGACGAGCAGCCGGGCGCCGAGAAGGCACTCGACCTCGGGCCGCACGACATCGGCT
GGGTGGCTGCCCGCACCGGCCTGCCGGTCGTCGTGAAGGGCGTGCTCCGGCCCGAGGACGCGCTGCGCTGTGCCCAGGCC
GGCGCCGGTGCCGTCTGGGTCTCCAACCACGGCGGTCGCCAGCTCGACCGGTCGGCGAGCACCGCCGCATGCCTGCCGGA
TGTCGTCGACGCGGTGGGGGACCAGGCCGAGGTGTACGTCGACGGCGGCCTCCGGACCGGGCTGGACGTCGTGGCCGCGT
TGGCGCTGGGGGCGCGCGCGGTGTTCCTGGGTCGATCGCCGCTCCTGGCGTTGCTCGACGGGGCCGAGGGCGTGGCCCGG
CTGCACCAGGAGCTGCTCGAGCAGACCGTCGAGACGCTGCGGCTGGCCGGCTGCCGGACGCCCGCCGACGCGCCGGGACT
GGCCGCGGGTGGACGCCTTACCCCTCGCTGA

Upstream 100 bases:

>100_bases
ATCCCGACCACGTCCCGGCCCCGGAGGACCTGATCGACGGCACCTGGCTGGTGCTGCGGCGGGGCAAGAAGAACTTCGCC
GGCGTCGAGGTGCGCTGAGC

Downstream 100 bases:

>100_bases
CCTGCACAAACGTGGTTGTGGCCCGGGTCACGTGGGGCCGATTTGAACTCCCGGGGTCGGGTCCCCTAATGTTCTCCGGG
TCGCCAGGGAGCGGCGGGAG

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MAPAAERDPRWLDTLAERARDRLPASVLEYVLQGARDSLTAGEAVAAWRAVRLLPRVLHDVTQVETSVSLLGHPAQVPWG
VAPSTLQRAVHPDGELAMARACAAAGSVMVVSSNAGTAFSEIGGTGVHWWLQAYLPADRTLAGPMLDRAVAAGARAVVLT
VDTPVVGTKYASPGTALVWETVDPALLRVNFEPGYDEQPGAEKALDLGPHDIGWVAARTGLPVVVKGVLRPEDALRCAQA
GAGAVWVSNHGGRQLDRSASTAACLPDVVDAVGDQAEVYVDGGLRTGLDVVAALALGARAVFLGRSPLLALLDGAEGVAR
LHQELLEQTVETLRLAGCRTPADAPGLAAGGRLTPR

Sequences:

>Translated_356_residues
MAPAAERDPRWLDTLAERARDRLPASVLEYVLQGARDSLTAGEAVAAWRAVRLLPRVLHDVTQVETSVSLLGHPAQVPWG
VAPSTLQRAVHPDGELAMARACAAAGSVMVVSSNAGTAFSEIGGTGVHWWLQAYLPADRTLAGPMLDRAVAAGARAVVLT
VDTPVVGTKYASPGTALVWETVDPALLRVNFEPGYDEQPGAEKALDLGPHDIGWVAARTGLPVVVKGVLRPEDALRCAQA
GAGAVWVSNHGGRQLDRSASTAACLPDVVDAVGDQAEVYVDGGLRTGLDVVAALALGARAVFLGRSPLLALLDGAEGVAR
LHQELLEQTVETLRLAGCRTPADAPGLAAGGRLTPR
>Mature_355_residues
APAAERDPRWLDTLAERARDRLPASVLEYVLQGARDSLTAGEAVAAWRAVRLLPRVLHDVTQVETSVSLLGHPAQVPWGV
APSTLQRAVHPDGELAMARACAAAGSVMVVSSNAGTAFSEIGGTGVHWWLQAYLPADRTLAGPMLDRAVAAGARAVVLTV
DTPVVGTKYASPGTALVWETVDPALLRVNFEPGYDEQPGAEKALDLGPHDIGWVAARTGLPVVVKGVLRPEDALRCAQAG
AGAVWVSNHGGRQLDRSASTAACLPDVVDAVGDQAEVYVDGGLRTGLDVVAALALGARAVFLGRSPLLALLDGAEGVARL
HQELLEQTVETLRLAGCRTPADAPGLAAGGRLTPR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=351, Percent_Identity=36.1823361823362, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI54234014, Length=339, Percent_Identity=35.1032448377581, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI7705393, Length=339, Percent_Identity=35.1032448377581, Blast_Score=191, Evalue=9e-49,
Organism=Escherichia coli, GI1790033, Length=356, Percent_Identity=30.3370786516854, Blast_Score=130, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI193208036, Length=349, Percent_Identity=33.810888252149, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI32566217, Length=296, Percent_Identity=30.7432432432432, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323587, Length=335, Percent_Identity=31.9402985074627, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI78707188, Length=349, Percent_Identity=33.810888252149, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI281363140, Length=349, Percent_Identity=33.810888252149, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI78707190, Length=349, Percent_Identity=33.810888252149, Blast_Score=185, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 37034; Mature: 36902

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAAERDPRWLDTLAERARDRLPASVLEYVLQGARDSLTAGEAVAAWRAVRLLPRVLHD
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
VTQVETSVSLLGHPAQVPWGVAPSTLQRAVHPDGELAMARACAAAGSVMVVSSNAGTAFS
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCHHH
EIGGTGVHWWLQAYLPADRTLAGPMLDRAVAAGARAVVLTVDTPVVGTKYASPGTALVWE
HCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEE
TVDPALLRVNFEPGYDEQPGAEKALDLGPHDIGWVAARTGLPVVVKGVLRPEDALRCAQA
CCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCCHHHHHHCCCHHHHHHHHC
GAGAVWVSNHGGRQLDRSASTAACLPDVVDAVGDQAEVYVDGGLRTGLDVVAALALGARA
CCCEEEEECCCCCHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHH
VFLGRSPLLALLDGAEGVARLHQELLEQTVETLRLAGCRTPADAPGLAAGGRLTPR
EEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
APAAERDPRWLDTLAERARDRLPASVLEYVLQGARDSLTAGEAVAAWRAVRLLPRVLHD
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
VTQVETSVSLLGHPAQVPWGVAPSTLQRAVHPDGELAMARACAAAGSVMVVSSNAGTAFS
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCHHH
EIGGTGVHWWLQAYLPADRTLAGPMLDRAVAAGARAVVLTVDTPVVGTKYASPGTALVWE
HCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEE
TVDPALLRVNFEPGYDEQPGAEKALDLGPHDIGWVAARTGLPVVVKGVLRPEDALRCAQA
CCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCCHHHHHHCCCHHHHHHHHC
GAGAVWVSNHGGRQLDRSASTAACLPDVVDAVGDQAEVYVDGGLRTGLDVVAALALGARA
CCCEEEEECCCCCHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHH
VFLGRSPLLALLDGAEGVARLHQELLEQTVETLRLAGCRTPADAPGLAAGGRLTPR
EEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]