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The map label for this gene is fdh [H]

Identifier: 119716158

GI number: 119716158

Start: 2053169

End: 2054350

Strand: Direct

Name: fdh [H]

Synonym: Noca_1926

Alternate gene names: 119716158

Gene position: 2053169-2054350 (Clockwise)

Preceding gene: 119716155

Following gene: 119716159

Centisome position: 41.18

GC content: 71.74

Gene sequence:

>1182_bases
ATGAAGGCAGTGACCTGGCAGGGCCGCAAGGACATCCGTGTCGAGGAGGTGCCCGACCCCCGGATCGAGGAGCCGACGGA
CGCGATCATCCGGGTCACCACGACCGGGCTGTGCGGGTCGGACCTGCACCTCTACGACCCGCTCACCCCGTTCATGACGC
CGGGCGACATCGTCGGTCACGAGCCGATGGGCGTGGTCGAGGCGGTCGGCTCGGAGGTGACGGAGCTCGCCGTCGGGGAC
CGGGTGGTCGTCCCCTTCAACATCAGCTGCGGCTCCTGCTGGATGTGCGAGCGCGGGCTCCACAGCCAGTGCGAGACCAC
GCAGAACCGCGACACGGGCACCGGCGCGAGCCTGTTCGGCTACAGCTCGCTGTACGGCGCGGTCCCCGGCGGCCAGGCCG
AGCTGCTGCGGGTGCCGTTCGCGGACTTCCTGCCCGTGCAGGTGCCGCACGGGCCCCCCGACGACCGGTTCATCTACCTG
TCCGACGTGCTGCCGACGGCCTGGCAGGGCATCGCGTACGCCGGGGTGCCCGAGGGCGGCACCCTCCTCGTGCTCGGCGC
CGGGCCGATCGGGGACATGGCCACCCGGATCGCGCTGCACCGCGGGATCCGGGTGATCGTCGTCGACCGGGTGCCCGAGC
GGCTCGCTCGGGTCTCCGCCCGGGGCGCGGAGATCCTCGACCTCGGGGAGATCGACGACGTCGCCGAGCAGGTCCGGGGC
CTGACCGGGGGCCGCGGCGCGGACAGCGTGCTCGAAGCCGTCGGCATGGAGGCGCACGGCTCGCCGGTCGCCGAGGCGGT
GCAGAAGTCGCTGCGGCTGCTGCCCAAGAAGCTCCAGCAGCTGATGATGACCAACCTGAGCGTCGAGCGGCTCGCGGCGC
TCTACCTGGCGTTCGAGGCGGTCCGCCGGGGCGGGACCGTCTCGATCTCGGGGGTGTACGGCGGCACCTCCGACCCGATG
CCGATGATGCAGCTCTTCGACAAGCAGCTGCAGCTGCGGATGGGCCAGGCGAACGTCCGGGCCTGGACCGACGAGCTGCG
GACGCTGCTCGAGCAGGACGAGGACCACCTCGACGTCGAGGGCTTCGCGACCCACCACCTGCCGCTCGACGCGGCACCTC
AGGCGTACGCGTCCTTCCAGGCCAAGGACGACGGGATGGTCAAGGTCCTGTTCCGGCCCTGA

Upstream 100 bases:

>100_bases
AAGACCACCCCCAGGGGTGGGGTGATCGGCGTGTGGGCGGGCTCGTGCTGGGTACCCGGCGAGGAACCGTCGACCGCAGC
TGAGAGGACGTCCGAGGAGC

Downstream 100 bases:

>100_bases
CACCACGTGGGCTAGAGTGGCCCCGTCATGACGCGCAGCCTCCTCCTTCGCTGCCGCAGCGAGGTCTGAGCCCACCAGGG
CAGAGTCCGGACCCCCTCGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKAVTWQGRKDIRVEEVPDPRIEEPTDAIIRVTTTGLCGSDLHLYDPLTPFMTPGDIVGHEPMGVVEAVGSEVTELAVGD
RVVVPFNISCGSCWMCERGLHSQCETTQNRDTGTGASLFGYSSLYGAVPGGQAELLRVPFADFLPVQVPHGPPDDRFIYL
SDVLPTAWQGIAYAGVPEGGTLLVLGAGPIGDMATRIALHRGIRVIVVDRVPERLARVSARGAEILDLGEIDDVAEQVRG
LTGGRGADSVLEAVGMEAHGSPVAEAVQKSLRLLPKKLQQLMMTNLSVERLAALYLAFEAVRRGGTVSISGVYGGTSDPM
PMMQLFDKQLQLRMGQANVRAWTDELRTLLEQDEDHLDVEGFATHHLPLDAAPQAYASFQAKDDGMVKVLFRP

Sequences:

>Translated_393_residues
MKAVTWQGRKDIRVEEVPDPRIEEPTDAIIRVTTTGLCGSDLHLYDPLTPFMTPGDIVGHEPMGVVEAVGSEVTELAVGD
RVVVPFNISCGSCWMCERGLHSQCETTQNRDTGTGASLFGYSSLYGAVPGGQAELLRVPFADFLPVQVPHGPPDDRFIYL
SDVLPTAWQGIAYAGVPEGGTLLVLGAGPIGDMATRIALHRGIRVIVVDRVPERLARVSARGAEILDLGEIDDVAEQVRG
LTGGRGADSVLEAVGMEAHGSPVAEAVQKSLRLLPKKLQQLMMTNLSVERLAALYLAFEAVRRGGTVSISGVYGGTSDPM
PMMQLFDKQLQLRMGQANVRAWTDELRTLLEQDEDHLDVEGFATHHLPLDAAPQAYASFQAKDDGMVKVLFRP
>Mature_393_residues
MKAVTWQGRKDIRVEEVPDPRIEEPTDAIIRVTTTGLCGSDLHLYDPLTPFMTPGDIVGHEPMGVVEAVGSEVTELAVGD
RVVVPFNISCGSCWMCERGLHSQCETTQNRDTGTGASLFGYSSLYGAVPGGQAELLRVPFADFLPVQVPHGPPDDRFIYL
SDVLPTAWQGIAYAGVPEGGTLLVLGAGPIGDMATRIALHRGIRVIVVDRVPERLARVSARGAEILDLGEIDDVAEQVRG
LTGGRGADSVLEAVGMEAHGSPVAEAVQKSLRLLPKKLQQLMMTNLSVERLAALYLAFEAVRRGGTVSISGVYGGTSDPM
PMMQLFDKQLQLRMGQANVRAWTDELRTLLEQDEDHLDVEGFATHHLPLDAAPQAYASFQAKDDGMVKVLFRP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786825, Length=406, Percent_Identity=40.3940886699507, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI87082125, Length=261, Percent_Identity=33.7164750957854, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI226510992, Length=382, Percent_Identity=26.4397905759162, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787863, Length=211, Percent_Identity=31.7535545023697, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790045, Length=217, Percent_Identity=31.7972350230415, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788073, Length=259, Percent_Identity=29.3436293436293, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788407, Length=232, Percent_Identity=28.0172413793103, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=30.4545454545455, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790718, Length=210, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788075, Length=263, Percent_Identity=27.3764258555133, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=268, Percent_Identity=29.4776119402985, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=231, Percent_Identity=30.3030303030303, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=277, Percent_Identity=31.4079422382672, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=291, Percent_Identity=28.1786941580756, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=261, Percent_Identity=30.2681992337165, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=267, Percent_Identity=29.2134831460674, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=267, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=262, Percent_Identity=25.9541984732824, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=251, Percent_Identity=24.3027888446215, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137530, Length=262, Percent_Identity=28.6259541984733, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737897, Length=238, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42449; Mature: 42449

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVTWQGRKDIRVEEVPDPRIEEPTDAIIRVTTTGLCGSDLHLYDPLTPFMTPGDIVGH
CCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCCCCCCEECCCCCCCCCCCCCCCC
EPMGVVEAVGSEVTELAVGDRVVVPFNISCGSCWMCERGLHSQCETTQNRDTGTGASLFG
CCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCHHHHHCCCCCCCCCCCHHHH
YSSLYGAVPGGQAELLRVPFADFLPVQVPHGPPDDRFIYLSDVLPTAWQGIAYAGVPEGG
HHHHHCCCCCCCCEEEECCCHHCCEEECCCCCCCCCEEEEECCCHHHHCCCEEECCCCCC
TLLVLGAGPIGDMATRIALHRGIRVIVVDRVPERLARVSARGAEILDLGEIDDVAEQVRG
EEEEECCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCEEECCCHHHHHHHHHC
LTGGRGADSVLEAVGMEAHGSPVAEAVQKSLRLLPKKLQQLMMTNLSVERLAALYLAFEA
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VRRGGTVSISGVYGGTSDPMPMMQLFDKQLQLRMGQANVRAWTDELRTLLEQDEDHLDVE
HHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
GFATHHLPLDAAPQAYASFQAKDDGMVKVLFRP
CEEEECCCCCCCCHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure
MKAVTWQGRKDIRVEEVPDPRIEEPTDAIIRVTTTGLCGSDLHLYDPLTPFMTPGDIVGH
CCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCCCCCCEECCCCCCCCCCCCCCCC
EPMGVVEAVGSEVTELAVGDRVVVPFNISCGSCWMCERGLHSQCETTQNRDTGTGASLFG
CCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCHHHHHCCCCCCCCCCCHHHH
YSSLYGAVPGGQAELLRVPFADFLPVQVPHGPPDDRFIYLSDVLPTAWQGIAYAGVPEGG
HHHHHCCCCCCCCEEEECCCHHCCEEECCCCCCCCCEEEEECCCHHHHCCCEEECCCCCC
TLLVLGAGPIGDMATRIALHRGIRVIVVDRVPERLARVSARGAEILDLGEIDDVAEQVRG
EEEEECCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCEEECCCHHHHHHHHHC
LTGGRGADSVLEAVGMEAHGSPVAEAVQKSLRLLPKKLQQLMMTNLSVERLAALYLAFEA
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VRRGGTVSISGVYGGTSDPMPMMQLFDKQLQLRMGQANVRAWTDELRTLLEQDEDHLDVE
HHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
GFATHHLPLDAAPQAYASFQAKDDGMVKVLFRP
CEEEECCCCCCCCHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]