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The map label for this gene is sph [H]

Identifier: 119716124

GI number: 119716124

Start: 2019140

End: 2020051

Strand: Direct

Name: sph [H]

Synonym: Noca_1892

Alternate gene names: 119716124

Gene position: 2019140-2020051 (Clockwise)

Preceding gene: 119716123

Following gene: 119716125

Centisome position: 40.5

GC content: 74.34

Gene sequence:

>912_bases
GTGATCCCGCCAGGGTTCTCGGCGTACGCCGCGCGCGGCGCGGACTGGGCCGCGTTCCTCGATCGTCTTCCCGGGCTGGT
CCGCGACCTGCTGGAGGAGTGGCAGCTCACGGAGGACGGGCCCGCGACACACGGCTTCTGCGCTCTGGTGCTGCCGGTGC
GGACGGCCGGCGGGCGCCCGGCGGTGCTCAAGATGAGCTGGCCGCACTGGGAGGCCGAGCACGAGCACCTGGCGCTCCAG
CGCTGGCACGGCGCCGGCGCGGTCGAGCTGCTCCGGGCCGACCCGTACCGGTACGCGCTGCTGCTGGAGCGGCTGCACCC
GGAGGACCTGCGCGACCTGTGGGACGTCGAGGCGTGCGCCGTCGTCGGTGCGCTGTACGAGCGGCTGCACGTGCCGGCCC
CGCCCCAGCTGGTGACCCTGTCCTCGTGCGTGGCTCGGTGGGGCGTCGAGCTCGCCGCGCTCCCGCGGGACGCGCCGCTG
CCGCGCCGGCTGGTGGAGCAGGCGGCGTCGCTGTGCCGGAGCCTGGCGGCCGACGAGGCGACCGACGGGCGGCTGGTGCA
CACCGACCTGCACTACGAGAACGTGTTGGCGGCCGATCGGGAGCCGTGGCTGGCGATCGACCCGAAGCCGCTCAGCGGAG
ACCCCCACTACGAGGTCGCGCCGATGCTGTGGAACCGGTGGGACGACCTGCTCTCGGCGTCCCGGAGCGTGCGGGACGGG
ATCCGGCTGCGGTTCCACACCCTCGTCGACGTGGCCGGGCTCGACGAGCGCCGGGCCCGCGACTGGGTCGTGGTCCGGAT
GCTGTGCAATGCGCTGTGGCGGCTGCAGGACCCGCCCGGGGTGCACCGGAGCACCCCGACCGGGGAGTACCTGACCCGGT
GCGTGACCGTGGCGAAATCGGTGCAGGATTGA

Upstream 100 bases:

>100_bases
GCAAGAAGCGGATGAAGAACATCGGCACCGTCGAGGTGCCGCCGGAGGCGTTCATCGCCGCGCTCTCCAACGCGCCCACC
TCGGAGAAGACCAAGAAGTA

Downstream 100 bases:

>100_bases
CTGCGGGTGCTGGGAGGATGGCCGTCGTGGGCATCCTGCACTCCGTCAACGTGGGCCGCGACCGGGACGCGCCGTACGCG
AACCTGGGGCACTCCGGCAT

Product: aminoglycoside/hydroxyurea antibiotic resistance kinase

Products: NA

Alternate protein names: APH(6); Streptidine kinase; Streptomycin 6-phosphotransferase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIPPGFSAYAARGADWAAFLDRLPGLVRDLLEEWQLTEDGPATHGFCALVLPVRTAGGRPAVLKMSWPHWEAEHEHLALQ
RWHGAGAVELLRADPYRYALLLERLHPEDLRDLWDVEACAVVGALYERLHVPAPPQLVTLSSCVARWGVELAALPRDAPL
PRRLVEQAASLCRSLAADEATDGRLVHTDLHYENVLAADREPWLAIDPKPLSGDPHYEVAPMLWNRWDDLLSASRSVRDG
IRLRFHTLVDVAGLDERRARDWVVVRMLCNALWRLQDPPGVHRSTPTGEYLTRCVTVAKSVQD

Sequences:

>Translated_303_residues
MIPPGFSAYAARGADWAAFLDRLPGLVRDLLEEWQLTEDGPATHGFCALVLPVRTAGGRPAVLKMSWPHWEAEHEHLALQ
RWHGAGAVELLRADPYRYALLLERLHPEDLRDLWDVEACAVVGALYERLHVPAPPQLVTLSSCVARWGVELAALPRDAPL
PRRLVEQAASLCRSLAADEATDGRLVHTDLHYENVLAADREPWLAIDPKPLSGDPHYEVAPMLWNRWDDLLSASRSVRDG
IRLRFHTLVDVAGLDERRARDWVVVRMLCNALWRLQDPPGVHRSTPTGEYLTRCVTVAKSVQD
>Mature_303_residues
MIPPGFSAYAARGADWAAFLDRLPGLVRDLLEEWQLTEDGPATHGFCALVLPVRTAGGRPAVLKMSWPHWEAEHEHLALQ
RWHGAGAVELLRADPYRYALLLERLHPEDLRDLWDVEACAVVGALYERLHVPAPPQLVTLSSCVARWGVELAALPRDAPL
PRRLVEQAASLCRSLAADEATDGRLVHTDLHYENVLAADREPWLAIDPKPLSGDPHYEVAPMLWNRWDDLLSASRSVRDG
IRLRFHTLVDVAGLDERRARDWVVVRMLCNALWRLQDPPGVHRSTPTGEYLTRCVTVAKSVQD

Specific function: The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation [H]

COG id: COG3570

COG function: function code V; Streptomycin 6-kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aminoglycoside phosphotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR006748 [H]

Pfam domain/function: PF04655 APH_6_hur [H]

EC number: =2.7.1.72 [H]

Molecular weight: Translated: 34012; Mature: 34012

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPPGFSAYAARGADWAAFLDRLPGLVRDLLEEWQLTEDGPATHGFCALVLPVRTAGGRP
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHCCCCCCC
AVLKMSWPHWEAEHEHLALQRWHGAGAVELLRADPYRYALLLERLHPEDLRDLWDVEACA
EEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHH
VVGALYERLHVPAPPQLVTLSSCVARWGVELAALPRDAPLPRRLVEQAASLCRSLAADEA
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHHHHCCCC
TDGRLVHTDLHYENVLAADREPWLAIDPKPLSGDPHYEVAPMLWNRWDDLLSASRSVRDG
CCCEEEEECCCHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IRLRFHTLVDVAGLDERRARDWVVVRMLCNALWRLQDPPGVHRSTPTGEYLTRCVTVAKS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
VQD
CCC
>Mature Secondary Structure
MIPPGFSAYAARGADWAAFLDRLPGLVRDLLEEWQLTEDGPATHGFCALVLPVRTAGGRP
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHCCCCCCC
AVLKMSWPHWEAEHEHLALQRWHGAGAVELLRADPYRYALLLERLHPEDLRDLWDVEACA
EEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHH
VVGALYERLHVPAPPQLVTLSSCVARWGVELAALPRDAPLPRRLVEQAASLCRSLAADEA
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHHHHCCCC
TDGRLVHTDLHYENVLAADREPWLAIDPKPLSGDPHYEVAPMLWNRWDDLLSASRSVRDG
CCCEEEEECCCHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IRLRFHTLVDVAGLDERRARDWVVVRMLCNALWRLQDPPGVHRSTPTGEYLTRCVTVAKS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
VQD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3039305 [H]