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The map label for this gene is comEC [H]

Identifier: 119716119

GI number: 119716119

Start: 2012221

End: 2014539

Strand: Direct

Name: comEC [H]

Synonym: Noca_1887

Alternate gene names: 119716119

Gene position: 2012221-2014539 (Clockwise)

Preceding gene: 119716118

Following gene: 119716120

Centisome position: 40.36

GC content: 77.36

Gene sequence:

>2319_bases
GTGGCCGAGGTCCAGCGCCGCCGACCGCCGGACCTGCGGATGCTGCTGCTCGGCGGCGTGGCGTGGGGCGGGGCTCTGGC
AGCCCGTGCGCTCGGATGGTGGTTGCTCCCGGCGGCGTTGGGGATCGGCCTGGTGGCCTGGCCGCTCGCCCACGGCCGCG
GACGGGCGGCGGTGCGCACAACCGCGGCGGTCGTCGTCGTCGCCGCCGCGGTGGGTGCGGTCGCCGTGCTGCGACTCGAT
CAGGTCGCCCACAGCCCGGTCGCGCGCCTCGCCCAGGAGGGCGCGGCAGTGCGCCTGGTCGGCACCGTGACCTCGGATCC
GCGGCGCACCGAGGGCCGGTTCGGCGAGGTCGTGACGGTGCGCCTCGACGTCCGCGAAGTGACCGGACGCGGAGCGACGT
ACGCGCTCGTTGCCCCGGTGCTGGTGCTGGCCGACGACGACTGGGCGGACCTGCCGCTGGGCGCCACGGTCACGGGCAGC
GGCCGGCTCTCGGTCGCTGAGGGCGGCGACCTCGCGGCGGTGCTCGGTGCCCGGGGCCCGCCGGAGGTGGTCGACGACCC
GGACGTGTGGTGGGATGCCGCCGCCGCGGTCCGCGGCTCGATCCGCGGGGCCGTCGCCCACCGGCCCGACACCCAGCGGG
CGCTGGTCCCCGCGCTGGTCGACGGCGACGACGCCGCCGTCGACGAGGCGCTCGCCGAGGACTTCCGGACCACCGGGCTG
ACCCACCTGCTCGCCGTCTCGGGCACCAACCTCACCCTGGTGGTCGGGTTCGTGCTCGTCCTCGCCCGCTGGTGCGGGGT
CCGTGGCCGCCTGCTGTATGCCGTGGGCGCGCTGGGGATCGTCGGCTTCGTGCTCCTGGCCCGCACCGAGCCGAGCGTGC
TGCGGGCCGCGGTGATGGGAGCGGTCGCGCTGTTCGCGATGGGTCCCGAGGGTCGGGAGCGCGGTTCCCGGGCGCTCGGC
GTCGCGGTGCTCGCGCTCCTGCTGGTCCGCCCGGATCTCGCCGCGTCGGCGGGCTTCACGCTCTCGGTGCTCGCCACGGC
CGGCATCCTGCTGCTCGCACCGGGCTGGCGCGACGCCCTCGCGCGCTGGCTGCCCCGCTGGGTGGCCGAGGCGATCGCGG
TGCCGGCCGCGGCCCAGCTGGCCTGCACCCCGGTCGTCGCAGCGATCTCCGGCCAGGTCAGCCTGGTCGCCGTCGCTGCC
AACCTGGCCGCTGCCCCTGTCGTGGGCCCGGCGACCGTGCTCGGGCTCGGCGGCGGCCTGGCGGGCCTGGTGTGGGAGCC
GGCCGGCCGGCTGCTCGGGACGCTCGCCGGCTGGTGCGTCGGCTGGCTCGTCGTGGTCGCGACCCGGGGTGCCCGCCTGC
CGTCCGCGGCGCTCGGATGGGGGACCGGGGCGGTCGCGCTGGCCCTACTGACCCTGGTGGTGGTGGCGATCGCGCTCGCC
GGCCCACTGCTCCTGCGCCGCAGGTCCACCGGGCTGGGGTGCTGCGCGCTGCTCGTCGCGACCGTGCTGGTGCGGCTGCC
GACGCCGGGCTGGCCGCCCGACGGCTGGGTCCTGGTCGCGTGCGACGTCGGCCAGGGTGACGCGCTGGTGCTCAACGCCG
GGCCGCACGCCGCGGTCGTCGTCGACGCCGGACCGGACCCGACCCTGGTGGACGCCTGCCTCGACCGGCTCGACATCGAC
AGCGTGCCGTTGGTGGTGCTCACCCACTTCCACGCCGACCACGTCGACGGCCTGCCCGGGGTGCTCGACGGTCGCACGGT
CGGCGCCATCGAGACGACCCGGCTGCTCGACCCGCCGGTGGGGGTCACCGAGGTCGCCGACGCGCTGGCCGGGACCGGGC
TGGCGACCGGGCCCGCGCCGTACGGTGCCACCCGGCACGTGGGTGCGGTGTCCTTCCAGGTGCTGTGGCCACCGGCGGAC
TCCCCGACCGTCGGCCCCGGCGACGGGAGCACCGCCAACGAGGCCAGCGTGGTGCTGCTGGTGGAGGTGCGCGGCGTGCG
GATCCTGCTGGGCGGCGACATCGAGCCCGAGGGCCAGGCCGCGCTCGCACGGGCGCTGCCGGGGCTACGGGTGGACGTGC
TCAAGGTGCCCCACCACGGCAGCCGCTACCAGGACGAGGACTGGCTGCTGAGCCTCGGCGCGCGGGTGGCGCTCGTCTCG
GTCGGGGCCGACAACGACTACGGCCACCCCGCCGCGGAGACCCTCGCGCCCCTCGAGGCGGCCGGCGTACGGGTGCTGCG
CACCGACCGCGACGGCGACCTCGCGGTGCTCGCCGACCGCGACGGCTCGGGCGCCGGGCTGTCGGTGGCCACGCGTTAG

Upstream 100 bases:

>100_bases
GAGCACGGTGGCTTCACCTCGGTCGACGAGCTCCTGGAGGTCGACGGCATCGGCGACGCGACGCTCGGGCAGCTCGCCCC
GTTCGTGACGGTCTGAGCAC

Downstream 100 bases:

>100_bases
GGTATGCCCACCATGGCAGGCCCCTCTCACCCGCGCGCGGCGGACGTTCTCGGCCGGGTCACGCTGGTGACCGGCAAGGA
GGAGTTCCTCAACGAGCGCA

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MAEVQRRRPPDLRMLLLGGVAWGGALAARALGWWLLPAALGIGLVAWPLAHGRGRAAVRTTAAVVVVAAAVGAVAVLRLD
QVAHSPVARLAQEGAAVRLVGTVTSDPRRTEGRFGEVVTVRLDVREVTGRGATYALVAPVLVLADDDWADLPLGATVTGS
GRLSVAEGGDLAAVLGARGPPEVVDDPDVWWDAAAAVRGSIRGAVAHRPDTQRALVPALVDGDDAAVDEALAEDFRTTGL
THLLAVSGTNLTLVVGFVLVLARWCGVRGRLLYAVGALGIVGFVLLARTEPSVLRAAVMGAVALFAMGPEGRERGSRALG
VAVLALLLVRPDLAASAGFTLSVLATAGILLLAPGWRDALARWLPRWVAEAIAVPAAAQLACTPVVAAISGQVSLVAVAA
NLAAAPVVGPATVLGLGGGLAGLVWEPAGRLLGTLAGWCVGWLVVVATRGARLPSAALGWGTGAVALALLTLVVVAIALA
GPLLLRRRSTGLGCCALLVATVLVRLPTPGWPPDGWVLVACDVGQGDALVLNAGPHAAVVVDAGPDPTLVDACLDRLDID
SVPLVVLTHFHADHVDGLPGVLDGRTVGAIETTRLLDPPVGVTEVADALAGTGLATGPAPYGATRHVGAVSFQVLWPPAD
SPTVGPGDGSTANEASVVLLVEVRGVRILLGGDIEPEGQAALARALPGLRVDVLKVPHHGSRYQDEDWLLSLGARVALVS
VGADNDYGHPAAETLAPLEAAGVRVLRTDRDGDLAVLADRDGSGAGLSVATR

Sequences:

>Translated_772_residues
MAEVQRRRPPDLRMLLLGGVAWGGALAARALGWWLLPAALGIGLVAWPLAHGRGRAAVRTTAAVVVVAAAVGAVAVLRLD
QVAHSPVARLAQEGAAVRLVGTVTSDPRRTEGRFGEVVTVRLDVREVTGRGATYALVAPVLVLADDDWADLPLGATVTGS
GRLSVAEGGDLAAVLGARGPPEVVDDPDVWWDAAAAVRGSIRGAVAHRPDTQRALVPALVDGDDAAVDEALAEDFRTTGL
THLLAVSGTNLTLVVGFVLVLARWCGVRGRLLYAVGALGIVGFVLLARTEPSVLRAAVMGAVALFAMGPEGRERGSRALG
VAVLALLLVRPDLAASAGFTLSVLATAGILLLAPGWRDALARWLPRWVAEAIAVPAAAQLACTPVVAAISGQVSLVAVAA
NLAAAPVVGPATVLGLGGGLAGLVWEPAGRLLGTLAGWCVGWLVVVATRGARLPSAALGWGTGAVALALLTLVVVAIALA
GPLLLRRRSTGLGCCALLVATVLVRLPTPGWPPDGWVLVACDVGQGDALVLNAGPHAAVVVDAGPDPTLVDACLDRLDID
SVPLVVLTHFHADHVDGLPGVLDGRTVGAIETTRLLDPPVGVTEVADALAGTGLATGPAPYGATRHVGAVSFQVLWPPAD
SPTVGPGDGSTANEASVVLLVEVRGVRILLGGDIEPEGQAALARALPGLRVDVLKVPHHGSRYQDEDWLLSLGARVALVS
VGADNDYGHPAAETLAPLEAAGVRVLRTDRDGDLAVLADRDGSGAGLSVATR
>Mature_771_residues
AEVQRRRPPDLRMLLLGGVAWGGALAARALGWWLLPAALGIGLVAWPLAHGRGRAAVRTTAAVVVVAAAVGAVAVLRLDQ
VAHSPVARLAQEGAAVRLVGTVTSDPRRTEGRFGEVVTVRLDVREVTGRGATYALVAPVLVLADDDWADLPLGATVTGSG
RLSVAEGGDLAAVLGARGPPEVVDDPDVWWDAAAAVRGSIRGAVAHRPDTQRALVPALVDGDDAAVDEALAEDFRTTGLT
HLLAVSGTNLTLVVGFVLVLARWCGVRGRLLYAVGALGIVGFVLLARTEPSVLRAAVMGAVALFAMGPEGRERGSRALGV
AVLALLLVRPDLAASAGFTLSVLATAGILLLAPGWRDALARWLPRWVAEAIAVPAAAQLACTPVVAAISGQVSLVAVAAN
LAAAPVVGPATVLGLGGGLAGLVWEPAGRLLGTLAGWCVGWLVVVATRGARLPSAALGWGTGAVALALLTLVVVAIALAG
PLLLRRRSTGLGCCALLVATVLVRLPTPGWPPDGWVLVACDVGQGDALVLNAGPHAAVVVDAGPDPTLVDACLDRLDIDS
VPLVVLTHFHADHVDGLPGVLDGRTVGAIETTRLLDPPVGVTEVADALAGTGLATGPAPYGATRHVGAVSFQVLWPPADS
PTVGPGDGSTANEASVVLLVEVRGVRILLGGDIEPEGQAALARALPGLRVDVLKVPHHGSRYQDEDWLLSLGARVALVSV
GADNDYGHPAAETLAPLEAAGVRVLRTDRDGDLAVLADRDGSGAGLSVATR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 78473; Mature: 78341

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVQRRRPPDLRMLLLGGVAWGGALAARALGWWLLPAALGIGLVAWPLAHGRGRAAVRT
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TAAVVVVAAAVGAVAVLRLDQVAHSPVARLAQEGAAVRLVGTVTSDPRRTEGRFGEVVTV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEE
RLDVREVTGRGATYALVAPVLVLADDDWADLPLGATVTGSGRLSVAEGGDLAAVLGARGP
EEEEEHHCCCCCCHHHCCCEEEEECCCCCCCCCCEEEECCCEEEEECCCCEEEEECCCCC
PEVVDDPDVWWDAAAAVRGSIRGAVAHRPDTQRALVPALVDGDDAAVDEALAEDFRTTGL
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCH
THLLAVSGTNLTLVVGFVLVLARWCGVRGRLLYAVGALGIVGFVLLARTEPSVLRAAVMG
HEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AVALFAMGPEGRERGSRALGVAVLALLLVRPDLAASAGFTLSVLATAGILLLAPGWRDAL
HHHHHEECCCHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHCCEEEECCCHHHHH
ARWLPRWVAEAIAVPAAAQLACTPVVAAISGQVSLVAVAANLAAAPVVGPATVLGLGGGL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCCCHHHEECCCCH
AGLVWEPAGRLLGTLAGWCVGWLVVVATRGARLPSAALGWGTGAVALALLTLVVVAIALA
HHHEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHH
GPLLLRRRSTGLGCCALLVATVLVRLPTPGWPPDGWVLVACDVGQGDALVLNAGPHAAVV
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEE
VDAGPDPTLVDACLDRLDIDSVPLVVLTHFHADHVDGLPGVLDGRTVGAIETTRLLDPPV
EECCCCCHHHHHHHHHCCCCCCCEEEEEECCHHCCCCCCCCCCCCEECCEEEHHCCCCCC
GVTEVADALAGTGLATGPAPYGATRHVGAVSFQVLWPPADSPTVGPGDGSTANEASVVLL
CHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEE
VEVRGVRILLGGDIEPEGQAALARALPGLRVDVLKVPHHGSRYQDEDWLLSLGARVALVS
EEECCEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHCCCEEEEEE
VGADNDYGHPAAETLAPLEAAGVRVLRTDRDGDLAVLADRDGSGAGLSVATR
ECCCCCCCCCHHHHHCCHHHCCEEEEEECCCCCEEEEEECCCCCCCCEEECC
>Mature Secondary Structure 
AEVQRRRPPDLRMLLLGGVAWGGALAARALGWWLLPAALGIGLVAWPLAHGRGRAAVRT
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TAAVVVVAAAVGAVAVLRLDQVAHSPVARLAQEGAAVRLVGTVTSDPRRTEGRFGEVVTV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEE
RLDVREVTGRGATYALVAPVLVLADDDWADLPLGATVTGSGRLSVAEGGDLAAVLGARGP
EEEEEHHCCCCCCHHHCCCEEEEECCCCCCCCCCEEEECCCEEEEECCCCEEEEECCCCC
PEVVDDPDVWWDAAAAVRGSIRGAVAHRPDTQRALVPALVDGDDAAVDEALAEDFRTTGL
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCH
THLLAVSGTNLTLVVGFVLVLARWCGVRGRLLYAVGALGIVGFVLLARTEPSVLRAAVMG
HEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AVALFAMGPEGRERGSRALGVAVLALLLVRPDLAASAGFTLSVLATAGILLLAPGWRDAL
HHHHHEECCCHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHCCEEEECCCHHHHH
ARWLPRWVAEAIAVPAAAQLACTPVVAAISGQVSLVAVAANLAAAPVVGPATVLGLGGGL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCCCHHHEECCCCH
AGLVWEPAGRLLGTLAGWCVGWLVVVATRGARLPSAALGWGTGAVALALLTLVVVAIALA
HHHEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHH
GPLLLRRRSTGLGCCALLVATVLVRLPTPGWPPDGWVLVACDVGQGDALVLNAGPHAAVV
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEE
VDAGPDPTLVDACLDRLDIDSVPLVVLTHFHADHVDGLPGVLDGRTVGAIETTRLLDPPV
EECCCCCHHHHHHHHHCCCCCCCEEEEEECCHHCCCCCCCCCCCCEECCEEEHHCCCCCC
GVTEVADALAGTGLATGPAPYGATRHVGAVSFQVLWPPADSPTVGPGDGSTANEASVVLL
CHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEE
VEVRGVRILLGGDIEPEGQAALARALPGLRVDVLKVPHHGSRYQDEDWLLSLGARVALVS
EEECCEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHCCCEEEEEE
VGADNDYGHPAAETLAPLEAAGVRVLRTDRDGDLAVLADRDGSGAGLSVATR
ECCCCCCCCCHHHHHCCHHHCCEEEEEECCCCCEEEEEECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]