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The map label for this gene is proA

Identifier: 119716052

GI number: 119716052

Start: 1939486

End: 1940775

Strand: Direct

Name: proA

Synonym: Noca_1818

Alternate gene names: 119716052

Gene position: 1939486-1940775 (Clockwise)

Preceding gene: 119716050

Following gene: 119716053

Centisome position: 38.9

GC content: 73.72

Gene sequence:

>1290_bases
ATGAGCACGCAGCACGACGAGCACGACGCGGCCGGGGCCACCGGCGTGGCCGACCAGGTGGTGGCGGCCGCCGAGCGCGC
CCGGGCCGCCAGCCACGGCCTCGCCCTGGCCACGCGGGCCGAGAAGGACGCGGCCCTCCAGGCGATGGCCGAGGCGCTGC
TGACCCGCGAGCCCGAGGTCCTGGCCGCCAACGGCGAGGACGTGGCGCGCGCCGAGGCGAACGGCACGCCGCCGAACATC
GTCGACCGGCTCCGGCTCACCCAGGAGCGGGTGGCCGCCATGGCGCAGGGACTGCGCGACGTCGCCGCACTGCCCGACCC
CGTGGGCGAGGTGCTGCGCGGCAGCACCCTGGCCAACGGCCTCGAGATGCGCCAGGTCCGGGTGCCCTTCGGCGTGGTCG
GGATGATCTACGAGGCCCGGCCCAACGTCACCGCCGACGCCGCCGGCATCTGCCTGAAGTCCGGCAACGCCGTCCTGCTG
CGCGGCAGCTCCAGCGCCCGCTCCAGCAACGCCGCGATCGTGGCGGCGCTGCGCGACGCCATCGCCGGAACCGGCCTGGA
CCCCGACGTCGTGCAGCAGGTCCCCGGAGACTCCCACGACAGCGTGAAGGCGCTGATGCGCGCCCGCGGTCACGTGGACG
TGCTGATCCCGCGCGGCGGGGCGGGGCTGATTCGCTCCGTCGTGGAGGAGTCCACGGTGCCCGTCATCGAGACCGGCGTC
GGCAACTGCCACGTCTACGTCGACCGGGCGGCCGATCTCGACAAGGCGCTCGCGATCGTGCTCAACGCCAAGACCCACCG
GACCAGCGTGTGCAACGCCGCGGAGTCGCTGCTGGTGCACGCGGACCTGGCCGACACGTTCGTCCCGCGCGTGGTCGCGG
CGCTGCAGGAGGCCGGCGTGACGGTGCACGGCGACGAGCGCTTCCAGGCCGAGGACGGGGTGCTGCCGGCCACCGACGAG
GACTACGGGCAGGAGTACCTCTCCCTGGACATCTCCGCTGCCGTCGTACCCGACCTGGACGGCGCCATCGCGCACATCCG
ACGCTGGTCGAGCCAGCACACCGAGGCGATCGTCACCGAGGACCTCGCGGCGGCGCGGCGGTTCACCGCTGCGGTCGACT
CGGCCGCGGTCCTGGTCAACGCCTCGACCCGGTTCACCGACGGCGGGGAGTTCGGCTTCGGCGCCGAGATCGGCATCAGC
ACCCAGAAGCTGCACGCCCGGGGGCCGATGGGGCTGACGGAGATGACGTCGACCAAGTACGTCGTCACCGGCGACGGGCA
CGTCCGGTGA

Upstream 100 bases:

>100_bases
CGGTGAGCTGACGCAGCGTACGACGCGGCCGGCCCCGGATTGGTTGCCGAGCGGCAAGACGGGGCACGCGTCCAGACCGG
CCCGAACTACCCTCGGAGCC

Downstream 100 bases:

>100_bases
CACGGCCTCCGGCGTGGGCCCGGTAGGGTGTCGGCCATGCTGAACGCGTTCGCCATCGCCCTGGCCGCCGAGGAGCACGT
CAACGAGAGCGTGCCCAACC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSTQHDEHDAAGATGVADQVVAAAERARAASHGLALATRAEKDAALQAMAEALLTREPEVLAANGEDVARAEANGTPPNI
VDRLRLTQERVAAMAQGLRDVAALPDPVGEVLRGSTLANGLEMRQVRVPFGVVGMIYEARPNVTADAAGICLKSGNAVLL
RGSSSARSSNAAIVAALRDAIAGTGLDPDVVQQVPGDSHDSVKALMRARGHVDVLIPRGGAGLIRSVVEESTVPVIETGV
GNCHVYVDRAADLDKALAIVLNAKTHRTSVCNAAESLLVHADLADTFVPRVVAALQEAGVTVHGDERFQAEDGVLPATDE
DYGQEYLSLDISAAVVPDLDGAIAHIRRWSSQHTEAIVTEDLAAARRFTAAVDSAAVLVNASTRFTDGGEFGFGAEIGIS
TQKLHARGPMGLTEMTSTKYVVTGDGHVR

Sequences:

>Translated_429_residues
MSTQHDEHDAAGATGVADQVVAAAERARAASHGLALATRAEKDAALQAMAEALLTREPEVLAANGEDVARAEANGTPPNI
VDRLRLTQERVAAMAQGLRDVAALPDPVGEVLRGSTLANGLEMRQVRVPFGVVGMIYEARPNVTADAAGICLKSGNAVLL
RGSSSARSSNAAIVAALRDAIAGTGLDPDVVQQVPGDSHDSVKALMRARGHVDVLIPRGGAGLIRSVVEESTVPVIETGV
GNCHVYVDRAADLDKALAIVLNAKTHRTSVCNAAESLLVHADLADTFVPRVVAALQEAGVTVHGDERFQAEDGVLPATDE
DYGQEYLSLDISAAVVPDLDGAIAHIRRWSSQHTEAIVTEDLAAARRFTAAVDSAAVLVNASTRFTDGGEFGFGAEIGIS
TQKLHARGPMGLTEMTSTKYVVTGDGHVR
>Mature_428_residues
STQHDEHDAAGATGVADQVVAAAERARAASHGLALATRAEKDAALQAMAEALLTREPEVLAANGEDVARAEANGTPPNIV
DRLRLTQERVAAMAQGLRDVAALPDPVGEVLRGSTLANGLEMRQVRVPFGVVGMIYEARPNVTADAAGICLKSGNAVLLR
GSSSARSSNAAIVAALRDAIAGTGLDPDVVQQVPGDSHDSVKALMRARGHVDVLIPRGGAGLIRSVVEESTVPVIETGVG
NCHVYVDRAADLDKALAIVLNAKTHRTSVCNAAESLLVHADLADTFVPRVVAALQEAGVTVHGDERFQAEDGVLPATDED
YGQEYLSLDISAAVVPDLDGAIAHIRRWSSQHTEAIVTEDLAAARRFTAAVDSAAVLVNASTRFTDGGEFGFGAEIGIST
QKLHARGPMGLTEMTSTKYVVTGDGHVR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=407, Percent_Identity=36.6093366093366, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI62912457, Length=407, Percent_Identity=36.6093366093366, Blast_Score=254, Evalue=8e-68,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=47.5490196078431, Blast_Score=381, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17569967, Length=409, Percent_Identity=37.6528117359413, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17569969, Length=409, Percent_Identity=37.6528117359413, Blast_Score=275, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=36.4485981308411, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=38.8206388206388, Blast_Score=284, Evalue=7e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_NOCSJ (A1SHP5)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923017.1
- ProteinModelPortal:   A1SHP5
- SMR:   A1SHP5
- STRING:   A1SHP5
- GeneID:   4597655
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_1818
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   A1SHP5
- ProtClustDB:   PRK00197
- BioCyc:   NSP35761:NOCA_1818-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44695; Mature: 44563

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQHDEHDAAGATGVADQVVAAAERARAASHGLALATRAEKDAALQAMAEALLTREPEV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHCCCCCE
LAANGEDVARAEANGTPPNIVDRLRLTQERVAAMAQGLRDVAALPDPVGEVLRGSTLANG
EEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHCC
LEMRQVRVPFGVVGMIYEARPNVTADAAGICLKSGNAVLLRGSSSARSSNAAIVAALRDA
HHHEEEECCHHHEEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCHHHHHHHHH
IAGTGLDPDVVQQVPGDSHDSVKALMRARGHVDVLIPRGGAGLIRSVVEESTVPVIETGV
HHCCCCCHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCEEECCC
GNCHVYVDRAADLDKALAIVLNAKTHRTSVCNAAESLLVHADLADTFVPRVVAALQEAGV
CCEEEEEECCCCHHHHEEEEEECCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCC
TVHGDERFQAEDGVLPATDEDYGQEYLSLDISAAVVPDLDGAIAHIRRWSSQHTEAIVTE
EEECCCCCCCCCCCCCCCCHHHCHHHHEEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHH
DLAAARRFTAAVDSAAVLVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLTEMTSTKY
HHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEECCCHHHHHCCCCCCCCCCCCCEE
VVTGDGHVR
EEECCCCCC
>Mature Secondary Structure 
STQHDEHDAAGATGVADQVVAAAERARAASHGLALATRAEKDAALQAMAEALLTREPEV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHCCCCCE
LAANGEDVARAEANGTPPNIVDRLRLTQERVAAMAQGLRDVAALPDPVGEVLRGSTLANG
EEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHCC
LEMRQVRVPFGVVGMIYEARPNVTADAAGICLKSGNAVLLRGSSSARSSNAAIVAALRDA
HHHEEEECCHHHEEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCHHHHHHHHH
IAGTGLDPDVVQQVPGDSHDSVKALMRARGHVDVLIPRGGAGLIRSVVEESTVPVIETGV
HHCCCCCHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCEEECCC
GNCHVYVDRAADLDKALAIVLNAKTHRTSVCNAAESLLVHADLADTFVPRVVAALQEAGV
CCEEEEEECCCCHHHHEEEEEECCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCC
TVHGDERFQAEDGVLPATDEDYGQEYLSLDISAAVVPDLDGAIAHIRRWSSQHTEAIVTE
EEECCCCCCCCCCCCCCCCHHHCHHHHEEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHH
DLAAARRFTAAVDSAAVLVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLTEMTSTKY
HHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEECCCHHHHHCCCCCCCCCCCCCEE
VVTGDGHVR
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA