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The map label for this gene is flp [H]

Identifier: 119715855

GI number: 119715855

Start: 1718289

End: 1718996

Strand: Direct

Name: flp [H]

Synonym: Noca_1619

Alternate gene names: 119715855

Gene position: 1718289-1718996 (Clockwise)

Preceding gene: 119715850

Following gene: 119715857

Centisome position: 34.46

GC content: 74.01

Gene sequence:

>708_bases
ATGCGCGACCACGACCACAGGTTCGAGTGCGTGCGGCTCGTGCCGATCTTCGACGGCCTGTCGGAGGCCGACCAGCACCG
GATCGCCGAGACCGCCGTGACCCGCACGTTCGAGCCGCGCGAGCAGGTGTACGGCGCCGGGGACCGGACCGGCCTGCACA
TCGTGCACCGCGGCCAGGTCAAGGCGTACCGACTCACCGAGGGCGGCTCCGAGCAGCTGGTCCGGCTGTTGTCCCCCGGA
GACTTCCTCGGCGAGTCGGCGCTGCTCGCCGACTCGGTCAGCGATCACTTCGCGATGGCCATCCGGCGCAGTGAGGTGTG
CTCGGTGCCGCGGGCGGGGATGCGCCAGCTCCTGGTCGAGAGGCCGGCGGTCGCGCTGCAGATGCTGCAGACCGTCTCGG
GGCGGCTCGCCGCCGCGGAGGAGATGCTCGCGGCCGTCACCGGCCAGTCGGTCGGCGAGCGGCTGGCCCAGCAGCTCCTG
CACCTGGCCGACGAGGCGGGCTCCGCCAGTTTCCGGCTGCCGACGTCCAAGCGGGACCTCGCGTCCTACCTGGGCACCAC
TCCCGAGACGCTCAGCCGTCGCCTCGGCGCGCTGCAGCGGTCCGGTGCGGTCCGACTGGGGCCGCAGCGGACCGTGACGG
TCGTGGACCGGCGCCGCCTGGAGCAGCTGGGCGCCGGGGCCGGGCCACCCGACCGCGGACCGCACTGA

Upstream 100 bases:

>100_bases
GGAGCGCGACGACCTTGACCCGGATCAAGGAGGTCCAGATTCGCGAGATCCGATGACGTCCTCGCTGTTCGAGTGGTGTG
GTGGTGGCGGAGGTGAGGGG

Downstream 100 bases:

>100_bases
CGGGCAGGTACGGCGCGCGCCAGGCCCGCGCGTCGCTCGAGGCCGCGCGGTTGTCGCCGAGGAGCAGCAGGTGCCCCGCC
GGCACGTCGAACGTCCCGGG

Product: cyclic nucleotide-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MRDHDHRFECVRLVPIFDGLSEADQHRIAETAVTRTFEPREQVYGAGDRTGLHIVHRGQVKAYRLTEGGSEQLVRLLSPG
DFLGESALLADSVSDHFAMAIRRSEVCSVPRAGMRQLLVERPAVALQMLQTVSGRLAAAEEMLAAVTGQSVGERLAQQLL
HLADEAGSASFRLPTSKRDLASYLGTTPETLSRRLGALQRSGAVRLGPQRTVTVVDRRRLEQLGAGAGPPDRGPH

Sequences:

>Translated_235_residues
MRDHDHRFECVRLVPIFDGLSEADQHRIAETAVTRTFEPREQVYGAGDRTGLHIVHRGQVKAYRLTEGGSEQLVRLLSPG
DFLGESALLADSVSDHFAMAIRRSEVCSVPRAGMRQLLVERPAVALQMLQTVSGRLAAAEEMLAAVTGQSVGERLAQQLL
HLADEAGSASFRLPTSKRDLASYLGTTPETLSRRLGALQRSGAVRLGPQRTVTVVDRRRLEQLGAGAGPPDRGPH
>Mature_235_residues
MRDHDHRFECVRLVPIFDGLSEADQHRIAETAVTRTFEPREQVYGAGDRTGLHIVHRGQVKAYRLTEGGSEQLVRLLSPG
DFLGESALLADSVSDHFAMAIRRSEVCSVPRAGMRQLLVERPAVALQMLQTVSGRLAAAEEMLAAVTGQSVGERLAQQLL
HLADEAGSASFRLPTSKRDLASYLGTTPETLSRRLGALQRSGAVRLGPQRTVTVVDRRRLEQLGAGAGPPDRGPH

Specific function: Global Transcription Factor That Controls The Expression Of Over 100 Target Genes In Response To Anoxia. It Facilitates The Adaptation To Anaerobic Growth Conditions By Regulating The Expression Of Gene Products That Are Involved In Anaerobic Energy Metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=189, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25589; Mature: 25589

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00519 HTH_ASNC_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDHDHRFECVRLVPIFDGLSEADQHRIAETAVTRTFEPREQVYGAGDRTGLHIVHRGQV
CCCCCCHHHEEEEEHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEEEECCCE
KAYRLTEGGSEQLVRLLSPGDFLGESALLADSVSDHFAMAIRRSEVCSVPRAGMRQLLVE
EEEEECCCCHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RPAVALQMLQTVSGRLAAAEEMLAAVTGQSVGERLAQQLLHLADEAGSASFRLPTSKRDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHH
ASYLGTTPETLSRRLGALQRSGAVRLGPQRTVTVVDRRRLEQLGAGAGPPDRGPH
HHHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRDHDHRFECVRLVPIFDGLSEADQHRIAETAVTRTFEPREQVYGAGDRTGLHIVHRGQV
CCCCCCHHHEEEEEHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEEEECCCE
KAYRLTEGGSEQLVRLLSPGDFLGESALLADSVSDHFAMAIRRSEVCSVPRAGMRQLLVE
EEEEECCCCHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RPAVALQMLQTVSGRLAAAEEMLAAVTGQSVGERLAQQLLHLADEAGSASFRLPTSKRDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHH
ASYLGTTPETLSRRLGALQRSGAVRLGPQRTVTVVDRRRLEQLGAGAGPPDRGPH
HHHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113923; 8441692 [H]