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The map label for this gene is mprB [H]

Identifier: 119715796

GI number: 119715796

Start: 1653915

End: 1655375

Strand: Direct

Name: mprB [H]

Synonym: Noca_1560

Alternate gene names: 119715796

Gene position: 1653915-1655375 (Clockwise)

Preceding gene: 119715795

Following gene: 119715797

Centisome position: 33.17

GC content: 72.21

Gene sequence:

>1461_bases
ATGAGCAGGCTCTGGGCACGCCTCTCCCGGTTGCCGCTGCGGGTCCGTCTGGTCGCCGGCTTCTCCGCCGCCAGCCTTGT
GGTGCTGATCGGTGCCGGGGTGTTCGTGTACTGGCGCGTCGACTACGCCCTGGACCGCGGCCTGGACACCGAGCTCACCC
AGGCCAGCCAGACGCTCAGGCCACTGGTGCGGTCCAACGGCGCGGTGAGCAGCCGGACGGCGGCCGACGCCACCGGCGTG
GCCTGGCAGGTACTCGACGCGGACGGCACCGTCCTCGACCACGGTGGTCCGGCCGGCGCGACCAGCCTGTTGAGCTCACG
ACAGCTGGACCGGGTGACGACGACGCCACGCACCTTCGATGTCGGCGACTTCCTCCCCGTCTCATCCGAGCCGTATCGCC
TGCAGGTCGTCGAGCTGTCGGCGACCCCCCAGCGCTACCTGCTGGTCGGGGTACGGCGCGATCACCGCGACGAGGCGCTG
CGGGAACTCCTCGTGCAGCTCACCGTCGCCGGGCTCGGGGCTCTTCTCGTTACTGGCCTGGTGGGCGAGCGACTGGCCCG
GGCCGCGCTGCGACCTGTCGAGCGGTACCGCCGCCGTGCCGCCGCGATCGCGGCCGGCAACACCAGCCTCCGGCTCGACG
TGCCGCCCCTGCGCGAGGACGAGATCACCCGCCTGGGGCACACCTTCAACGACATGCTCACCACCCTCGAGGGCGCCCTG
GACCGAGAACGGCAATTCGTCACCGAGGCCAGCCACGAGCTACGCACCCCGATCACGCTGCTGACTAGCCGGATCCAGTT
GGCCCTGCGGCGCCCCCGCAGCCCGGCCGACCACGAACGCATCCTCACCGAGCTCAAGGTCGACCTCGACCGGCTCGCCG
CGCTCTCCGAGCAGCTCCTCCAACTCGGCCGGGTCGACGGCAACCACATCGCCGGGCGTAGCGACCTGGTGAGCGTCGCC
AGCCGCACGGTCAACCAACGGCGTCTCGCCGATCCCCGGCACGCGGGGAACATCACCGTCACCCTGCCCGAACGCCGCGT
GCCGGTGCCGATGGCCGACTTCGAGCTGGAGCGGGTGGTCACCAACCTCCTGGACAACGCCGTCGTCCACGGGGCCCCGC
CGGTCGAGGTGAGCGTCGATGAACCGGCCCCGGGGTGGGCGCGGCTGATCGTCACCGACGCCGGGGTCGGCATGCCACCC
GGCCTGTTGGCAACCGCGACCCAGCGCTTCGCCCGGGCGGACGACGCGCGACCGCGCCCCGGGTCGGGGCTCGGGCTCGC
CCTGGTCGACGCGCTGGTCACCGGAGCGAGCGGTGAGCTGCGGCTGTGCCACGACGGGCGGCACTCCATTCACGGTCACC
CCGCACCGATCGCCTGTGCCCACGGGCCGCAGATGACGGTCACGGTGCTCCTGCCGACGACACCCGAGTCCGACGCATCA
GCGGCACTGCCTGCTGCGTAG

Upstream 100 bases:

>100_bases
TCGCCGCCATCCGCGGCAAGATCGACAAGCCGTTTGGCACCGACACCATCACCACGCTGCGGGGGGTCGGCTACCGGCTC
GACATCCCAGCCGGGAAACG

Downstream 100 bases:

>100_bases
CCGCCGGCATGTCCTACGCCTGTTCATGCGGCCTTCATGCCCAGGCACCTACCGTCCGGGCGTGAAGGAGATCAAGAGGT
GAGCGCCCTTCGGGAAGCGG

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSRLWARLSRLPLRVRLVAGFSAASLVVLIGAGVFVYWRVDYALDRGLDTELTQASQTLRPLVRSNGAVSSRTAADATGV
AWQVLDADGTVLDHGGPAGATSLLSSRQLDRVTTTPRTFDVGDFLPVSSEPYRLQVVELSATPQRYLLVGVRRDHRDEAL
RELLVQLTVAGLGALLVTGLVGERLARAALRPVERYRRRAAAIAAGNTSLRLDVPPLREDEITRLGHTFNDMLTTLEGAL
DRERQFVTEASHELRTPITLLTSRIQLALRRPRSPADHERILTELKVDLDRLAALSEQLLQLGRVDGNHIAGRSDLVSVA
SRTVNQRRLADPRHAGNITVTLPERRVPVPMADFELERVVTNLLDNAVVHGAPPVEVSVDEPAPGWARLIVTDAGVGMPP
GLLATATQRFARADDARPRPGSGLGLALVDALVTGASGELRLCHDGRHSIHGHPAPIACAHGPQMTVTVLLPTTPESDAS
AALPAA

Sequences:

>Translated_486_residues
MSRLWARLSRLPLRVRLVAGFSAASLVVLIGAGVFVYWRVDYALDRGLDTELTQASQTLRPLVRSNGAVSSRTAADATGV
AWQVLDADGTVLDHGGPAGATSLLSSRQLDRVTTTPRTFDVGDFLPVSSEPYRLQVVELSATPQRYLLVGVRRDHRDEAL
RELLVQLTVAGLGALLVTGLVGERLARAALRPVERYRRRAAAIAAGNTSLRLDVPPLREDEITRLGHTFNDMLTTLEGAL
DRERQFVTEASHELRTPITLLTSRIQLALRRPRSPADHERILTELKVDLDRLAALSEQLLQLGRVDGNHIAGRSDLVSVA
SRTVNQRRLADPRHAGNITVTLPERRVPVPMADFELERVVTNLLDNAVVHGAPPVEVSVDEPAPGWARLIVTDAGVGMPP
GLLATATQRFARADDARPRPGSGLGLALVDALVTGASGELRLCHDGRHSIHGHPAPIACAHGPQMTVTVLLPTTPESDAS
AALPAA
>Mature_485_residues
SRLWARLSRLPLRVRLVAGFSAASLVVLIGAGVFVYWRVDYALDRGLDTELTQASQTLRPLVRSNGAVSSRTAADATGVA
WQVLDADGTVLDHGGPAGATSLLSSRQLDRVTTTPRTFDVGDFLPVSSEPYRLQVVELSATPQRYLLVGVRRDHRDEALR
ELLVQLTVAGLGALLVTGLVGERLARAALRPVERYRRRAAAIAAGNTSLRLDVPPLREDEITRLGHTFNDMLTTLEGALD
RERQFVTEASHELRTPITLLTSRIQLALRRPRSPADHERILTELKVDLDRLAALSEQLLQLGRVDGNHIAGRSDLVSVAS
RTVNQRRLADPRHAGNITVTLPERRVPVPMADFELERVVTNLLDNAVVHGAPPVEVSVDEPAPGWARLIVTDAGVGMPPG
LLATATQRFARADDARPRPGSGLGLALVDALVTGASGELRLCHDGRHSIHGHPAPIACAHGPQMTVTVLLPTTPESDASA
ALPAA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=269, Percent_Identity=27.1375464684015, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788279, Length=299, Percent_Identity=23.4113712374582, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786600, Length=215, Percent_Identity=29.7674418604651, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=28.5087719298246, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789808, Length=256, Percent_Identity=29.6875, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=257, Percent_Identity=26.8482490272374, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788393, Length=300, Percent_Identity=28, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1787894, Length=237, Percent_Identity=29.535864978903, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789403, Length=445, Percent_Identity=25.1685393258427, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52370; Mature: 52238

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLWARLSRLPLRVRLVAGFSAASLVVLIGAGVFVYWRVDYALDRGLDTELTQASQTLR
CCHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCEEEEEEEEHHHCCCCCHHHHHHHHHHH
PLVRSNGAVSSRTAADATGVAWQVLDADGTVLDHGGPAGATSLLSSRQLDRVTTTPRTFD
HHHHCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEC
VGDFLPVSSEPYRLQVVELSATPQRYLLVGVRRDHRDEALRELLVQLTVAGLGALLVTGL
CCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VGERLARAALRPVERYRRRAAAIAAGNTSLRLDVPPLREDEITRLGHTFNDMLTTLEGAL
HHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DRERQFVTEASHELRTPITLLTSRIQLALRRPRSPADHERILTELKVDLDRLAALSEQLL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLGRVDGNHIAGRSDLVSVASRTVNQRRLADPRHAGNITVTLPERRVPVPMADFELERVV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHH
TNLLDNAVVHGAPPVEVSVDEPAPGWARLIVTDAGVGMPPGLLATATQRFARADDARPRP
HHHHHCCEECCCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
GSGLGLALVDALVTGASGELRLCHDGRHSIHGHPAPIACAHGPQMTVTVLLPTTPESDAS
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCC
AALPAA
CCCCCC
>Mature Secondary Structure 
SRLWARLSRLPLRVRLVAGFSAASLVVLIGAGVFVYWRVDYALDRGLDTELTQASQTLR
CHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCEEEEEEEEHHHCCCCCHHHHHHHHHHH
PLVRSNGAVSSRTAADATGVAWQVLDADGTVLDHGGPAGATSLLSSRQLDRVTTTPRTFD
HHHHCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEC
VGDFLPVSSEPYRLQVVELSATPQRYLLVGVRRDHRDEALRELLVQLTVAGLGALLVTGL
CCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VGERLARAALRPVERYRRRAAAIAAGNTSLRLDVPPLREDEITRLGHTFNDMLTTLEGAL
HHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DRERQFVTEASHELRTPITLLTSRIQLALRRPRSPADHERILTELKVDLDRLAALSEQLL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLGRVDGNHIAGRSDLVSVASRTVNQRRLADPRHAGNITVTLPERRVPVPMADFELERVV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHH
TNLLDNAVVHGAPPVEVSVDEPAPGWARLIVTDAGVGMPPGLLATATQRFARADDARPRP
HHHHHCCEECCCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
GSGLGLALVDALVTGASGELRLCHDGRHSIHGHPAPIACAHGPQMTVTVLLPTTPESDAS
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCC
AALPAA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA