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The map label for this gene is hemY [H]

Identifier: 119715665

GI number: 119715665

Start: 1512660

End: 1514081

Strand: Direct

Name: hemY [H]

Synonym: Noca_1429

Alternate gene names: 119715665

Gene position: 1512660-1514081 (Clockwise)

Preceding gene: 119715664

Following gene: 119715666

Centisome position: 30.34

GC content: 77.0

Gene sequence:

>1422_bases
ATGACCGGTTCCGGTGGGCACGAGCGCGCGCACACGGTCGTGGTGGGCGGCGGGATCAGCGGACTGACGACGGCGTACTT
CCTGCGGCAGCGTCTCGGTCCGGACGCCGTGCTGCGGGTCGTCGAGGCCTCGGACGCCCCCGGCGGCAAGATCCGCACCG
CGTCGATCGCCGGGCACCCGGTCGACACCGGCCCGGACGCCTTCCTCTCCCGGGCGCCCGAGCTGCGGCGCGTGGTCGAC
GCGCTCGGGCTGGCCGACCTGGTCGTCGAGCCGCAGAGCACGGGCACGTTCATCTGGTCCCGCGGCCGGCTCCGACGGCT
GCCCCCCGGCACCGCGTTCGGCCTGCCGGAGCGGCTGTGGCCGCTGTTGCGGTCCGGGCTGCTCGGCCCCGCGGCGGTGG
CGCGCGCCGGTCTCGACCTGGTGCTCCCGCGGACCGCGCTGCCGGACGACCCCTCGGTCGCGGACGTGGTCCGGCCCCGG
TTCGGCGCCGGCGTCTACGACCGGCTCGTCGTGCCGCTGCTCGGCGGCGTGCACGCCGGCGATCCGGCACTCCTCAGTGC
GACCAGCACCGTGCCCGAGATCGCCGCGATGGCCCGCTCGGGCCGCAGCCTCTACCGCACCCTGCGCCGCCGGCGCCGGT
CCGCGCCCCCGGCCACCGGCCGGCCGAGTGCCCCGCTGGTGTCCCTGCGCGGCGGCCTCGCGGCGCTCACCGACCGCCTG
GTGGAGGAGCTCGGTCCCGACACCGTGCTGACCGGGACGCCGGCCCGCGCCATCGAGCGCGACGAGAACGGGGGCTACAC
GGTGCGCACCGACCGCGGCGCCTTCGCGGCCCGGCAGGTCGTCCTCGCGACCCCGGCGTACGTCGCCGCGGAGCTGGTCG
CCGACCTCGCGCCCGATGCGGCCGCGCTGCTCCGGGAGATCGGGTACGTCGACGTCGCGAACGTGACCCTGGCGTTCCGG
CGCGACCAGGTGCCGGCGCTGCCCGCAGGCACCGGGTTCCTGGTGCCGCCGGTCGAGGACGAGCTGGTCGTCGGCTGCAG
CTGGCTGTCCCAGAAGTGGCCGCAGCCGGCCGACGCCGGCGACTACGTCCTGCTCAAGGTCATGGTCGGCCGATCGGGCG
ACACCCGGTGGCTCGCCATGGACGACGCCGAGCTGGTGCGCCACGTGCGCGAGGCCCTGCGCCGGATGCTCGGCGTCACC
GCGGACCCGGTGGAGAGCCTGGTGCAGCGATGGCCCCGCGCGATGCCGCAGTACGTCGTCGGGCACGCCGCCCGGCTCGC
GGCCCTCGACACCGCACTGGCCGCGGCGCCGGGCCTGCTGGTGACCGGTGCGGCCTACCGCGGCGTCGGCCTGGCCGGCT
GCGTCGCCCAGGCCGACGCGACCGCCACGTCCCTGCTCGCAACGCAAGGAGCGCCCACATGA

Upstream 100 bases:

>100_bases
GGGCGGCGCTGAGCCTCGCGGGTGGGGCGTGACGAGGGCCACGCGGATCAAGGACCTTCGGTCCAGGTGCCCCGGCCCCT
CGCGCGGCGAGGATGGCAGC

Downstream 100 bases:

>100_bases
CCCACCCGGCGACACCCCCGACCGGCCGCCACCCCGGCAGCCACCCGGCCGGCCTGGAGCTGCCCCGCACCATCGACTAC
TCCCAGCGTCCGATGCTGGT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTGSGGHERAHTVVVGGGISGLTTAYFLRQRLGPDAVLRVVEASDAPGGKIRTASIAGHPVDTGPDAFLSRAPELRRVVD
ALGLADLVVEPQSTGTFIWSRGRLRRLPPGTAFGLPERLWPLLRSGLLGPAAVARAGLDLVLPRTALPDDPSVADVVRPR
FGAGVYDRLVVPLLGGVHAGDPALLSATSTVPEIAAMARSGRSLYRTLRRRRRSAPPATGRPSAPLVSLRGGLAALTDRL
VEELGPDTVLTGTPARAIERDENGGYTVRTDRGAFAARQVVLATPAYVAAELVADLAPDAAALLREIGYVDVANVTLAFR
RDQVPALPAGTGFLVPPVEDELVVGCSWLSQKWPQPADAGDYVLLKVMVGRSGDTRWLAMDDAELVRHVREALRRMLGVT
ADPVESLVQRWPRAMPQYVVGHAARLAALDTALAAAPGLLVTGAAYRGVGLAGCVAQADATATSLLATQGAPT

Sequences:

>Translated_473_residues
MTGSGGHERAHTVVVGGGISGLTTAYFLRQRLGPDAVLRVVEASDAPGGKIRTASIAGHPVDTGPDAFLSRAPELRRVVD
ALGLADLVVEPQSTGTFIWSRGRLRRLPPGTAFGLPERLWPLLRSGLLGPAAVARAGLDLVLPRTALPDDPSVADVVRPR
FGAGVYDRLVVPLLGGVHAGDPALLSATSTVPEIAAMARSGRSLYRTLRRRRRSAPPATGRPSAPLVSLRGGLAALTDRL
VEELGPDTVLTGTPARAIERDENGGYTVRTDRGAFAARQVVLATPAYVAAELVADLAPDAAALLREIGYVDVANVTLAFR
RDQVPALPAGTGFLVPPVEDELVVGCSWLSQKWPQPADAGDYVLLKVMVGRSGDTRWLAMDDAELVRHVREALRRMLGVT
ADPVESLVQRWPRAMPQYVVGHAARLAALDTALAAAPGLLVTGAAYRGVGLAGCVAQADATATSLLATQGAPT
>Mature_472_residues
TGSGGHERAHTVVVGGGISGLTTAYFLRQRLGPDAVLRVVEASDAPGGKIRTASIAGHPVDTGPDAFLSRAPELRRVVDA
LGLADLVVEPQSTGTFIWSRGRLRRLPPGTAFGLPERLWPLLRSGLLGPAAVARAGLDLVLPRTALPDDPSVADVVRPRF
GAGVYDRLVVPLLGGVHAGDPALLSATSTVPEIAAMARSGRSLYRTLRRRRRSAPPATGRPSAPLVSLRGGLAALTDRLV
EELGPDTVLTGTPARAIERDENGGYTVRTDRGAFAARQVVLATPAYVAAELVADLAPDAAALLREIGYVDVANVTLAFRR
DQVPALPAGTGFLVPPVEDELVVGCSWLSQKWPQPADAGDYVLLKVMVGRSGDTRWLAMDDAELVRHVREALRRMLGVTA
DPVESLVQRWPRAMPQYVVGHAARLAALDTALAAAPGLLVTGAAYRGVGLAGCVAQADATATSLLATQGAPT

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=498, Percent_Identity=29.9196787148594, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI4506001, Length=498, Percent_Identity=29.9196787148594, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24649745, Length=393, Percent_Identity=25.6997455470738, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 49529; Mature: 49398

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSGGHERAHTVVVGGGISGLTTAYFLRQRLGPDAVLRVVEASDAPGGKIRTASIAGHP
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEECCCC
VDTGPDAFLSRAPELRRVVDALGLADLVVEPQSTGTFIWSRGRLRRLPPGTAFGLPERLW
CCCCHHHHHHCCHHHHHHHHHHCHHHHEECCCCCCCEEECCCCCCCCCCCCCCCCHHHHH
PLLRSGLLGPAAVARAGLDLVLPRTALPDDPSVADVVRPRFGAGVYDRLVVPLLGGVHAG
HHHHHCCCCHHHHHHCCCCEEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCC
DPALLSATSTVPEIAAMARSGRSLYRTLRRRRRSAPPATGRPSAPLVSLRGGLAALTDRL
CCHHEECHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHH
VEELGPDTVLTGTPARAIERDENGGYTVRTDRGAFAARQVVLATPAYVAAELVADLAPDA
HHHCCCCCEECCCCHHHHCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHCCHH
AALLREIGYVDVANVTLAFRRDQVPALPAGTGFLVPPVEDELVVGCSWLSQKWPQPADAG
HHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEECHHHHHHCCCCCCCCC
DYVLLKVMVGRSGDTRWLAMDDAELVRHVREALRRMLGVTADPVESLVQRWPRAMPQYVV
CEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
GHAARLAALDTALAAAPGLLVTGAAYRGVGLAGCVAQADATATSLLATQGAPT
HHHHHHHHHHHHHHHCCCCEEECCHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TGSGGHERAHTVVVGGGISGLTTAYFLRQRLGPDAVLRVVEASDAPGGKIRTASIAGHP
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEECCCC
VDTGPDAFLSRAPELRRVVDALGLADLVVEPQSTGTFIWSRGRLRRLPPGTAFGLPERLW
CCCCHHHHHHCCHHHHHHHHHHCHHHHEECCCCCCCEEECCCCCCCCCCCCCCCCHHHHH
PLLRSGLLGPAAVARAGLDLVLPRTALPDDPSVADVVRPRFGAGVYDRLVVPLLGGVHAG
HHHHHCCCCHHHHHHCCCCEEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCC
DPALLSATSTVPEIAAMARSGRSLYRTLRRRRRSAPPATGRPSAPLVSLRGGLAALTDRL
CCHHEECHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHH
VEELGPDTVLTGTPARAIERDENGGYTVRTDRGAFAARQVVLATPAYVAAELVADLAPDA
HHHCCCCCEECCCCHHHHCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHCCHH
AALLREIGYVDVANVTLAFRRDQVPALPAGTGFLVPPVEDELVVGCSWLSQKWPQPADAG
HHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEECHHHHHHCCCCCCCCC
DYVLLKVMVGRSGDTRWLAMDDAELVRHVREALRRMLGVTADPVESLVQRWPRAMPQYVV
CEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
GHAARLAALDTALAAAPGLLVTGAAYRGVGLAGCVAQADATATSLLATQGAPT
HHHHHHHHHHHHHHHCCCCEEECCHHHCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]