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The map label for this gene is pepA [H]

Identifier: 119715443

GI number: 119715443

Start: 1281070

End: 1282653

Strand: Direct

Name: pepA [H]

Synonym: Noca_1207

Alternate gene names: 119715443

Gene position: 1281070-1282653 (Clockwise)

Preceding gene: 119715440

Following gene: 119715444

Centisome position: 25.69

GC content: 76.07

Gene sequence:

>1584_bases
GTGCCTGCGACCCCCTCATCGGCCCCCTCATCGGCCCCGTCCTCACCGGCCCTCCCGAGCCAGGTCTCCCCACCCGAGTT
CGCGCTGAGCGCGGCGCTCCCGCACGCCATCCTCGGGGTCGAGGTGGTGGCCCTACCGGTGCTCCCCGGCGACGACGGCG
GCCCGGTCGCGTTGGGTCCCGGTGCGGCCGAGCTCGGCGAGCAGCTCGGGCTCGACCTGCTCGCGTACCTCGAGGGTGAC
GGCGCGACCGGTGCGGCCGGCGAGATCCTCTCGGTGCCCGTGCCGCTCGGTACGCCGGACAACGCGGGGCTGCGATGCGT
GCTGCTCGCCGGCGTCGGCGCCCAGACGGCCGCGGACCTCCGGCGCGCCGGGGCGGCCCTCGCGCGGGCGACGTACGACC
GCAGGTCGCTGGCGACCACGGTCCCGGCGATCGCCCCGGACGACGGGCTGGAGGCGTTCGTGGTCGGCGCCATGCTCGGC
TCGTTCGGGTTCAGCTGGCGCTCCGGCCCGCCCCCGCACCAGCCGGTGAAGCGGGTCGTGCTCGCGGGGCTGCCTGACCC
GCGGCCGCTCGCGCCGGTGCTCGACCGGGCGGTGGCCATCGGGGGCGCCGGCTGGCGCTCGCGGCTGCTGGCCACGGTGC
CGTCCAACCTCAAGAACCCGCCCTGGCTCGCCGACCAGGCCGAGCAGATCGGCCGCGAGGCCGGCCTCGAGGTCACCGTG
TGGGACGAGCACCGGCTCGCGGAGGAGGGATTCGGCGGCCTGCTCGGCGTCGGCCGGGCCTCGGCGACGCCGCCCCGCCT
GATCCGCCTCGACTACAGCCCGCGCAAGGCGGGCCGCCGTACGCCCACCGTCGCGCTGGTCGGCAAGGGCATCACCTTCG
ACACCGGCGGCCTGTCGATCAAGCCGGGCGAGGCGATGGTGAACATGAAGCGCGACATGACCGGCGGCGCCGTCGTGCTC
GCGACGATGGCCGCGCTGAGCGCCGTCGACTGCCCGGTGCGGGTGGTCGGCCTGGTCGTCGCCGCGGAGAACGCCATCGG
CGGCGACGCGCTGCGGCCCGGCGACGTGATCCGTCACTACGGCGGCCGCACCAGCGAGGTCACCAACACCGACGCCGAGG
GGCGGCTGGTGCTCGCCGACGCTCTCGCGTACGCCGTCGCCGAGGTGAAGCCGGACGCCGTGGTCGATGTCGCGACGCTG
ACTGGCGCCATGAAGGTCGCCCTCGGCCAGCGGACCGGCGGCCTGTTCGCCAACGACGACGCGCTGGCCGCGACCCTGGT
CGCCGCCGCGGAGCGGGCCGGCGAGCCGCTGTGGCGGTTCCCGCTGGCGAGCGTCTACGAGCCCAAGCTCTCCTCCACCG
TGGCCGACGCCGACAACGCCCCCAGCGGGCCCGGCGCGATCGTGGCCGCCCTGTTCCTGCAGCACTTCGTCGGCGACCTG
CCCTGGGCGCACCTGGACATCGCGTCGGCCGGCGACTCCCCGGACGAGCGGCACGAGTGGACCACCGGGCCGACCGGCTT
CGGCGCCCGCGCCCTGCTCGCCTGGCTCGGCACCGGGCACCCCCTCGAAGGAGTCGGATCATGA

Upstream 100 bases:

>100_bases
GCGTCCCGCTCGAGGGCGGTGGCCGCCTCGTAGTCGAGCTGAACGCCGAGGAAGCAGGCGCTCTCGGGGATGCCCTCAAG
GACGTCGTCGGCTGACCCCG

Downstream 100 bases:

>100_bases
AGGGTCTCACCGTCCGCTGGTCGCTCGCCGACGCCCCCGCCGGGGTCGAGGAGCAGCTCGCGTCGTACGTCGCCGACAGC
TCGCACGCGCGGTTCACCGG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPATPSSAPSSAPSSPALPSQVSPPEFALSAALPHAILGVEVVALPVLPGDDGGPVALGPGAAELGEQLGLDLLAYLEGD
GATGAAGEILSVPVPLGTPDNAGLRCVLLAGVGAQTAADLRRAGAALARATYDRRSLATTVPAIAPDDGLEAFVVGAMLG
SFGFSWRSGPPPHQPVKRVVLAGLPDPRPLAPVLDRAVAIGGAGWRSRLLATVPSNLKNPPWLADQAEQIGREAGLEVTV
WDEHRLAEEGFGGLLGVGRASATPPRLIRLDYSPRKAGRRTPTVALVGKGITFDTGGLSIKPGEAMVNMKRDMTGGAVVL
ATMAALSAVDCPVRVVGLVVAAENAIGGDALRPGDVIRHYGGRTSEVTNTDAEGRLVLADALAYAVAEVKPDAVVDVATL
TGAMKVALGQRTGGLFANDDALAATLVAAAERAGEPLWRFPLASVYEPKLSSTVADADNAPSGPGAIVAALFLQHFVGDL
PWAHLDIASAGDSPDERHEWTTGPTGFGARALLAWLGTGHPLEGVGS

Sequences:

>Translated_527_residues
MPATPSSAPSSAPSSPALPSQVSPPEFALSAALPHAILGVEVVALPVLPGDDGGPVALGPGAAELGEQLGLDLLAYLEGD
GATGAAGEILSVPVPLGTPDNAGLRCVLLAGVGAQTAADLRRAGAALARATYDRRSLATTVPAIAPDDGLEAFVVGAMLG
SFGFSWRSGPPPHQPVKRVVLAGLPDPRPLAPVLDRAVAIGGAGWRSRLLATVPSNLKNPPWLADQAEQIGREAGLEVTV
WDEHRLAEEGFGGLLGVGRASATPPRLIRLDYSPRKAGRRTPTVALVGKGITFDTGGLSIKPGEAMVNMKRDMTGGAVVL
ATMAALSAVDCPVRVVGLVVAAENAIGGDALRPGDVIRHYGGRTSEVTNTDAEGRLVLADALAYAVAEVKPDAVVDVATL
TGAMKVALGQRTGGLFANDDALAATLVAAAERAGEPLWRFPLASVYEPKLSSTVADADNAPSGPGAIVAALFLQHFVGDL
PWAHLDIASAGDSPDERHEWTTGPTGFGARALLAWLGTGHPLEGVGS
>Mature_526_residues
PATPSSAPSSAPSSPALPSQVSPPEFALSAALPHAILGVEVVALPVLPGDDGGPVALGPGAAELGEQLGLDLLAYLEGDG
ATGAAGEILSVPVPLGTPDNAGLRCVLLAGVGAQTAADLRRAGAALARATYDRRSLATTVPAIAPDDGLEAFVVGAMLGS
FGFSWRSGPPPHQPVKRVVLAGLPDPRPLAPVLDRAVAIGGAGWRSRLLATVPSNLKNPPWLADQAEQIGREAGLEVTVW
DEHRLAEEGFGGLLGVGRASATPPRLIRLDYSPRKAGRRTPTVALVGKGITFDTGGLSIKPGEAMVNMKRDMTGGAVVLA
TMAALSAVDCPVRVVGLVVAAENAIGGDALRPGDVIRHYGGRTSEVTNTDAEGRLVLADALAYAVAEVKPDAVVDVATLT
GAMKVALGQRTGGLFANDDALAATLVAAAERAGEPLWRFPLASVYEPKLSSTVADADNAPSGPGAIVAALFLQHFVGDLP
WAHLDIASAGDSPDERHEWTTGPTGFGARALLAWLGTGHPLEGVGS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=315, Percent_Identity=37.7777777777778, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI47155554, Length=370, Percent_Identity=36.2162162162162, Blast_Score=182, Evalue=9e-46,
Organism=Escherichia coli, GI1790710, Length=337, Percent_Identity=41.2462908011869, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87082123, Length=274, Percent_Identity=45.2554744525547, Blast_Score=200, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=293, Percent_Identity=36.8600682593857, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17565172, Length=198, Percent_Identity=34.3434343434343, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221379063, Length=324, Percent_Identity=38.5802469135802, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI221379062, Length=324, Percent_Identity=38.5802469135802, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21357381, Length=324, Percent_Identity=38.5802469135802, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21355725, Length=320, Percent_Identity=34.6875, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24661038, Length=328, Percent_Identity=33.8414634146341, Blast_Score=178, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24662227, Length=323, Percent_Identity=27.8637770897833, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI20129969, Length=316, Percent_Identity=27.8481012658228, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI21355645, Length=346, Percent_Identity=28.3236994219653, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24662223, Length=346, Percent_Identity=28.3236994219653, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077148, Length=287, Percent_Identity=29.2682926829268, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI20130057, Length=287, Percent_Identity=29.2682926829268, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI20129963, Length=287, Percent_Identity=29.9651567944251, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI19922386, Length=288, Percent_Identity=29.5138888888889, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646701, Length=298, Percent_Identity=30.8724832214765, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646703, Length=298, Percent_Identity=30.8724832214765, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21358201, Length=298, Percent_Identity=30.8724832214765, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53560; Mature: 53429

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPATPSSAPSSAPSSPALPSQVSPPEFALSAALPHAILGVEVVALPVLPGDDGGPVALGP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEEEECCCCCCCEEECC
GAAELGEQLGLDLLAYLEGDGATGAAGEILSVPVPLGTPDNAGLRCVLLAGVGAQTAADL
CHHHHHHHHCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHH
RRAGAALARATYDRRSLATTVPAIAPDDGLEAFVVGAMLGSFGFSWRSGPPPHQPVKRVV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LAGLPDPRPLAPVLDRAVAIGGAGWRSRLLATVPSNLKNPPWLADQAEQIGREAGLEVTV
HHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEEE
WDEHRLAEEGFGGLLGVGRASATPPRLIRLDYSPRKAGRRTPTVALVGKGITFDTGGLSI
ECCHHHHHHCCCCEEECCCCCCCCCEEEEECCCHHHCCCCCCEEEEEECCEEECCCCCEE
KPGEAMVNMKRDMTGGAVVLATMAALSAVDCPVRVVGLVVAAENAIGGDALRPGDVIRHY
CCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHC
GGRTSEVTNTDAEGRLVLADALAYAVAEVKPDAVVDVATLTGAMKVALGQRTGGLFANDD
CCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCEEECCH
ALAATLVAAAERAGEPLWRFPLASVYEPKLSSTVADADNAPSGPGAIVAALFLQHFVGDL
HHHHHHHHHHHHCCCCHHHCCCHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
PWAHLDIASAGDSPDERHEWTTGPTGFGARALLAWLGTGHPLEGVGS
CEEEEEECCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PATPSSAPSSAPSSPALPSQVSPPEFALSAALPHAILGVEVVALPVLPGDDGGPVALGP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEEEECCCCCCCEEECC
GAAELGEQLGLDLLAYLEGDGATGAAGEILSVPVPLGTPDNAGLRCVLLAGVGAQTAADL
CHHHHHHHHCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHH
RRAGAALARATYDRRSLATTVPAIAPDDGLEAFVVGAMLGSFGFSWRSGPPPHQPVKRVV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LAGLPDPRPLAPVLDRAVAIGGAGWRSRLLATVPSNLKNPPWLADQAEQIGREAGLEVTV
HHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEEE
WDEHRLAEEGFGGLLGVGRASATPPRLIRLDYSPRKAGRRTPTVALVGKGITFDTGGLSI
ECCHHHHHHCCCCEEECCCCCCCCCEEEEECCCHHHCCCCCCEEEEEECCEEECCCCCEE
KPGEAMVNMKRDMTGGAVVLATMAALSAVDCPVRVVGLVVAAENAIGGDALRPGDVIRHY
CCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHC
GGRTSEVTNTDAEGRLVLADALAYAVAEVKPDAVVDVATLTGAMKVALGQRTGGLFANDD
CCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCEEECCH
ALAATLVAAAERAGEPLWRFPLASVYEPKLSSTVADADNAPSGPGAIVAALFLQHFVGDL
HHHHHHHHHHHHCCCCHHHCCCHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
PWAHLDIASAGDSPDERHEWTTGPTGFGARALLAWLGTGHPLEGVGS
CEEEEEECCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]