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The map label for this gene is ndhS [H]

Identifier: 119715405

GI number: 119715405

Start: 1240538

End: 1241059

Strand: Direct

Name: ndhS [H]

Synonym: Noca_1168

Alternate gene names: 119715405

Gene position: 1240538-1241059 (Clockwise)

Preceding gene: 119715404

Following gene: 119715406

Centisome position: 24.88

GC content: 69.16

Gene sequence:

>522_bases
ATGATCCCTACCGCCGACCCGTCCGCCGACGACGTCGGAGCCGACCTCGTCGCTGTCACGTGCACCGTCAACGGGCGGTC
CGCCGGGTTCTCGGTGCCACCCCATCGCACGCTGATGGACACGCTCCGCTACGAGCTGGGTCTCACGGGTACCAAGACCT
GCTGCGCCGAGGGGGAGTGCGGCGCGTGCACGGTGATCGTCGACGGCGTCACCGTGAACAGCTGCCTGATGCTCGCGGCC
GAAGCAGAGGGCTGCGACATCCTCACGGTCGAGGGCCTCGGCGCAGGGGAGCCGAGCGGCCTGTGCGATCTGCAGGAGTC
CTTCCTCCAGACCGGTGCCGTGCAGTGCGGCTTCTGCATCCCGGGCCAGGTCATGGCGGCGGAGCACCTGCTGCGCGCCA
ACCCGGATCCGTCCGTGGAGGAGATTCGGGAAGGGATGTCGGGCAACCTGTGTCGCTGTGCGGGCTACCAGCGCATCGTC
GCCGCAGTCGAACTGACCTCGCGGAAGCGGGCGACCCGATGA

Upstream 100 bases:

>100_bases
AGCCGTATCGGACCGCCATGGCTCGCGTGCTCGCCAGACGTACCGTCCTCCGGGCCGCCGGGCGCCGCACCGACCCCGAC
CGACAGACAGGGAGAAGCTC

Downstream 100 bases:

>100_bases
TCGAGCAGCAGGGCTCCGAACGGGAGGCACTGCGGACGGTGGGGGAGCCGATCCGACGCTACGGCGGTGCGGCCCGGGTC
GCCGGCCAGCAGGAGTTCCT

Product: 2Fe-2S iron-sulfur cluster binding domain-containing protein

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MIPTADPSADDVGADLVAVTCTVNGRSAGFSVPPHRTLMDTLRYELGLTGTKTCCAEGECGACTVIVDGVTVNSCLMLAA
EAEGCDILTVEGLGAGEPSGLCDLQESFLQTGAVQCGFCIPGQVMAAEHLLRANPDPSVEEIREGMSGNLCRCAGYQRIV
AAVELTSRKRATR

Sequences:

>Translated_173_residues
MIPTADPSADDVGADLVAVTCTVNGRSAGFSVPPHRTLMDTLRYELGLTGTKTCCAEGECGACTVIVDGVTVNSCLMLAA
EAEGCDILTVEGLGAGEPSGLCDLQESFLQTGAVQCGFCIPGQVMAAEHLLRANPDPSVEEIREGMSGNLCRCAGYQRIV
AAVELTSRKRATR
>Mature_173_residues
MIPTADPSADDVGADLVAVTCTVNGRSAGFSVPPHRTLMDTLRYELGLTGTKTCCAEGECGACTVIVDGVTVNSCLMLAA
EAEGCDILTVEGLGAGEPSGLCDLQESFLQTGAVQCGFCIPGQVMAAEHLLRANPDPSVEEIREGMSGNLCRCAGYQRIV
AAVELTSRKRATR

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=157, Percent_Identity=39.4904458598726, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI71773480, Length=90, Percent_Identity=38.8888888888889, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1786480, Length=178, Percent_Identity=38.7640449438202, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789232, Length=152, Percent_Identity=46.0526315789474, Blast_Score=125, Evalue=1e-30,
Organism=Escherichia coli, GI1789246, Length=153, Percent_Identity=28.7581699346405, Blast_Score=70, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17540638, Length=149, Percent_Identity=44.2953020134228, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17539860, Length=143, Percent_Identity=41.2587412587413, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32566215, Length=159, Percent_Identity=36.4779874213836, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737937, Length=160, Percent_Identity=39.375, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24647201, Length=156, Percent_Identity=37.8205128205128, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24647199, Length=139, Percent_Identity=38.8489208633094, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24647197, Length=143, Percent_Identity=37.7622377622378, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24647195, Length=143, Percent_Identity=37.7622377622378, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24647193, Length=157, Percent_Identity=35.031847133758, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17971; Mature: 17971

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
9.8 %Cys+Met (Translated Protein)
6.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
9.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTADPSADDVGADLVAVTCTVNGRSAGFSVPPHRTLMDTLRYELGLTGTKTCCAEGEC
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
GACTVIVDGVTVNSCLMLAAEAEGCDILTVEGLGAGEPSGLCDLQESFLQTGAVQCGFCI
CEEEEEECCEECCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEECCCC
PGQVMAAEHLLRANPDPSVEEIREGMSGNLCRCAGYQRIVAAVELTSRKRATR
CCHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIPTADPSADDVGADLVAVTCTVNGRSAGFSVPPHRTLMDTLRYELGLTGTKTCCAEGEC
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
GACTVIVDGVTVNSCLMLAAEAEGCDILTVEGLGAGEPSGLCDLQESFLQTGAVQCGFCI
CEEEEEECCEECCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEECCCC
PGQVMAAEHLLRANPDPSVEEIREGMSGNLCRCAGYQRIVAAVELTSRKRATR
CCHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA