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The map label for this gene is gabT [H]

Identifier: 119714893

GI number: 119714893

Start: 684225

End: 685583

Strand: Direct

Name: gabT [H]

Synonym: Noca_0645

Alternate gene names: 119714893

Gene position: 684225-685583 (Clockwise)

Preceding gene: 119714891

Following gene: 119714894

Centisome position: 13.72

GC content: 68.65

Gene sequence:

>1359_bases
ATGACTGCTGTATCCGACGAGAAGCCCAGCAAGTTGTCCGCCGTTCACCAGCAGCGCCTGCTGCGCACCGAGCTTCCCGG
GCCGGCGTCGCGCCGGCTGATGGCGCGCAAGTCCGCCGCTGTCGCGCAAGGCGTCGGCACGACGATGCCGGTCTTTGCGG
CCAACGCCGACGGCGGCGTCGTGGTCGACGTCGACGGGAACCAGTTCATCGACCTCGGCTCGGGCATCGCTGTCACGTCG
GTTGGCGCCAGTGCCTCACGCGTGGTCGCCGCCGTGCAGGAGCAGGTTGCCGCTTTTACCCACACCTGCTTCATGGTTAC
CCCCTACGCGGGCTACGTCAGCGTCGCCGAGGCGCTGAATCGGCTCACCCCCGGCGGCCACGAGAAGCGCACCGCGCTGT
TCAACTCCGGCGCCGAGGCCGTCGAGAACGCCGTGAAGATCGCGCGCTCACACACCGGCCGCCAGGCGGTCGTCGTCTTT
GACCACGCCTACCATGGTCGGACCAACCTGACGATGGCGATGACTGCGAAGAACATGCCATACAAGCACGGCTTCGGTCC
GTTCGCCGGCGAGGTCTACCGCGCGCCCCTTTCCTACCCCTATCGCGACGGCGGCGTCGGTGGTGCAACGGCTGCGGCCC
GGGCCATCGATGTGATCGAGAAGCAGGTCGGCACCGCCAATTTGGCCGCTGTAGTGATCGAGCCGATCCAAGGCGAGGGC
GGGTTCATCGAGCCTGCTGCGGGCTTTCTGCCGGCCCTTGTGGCCTGGTGCCGCGCGAACGCGGCCGTCTTCGTGGCTGA
CGAGGTGCAGACCGGCTTCGCCCGTACCGGCGACTGGTTCGCGTGCGACCGTGAAGGCGTCGTTCCCGATCTCATCGTCA
CAGCCAAGGGCATCGCCGGCGGCCTGCCGCTCTCAGCGGTCACCGGCCGTGCGGAGATGATGGACGCCGCCCACGTTGGT
GGTCTCGGCGGCACCTACGGCGGCAATCCGATCGCCTGCGCGGCCGCGCTCGCGTCGATCGAGACCATCGAGGCCGAGGG
CTTGGTCGCCCGGGCCCGCGAGATCGAAGGGCTCCTCCTCGGCCGGCTCCGTGCCATCGAGGCCCGCGACTCCCGGATCG
GGAACGTCCGCGGTCGTGGCGCCATGATTGCCGTCGAGTTGGTCCGGGCCGGCACCGATGAGCCGGACCCCGAGCTCGCC
AAGGCCGTTGCCGCCGCGGCGCACCGGCAGGGCGTCATCGTCCTGACATGCGGCACGTACGGCAATGTGCTCCGCTTCTT
GCCGCCGCTCTCGATCTCCGACGACCTTCTAAACGATGCCTTCGACGTGCTCGCCGCGACTTTCGAGGTGACGAAGTGA

Upstream 100 bases:

>100_bases
AGGTGGCGCAACTGCACTTAGCCTCCTATGTCGACAGGGCATGGGAATGGACTGAAATAGGTATTGGACAGCATAACTTC
CTAGTCGCGAAACTGACTGC

Downstream 100 bases:

>100_bases
CGACGTTCGGCGTCGAGGACCCTGCCTCCCTCGAGATCATCGCGCAGGTGCCGGACCAGGGTCCCGACGAGGCACGCGTC
GCCGTCGACCGCGCGGCCGC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTAVSDEKPSKLSAVHQQRLLRTELPGPASRRLMARKSAAVAQGVGTTMPVFAANADGGVVVDVDGNQFIDLGSGIAVTS
VGASASRVVAAVQEQVAAFTHTCFMVTPYAGYVSVAEALNRLTPGGHEKRTALFNSGAEAVENAVKIARSHTGRQAVVVF
DHAYHGRTNLTMAMTAKNMPYKHGFGPFAGEVYRAPLSYPYRDGGVGGATAAARAIDVIEKQVGTANLAAVVIEPIQGEG
GFIEPAAGFLPALVAWCRANAAVFVADEVQTGFARTGDWFACDREGVVPDLIVTAKGIAGGLPLSAVTGRAEMMDAAHVG
GLGGTYGGNPIACAAALASIETIEAEGLVARAREIEGLLLGRLRAIEARDSRIGNVRGRGAMIAVELVRAGTDEPDPELA
KAVAAAAHRQGVIVLTCGTYGNVLRFLPPLSISDDLLNDAFDVLAATFEVTK

Sequences:

>Translated_452_residues
MTAVSDEKPSKLSAVHQQRLLRTELPGPASRRLMARKSAAVAQGVGTTMPVFAANADGGVVVDVDGNQFIDLGSGIAVTS
VGASASRVVAAVQEQVAAFTHTCFMVTPYAGYVSVAEALNRLTPGGHEKRTALFNSGAEAVENAVKIARSHTGRQAVVVF
DHAYHGRTNLTMAMTAKNMPYKHGFGPFAGEVYRAPLSYPYRDGGVGGATAAARAIDVIEKQVGTANLAAVVIEPIQGEG
GFIEPAAGFLPALVAWCRANAAVFVADEVQTGFARTGDWFACDREGVVPDLIVTAKGIAGGLPLSAVTGRAEMMDAAHVG
GLGGTYGGNPIACAAALASIETIEAEGLVARAREIEGLLLGRLRAIEARDSRIGNVRGRGAMIAVELVRAGTDEPDPELA
KAVAAAAHRQGVIVLTCGTYGNVLRFLPPLSISDDLLNDAFDVLAATFEVTK
>Mature_451_residues
TAVSDEKPSKLSAVHQQRLLRTELPGPASRRLMARKSAAVAQGVGTTMPVFAANADGGVVVDVDGNQFIDLGSGIAVTSV
GASASRVVAAVQEQVAAFTHTCFMVTPYAGYVSVAEALNRLTPGGHEKRTALFNSGAEAVENAVKIARSHTGRQAVVVFD
HAYHGRTNLTMAMTAKNMPYKHGFGPFAGEVYRAPLSYPYRDGGVGGATAAARAIDVIEKQVGTANLAAVVIEPIQGEGG
FIEPAAGFLPALVAWCRANAAVFVADEVQTGFARTGDWFACDREGVVPDLIVTAKGIAGGLPLSAVTGRAEMMDAAHVGG
LGGTYGGNPIACAAALASIETIEAEGLVARAREIEGLLLGRLRAIEARDSRIGNVRGRGAMIAVELVRAGTDEPDPELAK
AVAAAAHRQGVIVLTCGTYGNVLRFLPPLSISDDLLNDAFDVLAATFEVTK

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=409, Percent_Identity=31.2958435207824, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI37574042, Length=449, Percent_Identity=28.0623608017817, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI13994255, Length=421, Percent_Identity=30.4038004750594, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI24119277, Length=404, Percent_Identity=32.1782178217822, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI226442705, Length=419, Percent_Identity=28.1622911694511, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=29.1338582677165, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=33.3333333333333, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI188536080, Length=475, Percent_Identity=25.8947368421053, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI38679950, Length=475, Percent_Identity=25.8947368421053, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI38679946, Length=475, Percent_Identity=25.8947368421053, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1789016, Length=425, Percent_Identity=44.4705882352941, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1787560, Length=422, Percent_Identity=44.7867298578199, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI1788044, Length=409, Percent_Identity=32.7628361858191, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI145693181, Length=384, Percent_Identity=34.6354166666667, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=30.9927360774818, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786349, Length=329, Percent_Identity=32.5227963525836, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786991, Length=408, Percent_Identity=29.1666666666667, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=424, Percent_Identity=32.5471698113208, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=29.2270531400966, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=416, Percent_Identity=30.5288461538462, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=297, Percent_Identity=30.976430976431, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=494, Percent_Identity=24.4939271255061, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=399, Percent_Identity=29.5739348370927, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=28.8095238095238, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324386, Length=442, Percent_Identity=24.8868778280543, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574759, Length=416, Percent_Identity=33.4134615384615, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161085790, Length=420, Percent_Identity=32.3809523809524, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI21357415, Length=414, Percent_Identity=29.7101449275362, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21356575, Length=451, Percent_Identity=31.0421286031042, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI281366494, Length=463, Percent_Identity=23.5421166306695, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24667139, Length=463, Percent_Identity=23.5421166306695, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24667143, Length=463, Percent_Identity=23.5421166306695, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 46846; Mature: 46715

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVSDEKPSKLSAVHQQRLLRTELPGPASRRLMARKSAAVAQGVGTTMPVFAANADGGV
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCE
VVDVDGNQFIDLGSGIAVTSVGASASRVVAAVQEQVAAFTHTCFMVTPYAGYVSVAEALN
EEEECCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHH
RLTPGGHEKRTALFNSGAEAVENAVKIARSHTGRQAVVVFDHAYHGRTNLTMAMTAKNMP
HCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEECCCC
YKHGFGPFAGEVYRAPLSYPYRDGGVGGATAAARAIDVIEKQVGTANLAAVVIEPIQGEG
CCCCCCCCCHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCC
GFIEPAAGFLPALVAWCRANAAVFVADEVQTGFARTGDWFACDREGVVPDLIVTAKGIAG
CCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCHHEEEECCCCC
GLPLSAVTGRAEMMDAAHVGGLGGTYGGNPIACAAALASIETIEAEGLVARAREIEGLLL
CCCHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GRLRAIEARDSRIGNVRGRGAMIAVELVRAGTDEPDPELAKAVAAAAHRQGVIVLTCGTY
HHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCH
GNVLRFLPPLSISDDLLNDAFDVLAATFEVTK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAVSDEKPSKLSAVHQQRLLRTELPGPASRRLMARKSAAVAQGVGTTMPVFAANADGGV
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCE
VVDVDGNQFIDLGSGIAVTSVGASASRVVAAVQEQVAAFTHTCFMVTPYAGYVSVAEALN
EEEECCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHH
RLTPGGHEKRTALFNSGAEAVENAVKIARSHTGRQAVVVFDHAYHGRTNLTMAMTAKNMP
HCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEECCCC
YKHGFGPFAGEVYRAPLSYPYRDGGVGGATAAARAIDVIEKQVGTANLAAVVIEPIQGEG
CCCCCCCCCHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCC
GFIEPAAGFLPALVAWCRANAAVFVADEVQTGFARTGDWFACDREGVVPDLIVTAKGIAG
CCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCHHEEEECCCCC
GLPLSAVTGRAEMMDAAHVGGLGGTYGGNPIACAAALASIETIEAEGLVARAREIEGLLL
CCCHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GRLRAIEARDSRIGNVRGRGAMIAVELVRAGTDEPDPELAKAVAAAAHRQGVIVLTCGTY
HHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCH
GNVLRFLPPLSISDDLLNDAFDVLAATFEVTK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]