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The map label for this gene is nuoL [H]

Identifier: 119714795

GI number: 119714795

Start: 561784

End: 563715

Strand: Direct

Name: nuoL [H]

Synonym: Noca_0531

Alternate gene names: 119714795

Gene position: 561784-563715 (Clockwise)

Preceding gene: 119714794

Following gene: 119714796

Centisome position: 11.27

GC content: 67.39

Gene sequence:

>1932_bases
ATGTACGCATTGAACGAGGGCGCCATCCCGGTGGTGCACGCCGCGAGCGCCGACGGCGTCTACTCGCTGCTGTGGCTGGT
GGTCGCGCTGCCGCTCGCCGGCGCCGCGATCCTGCTGGTCGGTGGCAGGTACACCGACAAGTGGGGGCACCTGCTCGGCA
CGCTCCTGCCGGTCGTGTCCTTCATCCTGTCGCTGGTCCTGTTCTTCGACCTGCTCGGCCGTGACGAAGGCGATCGCCAG
TTCAACCAGCACGTGTTCACCTGGTTCCAGACCGGTCACCTCGACGTGGGCATGGACCTGCTGTACGACCCGCTGTCGGC
GCTGTTCCTGCTGCTGATCACCGGTGTCGGATCGCTGATCCACGTCTACTCGATCGGCTACATGGCCCACGACCCGCGTC
GTCGCCGGTTCTTCGGCTACCTGAACCTGTTCGTCGCGGCGATGCTGCTGCTGGTGCTCTCGGAGAACTACCTCGGGCTG
TTCCTCGGCTGGGAGGGTGTCGGCCTCGCGTCGTACCTCCTCATCGGCTTCTGGCAGCACCGGCCGTCGGCCGCGGCGGC
AGGGAAGAAGGCCTTCGTCATCAACCGGGTCGGCGACATGGGCATGTCGACGGCGATCATGATGTTCTACGTGACCTTCG
GGTCGACGAGCTTCACCGTGATCAGTGCGAACGCACCGGGCGCCTCGGACACCCAGCTCACCATCCTCGGGCTGCTGCTC
CTGCTCGGCGCCTGCGCCAAGTCCGCCCAGTTCCCGCTGCAGGCCTGGCTGCTCGACGCGATGGAAGGCCCGACGCCGGT
GTCGGCGCTGATCCACGCCGCGACCATGGTGACCGCGGGCGTCTACCTGATCGTCCGCTCGAACTTCATCTTCGAGGCGG
CGCCGCACGCGCAGACCGCCGTCGTGGTGGTCGCCCTGATCTCGATCCTCTGGGGTGCTGCGATCGGATGCGCCAAGGAC
GACATCAAGAAGGGCCTGGCGGGCTCGACGATGAGCCAGATCGGATACATGATGCTCGGCGCCGGCCTGGGCGCAGCGGG
CTACGCGTTCGCGATCTTCCACCTGCTGACGCACGGCTTCTTCAAGGCCAACATGTTCCTCGGAGCCGGCTCGGTCATGC
ACGGCATGAACGACGACGTCGACATGCGCCACTACGGCGCGCTGCGCAAGATGATGCCGGTGACCTTCCTGACCTTCGCG
ATGGGCTACCTCGCGATCATCGGGTTCCCGGGCTTCTCCGGGTTCTGGTCGAAGGACAAGATCATCGAGACCGCGCTGGC
CGACAACTGGCTGGTCGGACTCTGCGCGATCATCGGCGCCGGCGTCACCGGGTTCTACATGACCCGGATGATGCTGATGA
CCTTCTTCGGTGACGACCGGCGCTGGGAGAAGGACGTGCACCCCCACGAGTCACCCTCGGTGATGACGGTGCCGCTGGTC
GTCCTCGCGGCACTCTCGGTCCTCGGCGGCCTGATGCTCGCCGGCGACTGGATCCAGGACTTCCTGGCGCCCGTCGTCGG
GGTCGGCGCCCACGACGACCCACCGGTGCCCGCCCTCCTGGTCACCGCGATCATCGTGGTCGTCGTCGGCGCCGGTGTCG
CGCTCGCCTGGATGCTGTTCGGCCGGCGCGAGATCCCGCGGACCGCTCCGCAGGACGTGTCGTTCGTGACCCGGGCGGCC
CGTGAGGAGCTCTACGGCAACCAGATCAACGACGGCTTGGTCGTGAACCCCGGTCGCCACCTGGTGGGTGGGCTCCTGAC
GATCGACAAGCACGTCATCGACGGCACCTTCACCGGCGGCCCGGTCGCGCTCGGGTCCTTCGCCGGGGTCGCCCGGCGGG
TCCAGAACGGCTTCGTCCGCACCTACGCCCTGTCCCTCCTCGGCGGCGCCCTCATCGTCGTCCTCGCTCTCCTGGCGGTG
AATCTCGCATGA

Upstream 100 bases:

>100_bases
GTGGTCGTGGGGCTCGCGATCATCATGACCATCTTCCGGACCCGCCGCTCGGCCTCGGTCGACGACGCCAGCCTGCTGAA
GTACTAGGAGCCACGCTCAC

Downstream 100 bases:

>100_bases
ACGACCTTCCCTGGCTCACCGCGCTCTGGGTGCTGCCGCTGGTCGGCGCCCTGGTGACGGCGTTCGTGCCCCGGGCGACC
GGGTCGGCGCTGCCCAAGCA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MYALNEGAIPVVHAASADGVYSLLWLVVALPLAGAAILLVGGRYTDKWGHLLGTLLPVVSFILSLVLFFDLLGRDEGDRQ
FNQHVFTWFQTGHLDVGMDLLYDPLSALFLLLITGVGSLIHVYSIGYMAHDPRRRRFFGYLNLFVAAMLLLVLSENYLGL
FLGWEGVGLASYLLIGFWQHRPSAAAAGKKAFVINRVGDMGMSTAIMMFYVTFGSTSFTVISANAPGASDTQLTILGLLL
LLGACAKSAQFPLQAWLLDAMEGPTPVSALIHAATMVTAGVYLIVRSNFIFEAAPHAQTAVVVVALISILWGAAIGCAKD
DIKKGLAGSTMSQIGYMMLGAGLGAAGYAFAIFHLLTHGFFKANMFLGAGSVMHGMNDDVDMRHYGALRKMMPVTFLTFA
MGYLAIIGFPGFSGFWSKDKIIETALADNWLVGLCAIIGAGVTGFYMTRMMLMTFFGDDRRWEKDVHPHESPSVMTVPLV
VLAALSVLGGLMLAGDWIQDFLAPVVGVGAHDDPPVPALLVTAIIVVVVGAGVALAWMLFGRREIPRTAPQDVSFVTRAA
REELYGNQINDGLVVNPGRHLVGGLLTIDKHVIDGTFTGGPVALGSFAGVARRVQNGFVRTYALSLLGGALIVVLALLAV
NLA

Sequences:

>Translated_643_residues
MYALNEGAIPVVHAASADGVYSLLWLVVALPLAGAAILLVGGRYTDKWGHLLGTLLPVVSFILSLVLFFDLLGRDEGDRQ
FNQHVFTWFQTGHLDVGMDLLYDPLSALFLLLITGVGSLIHVYSIGYMAHDPRRRRFFGYLNLFVAAMLLLVLSENYLGL
FLGWEGVGLASYLLIGFWQHRPSAAAAGKKAFVINRVGDMGMSTAIMMFYVTFGSTSFTVISANAPGASDTQLTILGLLL
LLGACAKSAQFPLQAWLLDAMEGPTPVSALIHAATMVTAGVYLIVRSNFIFEAAPHAQTAVVVVALISILWGAAIGCAKD
DIKKGLAGSTMSQIGYMMLGAGLGAAGYAFAIFHLLTHGFFKANMFLGAGSVMHGMNDDVDMRHYGALRKMMPVTFLTFA
MGYLAIIGFPGFSGFWSKDKIIETALADNWLVGLCAIIGAGVTGFYMTRMMLMTFFGDDRRWEKDVHPHESPSVMTVPLV
VLAALSVLGGLMLAGDWIQDFLAPVVGVGAHDDPPVPALLVTAIIVVVVGAGVALAWMLFGRREIPRTAPQDVSFVTRAA
REELYGNQINDGLVVNPGRHLVGGLLTIDKHVIDGTFTGGPVALGSFAGVARRVQNGFVRTYALSLLGGALIVVLALLAV
NLA
>Mature_643_residues
MYALNEGAIPVVHAASADGVYSLLWLVVALPLAGAAILLVGGRYTDKWGHLLGTLLPVVSFILSLVLFFDLLGRDEGDRQ
FNQHVFTWFQTGHLDVGMDLLYDPLSALFLLLITGVGSLIHVYSIGYMAHDPRRRRFFGYLNLFVAAMLLLVLSENYLGL
FLGWEGVGLASYLLIGFWQHRPSAAAAGKKAFVINRVGDMGMSTAIMMFYVTFGSTSFTVISANAPGASDTQLTILGLLL
LLGACAKSAQFPLQAWLLDAMEGPTPVSALIHAATMVTAGVYLIVRSNFIFEAAPHAQTAVVVVALISILWGAAIGCAKD
DIKKGLAGSTMSQIGYMMLGAGLGAAGYAFAIFHLLTHGFFKANMFLGAGSVMHGMNDDVDMRHYGALRKMMPVTFLTFA
MGYLAIIGFPGFSGFWSKDKIIETALADNWLVGLCAIIGAGVTGFYMTRMMLMTFFGDDRRWEKDVHPHESPSVMTVPLV
VLAALSVLGGLMLAGDWIQDFLAPVVGVGAHDDPPVPALLVTAIIVVVVGAGVALAWMLFGRREIPRTAPQDVSFVTRAA
REELYGNQINDGLVVNPGRHLVGGLLTIDKHVIDGTFTGGPVALGSFAGVARRVQNGFVRTYALSLLGGALIVVLALLAV
NLA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=464, Percent_Identity=34.9137931034483, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1788614, Length=622, Percent_Identity=36.8167202572347, Blast_Score=320, Evalue=2e-88,
Organism=Escherichia coli, GI1788829, Length=417, Percent_Identity=31.89448441247, Blast_Score=166, Evalue=5e-42,
Organism=Escherichia coli, GI1788831, Length=365, Percent_Identity=30.6849315068493, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788827, Length=475, Percent_Identity=29.4736842105263, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI2367154, Length=440, Percent_Identity=25.9090909090909, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788613, Length=396, Percent_Identity=23.2323232323232, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI145693160, Length=445, Percent_Identity=22.9213483146067, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68720; Mature: 68720

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALNEGAIPVVHAASADGVYSLLWLVVALPLAGAAILLVGGRYTDKWGHLLGTLLPVVS
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHH
FILSLVLFFDLLGRDEGDRQFNQHVFTWFQTGHLDVGMDLLYDPLSALFLLLITGVGSLI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HVYSIGYMAHDPRRRRFFGYLNLFVAAMLLLVLSENYLGLFLGWEGVGLASYLLIGFWQH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHC
RPSAAAAGKKAFVINRVGDMGMSTAIMMFYVTFGSTSFTVISANAPGASDTQLTILGLLL
CCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHH
LLGACAKSAQFPLQAWLLDAMEGPTPVSALIHAATMVTAGVYLIVRSNFIFEAAPHAQTA
HHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCEEEECCCCHHHH
VVVVALISILWGAAIGCAKDDIKKGLAGSTMSQIGYMMLGAGLGAAGYAFAIFHLLTHGF
HHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FKANMFLGAGSVMHGMNDDVDMRHYGALRKMMPVTFLTFAMGYLAIIGFPGFSGFWSKDK
HHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
IIETALADNWLVGLCAIIGAGVTGFYMTRMMLMTFFGDDRRWEKDVHPHESPSVMTVPLV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHH
VLAALSVLGGLMLAGDWIQDFLAPVVGVGAHDDPPVPALLVTAIIVVVVGAGVALAWMLF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GRREIPRTAPQDVSFVTRAAREELYGNQINDGLVVNPGRHLVGGLLTIDKHVIDGTFTGG
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCC
PVALGSFAGVARRVQNGFVRTYALSLLGGALIVVLALLAVNLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYALNEGAIPVVHAASADGVYSLLWLVVALPLAGAAILLVGGRYTDKWGHLLGTLLPVVS
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHH
FILSLVLFFDLLGRDEGDRQFNQHVFTWFQTGHLDVGMDLLYDPLSALFLLLITGVGSLI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HVYSIGYMAHDPRRRRFFGYLNLFVAAMLLLVLSENYLGLFLGWEGVGLASYLLIGFWQH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHC
RPSAAAAGKKAFVINRVGDMGMSTAIMMFYVTFGSTSFTVISANAPGASDTQLTILGLLL
CCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHH
LLGACAKSAQFPLQAWLLDAMEGPTPVSALIHAATMVTAGVYLIVRSNFIFEAAPHAQTA
HHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCEEEECCCCHHHH
VVVVALISILWGAAIGCAKDDIKKGLAGSTMSQIGYMMLGAGLGAAGYAFAIFHLLTHGF
HHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FKANMFLGAGSVMHGMNDDVDMRHYGALRKMMPVTFLTFAMGYLAIIGFPGFSGFWSKDK
HHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
IIETALADNWLVGLCAIIGAGVTGFYMTRMMLMTFFGDDRRWEKDVHPHESPSVMTVPLV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHH
VLAALSVLGGLMLAGDWIQDFLAPVVGVGAHDDPPVPALLVTAIIVVVVGAGVALAWMLF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GRREIPRTAPQDVSFVTRAAREELYGNQINDGLVVNPGRHLVGGLLTIDKHVIDGTFTGG
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCC
PVALGSFAGVARRVQNGFVRTYALSLLGGALIVVLALLAVNLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]