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The map label for this gene is nuoF [H]

Identifier: 119714789

GI number: 119714789

Start: 554960

End: 556282

Strand: Direct

Name: nuoF [H]

Synonym: Noca_0525

Alternate gene names: 119714789

Gene position: 554960-556282 (Clockwise)

Preceding gene: 119714788

Following gene: 119714790

Centisome position: 11.13

GC content: 69.54

Gene sequence:

>1323_bases
GTGAGCGATGCAGTGACCGACGTGCTCACTCCCGTCCTCACCGACAACTGGGACCAGGAGCGCTCCTGGACCCTGGCCGC
CTACGAGTCACGCGGCGGCTACCGCGCCGTCGACACCGCGTTCGCGATGGAGCCCGACGCGGTCATCGACGCGGTGAAGG
AGTCCGGGCTGCGCGGCCGCGGGGGCGCGGGCTTCCCGACCGGCATGAAGTGGGGCTTCATCCCGCAGGACAACCCCCGA
CCGAAGTACCTCGTCGTCAACGCCGACGAGTCCGAGCCGGGCACCTGCAAGGACATCCCGTTGATGATGGCCAGCCCGCA
CACGCTCGTCGAGGGCGTGATCATCAGCTCCTACGCGATCCGCGCCAACAAGGCGTTCATCTACATCCGCGGCGAGGTCC
TTCACGTGATCCGCCGCGTGCAGCGCGCGGTCCAGGAGGCGTACGCCGCCGGCCACCTCGGCACGAACATCCACGGCTCC
GGTTTCGACCTGGACGTTGTCGTTCATGCGGGTGCGGGTGCCTACATCTGCGGCGAGGAGACGGCGCTGCTCGAGGGCCT
CGAGGGCCGCCGCGGCCAGCCCCGGCTCCGCCCGCCCTTCCCCGCTGTCGCCGGCCTCTACGCGAGCCCGACCGTCATCA
ACAACGTCGAGTCGATCTCCTCGGTGCCGAGCATCATCGGCCGGGGACACGCCTGGTTCGCCTCCATGGGCACCGAGAAG
TCCAAGGGTGTCGGCATCTTCTCGCTCTCCGGGCACGTCAAGCGGCCCGGCCAGTACGAAGCCCCGCTGGGCATCACCCT
GCGGACCCTCATCGACTTGGCCGGCGGCATCCGTGAGGGCCACGAGCTGAAGTTCTGGACCCCCGGCGGGTCGAGCACGC
CGCTGCTGACCGCCGAGCACCTCGACGTGCCCCTCGACTTCGAGGGCGTCGGGTCGGCCGGCTCGATGCTCGGCACCCGC
GCGCTGCAGATCTTCGACGACTCGGTCTGCGTGGTCCGCGCCGTGCTGCGCTGGTCGGAGTTCTACAAGCACGAGTCCTG
TGGCAAGTGCACCCCGTGCCGCGAGGGCACCTGGTGGCTGGTCCAGGTGCTCACCGCGCTCGAGAAGGGCGACGGGACCG
AGGAGGACCTCGACCTGTTGCTGGACCAGTGCGACAACATCCTGGGCCGGTCGTTCTGCGCCCTGGCAGACGGCGCCACC
AGCCCGATCGTCAGCTCGATCCAGTTCTTCCGCGACGAGTACGTCGCCCACCTCACCCATGGCGGCTGTCCGTTCGACCC
GGCGGCGGCCACCCTCTTCGCGACAGCCGGAGCCCAGGCATGA

Upstream 100 bases:

>100_bases
AGCAGGCAGCGGCCGACGCGAGCCCGCCGCCGTCCGAGGCCGCCACGGTGGAGAAGGAGAGCGGCACGTCCGAGACGGCC
GCCGAGAAGGGAGACGCCCA

Downstream 100 bases:

>100_bases
CAAGCACACCCGAGAAGGCCGCGGTCGACACGGTCTCCGTCACCATCGACGGGATCCAGGTCGACGTCCCCAAGGGGACC
CTGGTGATCCGGGCCGCCGA

Product: NADH-quinone oxidoreductase subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSDAVTDVLTPVLTDNWDQERSWTLAAYESRGGYRAVDTAFAMEPDAVIDAVKESGLRGRGGAGFPTGMKWGFIPQDNPR
PKYLVVNADESEPGTCKDIPLMMASPHTLVEGVIISSYAIRANKAFIYIRGEVLHVIRRVQRAVQEAYAAGHLGTNIHGS
GFDLDVVVHAGAGAYICGEETALLEGLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISSVPSIIGRGHAWFASMGTEK
SKGVGIFSLSGHVKRPGQYEAPLGITLRTLIDLAGGIREGHELKFWTPGGSSTPLLTAEHLDVPLDFEGVGSAGSMLGTR
ALQIFDDSVCVVRAVLRWSEFYKHESCGKCTPCREGTWWLVQVLTALEKGDGTEEDLDLLLDQCDNILGRSFCALADGAT
SPIVSSIQFFRDEYVAHLTHGGCPFDPAAATLFATAGAQA

Sequences:

>Translated_440_residues
MSDAVTDVLTPVLTDNWDQERSWTLAAYESRGGYRAVDTAFAMEPDAVIDAVKESGLRGRGGAGFPTGMKWGFIPQDNPR
PKYLVVNADESEPGTCKDIPLMMASPHTLVEGVIISSYAIRANKAFIYIRGEVLHVIRRVQRAVQEAYAAGHLGTNIHGS
GFDLDVVVHAGAGAYICGEETALLEGLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISSVPSIIGRGHAWFASMGTEK
SKGVGIFSLSGHVKRPGQYEAPLGITLRTLIDLAGGIREGHELKFWTPGGSSTPLLTAEHLDVPLDFEGVGSAGSMLGTR
ALQIFDDSVCVVRAVLRWSEFYKHESCGKCTPCREGTWWLVQVLTALEKGDGTEEDLDLLLDQCDNILGRSFCALADGAT
SPIVSSIQFFRDEYVAHLTHGGCPFDPAAATLFATAGAQA
>Mature_439_residues
SDAVTDVLTPVLTDNWDQERSWTLAAYESRGGYRAVDTAFAMEPDAVIDAVKESGLRGRGGAGFPTGMKWGFIPQDNPRP
KYLVVNADESEPGTCKDIPLMMASPHTLVEGVIISSYAIRANKAFIYIRGEVLHVIRRVQRAVQEAYAAGHLGTNIHGSG
FDLDVVVHAGAGAYICGEETALLEGLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISSVPSIIGRGHAWFASMGTEKS
KGVGIFSLSGHVKRPGQYEAPLGITLRTLIDLAGGIREGHELKFWTPGGSSTPLLTAEHLDVPLDFEGVGSAGSMLGTRA
LQIFDDSVCVVRAVLRWSEFYKHESCGKCTPCREGTWWLVQVLTALEKGDGTEEDLDLLLDQCDNILGRSFCALADGATS
PIVSSIQFFRDEYVAHLTHGGCPFDPAAATLFATAGAQA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=396, Percent_Identity=47.2222222222222, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI260656005, Length=396, Percent_Identity=47.2222222222222, Blast_Score=360, Evalue=1e-99,
Organism=Escherichia coli, GI1788620, Length=419, Percent_Identity=45.8233890214797, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17531727, Length=395, Percent_Identity=45.5696202531646, Blast_Score=352, Evalue=2e-97,
Organism=Drosophila melanogaster, GI19920794, Length=396, Percent_Identity=47.979797979798, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI45550452, Length=394, Percent_Identity=46.4467005076142, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24653819, Length=394, Percent_Identity=35.7868020304569, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24653817, Length=347, Percent_Identity=35.1585014409222, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47192; Mature: 47061

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAVTDVLTPVLTDNWDQERSWTLAAYESRGGYRAVDTAFAMEPDAVIDAVKESGLRGR
CCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEHHHHHCCCCHHHHHHHHHCCCCCC
GGAGFPTGMKWGFIPQDNPRPKYLVVNADESEPGTCKDIPLMMASPHTLVEGVIISSYAI
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHEEE
RANKAFIYIRGEVLHVIRRVQRAVQEAYAAGHLGTNIHGSGFDLDVVVHAGAGAYICGEE
ECCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCH
TALLEGLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISSVPSIIGRGHAWFASMGTEK
HHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHCCCCC
SKGVGIFSLSGHVKRPGQYEAPLGITLRTLIDLAGGIREGHELKFWTPGGSSTPLLTAEH
CCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEHHC
LDVPLDFEGVGSAGSMLGTRALQIFDDSVCVVRAVLRWSEFYKHESCGKCTPCREGTWWL
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VQVLTALEKGDGTEEDLDLLLDQCDNILGRSFCALADGATSPIVSSIQFFRDEYVAHLTH
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGCPFDPAAATLFATAGAQA
CCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDAVTDVLTPVLTDNWDQERSWTLAAYESRGGYRAVDTAFAMEPDAVIDAVKESGLRGR
CCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEHHHHHCCCCHHHHHHHHHCCCCCC
GGAGFPTGMKWGFIPQDNPRPKYLVVNADESEPGTCKDIPLMMASPHTLVEGVIISSYAI
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHEEE
RANKAFIYIRGEVLHVIRRVQRAVQEAYAAGHLGTNIHGSGFDLDVVVHAGAGAYICGEE
ECCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCH
TALLEGLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISSVPSIIGRGHAWFASMGTEK
HHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHCCCCC
SKGVGIFSLSGHVKRPGQYEAPLGITLRTLIDLAGGIREGHELKFWTPGGSSTPLLTAEH
CCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEHHC
LDVPLDFEGVGSAGSMLGTRALQIFDDSVCVVRAVLRWSEFYKHESCGKCTPCREGTWWL
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VQVLTALEKGDGTEEDLDLLLDQCDNILGRSFCALADGATSPIVSSIQFFRDEYVAHLTH
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGCPFDPAAATLFATAGAQA
CCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]