Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 119714651

GI number: 119714651

Start: 417242

End: 417910

Strand: Direct

Name: tmk [H]

Synonym: Noca_0386

Alternate gene names: 119714651

Gene position: 417242-417910 (Clockwise)

Preceding gene: 119714650

Following gene: 119714652

Centisome position: 8.37

GC content: 72.5

Gene sequence:

>669_bases
GTGAGCACTGGACCCGCCGCGGCGCGACCCGGGGTGTACGCCGACACCGGCGTCTTCGTGTGTCTCGAGGGTGGCGAGGG
GTCCGGGAAGTCCACCCAGTCCGGACTGCTGCGCGACTGGCTCGAGACGCAGGGATTCGAGGTGCTGCTCACCTTCGAGC
CCGGCGATACCGAGGTGGGACGCAAGCTGCGCGCCATCGTGCTCAGCCCGGAGACCGGTGCGATCTCCGACCGCACCGAG
GCGCTGCTCTACGCCGCGGACAAGGCCGAGCACGTCGACACCGTCGTCCAGCCCGCCCTGGACCGTGGCGCGGTCGTCAT
CACCGACCGCTACGTCGCCTCGATGCTCGCCTACCAGGGCGCGGGCCGGGCCCTCGACGTCGGCGAGGTCGAGCAGGTCG
CCCGATGGGCGACGCACGACCTACGTCCGCACCTGACCGTGGTACTCGACCTCGAGCCCGAGCACGGCCTGGGCCGGTTC
GAGGAGCGGGACCGGATCGAGGGGGAGTCCGTGGAGTTCCACCGCCGCGTGCGGGAAGGCTTCTTGGGGATGGCGGCAGC
AGATCCGGACCACTACCTGGTGCTCGACGCCCGGGGCGACCGCGAGGAGATCGCCGGCCGGGTCCGCGACCGCGTCGCCC
CCCTGCTCGACCGGGCGGCCCGGCGATGA

Upstream 100 bases:

>100_bases
GCAGGGTCGCGGCGGCGGGATCCGGCGGGGCCGGTCAGGGGCCGGCCAGGACTGTGGACCCGCGGTGGAAACCGTCGGCG
GCGCACCGTAGGTTCCTCGC

Downstream 100 bases:

>100_bases
CCGTCTGGGACGGCCTCGTCGGGCAGCATCGGCCGAGCGAGGCGCTGCGCGCGGCCGCCCACGGGCAGGGCATGAGCCAC
GCCTTCCTCTTCACCGGCCC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSTGPAAARPGVYADTGVFVCLEGGEGSGKSTQSGLLRDWLETQGFEVLLTFEPGDTEVGRKLRAIVLSPETGAISDRTE
ALLYAADKAEHVDTVVQPALDRGAVVITDRYVASMLAYQGAGRALDVGEVEQVARWATHDLRPHLTVVLDLEPEHGLGRF
EERDRIEGESVEFHRRVREGFLGMAAADPDHYLVLDARGDREEIAGRVRDRVAPLLDRAARR

Sequences:

>Translated_222_residues
MSTGPAAARPGVYADTGVFVCLEGGEGSGKSTQSGLLRDWLETQGFEVLLTFEPGDTEVGRKLRAIVLSPETGAISDRTE
ALLYAADKAEHVDTVVQPALDRGAVVITDRYVASMLAYQGAGRALDVGEVEQVARWATHDLRPHLTVVLDLEPEHGLGRF
EERDRIEGESVEFHRRVREGFLGMAAADPDHYLVLDARGDREEIAGRVRDRVAPLLDRAARR
>Mature_221_residues
STGPAAARPGVYADTGVFVCLEGGEGSGKSTQSGLLRDWLETQGFEVLLTFEPGDTEVGRKLRAIVLSPETGAISDRTEA
LLYAADKAEHVDTVVQPALDRGAVVITDRYVASMLAYQGAGRALDVGEVEQVARWATHDLRPHLTVVLDLEPEHGLGRFE
ERDRIEGESVEFHRRVREGFLGMAAADPDHYLVLDARGDREEIAGRVRDRVAPLLDRAARR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=202, Percent_Identity=37.1287128712871, Blast_Score=116, Evalue=9e-28,
Organism=Drosophila melanogaster, GI28573735, Length=214, Percent_Identity=25.7009345794392, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24259; Mature: 24128

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGPAAARPGVYADTGVFVCLEGGEGSGKSTQSGLLRDWLETQGFEVLLTFEPGDTEVG
CCCCCCCCCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHC
RKLRAIVLSPETGAISDRTEALLYAADKAEHVDTVVQPALDRGAVVITDRYVASMLAYQG
CEEEEEEECCCCCCCCCHHHEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCC
AGRALDVGEVEQVARWATHDLRPHLTVVLDLEPEHGLGRFEERDRIEGESVEFHRRVREG
CCCEECHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHH
FLGMAAADPDHYLVLDARGDREEIAGRVRDRVAPLLDRAARR
HHCCEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STGPAAARPGVYADTGVFVCLEGGEGSGKSTQSGLLRDWLETQGFEVLLTFEPGDTEVG
CCCCCCCCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHC
RKLRAIVLSPETGAISDRTEALLYAADKAEHVDTVVQPALDRGAVVITDRYVASMLAYQG
CEEEEEEECCCCCCCCCHHHEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCC
AGRALDVGEVEQVARWATHDLRPHLTVVLDLEPEHGLGRFEERDRIEGESVEFHRRVREG
CCCEECHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHH
FLGMAAADPDHYLVLDARGDREEIAGRVRDRVAPLLDRAARR
HHCCEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA