Click here to switch to the map view.

The map label for this gene is cof [H]

Identifier: 119714444

GI number: 119714444

Start: 190119

End: 190913

Strand: Direct

Name: cof [H]

Synonym: Noca_0177

Alternate gene names: 119714444

Gene position: 190119-190913 (Clockwise)

Preceding gene: 119714443

Following gene: 119714445

Centisome position: 3.81

GC content: 74.72

Gene sequence:

>795_bases
GTGACCCGCCCGCGCCTGGTCGCCACCGACCTCGACGGCACCCTGGTCCGCTCCGACGGCACGGTCTCGCCGTACACCCG
CGAGGTGCTCACGGCCGTCGAGGCCGCCGGCGCGATCGTGGTCTTCGTGACCGGCCGCCCCCTGCGCTGGGCCGAGGAGG
TCTTCGACCACGTCGGCGAGCACGGCCTCGCGGTCGTCGCGAACGGCGCGCTCGTCTGGGACGTCGGCCGCCACGACGTG
CACCTGCTCCGCCCGATCGACCCGGCGCTCGGGCTCGAGGCGTCCGAGCTGCTGCGCGCCGCGCTGCCCGGTACGACGTT
CGCCGTCGAGACCGTCGACGGGATCGGCCTCGAGCCGGAGTTCCTCGAGCGGCACCCGCTGCCCGAGGACGCCCGGCGGG
GCCCGCTCACCGAGCTGTTCGACCGCCCGGCGGTCAAGCTGCTCGCCCGGCACGAGGAGCTCGGGCCGCAGGAGTTCTGG
GACCTCGCCGAGGAGGCGCTCGGCGGCCGGCTGGTGATCACCTGGTCCTCCGCGAGCGCGCTGCTCGAGATCAGCGCGCC
GGGGGTGACCAAGGCCTCCACCCTCGCGCTGCTGTGCGCCGATCTCGGGGTCGAGGCGGAGGAGGTGATCGCCTTCGGCG
ACATGCCGAACGACCTGCCGATGCTCGCGTGGGCCGGCAGCTCCTACGCGATGGCCGACGCCCACCCGACGGTCACTGCG
GCGGCCGACCACGTCGCGCCGGGACACGACGAGGACGGCGTGGCCCGGGTCCTGGCTGGTGTGTTCGACCTGTGA

Upstream 100 bases:

>100_bases
ACACGGCCAGCGTCCGGGTGCTCGCGAAGTGCGGGTTCACCGAGCTGCGCGGCAGCAACGAGGACGGCGAGCTGGTCATG
GCCCGGCCGCTGCCGGCGTC

Downstream 100 bases:

>100_bases
TCTGTTGAGATGGACGCCGTGCCCGTGCCCGTTCCTGGGTCTGTGACCCGCCTGCCCCGGCTCCTGCTGGCCGCCCTGCT
GCTCGCCGGCGGCGGTGTCG

Product: HAD family hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTRPRLVATDLDGTLVRSDGTVSPYTREVLTAVEAAGAIVVFVTGRPLRWAEEVFDHVGEHGLAVVANGALVWDVGRHDV
HLLRPIDPALGLEASELLRAALPGTTFAVETVDGIGLEPEFLERHPLPEDARRGPLTELFDRPAVKLLARHEELGPQEFW
DLAEEALGGRLVITWSSASALLEISAPGVTKASTLALLCADLGVEAEEVIAFGDMPNDLPMLAWAGSSYAMADAHPTVTA
AADHVAPGHDEDGVARVLAGVFDL

Sequences:

>Translated_264_residues
MTRPRLVATDLDGTLVRSDGTVSPYTREVLTAVEAAGAIVVFVTGRPLRWAEEVFDHVGEHGLAVVANGALVWDVGRHDV
HLLRPIDPALGLEASELLRAALPGTTFAVETVDGIGLEPEFLERHPLPEDARRGPLTELFDRPAVKLLARHEELGPQEFW
DLAEEALGGRLVITWSSASALLEISAPGVTKASTLALLCADLGVEAEEVIAFGDMPNDLPMLAWAGSSYAMADAHPTVTA
AADHVAPGHDEDGVARVLAGVFDL
>Mature_263_residues
TRPRLVATDLDGTLVRSDGTVSPYTREVLTAVEAAGAIVVFVTGRPLRWAEEVFDHVGEHGLAVVANGALVWDVGRHDVH
LLRPIDPALGLEASELLRAALPGTTFAVETVDGIGLEPEFLERHPLPEDARRGPLTELFDRPAVKLLARHEELGPQEFWD
LAEEALGGRLVITWSSASALLEISAPGVTKASTLALLCADLGVEAEEVIAFGDMPNDLPMLAWAGSSYAMADAHPTVTAA
ADHVAPGHDEDGVARVLAGVFDL

Specific function: Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) [H]

COG id: COG0561

COG function: function code R; Predicted hydrolases of the HAD superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. Cof family [H]

Homologues:

Organism=Escherichia coli, GI87081790, Length=268, Percent_Identity=26.865671641791, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786982, Length=280, Percent_Identity=25.3571428571429, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006379
- InterPro:   IPR000150 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: NA

Molecular weight: Translated: 28052; Mature: 27921

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPRLVATDLDGTLVRSDGTVSPYTREVLTAVEAAGAIVVFVTGRPLRWAEEVFDHVGE
CCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCC
HGLAVVANGALVWDVGRHDVHLLRPIDPALGLEASELLRAALPGTTFAVETVDGIGLEPE
CCEEEEECCEEEEECCCCCEEEEECCCHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCHH
FLERHPLPEDARRGPLTELFDRPAVKLLARHEELGPQEFWDLAEEALGGRLVITWSSASA
HHHCCCCCCHHHCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCE
LLEISAPGVTKASTLALLCADLGVEAEEVIAFGDMPNDLPMLAWAGSSYAMADAHPTVTA
EEEECCCCCCHHHHHHHHHHHCCCCHHHEEEECCCCCCCCEEEECCCCEEECCCCCCEEH
AADHVAPGHDEDGVARVLAGVFDL
HHHCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TRPRLVATDLDGTLVRSDGTVSPYTREVLTAVEAAGAIVVFVTGRPLRWAEEVFDHVGE
CCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCC
HGLAVVANGALVWDVGRHDVHLLRPIDPALGLEASELLRAALPGTTFAVETVDGIGLEPE
CCEEEEECCEEEEECCCCCEEEEECCCHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCHH
FLERHPLPEDARRGPLTELFDRPAVKLLARHEELGPQEFWDLAEEALGGRLVITWSSASA
HHHCCCCCCHHHCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCE
LLEISAPGVTKASTLALLCADLGVEAEEVIAFGDMPNDLPMLAWAGSSYAMADAHPTVTA
EEEECCCCCCHHHHHHHHHHHCCCCHHHEEEECCCCCCCCEEEECCCCEEECCCCCCEEH
AADHVAPGHDEDGVARVLAGVFDL
HHHCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA