BacMap

Definition	Nocardioides sp. JS614 chromosome, complete genome.
Accession	NC_008699
Length	4,985,871

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The map label for this gene is cypB [H]

Identifier: 119714289

GI number: 119714289

Start: 19412

End: 19924

Strand: Direct

Name: cypB [H]

Synonym: Noca_0017

Alternate gene names: 119714289

Gene position: 19412-19924 (Clockwise)

Preceding gene: 119714287

Following gene: 119714290

Centisome position: 0.39

GC content: 69.01

Gene sequence:

>513_bases
ATGGCTGACCTTCAGGCCGTTCTCAAGACCAACCGGGGTGACATCACCCTCAACCTCTTCCCGGACCACGCGCCGGAGAC
GGTCGCCAACTTCACCGGCCTCGCCGAGGGCACCAAGGCGTACGACGCGGGCAACGGCAAGACCGGCCCGTTCTACGACG
GCCTCGGCTTCCACCGGGTCATCGAGGGCTTCATGATCCAGGGCGGCTGCCCGCTCGGCACCGGCACCGGCGGCCCCGGC
TACACCTTCAAGGACGAGCCGCACCCCGAGCTGACCTTCGACAAGCCGTACCTGCTCGCGATGGCGAATGCCGGCCCGGG
CACCAACGGCTCGCAGTTCTTCATCACGGTCGGCGCGACCACGTGGCTGAACTTCAAGCACACGATCTTCGGCGAGGTCG
CCGACCAGGCCTCCCGCGACGTCGTCGACGCGATCGCCACCACGGCCACCGGTCCGGGCGACCGCCCGGCCGAGCCGGTC
GTGATCGAGACCGTCGAGATCGTCCGCGGCTGA

Upstream 100 bases:

>100_bases
GAACCAGAGGCAAGGCTGCCGGGTGGGCTCCTTGCGGGCCGTGCGAGGATCGGACGGCACGTACACCGTGCCGTGTACCC
ATCTGACGTGAGAGGCACTC

Downstream 100 bases:

>100_bases
CCCAGGACCACCGAGCTTGTCCGAACACGCGACGCCCCCGGCCGGGGTGCCGACCTGCTATCGCCACCCCGGCCGCGAGG
CGCACATCCGCTGCCAGCGC

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase B; Cyclophilin ScCypB; Rotamase B; S-cyclophilin [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MADLQAVLKTNRGDITLNLFPDHAPETVANFTGLAEGTKAYDAGNGKTGPFYDGLGFHRVIEGFMIQGGCPLGTGTGGPG
YTFKDEPHPELTFDKPYLLAMANAGPGTNGSQFFITVGATTWLNFKHTIFGEVADQASRDVVDAIATTATGPGDRPAEPV
VIETVEIVRG

Sequences:

>Translated_170_residues
MADLQAVLKTNRGDITLNLFPDHAPETVANFTGLAEGTKAYDAGNGKTGPFYDGLGFHRVIEGFMIQGGCPLGTGTGGPG
YTFKDEPHPELTFDKPYLLAMANAGPGTNGSQFFITVGATTWLNFKHTIFGEVADQASRDVVDAIATTATGPGDRPAEPV
VIETVEIVRG
>Mature_169_residues
ADLQAVLKTNRGDITLNLFPDHAPETVANFTGLAEGTKAYDAGNGKTGPFYDGLGFHRVIEGFMIQGGCPLGTGTGGPGY
TFKDEPHPELTFDKPYLLAMANAGPGTNGSQFFITVGATTWLNFKHTIFGEVADQASRDVVDAIATTATGPGDRPAEPVV
IETVEIVRG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=166, Percent_Identity=45.7831325301205, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI7706339, Length=158, Percent_Identity=46.2025316455696, Blast_Score=126, Evalue=8e-30,
Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=39.5209580838323, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI4505991, Length=148, Percent_Identity=44.5945945945946, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI4758950, Length=154, Percent_Identity=42.8571428571429, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI19557636, Length=135, Percent_Identity=42.2222222222222, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI5454154, Length=159, Percent_Identity=42.1383647798742, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI10863927, Length=137, Percent_Identity=42.3357664233577, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI6631100, Length=148, Percent_Identity=41.8918918918919, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4826932, Length=154, Percent_Identity=42.8571428571429, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=42.0731707317073, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=42.0731707317073, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI310127646, Length=136, Percent_Identity=38.9705882352941, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI310114371, Length=136, Percent_Identity=38.9705882352941, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI310119221, Length=136, Percent_Identity=38.9705882352941, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=42.0731707317073, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI42560244, Length=162, Percent_Identity=37.6543209876543, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI256017253, Length=136, Percent_Identity=41.9117647058824, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI221139811, Length=136, Percent_Identity=41.9117647058824, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI256017251, Length=136, Percent_Identity=41.9117647058824, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI169164185, Length=137, Percent_Identity=40.8759124087591, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI169163623, Length=137, Percent_Identity=40.8759124087591, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI169163387, Length=137, Percent_Identity=40.8759124087591, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI178057341, Length=137, Percent_Identity=40.8759124087591, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI5031987, Length=154, Percent_Identity=40.9090909090909, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI310129267, Length=137, Percent_Identity=40.1459854014599, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI310120620, Length=137, Percent_Identity=40.1459854014599, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI5174637, Length=154, Percent_Identity=39.6103896103896, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI209417936, Length=137, Percent_Identity=40.1459854014599, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI30102944, Length=137, Percent_Identity=40.1459854014599, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI219842199, Length=137, Percent_Identity=40.1459854014599, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI310110104, Length=137, Percent_Identity=39.4160583941606, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI303305009, Length=127, Percent_Identity=42.5196850393701, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI45439316, Length=127, Percent_Identity=42.5196850393701, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI150418007, Length=145, Percent_Identity=38.6206896551724, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI310132444, Length=127, Percent_Identity=38.5826771653543, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310113152, Length=127, Percent_Identity=38.5826771653543, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310114540, Length=134, Percent_Identity=35.8208955223881, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI239751853, Length=158, Percent_Identity=32.9113924050633, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI113428306, Length=158, Percent_Identity=32.9113924050633, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310127745, Length=134, Percent_Identity=35.8208955223881, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310119290, Length=134, Percent_Identity=35.8208955223881, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI169214050, Length=126, Percent_Identity=38.0952380952381, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI20911035, Length=170, Percent_Identity=28.2352941176471, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1786736, Length=174, Percent_Identity=36.2068965517241, Blast_Score=79, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=168, Percent_Identity=45.8333333333333, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17539496, Length=159, Percent_Identity=44.0251572327044, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17552780, Length=154, Percent_Identity=47.4025974025974, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17551282, Length=162, Percent_Identity=45.679012345679, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551284, Length=162, Percent_Identity=45.679012345679, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17552784, Length=162, Percent_Identity=40.7407407407407, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17506307, Length=154, Percent_Identity=44.1558441558442, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17559074, Length=156, Percent_Identity=41.6666666666667, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71997782, Length=134, Percent_Identity=41.044776119403, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17565860, Length=154, Percent_Identity=43.5064935064935, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17566266, Length=161, Percent_Identity=39.1304347826087, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17532643, Length=156, Percent_Identity=42.3076923076923, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=167, Percent_Identity=35.3293413173653, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=38.4146341463415, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17552782, Length=154, Percent_Identity=41.5584415584416, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=156, Percent_Identity=35.8974358974359, Blast_Score=90, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17539498, Length=159, Percent_Identity=36.4779874213836, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323562, Length=166, Percent_Identity=42.7710843373494, Blast_Score=101, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320359, Length=159, Percent_Identity=41.5094339622642, Blast_Score=99, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323246, Length=160, Percent_Identity=41.875, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320510, Length=154, Percent_Identity=43.5064935064935, Blast_Score=91, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321848, Length=155, Percent_Identity=42.5806451612903, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=42.9447852760736, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=46.6666666666667, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19922376, Length=163, Percent_Identity=38.6503067484663, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24650807, Length=162, Percent_Identity=40.1234567901235, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI20130249, Length=154, Percent_Identity=42.2077922077922, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24664125, Length=155, Percent_Identity=41.2903225806452, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357783, Length=155, Percent_Identity=41.2903225806452, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357249, Length=133, Percent_Identity=39.8496240601504, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24586038, Length=162, Percent_Identity=41.9753086419753, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136360, Length=158, Percent_Identity=40.5063291139241, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45549139, Length=153, Percent_Identity=40.5228758169935, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24652460, Length=168, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647301, Length=154, Percent_Identity=38.3116883116883, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355677, Length=175, Percent_Identity=29.7142857142857, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17889; Mature: 17758

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLQAVLKTNRGDITLNLFPDHAPETVANFTGLAEGTKAYDAGNGKTGPFYDGLGFHRV
CCCCHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHH
IEGFMIQGGCPLGTGTGGPGYTFKDEPHPELTFDKPYLLAMANAGPGTNGSQFFITVGAT
HHHHEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEEECCE
TWLNFKHTIFGEVADQASRDVVDAIATTATGPGDRPAEPVVIETVEIVRG
EEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
ADLQAVLKTNRGDITLNLFPDHAPETVANFTGLAEGTKAYDAGNGKTGPFYDGLGFHRV
CCCHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHH
IEGFMIQGGCPLGTGTGGPGYTFKDEPHPELTFDKPYLLAMANAGPGTNGSQFFITVGAT
HHHHEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEEECCE
TWLNFKHTIFGEVADQASRDVVDAIATTATGPGDRPAEPVVIETVEIVRG
EEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9025285 [H]