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The map label for this gene is pdhR [H]

Identifier: 119387105

GI number: 119387105

Start: 1596412

End: 1597221

Strand: Direct

Name: pdhR [H]

Synonym: Pden_4400

Alternate gene names: 119387105

Gene position: 1596412-1597221 (Clockwise)

Preceding gene: 119387101

Following gene: 119387115

Centisome position: 92.27

GC content: 70.99

Gene sequence:

>810_bases
ATGACCAACGCATCCGTGAAATCCGAACGCGCCGCCGAGGCCGTGGCCCAGCATCTCGAATCGCTGATCCTGGAGGGCTC
GCTGCGCCCCGACGAACGGCTCTTGCCCGAGCGCGAGCTGGCCGAGCGGCTGAATGTCTCGCGCTCGACCCTGCGCGACG
GGTTGAAGATCCTGGAGGAACGCGGGCTTCTGACCAGCGCCGGCGGGCGCGGCAGCCGGGTGGCGGCCCTGGGCAAGGCG
GCGATCACCGACCCGTTGATCGCCATGCTGGTGCGCCATGCCGAGGCGGCGGACGATTACCTTGAGTTCCGCGGCATCGT
CGAAAGCGCGGCCGCGGCTTTGGCCGCGCAGCGCGCGACCGAGGTGGAACTGGCGCGCATCCGCGATTGCCTTGGCCGCA
TGGACCGCGCCCATGCCCGCGCCGATACCGGCGAGGAGGCCGAGGCGGATACCGAATTGCACCTGCTGATCTATGAGGCC
AGCCACAACATGACCCTGCTCCAGATCATGCAGGCTCTGGCGGGGGTCTTGCGTTCGGACGTGATCCAGAACCGCAGCCG
GCTGTTCGCCGTGCCGGCCATCCGCGAGTTGCTGCGCCAGCAGCACCGCGCCATCGCCGAGGCGATCCTTGCCCGCGATG
CGCAAGCCGCGCGGCAGGCGGCGGGCGAACATATCGGCTACCTGCGCCAGGCCAGCCGCGAGATCCGCGAGGCCGAGGCG
CGGCTGGACCTGTCGCTGCGCCGGCTGAACGGCGGCGGGGCCGGCACGCGCGCGGCCGGGACGAAATCCACCCCGGCCGC
AGAGGGCTAG

Upstream 100 bases:

>100_bases
GGTATAATTTTCAGACCACATTAGTCAATCGGTATTTTTCTGGACCGACACGCCCGTCCTGTGCTTACATGGCAGGGATC
CGACAACCGCATGAGCGCCC

Downstream 100 bases:

>100_bases
AGAGGACTGGCCGGCAAGGAAAAGGCCGGGACGAGGCCCGGCCTTTCGATAGCGCGTCAGTCCAGGCTGACGTTTGCGTC
GCGCACCACCGGCTCCCATT

Product: GntR domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTNASVKSERAAEAVAQHLESLILEGSLRPDERLLPERELAERLNVSRSTLRDGLKILEERGLLTSAGGRGSRVAALGKA
AITDPLIAMLVRHAEAADDYLEFRGIVESAAAALAAQRATEVELARIRDCLGRMDRAHARADTGEEAEADTELHLLIYEA
SHNMTLLQIMQALAGVLRSDVIQNRSRLFAVPAIRELLRQQHRAIAEAILARDAQAARQAAGEHIGYLRQASREIREAEA
RLDLSLRRLNGGGAGTRAAGTKSTPAAEG

Sequences:

>Translated_269_residues
MTNASVKSERAAEAVAQHLESLILEGSLRPDERLLPERELAERLNVSRSTLRDGLKILEERGLLTSAGGRGSRVAALGKA
AITDPLIAMLVRHAEAADDYLEFRGIVESAAAALAAQRATEVELARIRDCLGRMDRAHARADTGEEAEADTELHLLIYEA
SHNMTLLQIMQALAGVLRSDVIQNRSRLFAVPAIRELLRQQHRAIAEAILARDAQAARQAAGEHIGYLRQASREIREAEA
RLDLSLRRLNGGGAGTRAAGTKSTPAAEG
>Mature_268_residues
TNASVKSERAAEAVAQHLESLILEGSLRPDERLLPERELAERLNVSRSTLRDGLKILEERGLLTSAGGRGSRVAALGKAA
ITDPLIAMLVRHAEAADDYLEFRGIVESAAAALAAQRATEVELARIRDCLGRMDRAHARADTGEEAEADTELHLLIYEAS
HNMTLLQIMQALAGVLRSDVIQNRSRLFAVPAIRELLRQQHRAIAEAILARDAQAARQAAGEHIGYLRQASREIREAEAR
LDLSLRRLNGGGAGTRAAGTKSTPAAEG

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=230, Percent_Identity=33.9130434782609, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789353, Length=235, Percent_Identity=33.1914893617021, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790032, Length=240, Percent_Identity=34.5833333333333, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1790780, Length=229, Percent_Identity=30.1310043668122, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29098; Mature: 28967

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNASVKSERAAEAVAQHLESLILEGSLRPDERLLPERELAERLNVSRSTLRDGLKILEE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHCCHHHHHHHHHHHHHH
RGLLTSAGGRGSRVAALGKAAITDPLIAMLVRHAEAADDYLEFRGIVESAAAALAAQRAT
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVELARIRDCLGRMDRAHARADTGEEAEADTELHLLIYEASHNMTLLQIMQALAGVLRSD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
VIQNRSRLFAVPAIRELLRQQHRAIAEAILARDAQAARQAAGEHIGYLRQASREIREAEA
HHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLDLSLRRLNGGGAGTRAAGTKSTPAAEG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNASVKSERAAEAVAQHLESLILEGSLRPDERLLPERELAERLNVSRSTLRDGLKILEE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHCCHHHHHHHHHHHHHH
RGLLTSAGGRGSRVAALGKAAITDPLIAMLVRHAEAADDYLEFRGIVESAAAALAAQRAT
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVELARIRDCLGRMDRAHARADTGEEAEADTELHLLIYEASHNMTLLQIMQALAGVLRSD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
VIQNRSRLFAVPAIRELLRQQHRAIAEAILARDAQAARQAAGEHIGYLRQASREIREAEA
HHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLDLSLRRLNGGGAGTRAAGTKSTPAAEG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]