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The map label for this gene is hmuU [H]

Identifier: 119387089

GI number: 119387089

Start: 1577802

End: 1578797

Strand: Direct

Name: hmuU [H]

Synonym: Pden_4384

Alternate gene names: 119387089

Gene position: 1577802-1578797 (Clockwise)

Preceding gene: 119387088

Following gene: 119387090

Centisome position: 91.2

GC content: 73.49

Gene sequence:

>996_bases
ATGACCGCGCCGCGCTATCCGCTGCTGATCGCCGCGCTGTCGCTGCTGGTGGCTGCGCTGTTCCTGGCCTCGCTGCTGAC
CGGACCGGCGGGAATCGGCCCGGGCGAAAGCCTCGCCGCGCTGTTTCGCGGCGACGACCTGCTGGCGCTGGTGATGCGCG
AATTGCGCCTGCCGCGCGCCATCCTGGGCTTTCTGGTCGGTGCGGCGCTGGGGATGGCAGGCGCGGTGCTGCAAGGCTTC
CTGCGCAACCCGCTGGCCGAGCCGGGGCTGATCGGCACCAGCGCCTCGGCGGCGCTGGGGGCGGTGCTGGCGATCCAGAC
CGGGCTTTCGGCCACGTTCCCGCTGGCTTTGCCCCTGGCGGCGCTGGCCGGCGCGGCGCTGTCGGTGCTGCTGGTGCTGA
TGCTGGCCGGGCCGCGCGGGGGCGCACTGGCGCTGATCCTGGCCGGCATCGCCATTTCCGCGCTGGCAGGCGCGGCCACC
TCCCTGGTGCTGAACCTTTCGCCCAACCCCTTTGCCATCAACGAGATCGTGTTCTGGATGATGGGTTCGCTGGCGGATCG
CTCGATGCTGCATGTCTGGATCGCGGCGCCCTTCATGCTGCTGGGCTTTGCGCTGCTCTGGCCCACCCGCCGCGCGCTCG
AGGCGCTGACGCTGGGCGAGGATGCGGCGGCCTCCAGCGGCGTGCATCTGGGCCGGCTGCGGCTGATGCTGGTCGCGGGC
ATCGCCGCGCTGATCGGCGGCGCCACGGCGGTGGCCGGCACGGTGGGCTTCGTCGGGCTGGTGGTGCCGCATGTGCTGCG
CCGCGCGGTCGGCGCCAGCCCGGCGCGGCTGGTCCCGGCCGCGGCGCTGGGGGGCGCGGCGGTCGTTCTGGCCGCCGACA
TCGCCGTGCGGCGGATCGCGCCGGGCCATGACCTCAAGCTTGGTGTGCTGACGGCGCTGGTGGGGGCGCCCTTCTTCCTG
CACCTGATCCTCAGGACCCGGCGCGAGGGGCTGTGA

Upstream 100 bases:

>100_bases
CCGAGGTCATGTCCGATCCCGACTGGGTCTGCGGCACCCCCCACATCCTGCGCGCCATAGCCCAGTTGCGCGACGCGCGC
CTTGCCTTGCAGGCCCGGCC

Downstream 100 bases:

>100_bases
CCATGCTTGAGCTTCGCGCCCTCTCGTTCCACCGCGCCGGGCAGCCGGTGCTGGACGGTATCGACCTGCGGCTGGGGCCG
GGCGAGTTCGTCGGCCTGCT

Product: transport system permease protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTAPRYPLLIAALSLLVAALFLASLLTGPAGIGPGESLAALFRGDDLLALVMRELRLPRAILGFLVGAALGMAGAVLQGF
LRNPLAEPGLIGTSASAALGAVLAIQTGLSATFPLALPLAALAGAALSVLLVLMLAGPRGGALALILAGIAISALAGAAT
SLVLNLSPNPFAINEIVFWMMGSLADRSMLHVWIAAPFMLLGFALLWPTRRALEALTLGEDAAASSGVHLGRLRLMLVAG
IAALIGGATAVAGTVGFVGLVVPHVLRRAVGASPARLVPAAALGGAAVVLAADIAVRRIAPGHDLKLGVLTALVGAPFFL
HLILRTRREGL

Sequences:

>Translated_331_residues
MTAPRYPLLIAALSLLVAALFLASLLTGPAGIGPGESLAALFRGDDLLALVMRELRLPRAILGFLVGAALGMAGAVLQGF
LRNPLAEPGLIGTSASAALGAVLAIQTGLSATFPLALPLAALAGAALSVLLVLMLAGPRGGALALILAGIAISALAGAAT
SLVLNLSPNPFAINEIVFWMMGSLADRSMLHVWIAAPFMLLGFALLWPTRRALEALTLGEDAAASSGVHLGRLRLMLVAG
IAALIGGATAVAGTVGFVGLVVPHVLRRAVGASPARLVPAAALGGAAVVLAADIAVRRIAPGHDLKLGVLTALVGAPFFL
HLILRTRREGL
>Mature_330_residues
TAPRYPLLIAALSLLVAALFLASLLTGPAGIGPGESLAALFRGDDLLALVMRELRLPRAILGFLVGAALGMAGAVLQGFL
RNPLAEPGLIGTSASAALGAVLAIQTGLSATFPLALPLAALAGAALSVLLVLMLAGPRGGALALILAGIAISALAGAATS
LVLNLSPNPFAINEIVFWMMGSLADRSMLHVWIAAPFMLLGFALLWPTRRALEALTLGEDAAASSGVHLGRLRLMLVAGI
AALIGGATAVAGTVGFVGLVVPHVLRRAVGASPARLVPAAALGGAAVVLAADIAVRRIAPGHDLKLGVLTALVGAPFFLH
LILRTRREGL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=295, Percent_Identity=37.6271186440678, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788004, Length=303, Percent_Identity=35.973597359736, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790741, Length=340, Percent_Identity=32.9411764705882, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786805, Length=282, Percent_Identity=37.9432624113475, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1786804, Length=332, Percent_Identity=32.8313253012048, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786347, Length=275, Percent_Identity=31.6363636363636, Blast_Score=89, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 33324; Mature: 33192

Theoretical pI: Translated: 12.03; Mature: 12.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPRYPLLIAALSLLVAALFLASLLTGPAGIGPGESLAALFRGDDLLALVMRELRLPRA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHH
ILGFLVGAALGMAGAVLQGFLRNPLAEPGLIGTSASAALGAVLAIQTGLSATFPLALPLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
ALAGAALSVLLVLMLAGPRGGALALILAGIAISALAGAATSLVLNLSPNPFAINEIVFWM
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHH
MGSLADRSMLHVWIAAPFMLLGFALLWPTRRALEALTLGEDAAASSGVHLGRLRLMLVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHH
IAALIGGATAVAGTVGFVGLVVPHVLRRAVGASPARLVPAAALGGAAVVLAADIAVRRIA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHCC
PGHDLKLGVLTALVGAPFFLHLILRTRREGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAPRYPLLIAALSLLVAALFLASLLTGPAGIGPGESLAALFRGDDLLALVMRELRLPRA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHH
ILGFLVGAALGMAGAVLQGFLRNPLAEPGLIGTSASAALGAVLAIQTGLSATFPLALPLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
ALAGAALSVLLVLMLAGPRGGALALILAGIAISALAGAATSLVLNLSPNPFAINEIVFWM
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHH
MGSLADRSMLHVWIAAPFMLLGFALLWPTRRALEALTLGEDAAASSGVHLGRLRLMLVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHH
IAALIGGATAVAGTVGFVGLVVPHVLRRAVGASPARLVPAAALGGAAVVLAADIAVRRIA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHCC
PGHDLKLGVLTALVGAPFFLHLILRTRREGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]