Click here to switch to the map view.

The map label for this gene is tpiA [H]

Identifier: 119387010

GI number: 119387010

Start: 1484756

End: 1485499

Strand: Direct

Name: tpiA [H]

Synonym: Pden_4305

Alternate gene names: 119387010

Gene position: 1484756-1485499 (Clockwise)

Preceding gene: 119387009

Following gene: 119387011

Centisome position: 85.82

GC content: 71.24

Gene sequence:

>744_bases
ATGGCCCCGCGCAAGCTCGCCGCCGGCAACTGGAAGATGAACGGAACCCTGGCCGCACTGGCCGAGATCGACCGGCTGCT
GGCCGATCACCCGGCACCCGGCTGCGAGGTGCTGATCTGCCCGCCCGCCACGCTGATCCACCCCATGGCCGCCCGCAGCC
AGGGCAGGATCGCTGTCGGCGGCCAGGATTGCCACGCCAAGACCTCGGGCGCCCATACCGGCGACATCGCCGCCGCCCAG
CTTCGCGATGCGGGCTCGAGCCACGTCATCCTCGGCCATTCCGAGCGTCGCACCGACCATGCCGAGACCGACGAACAGGT
GCGCGCCAAGGCGGCCGCCGCGCATGAGGCTGGGCTTGTCGCGGTGATCTGCGTCGGCGAGACCGAGGTGCAGCGGGACG
CCGGCCAGACGCTCGACGTGATCTCGGCCCAGCTTGCCGGCTCGGTCCCGGATGGCGCGACGGCCGCGAACACGGTGATC
GCCTATGAGCCGGTCTGGGCCATCGGCACCGGCCGCACGCCCACCTCCGACCAGATCGCCGAGGTGCATGCCCTGATGCG
CGAGCGCCTGTCGGCCCGTCTGGGCGACGGCGCCGACTTCGCCCTGCTCTACGGCGGTTCGGTCAAGCCGGGCAACGCGG
CCGAGATATTTGCCATCCCGCATGTGAACGGCGCGCTGGTCGGCGGCGCCAGCCTCAAGGCCGAGGATTTCGGCCCGATC
ATCGCCGCGCTTTCCGCAGCGTAA

Upstream 100 bases:

>100_bases
GCCTTTTTGCCGCAAGTTAGCGCCCACATCGCGCCAGCCGTCTTGATCGCGGGGACCCCCCGGCCTAATCCCTGTCAGAC
CAAGACAGAGGGAGAGGCAG

Downstream 100 bases:

>100_bases
CGCCCCCGAAAAGAACGCCATTCCATCCGGCCGGCCCGGTTTGGAATGGCATTGCCCTTTTGCGGGGTGCCAGCCCCTTG
CAAAGCCCGGCCCGGCGGGC

Product: Triose-phosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MAPRKLAAGNWKMNGTLAALAEIDRLLADHPAPGCEVLICPPATLIHPMAARSQGRIAVGGQDCHAKTSGAHTGDIAAAQ
LRDAGSSHVILGHSERRTDHAETDEQVRAKAAAAHEAGLVAVICVGETEVQRDAGQTLDVISAQLAGSVPDGATAANTVI
AYEPVWAIGTGRTPTSDQIAEVHALMRERLSARLGDGADFALLYGGSVKPGNAAEIFAIPHVNGALVGGASLKAEDFGPI
IAALSAA

Sequences:

>Translated_247_residues
MAPRKLAAGNWKMNGTLAALAEIDRLLADHPAPGCEVLICPPATLIHPMAARSQGRIAVGGQDCHAKTSGAHTGDIAAAQ
LRDAGSSHVILGHSERRTDHAETDEQVRAKAAAAHEAGLVAVICVGETEVQRDAGQTLDVISAQLAGSVPDGATAANTVI
AYEPVWAIGTGRTPTSDQIAEVHALMRERLSARLGDGADFALLYGGSVKPGNAAEIFAIPHVNGALVGGASLKAEDFGPI
IAALSAA
>Mature_246_residues
APRKLAAGNWKMNGTLAALAEIDRLLADHPAPGCEVLICPPATLIHPMAARSQGRIAVGGQDCHAKTSGAHTGDIAAAQL
RDAGSSHVILGHSERRTDHAETDEQVRAKAAAAHEAGLVAVICVGETEVQRDAGQTLDVISAQLAGSVPDGATAANTVIA
YEPVWAIGTGRTPTSDQIAEVHALMRERLSARLGDGADFALLYGGSVKPGNAAEIFAIPHVNGALVGGASLKAEDFGPII
AALSAA

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=251, Percent_Identity=41.0358565737052, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI4507645, Length=251, Percent_Identity=41.0358565737052, Blast_Score=164, Evalue=9e-41,
Organism=Escherichia coli, GI1790353, Length=248, Percent_Identity=43.5483870967742, Blast_Score=187, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17536593, Length=250, Percent_Identity=42, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320255, Length=245, Percent_Identity=40.8163265306122, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28572008, Length=248, Percent_Identity=43.1451612903226, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI28572006, Length=248, Percent_Identity=43.1451612903226, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI28572004, Length=248, Percent_Identity=43.1451612903226, Blast_Score=177, Evalue=7e-45,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 25190; Mature: 25058

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRKLAAGNWKMNGTLAALAEIDRLLADHPAPGCEVLICPPATLIHPMAARSQGRIAVG
CCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEC
GQDCHAKTSGAHTGDIAAAQLRDAGSSHVILGHSERRTDHAETDEQVRAKAAAAHEAGLV
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEE
AVICVGETEVQRDAGQTLDVISAQLAGSVPDGATAANTVIAYEPVWAIGTGRTPTSDQIA
EEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCHHCEEEEECCEEEEECCCCCCHHHHH
EVHALMRERLSARLGDGADFALLYGGSVKPGNAAEIFAIPHVNGALVGGASLKAEDFGPI
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCCCHHHHH
IAALSAA
HHHHCCC
>Mature Secondary Structure 
APRKLAAGNWKMNGTLAALAEIDRLLADHPAPGCEVLICPPATLIHPMAARSQGRIAVG
CCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEC
GQDCHAKTSGAHTGDIAAAQLRDAGSSHVILGHSERRTDHAETDEQVRAKAAAAHEAGLV
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEE
AVICVGETEVQRDAGQTLDVISAQLAGSVPDGATAANTVIAYEPVWAIGTGRTPTSDQIA
EEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCHHCEEEEECCEEEEECCCCCCHHHHH
EVHALMRERLSARLGDGADFALLYGGSVKPGNAAEIFAIPHVNGALVGGASLKAEDFGPI
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCCCHHHHH
IAALSAA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA