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The map label for this gene is guaD [H]

Identifier: 119386956

GI number: 119386956

Start: 1417634

End: 1418107

Strand: Direct

Name: guaD [H]

Synonym: Pden_4251

Alternate gene names: 119386956

Gene position: 1417634-1418107 (Clockwise)

Preceding gene: 119386955

Following gene: 119386957

Centisome position: 81.94

GC content: 69.62

Gene sequence:

>474_bases
ATGTCCGATCAGGCGAAGCACTATCTGGAGCAGGCGGTGATGCTGGCGCATCGCAACGTGCAGGCTGGCGGCCGGCCCTT
TGGCGCGGTGGTGGTGCGGGACGGCGAGGTGCTGGCCACCGGCGTCAACGAAACCGTCGCCACCCATGACCCGACCGCCC
ATGCCGAACTGGTGGCGCTGCGTGCCGCCGCGCTGCGGCTGGGCTCGCCCGATCTTTCGGCCTGCGTGGTCCATGCCAGC
GGCCAGCCCTGCCCCATGTGCCTGGCGGCCATGCGGCTGGCCGGCGTGACCAAGGTGCATTACGCCTATTCGAACCAGGA
CGGCGCACCCTACGGCCTGTCCACGGCCGCGCTTTACGAAGAACTGGCCAGGCCCCTCGACCAGCAATCCATCGCCATCC
GCCACCTGCCCGTGCGGCCCGAGGGCGCCGGCGATCTTTATGCCGACTGGAAAGCACGGCAGGAGCGGGCGTGA

Upstream 100 bases:

>100_bases
ATGGCGAGGGGGTCTCGCCGCTGGCCCATGCCCGCCGCATGGGGTTCGACGCGATCGCGGCGCGGCTGGTCGCCGCCGGC
GCAAGGTGAAGTGAGGGGCG

Downstream 100 bases:

>100_bases
AGGCGAACAGGCAGCCGCTGATGCTGGCCGTGGTGGCCATGGTCGGGCTGGCGCTGCGGCCGTTCCTGACCGGGGTCGGC
CCCGTCGCGACGCCGATCTC

Product: CMP/dCMP deaminase, zinc-binding

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MSDQAKHYLEQAVMLAHRNVQAGGRPFGAVVVRDGEVLATGVNETVATHDPTAHAELVALRAAALRLGSPDLSACVVHAS
GQPCPMCLAAMRLAGVTKVHYAYSNQDGAPYGLSTAALYEELARPLDQQSIAIRHLPVRPEGAGDLYADWKARQERA

Sequences:

>Translated_157_residues
MSDQAKHYLEQAVMLAHRNVQAGGRPFGAVVVRDGEVLATGVNETVATHDPTAHAELVALRAAALRLGSPDLSACVVHAS
GQPCPMCLAAMRLAGVTKVHYAYSNQDGAPYGLSTAALYEELARPLDQQSIAIRHLPVRPEGAGDLYADWKARQERA
>Mature_156_residues
SDQAKHYLEQAVMLAHRNVQAGGRPFGAVVVRDGEVLATGVNETVATHDPTAHAELVALRAAALRLGSPDLSACVVHASG
QPCPMCLAAMRLAGVTKVHYAYSNQDGAPYGLSTAALYEELARPLDQQSIAIRHLPVRPEGAGDLYADWKARQERA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=96, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17554608, Length=132, Percent_Identity=34.8484848484849, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555996, Length=131, Percent_Identity=37.4045801526718, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 16738; Mature: 16607

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQAKHYLEQAVMLAHRNVQAGGRPFGAVVVRDGEVLATGVNETVATHDPTAHAELVAL
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
RAAALRLGSPDLSACVVHASGQPCPMCLAAMRLAGVTKVHYAYSNQDGAPYGLSTAALYE
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHH
ELARPLDQQSIAIRHLPVRPEGAGDLYADWKARQERA
HHHCCCCCCCEEEEECCCCCCCCCCCHHCCHHHCCCC
>Mature Secondary Structure 
SDQAKHYLEQAVMLAHRNVQAGGRPFGAVVVRDGEVLATGVNETVATHDPTAHAELVAL
CHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
RAAALRLGSPDLSACVVHASGQPCPMCLAAMRLAGVTKVHYAYSNQDGAPYGLSTAALYE
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHH
ELARPLDQQSIAIRHLPVRPEGAGDLYADWKARQERA
HHHCCCCCCCEEEEECCCCCCCCCCCHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]