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The map label for this gene is sdaA [H]

Identifier: 119386837

GI number: 119386837

Start: 1288663

End: 1290045

Strand: Direct

Name: sdaA [H]

Synonym: Pden_4132

Alternate gene names: 119386837

Gene position: 1288663-1290045 (Clockwise)

Preceding gene: 119386824

Following gene: 119386838

Centisome position: 74.49

GC content: 68.62

Gene sequence:

>1383_bases
ATGTTTCTTTCCGTCTTCGACATCTTCAAGATCGGAGTCGGCCCGTCCTCGTCCCATACCATGGGGCCGATGGTGGCCGC
AGGCCGCTTTCTGGACGCGCTGCGCGAACAGCCCTTTCGCGCGCACGGGCTGCGCGCCAGCCTGCACGGCAGCCTGGCCT
TCACCGGCAAGGGCCACGCCACCGACCGCGCCACCATCCTTGGCCTGGCCGGATTCCTGCCCGAAACCATGGATGCCGAG
GCGGCCGAGGCCGTGCTGGAGAAAAACCGCGAGACGAAGATCCTGTCGCCGCGCGACCTGGGCGATCTGGCCTTCGACCC
GATGCGCGACCTGATCTTCGACTACGACCACGCCCTGCCCGGCCATGCCAACGGCATGGTCCTGATGGCGACCGACGCCC
AGGGCGACGTGATCTTTCGCGAGGTCTATTACTCGATCGGCGGCGGCTTCGTGCTGACCGAGGGCGAGTTGGCGGCGCGC
GGCGACGACACCCGCTCGGATGCCTCGCCCAAGGTGCCCTTCCCCTTCGCCTCGGCGGCCGAGATGCTGGAGATGGCCGA
AAGATCGGGCAAGTCCATCGCCCAGATGAAACGCGAGAACGAGCGGGTCTTTCGCAGCGATGCCGAGATTTCAGCCGGCA
TCCGCCGCATCTGGCAGGTGATGCGCGACTGCATGGACCGGGGGCTTGCGACCGGCGGCATACTGCCCGGCGGGCTGTCG
ATCCGCCGCCGCGCCGCCGGCATCCACGAGGCGCTGAAGGCCGAGGCCGGCATGAACCTGACCGCGCCGCATGTCATCAA
CGACTGGATGTCGATCTATGCCATGGCCGTGAACGAGGAGAACGCGGCCGGCGGCCAGGTCGTGACCGCGCCGACGAACG
GCGCGGCGGGCGTGGTGCCGGCGGTGATCCGCTATTGGCTGGACCATGTGCCGGGCGCGTCCGAGCGCCAGCTCGACGAG
TTCCTGCTGACCGCCGCGGCCATCGGCGGGCTGATCAAGCACAACGCCTCGATCTCGGGCGCGGAATGCGGCTGCCAGGC
CGAGGTCGGCTCGGCCAGCGCCATGGCGGCGGCAGGGATCTGCGCCGCGATGGGCGGCACCGTCACCCAGGTCGAGAACG
CCGCCGAGATCGCGCTGGAGCATCACCTGGGCATGACCTGCGACCCGGTAAAGGGACTGGTGCAGGTGCCCTGCATCGAA
AGGAACGGCCTTGGCGCCATCAAGGCGGTCTCGGCCGCCAGCCTGGCGCTGCGCGGCGACGGCCAGCATTTCGTGCCGCT
GGACGCCGCCATCGAGACCATGCGCCAGACCGGCCGCGACATGAGCGACAAATACAAGGAGACCTCGCTGGGCGGTCTGG
CCGTCAACGTGCCCAACTGCTGA

Upstream 100 bases:

>100_bases
TTTCGTCAAATGTCGCGGAGCTTCAAGTCCGCTGTCGCAACCGCGCTGGCCTGTCGGGCGCGCGGCGGCTAGGCTTTCCG
CGCCAGCCAGGGAGTGCGCG

Downstream 100 bases:

>100_bases
CCGCGTGCGAAGAATCGCGCAAACCCGGGCCCTGGCGGCGGTCGGGGCTTGTCGGCGCTTGCCCAAGTCCCGGGCTTCCT
GTAGCCAATCAGCATAAGCA

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MFLSVFDIFKIGVGPSSSHTMGPMVAAGRFLDALREQPFRAHGLRASLHGSLAFTGKGHATDRATILGLAGFLPETMDAE
AAEAVLEKNRETKILSPRDLGDLAFDPMRDLIFDYDHALPGHANGMVLMATDAQGDVIFREVYYSIGGGFVLTEGELAAR
GDDTRSDASPKVPFPFASAAEMLEMAERSGKSIAQMKRENERVFRSDAEISAGIRRIWQVMRDCMDRGLATGGILPGGLS
IRRRAAGIHEALKAEAGMNLTAPHVINDWMSIYAMAVNEENAAGGQVVTAPTNGAAGVVPAVIRYWLDHVPGASERQLDE
FLLTAAAIGGLIKHNASISGAECGCQAEVGSASAMAAAGICAAMGGTVTQVENAAEIALEHHLGMTCDPVKGLVQVPCIE
RNGLGAIKAVSAASLALRGDGQHFVPLDAAIETMRQTGRDMSDKYKETSLGGLAVNVPNC

Sequences:

>Translated_460_residues
MFLSVFDIFKIGVGPSSSHTMGPMVAAGRFLDALREQPFRAHGLRASLHGSLAFTGKGHATDRATILGLAGFLPETMDAE
AAEAVLEKNRETKILSPRDLGDLAFDPMRDLIFDYDHALPGHANGMVLMATDAQGDVIFREVYYSIGGGFVLTEGELAAR
GDDTRSDASPKVPFPFASAAEMLEMAERSGKSIAQMKRENERVFRSDAEISAGIRRIWQVMRDCMDRGLATGGILPGGLS
IRRRAAGIHEALKAEAGMNLTAPHVINDWMSIYAMAVNEENAAGGQVVTAPTNGAAGVVPAVIRYWLDHVPGASERQLDE
FLLTAAAIGGLIKHNASISGAECGCQAEVGSASAMAAAGICAAMGGTVTQVENAAEIALEHHLGMTCDPVKGLVQVPCIE
RNGLGAIKAVSAASLALRGDGQHFVPLDAAIETMRQTGRDMSDKYKETSLGGLAVNVPNC
>Mature_460_residues
MFLSVFDIFKIGVGPSSSHTMGPMVAAGRFLDALREQPFRAHGLRASLHGSLAFTGKGHATDRATILGLAGFLPETMDAE
AAEAVLEKNRETKILSPRDLGDLAFDPMRDLIFDYDHALPGHANGMVLMATDAQGDVIFREVYYSIGGGFVLTEGELAAR
GDDTRSDASPKVPFPFASAAEMLEMAERSGKSIAQMKRENERVFRSDAEISAGIRRIWQVMRDCMDRGLATGGILPGGLS
IRRRAAGIHEALKAEAGMNLTAPHVINDWMSIYAMAVNEENAAGGQVVTAPTNGAAGVVPAVIRYWLDHVPGASERQLDE
FLLTAAAIGGLIKHNASISGAECGCQAEVGSASAMAAAGICAAMGGTVTQVENAAEIALEHHLGMTCDPVKGLVQVPCIE
RNGLGAIKAVSAASLALRGDGQHFVPLDAAIETMRQTGRDMSDKYKETSLGGLAVNVPNC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=460, Percent_Identity=47.6086956521739, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1789161, Length=463, Percent_Identity=45.5723542116631, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1788116, Length=468, Percent_Identity=45.7264957264957, Blast_Score=385, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48530; Mature: 48530

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLSVFDIFKIGVGPSSSHTMGPMVAAGRFLDALREQPFRAHGLRASLHGSLAFTGKGHA
CEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCEEEECCCEEECCCCCC
TDRATILGLAGFLPETMDAEAAEAVLEKNRETKILSPRDLGDLAFDPMRDLIFDYDHALP
CCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GHANGMVLMATDAQGDVIFREVYYSIGGGFVLTEGELAARGDDTRSDASPKVPFPFASAA
CCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCEEECCCCCCCCCCCCCCCCHHHHH
EMLEMAERSGKSIAQMKRENERVFRSDAEISAGIRRIWQVMRDCMDRGLATGGILPGGLS
HHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
IRRRAAGIHEALKAEAGMNLTAPHVINDWMSIYAMAVNEENAAGGQVVTAPTNGAAGVVP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCCCCCEEEECCCCCCCHHHH
AVIRYWLDHVPGASERQLDEFLLTAAAIGGLIKHNASISGAECGCQAEVGSASAMAAAGI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
CAAMGGTVTQVENAAEIALEHHLGMTCDPVKGLVQVPCIERNGLGAIKAVSAASLALRGD
HHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCCCCCHHHHHHHHHEEEECC
GQHFVPLDAAIETMRQTGRDMSDKYKETSLGGLAVNVPNC
CCEEEEHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCC
>Mature Secondary Structure
MFLSVFDIFKIGVGPSSSHTMGPMVAAGRFLDALREQPFRAHGLRASLHGSLAFTGKGHA
CEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCEEEECCCEEECCCCCC
TDRATILGLAGFLPETMDAEAAEAVLEKNRETKILSPRDLGDLAFDPMRDLIFDYDHALP
CCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GHANGMVLMATDAQGDVIFREVYYSIGGGFVLTEGELAARGDDTRSDASPKVPFPFASAA
CCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCEEECCCCCCCCCCCCCCCCHHHHH
EMLEMAERSGKSIAQMKRENERVFRSDAEISAGIRRIWQVMRDCMDRGLATGGILPGGLS
HHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
IRRRAAGIHEALKAEAGMNLTAPHVINDWMSIYAMAVNEENAAGGQVVTAPTNGAAGVVP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCCCCCEEEECCCCCCCHHHH
AVIRYWLDHVPGASERQLDEFLLTAAAIGGLIKHNASISGAECGCQAEVGSASAMAAAGI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
CAAMGGTVTQVENAAEIALEHHLGMTCDPVKGLVQVPCIERNGLGAIKAVSAASLALRGD
HHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCCCCCHHHHHHHHHEEEECC
GQHFVPLDAAIETMRQTGRDMSDKYKETSLGGLAVNVPNC
CCEEEEHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]