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The map label for this gene is iscS [H]

Identifier: 119386670

GI number: 119386670

Start: 1101340

End: 1102407

Strand: Direct

Name: iscS [H]

Synonym: Pden_3963

Alternate gene names: 119386670

Gene position: 1101340-1102407 (Clockwise)

Preceding gene: 119386669

Following gene: 119386671

Centisome position: 63.66

GC content: 69.01

Gene sequence:

>1068_bases
ATGAACCGGGTCTATCTGGACTGGAACGCTACCGCGCCGCTGCGCCCCCAGGCGCGCGAGGCGATGCTGGCCGCGACCGG
GATCGTCGGCAACCCGTCCTCGGTCCACGCCGAGGGCAGGGCGGCGAAATCCGCGCTGGAACGGGCGCGCGAGGACGTCG
CCACGGCGCTTGGCGCCGAGGGGGCGGATGTGATCTTCACCTCGGGCGCGACCGAGGCGGCGGCACTGGCGCTTCAGGGC
CGGGGGCTGGCCTGTTCGCCGGTCGAGCATGCCGCCGTGCTGGCCTGGTGCAATGCCTCGCTGCGGACGGATCAGGCGGG
GCGGGTCGCGGTTCCCGATCCGGGCCGCGCGACGCTGCAACTCGCCAATGCCGAGACCGGCGTGATCCAGGACCTGCCGC
AAGGGCTGGCGGTCAGCGACCTGACGCAGGCCTTCGGAAAGATCCCCTTCGCCTTCAACTGGCTGGGTATCGAGGCCGGC
TTCGTCAGCGCCCACAAGCTGGGCGGGCCGCGCGGCATCGGCGCGCTGGTGGTGAAGCGCGGCACCGAGGTCGAGGCGCG
GATCAAGGGCGGCGGGCAGGAACAGGGCCGCCGTGCCGGGACCGAGAACCTGATCGGCATCATGGGCTTTGCAGCGGCCG
CAAAAGCGGCGCAGAATGATCTGGATCAAGGAATCGGGGAAAAAGTGTCGCAACTGCGCGATTCCCTGATGGCTGCTCTG
GAATCCGGGGCGGAAATGGTTACATTCCCGGGGCGCGAGGCCCGCCGCCTGCCCAATACATTGTCGATCCTGACGCCGGG
ATGGCGCGGAGAGACGCAGGTGATGCAGATGGACCTGGCCGGATTTGCCGTCTCGGCAGGCTCGGCCTGTTCTTCGGGCA
AGGTTCGGCCAAGTTCGGTTCTGACGGCCATGGGAATCGCGCCGGAATGGGCGGGCGATGCGATCCGCGTCTCGATCGGA
CCGACGACGGAGCCTGGAGACGTGATGCGTTTTGCGGATGCCTGGCTCGCGGCCCATGGCCGCTGGCGGCAAAGGAATGA
TGGGCGGGCGACCGCGGGAAGGGTTTGA

Upstream 100 bases:

>100_bases
GCTGGCCGCGCCTTTCCAAGCAGGAGGTCGCGCTACGGCTTGCCGAGCGCATCGCCGGGGCGTTGGACCATGCCCAGGAC
GGCATGCCGGAGGAGCGCAT

Downstream 100 bases:

>100_bases
GATGACTGTAGAGATCGGCGAGGCAATCGAAATCCGCGAGGGCGTAGACCGCGAGACCGTCGAGACCGTCCAGAACATGG
GGTCCTACAAATACGGCTGG

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNRVYLDWNATAPLRPQAREAMLAATGIVGNPSSVHAEGRAAKSALERAREDVATALGAEGADVIFTSGATEAAALALQG
RGLACSPVEHAAVLAWCNASLRTDQAGRVAVPDPGRATLQLANAETGVIQDLPQGLAVSDLTQAFGKIPFAFNWLGIEAG
FVSAHKLGGPRGIGALVVKRGTEVEARIKGGGQEQGRRAGTENLIGIMGFAAAAKAAQNDLDQGIGEKVSQLRDSLMAAL
ESGAEMVTFPGREARRLPNTLSILTPGWRGETQVMQMDLAGFAVSAGSACSSGKVRPSSVLTAMGIAPEWAGDAIRVSIG
PTTEPGDVMRFADAWLAAHGRWRQRNDGRATAGRV

Sequences:

>Translated_355_residues
MNRVYLDWNATAPLRPQAREAMLAATGIVGNPSSVHAEGRAAKSALERAREDVATALGAEGADVIFTSGATEAAALALQG
RGLACSPVEHAAVLAWCNASLRTDQAGRVAVPDPGRATLQLANAETGVIQDLPQGLAVSDLTQAFGKIPFAFNWLGIEAG
FVSAHKLGGPRGIGALVVKRGTEVEARIKGGGQEQGRRAGTENLIGIMGFAAAAKAAQNDLDQGIGEKVSQLRDSLMAAL
ESGAEMVTFPGREARRLPNTLSILTPGWRGETQVMQMDLAGFAVSAGSACSSGKVRPSSVLTAMGIAPEWAGDAIRVSIG
PTTEPGDVMRFADAWLAAHGRWRQRNDGRATAGRV
>Mature_355_residues
MNRVYLDWNATAPLRPQAREAMLAATGIVGNPSSVHAEGRAAKSALERAREDVATALGAEGADVIFTSGATEAAALALQG
RGLACSPVEHAAVLAWCNASLRTDQAGRVAVPDPGRATLQLANAETGVIQDLPQGLAVSDLTQAFGKIPFAFNWLGIEAG
FVSAHKLGGPRGIGALVVKRGTEVEARIKGGGQEQGRRAGTENLIGIMGFAAAAKAAQNDLDQGIGEKVSQLRDSLMAAL
ESGAEMVTFPGREARRLPNTLSILTPGWRGETQVMQMDLAGFAVSAGSACSSGKVRPSSVLTAMGIAPEWAGDAIRVSIG
PTTEPGDVMRFADAWLAAHGRWRQRNDGRATAGRV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=380, Percent_Identity=31.5789473684211, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI156713448, Length=401, Percent_Identity=29.1770573566085, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI48994898, Length=381, Percent_Identity=31.496062992126, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25143064, Length=382, Percent_Identity=31.9371727748691, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17533177, Length=327, Percent_Identity=26.9113149847095, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=356, Percent_Identity=33.1460674157303, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129463, Length=380, Percent_Identity=32.1052631578947, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 36853; Mature: 36853

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVYLDWNATAPLRPQAREAMLAATGIVGNPSSVHAEGRAAKSALERAREDVATALGAE
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GADVIFTSGATEAAALALQGRGLACSPVEHAAVLAWCNASLRTDQAGRVAVPDPGRATLQ
CCCEEEECCCCHHHEEEECCCCCEECCHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEE
LANAETGVIQDLPQGLAVSDLTQAFGKIPFAFNWLGIEAGFVSAHKLGGPRGIGALVVKR
ECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEEEEECCHHHHHHCCCCCCCEEEEEEC
GTEVEARIKGGGQEQGRRAGTENLIGIMGFAAAAKAAQNDLDQGIGEKVSQLRDSLMAAL
CCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESGAEMVTFPGREARRLPNTLSILTPGWRGETQVMQMDLAGFAVSAGSACSSGKVRPSSV
HCCCCEEEECCHHHHHCCCEEEEECCCCCCCCEEEEEEHHCEEEECCCCCCCCCCCHHHH
LTAMGIAPEWAGDAIRVSIGPTTEPGDVMRFADAWLAAHGRWRQRNDGRATAGRV
HHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNRVYLDWNATAPLRPQAREAMLAATGIVGNPSSVHAEGRAAKSALERAREDVATALGAE
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GADVIFTSGATEAAALALQGRGLACSPVEHAAVLAWCNASLRTDQAGRVAVPDPGRATLQ
CCCEEEECCCCHHHEEEECCCCCEECCHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEE
LANAETGVIQDLPQGLAVSDLTQAFGKIPFAFNWLGIEAGFVSAHKLGGPRGIGALVVKR
ECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEEEEECCHHHHHHCCCCCCCEEEEEEC
GTEVEARIKGGGQEQGRRAGTENLIGIMGFAAAAKAAQNDLDQGIGEKVSQLRDSLMAAL
CCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESGAEMVTFPGREARRLPNTLSILTPGWRGETQVMQMDLAGFAVSAGSACSSGKVRPSSV
HCCCCEEEECCHHHHHCCCEEEEECCCCCCCCEEEEEEHHCEEEECCCCCCCCCCCHHHH
LTAMGIAPEWAGDAIRVSIGPTTEPGDVMRFADAWLAAHGRWRQRNDGRATAGRV
HHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA