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The map label for this gene is coaBC [H]

Identifier: 119386669

GI number: 119386669

Start: 1100033

End: 1101343

Strand: Direct

Name: coaBC [H]

Synonym: Pden_3962

Alternate gene names: 119386669

Gene position: 1100033-1101343 (Clockwise)

Preceding gene: 119386667

Following gene: 119386670

Centisome position: 63.58

GC content: 69.95

Gene sequence:

>1311_bases
ATGTGCAGGGCGAATGACACGGCAGAGGACAGGCCCATGCAAGGCAGCCGCATATTGCTGATCGTCGGCGGGGGCATCGC
CGCGTTCAAGATACCCGAGCTGATCCGCATGATCCGGCGCGACGGCGGCTCGGTCGTGCCGGTGCTGACACGGGCGGGGG
CGGAGTTCGTCACGCCGCTGACGCTGTCGGCGCTGGCCGAGGCGCCCTGCCATACCGAGCTGTTCGACCTGACCCGCGAA
TCCGAAATGGGCCATATCCAGTTGTCGCGGGCCGCCGATCTGGTGGTGGTCGCGCCGGCGACCGCCAACCTGCTGGGGCG
GATGGCGGCAGGGATGGCGGACGACCTGGCCACCACCCTGCTTTTGGCGACCGACAAGCCGGTCCTGGCCGCGCCGGCGA
TGAACGTGCGCATGTGGCAGCATCCGGCGACACAGCGCAACATCGACACGCTGGAGAACGACGGCATCCGGCTCATTGGC
CCGGACGAGGGCGACATGGCCTGCGGCGAATACGGCCCCGGCCGCATGGCCGAGCCCGAGGCGATCCTGGGGGCGATTCG
CGCGGCCCTCGGTCGCGAGCGGCCGTTGCGCCTGCCGCCCGAAGCGGTGGTCTCGCTGCCCTCGCGGCGGCTGAGCGGCC
GGCATGTCATCGTGACCTCGGGGCCGACGCATGAGCCCATCGACCCGGTGCGCTATATCGCCAACCGCTCCAGCGGGGCG
CAGGGCACGGCCATCGCCGCCGCGTTGCGCGACCTGGGTGCGCGGGTCAGCTTCGTCACCGGCCCTGCCGAGGTGCCGCC
GCCCGAAGGGGTCGAGGTGATCGCGGTCGAGACCGCACGCGCGATGCGCGACGCCGTCGAGGCCGCCTTGCCGGCCGATG
CCGCGGTGATGGCCGCCGCCGTCGCCGATTGGCATGTCGCCAATGCCAGGGCGGGCAAGATCAAGAAGGATGGCTCGGGC
CGGTTGCCCGAACTGCAATTCGCGGAAAACCCCGACATCCTGGCATGGATCAGCCAGCTTGGCCGTGATCGTCCGTCGCT
GGTGGTGGGCTTTGCGGCCGAGACCGACGACGTGCTGGAAAACGCCACCCGCAAGCGCAAGCGCAAGGGTTGCGACTGGA
TCGTCGCCAACGACGTCAGCCCCGCCACCGGAATCATGGGCGGGACCGAGAATGCCGTCACGCTGATTTCCGAGGCCGGG
GCGGAAAGCTGGCCGCGCCTTTCCAAGCAGGAGGTCGCGCTACGGCTTGCCGAGCGCATCGCCGGGGCGTTGGACCATGC
CCAGGACGGCATGCCGGAGGAGCGCATATGA

Upstream 100 bases:

>100_bases
CATCGGCTCTCCCCGCATCATCCGCGGCCGGGTTAACCCGAAAGGGCTTAAAGATCGGTTAACGGGCGCGGCTTGCTTGT
TCCGCGGCCCGCTTCGGCCT

Downstream 100 bases:

>100_bases
ACCGGGTCTATCTGGACTGGAACGCTACCGCGCCGCTGCGCCCCCAGGCGCGCGAGGCGATGCTGGCCGCGACCGGGATC
GTCGGCAACCCGTCCTCGGT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MCRANDTAEDRPMQGSRILLIVGGGIAAFKIPELIRMIRRDGGSVVPVLTRAGAEFVTPLTLSALAEAPCHTELFDLTRE
SEMGHIQLSRAADLVVVAPATANLLGRMAAGMADDLATTLLLATDKPVLAAPAMNVRMWQHPATQRNIDTLENDGIRLIG
PDEGDMACGEYGPGRMAEPEAILGAIRAALGRERPLRLPPEAVVSLPSRRLSGRHVIVTSGPTHEPIDPVRYIANRSSGA
QGTAIAAALRDLGARVSFVTGPAEVPPPEGVEVIAVETARAMRDAVEAALPADAAVMAAAVADWHVANARAGKIKKDGSG
RLPELQFAENPDILAWISQLGRDRPSLVVGFAAETDDVLENATRKRKRKGCDWIVANDVSPATGIMGGTENAVTLISEAG
AESWPRLSKQEVALRLAERIAGALDHAQDGMPEERI

Sequences:

>Translated_436_residues
MCRANDTAEDRPMQGSRILLIVGGGIAAFKIPELIRMIRRDGGSVVPVLTRAGAEFVTPLTLSALAEAPCHTELFDLTRE
SEMGHIQLSRAADLVVVAPATANLLGRMAAGMADDLATTLLLATDKPVLAAPAMNVRMWQHPATQRNIDTLENDGIRLIG
PDEGDMACGEYGPGRMAEPEAILGAIRAALGRERPLRLPPEAVVSLPSRRLSGRHVIVTSGPTHEPIDPVRYIANRSSGA
QGTAIAAALRDLGARVSFVTGPAEVPPPEGVEVIAVETARAMRDAVEAALPADAAVMAAAVADWHVANARAGKIKKDGSG
RLPELQFAENPDILAWISQLGRDRPSLVVGFAAETDDVLENATRKRKRKGCDWIVANDVSPATGIMGGTENAVTLISEAG
AESWPRLSKQEVALRLAERIAGALDHAQDGMPEERI
>Mature_436_residues
MCRANDTAEDRPMQGSRILLIVGGGIAAFKIPELIRMIRRDGGSVVPVLTRAGAEFVTPLTLSALAEAPCHTELFDLTRE
SEMGHIQLSRAADLVVVAPATANLLGRMAAGMADDLATTLLLATDKPVLAAPAMNVRMWQHPATQRNIDTLENDGIRLIG
PDEGDMACGEYGPGRMAEPEAILGAIRAALGRERPLRLPPEAVVSLPSRRLSGRHVIVTSGPTHEPIDPVRYIANRSSGA
QGTAIAAALRDLGARVSFVTGPAEVPPPEGVEVIAVETARAMRDAVEAALPADAAVMAAAVADWHVANARAGKIKKDGSG
RLPELQFAENPDILAWISQLGRDRPSLVVGFAAETDDVLENATRKRKRKGCDWIVANDVSPATGIMGGTENAVTLISEAG
AESWPRLSKQEVALRLAERIAGALDHAQDGMPEERI

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=184, Percent_Identity=35.3260869565217, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI87082301, Length=415, Percent_Identity=42.1686746987952, Blast_Score=280, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17560194, Length=190, Percent_Identity=30, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322762, Length=198, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322925, Length=225, Percent_Identity=24.8888888888889, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=31.8918918918919, Blast_Score=89, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 46195; Mature: 46195

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCRANDTAEDRPMQGSRILLIVGGGIAAFKIPELIRMIRRDGGSVVPVLTRAGAEFVTPL
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHH
TLSALAEAPCHTELFDLTRESEMGHIQLSRAADLVVVAPATANLLGRMAAGMADDLATTL
HHHHHHCCCCCHHHHHHHHCCCCCEEEEECCCCEEEECCHHHHHHHHHHHCHHHHHHHHE
LLATDKPVLAAPAMNVRMWQHPATQRNIDTLENDGIRLIGPDEGDMACGEYGPGRMAEPE
EEECCCCEEECCCCCEEEECCCCCCCCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCHH
AILGAIRAALGRERPLRLPPEAVVSLPSRRLSGRHVIVTSGPTHEPIDPVRYIANRSSGA
HHHHHHHHHHCCCCCCCCCHHHHHHCCCHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCC
QGTAIAAALRDLGARVSFVTGPAEVPPPEGVEVIAVETARAMRDAVEAALPADAAVMAAA
CHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHH
VADWHVANARAGKIKKDGSGRLPELQFAENPDILAWISQLGRDRPSLVVGFAAETDDVLE
HHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHH
NATRKRKRKGCDWIVANDVSPATGIMGGTENAVTLISEAGAESWPRLSKQEVALRLAERI
HHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AGALDHAQDGMPEERI
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MCRANDTAEDRPMQGSRILLIVGGGIAAFKIPELIRMIRRDGGSVVPVLTRAGAEFVTPL
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHH
TLSALAEAPCHTELFDLTRESEMGHIQLSRAADLVVVAPATANLLGRMAAGMADDLATTL
HHHHHHCCCCCHHHHHHHHCCCCCEEEEECCCCEEEECCHHHHHHHHHHHCHHHHHHHHE
LLATDKPVLAAPAMNVRMWQHPATQRNIDTLENDGIRLIGPDEGDMACGEYGPGRMAEPE
EEECCCCEEECCCCCEEEECCCCCCCCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCHH
AILGAIRAALGRERPLRLPPEAVVSLPSRRLSGRHVIVTSGPTHEPIDPVRYIANRSSGA
HHHHHHHHHHCCCCCCCCCHHHHHHCCCHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCC
QGTAIAAALRDLGARVSFVTGPAEVPPPEGVEVIAVETARAMRDAVEAALPADAAVMAAA
CHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHH
VADWHVANARAGKIKKDGSGRLPELQFAENPDILAWISQLGRDRPSLVVGFAAETDDVLE
HHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHH
NATRKRKRKGCDWIVANDVSPATGIMGGTENAVTLISEAGAESWPRLSKQEVALRLAERI
HHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AGALDHAQDGMPEERI
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]