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The map label for this gene is lpxB [H]

Identifier: 119386616

GI number: 119386616

Start: 1044291

End: 1045454

Strand: Direct

Name: lpxB [H]

Synonym: Pden_3909

Alternate gene names: 119386616

Gene position: 1044291-1045454 (Clockwise)

Preceding gene: 119386615

Following gene: 119386619

Centisome position: 60.36

GC content: 70.36

Gene sequence:

>1164_bases
ATGAAATTCTTCCTGATCGCGGGCGAGCCTTCGGGCGACAATCTGGGCGGCGCCCTGATGGCCGGCTTGAAGCAGCTTGA
TCCGGATGCCGCGTTCCTGGGTGTCGGCGGTCCGGCCATGGCGGCCCAGGGGCTGGAGAGCCGCTTTCCCATGGAAGAGC
TGAGCCTGATGGGCATCTGGGAGGTGCTGCCGAAATACCGCGCGCTCAAGGCCCGGATCGCCGAGACTGCCCGCGCCGTC
GCCGAGGCCCGACCCGATGCGCTGATCACCATCGACAGCCCGGATTTCTGCCTGCGCGTGGCGCGCCAGGCCCGGGCGTT
GAACCCCGATTTGCGCACCATCCATTACGTCGCGCCCTCGGTCTGGGCCTGGCGGCCGGGGCGGGCCAGGAAGATGGCCG
AGGTGATCGATCATGTGCTGGCGATCCTGCCCTTCGAGCCGCCGCTGATGCAGGCCGCCGGCATGAGTTGCGATTTCGTC
GGCCATCCCATCGTCGCCGAGCCGGTGGCGGGCGAGGCCGAGGCAGCGGCGTTTCGTGCCGCGAACGGCATCGTGCCGGA
TGCGCCGCTGGTCTTGTGCCTGCCGGGTTCGCGCCGGACCGAGGTGGGCCGGCTCGGCCCGCGCTTCGACGAGGCGTTGA
TCCGGCTGCGCGACCGGGTGCCCGAGATTCGCGTGGTGATTCCGACCGTGCGGGGCGTTTCGGGGCTGGTGCGCGACATG
GCTCGGCGCTGGCCCACCGCCCCGGTCGTGGTCGAGAGCCCCGAGGAAAGGCGCGCCGCCTTTGCCGCCGCCGACCTGGC
GCTGGCGGCCTCGGGCACGGTCAGCCTGGATCTGGCCGCGAACGACGTGCCCATGGTCATCGGCTATGACGTGGCGCCGC
TCAGCCGGCTGATCATCGGGTTGCTGCTCAGGACCGATACGGTGACGCTGGTCAACCTGGTCAGCGAGACCCGCGCCGTG
CCGGAATATCTGGGCCGCAACTGCCAGCCCGGCCCCATGTCGCAGGCGCTTTACCGGCTGATCGAAAACGGCGAGGAACG
GAGCGAGCAACTGGCCGCCATGGCGCTGACCATGCAGCGGCTGGGGCGCGGCGGCGAGCCTCCCGGCCTGCGCGCCGCGC
GTTCGGTCATGGCGGCGATCAGTTCTGCGCCGCGACCACGATGA

Upstream 100 bases:

>100_bases
CCGCGAGAGTGGCAGCAGGGTATTTGACCGACGAAGAATGCCGGGGTGCTTCTCTGTTCTTCAAATACTCATGTCGGGGC
ATGGCAAGCGGAGCGGCGCG

Downstream 100 bases:

>100_bases
TCTCGACCTTGTAGTCGGGAGTCGCCAGGGCCGATTCGCCGGTGGCGCGGGCCGGGGCGTGGCCGGGGGCGACCCAACCG
TCCCAGACTGCGTTCATCTC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKFFLIAGEPSGDNLGGALMAGLKQLDPDAAFLGVGGPAMAAQGLESRFPMEELSLMGIWEVLPKYRALKARIAETARAV
AEARPDALITIDSPDFCLRVARQARALNPDLRTIHYVAPSVWAWRPGRARKMAEVIDHVLAILPFEPPLMQAAGMSCDFV
GHPIVAEPVAGEAEAAAFRAANGIVPDAPLVLCLPGSRRTEVGRLGPRFDEALIRLRDRVPEIRVVIPTVRGVSGLVRDM
ARRWPTAPVVVESPEERRAAFAAADLALAASGTVSLDLAANDVPMVIGYDVAPLSRLIIGLLLRTDTVTLVNLVSETRAV
PEYLGRNCQPGPMSQALYRLIENGEERSEQLAAMALTMQRLGRGGEPPGLRAARSVMAAISSAPRPR

Sequences:

>Translated_387_residues
MKFFLIAGEPSGDNLGGALMAGLKQLDPDAAFLGVGGPAMAAQGLESRFPMEELSLMGIWEVLPKYRALKARIAETARAV
AEARPDALITIDSPDFCLRVARQARALNPDLRTIHYVAPSVWAWRPGRARKMAEVIDHVLAILPFEPPLMQAAGMSCDFV
GHPIVAEPVAGEAEAAAFRAANGIVPDAPLVLCLPGSRRTEVGRLGPRFDEALIRLRDRVPEIRVVIPTVRGVSGLVRDM
ARRWPTAPVVVESPEERRAAFAAADLALAASGTVSLDLAANDVPMVIGYDVAPLSRLIIGLLLRTDTVTLVNLVSETRAV
PEYLGRNCQPGPMSQALYRLIENGEERSEQLAAMALTMQRLGRGGEPPGLRAARSVMAAISSAPRPR
>Mature_387_residues
MKFFLIAGEPSGDNLGGALMAGLKQLDPDAAFLGVGGPAMAAQGLESRFPMEELSLMGIWEVLPKYRALKARIAETARAV
AEARPDALITIDSPDFCLRVARQARALNPDLRTIHYVAPSVWAWRPGRARKMAEVIDHVLAILPFEPPLMQAAGMSCDFV
GHPIVAEPVAGEAEAAAFRAANGIVPDAPLVLCLPGSRRTEVGRLGPRFDEALIRLRDRVPEIRVVIPTVRGVSGLVRDM
ARRWPTAPVVVESPEERRAAFAAADLALAASGTVSLDLAANDVPMVIGYDVAPLSRLIIGLLLRTDTVTLVNLVSETRAV
PEYLGRNCQPGPMSQALYRLIENGEERSEQLAAMALTMQRLGRGGEPPGLRAARSVMAAISSAPRPR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=343, Percent_Identity=37.9008746355685, Blast_Score=201, Evalue=7e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41533; Mature: 41533

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFLIAGEPSGDNLGGALMAGLKQLDPDAAFLGVGGPAMAAQGLESRFPMEELSLMGIW
CEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHH
EVLPKYRALKARIAETARAVAEARPDALITIDSPDFCLRVARQARALNPDLRTIHYVAPS
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCHHEEEEECCC
VWAWRPGRARKMAEVIDHVLAILPFEPPLMQAAGMSCDFVGHPIVAEPVAGEAEAAAFRA
CEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
ANGIVPDAPLVLCLPGSRRTEVGRLGPRFDEALIRLRDRVPEIRVVIPTVRGVSGLVRDM
HCCCCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHH
ARRWPTAPVVVESPEERRAAFAAADLALAASGTVSLDLAANDVPMVIGYDVAPLSRLIIG
HHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCHHHHHHHHHH
LLLRTDTVTLVNLVSETRAVPEYLGRNCQPGPMSQALYRLIENGEERSEQLAAMALTMQR
HHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LGRGGEPPGLRAARSVMAAISSAPRPR
HCCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKFFLIAGEPSGDNLGGALMAGLKQLDPDAAFLGVGGPAMAAQGLESRFPMEELSLMGIW
CEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHH
EVLPKYRALKARIAETARAVAEARPDALITIDSPDFCLRVARQARALNPDLRTIHYVAPS
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCHHEEEEECCC
VWAWRPGRARKMAEVIDHVLAILPFEPPLMQAAGMSCDFVGHPIVAEPVAGEAEAAAFRA
CEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
ANGIVPDAPLVLCLPGSRRTEVGRLGPRFDEALIRLRDRVPEIRVVIPTVRGVSGLVRDM
HCCCCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHH
ARRWPTAPVVVESPEERRAAFAAADLALAASGTVSLDLAANDVPMVIGYDVAPLSRLIIG
HHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCHHHHHHHHHH
LLLRTDTVTLVNLVSETRAVPEYLGRNCQPGPMSQALYRLIENGEERSEQLAAMALTMQR
HHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LGRGGEPPGLRAARSVMAAISSAPRPR
HCCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA