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The map label for this gene is lpxA

Identifier: 119386614

GI number: 119386614

Start: 1042547

End: 1043332

Strand: Direct

Name: lpxA

Synonym: Pden_3907

Alternate gene names: 119386614

Gene position: 1042547-1043332 (Clockwise)

Preceding gene: 119386613

Following gene: 119386615

Centisome position: 60.26

GC content: 69.47

Gene sequence:

>786_bases
ATGGCTGAAACCCGCATCCACCCCTCGGCCGTCGTGGACCCCGCCGCGCAGGTCGGCGAGGGATGCGAGATCGGCCCGTT
CTGCGTGATCGGTCCCGAGGTCGGCCTCGGCCGGGGCGTGGTGCTGAAATCCCATGTCGTCGTGGCGGGCGAGACCCTGA
TCGGCGATGAGACCGTGGTCTTCCCCTTTGCCTCGCTGGGCGAGGTGCCGCAGGACCTGAAGTTCCGGGGCGAGCGCACG
CGGCTGGAAATCGGCGCCCGCAACCGCATCCGCGAATATGTCACCATGAACCCGGGCACCGAGGGCGGCGGCGGCGTCAC
CCGGATCGGCGACGACGGCCTTTTCATGGCGGGCAGCCATGTCGCGCATGACTGCCAGATCGGCAACCGGGTGATCCTGG
TCAACAACGCTTCGGTCGCCGGCCATTGCGTGCTCGAGGACGACGTGATCGTCGGCGGGCTGTCGGGCGTGCACCAGTTC
GTGCGCATCGGCCGCGGCGCGATGATCGGGGCGGTGACCATGGTGACGGCGGATGTGATCCCCTTCGGCCTGGTGCAGGG
GCCGCGCGGCCATCTGGACGGGCTGAACCTGGTGGGGCTGAAGCGCCGCGGCGCCTCGCGCGAGGAAATCCATGCGCTGC
GCGACATGCTGGCGCAACTGGGCCAGGGCAGCTTTCGCGATACCGCCCGGCACCTGGCCGAGGCCGAGAATGGCCCGATG
GTGCGCGAGGTGCTGGACTTCATCCTCGGTCCCTCGGACCGCAGCTTCCTGGCGCCCCATCCATGA

Upstream 100 bases:

>100_bases
CGCGGCGGCGGCAAGATCTGGAAGTTCGAGGGCCGCGCCATCGTCAACGGCCAGTTGGCCGCCGAGGCCGAGGTCATGGC
CATGCTGAACCGTGGCGACA

Downstream 100 bases:

>100_bases
GCCGCATCGCCCTGATCGCCGGCGAGGGCAGCCTTGCCCCCGCAATCGCCGCCGCGCTGGACCAGCCGCTGGTCTATGCG
CTGGACAACCTGAAACCGCA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAETRIHPSAVVDPAAQVGEGCEIGPFCVIGPEVGLGRGVVLKSHVVVAGETLIGDETVVFPFASLGEVPQDLKFRGERT
RLEIGARNRIREYVTMNPGTEGGGGVTRIGDDGLFMAGSHVAHDCQIGNRVILVNNASVAGHCVLEDDVIVGGLSGVHQF
VRIGRGAMIGAVTMVTADVIPFGLVQGPRGHLDGLNLVGLKRRGASREEIHALRDMLAQLGQGSFRDTARHLAEAENGPM
VREVLDFILGPSDRSFLAPHP

Sequences:

>Translated_261_residues
MAETRIHPSAVVDPAAQVGEGCEIGPFCVIGPEVGLGRGVVLKSHVVVAGETLIGDETVVFPFASLGEVPQDLKFRGERT
RLEIGARNRIREYVTMNPGTEGGGGVTRIGDDGLFMAGSHVAHDCQIGNRVILVNNASVAGHCVLEDDVIVGGLSGVHQF
VRIGRGAMIGAVTMVTADVIPFGLVQGPRGHLDGLNLVGLKRRGASREEIHALRDMLAQLGQGSFRDTARHLAEAENGPM
VREVLDFILGPSDRSFLAPHP
>Mature_260_residues
AETRIHPSAVVDPAAQVGEGCEIGPFCVIGPEVGLGRGVVLKSHVVVAGETLIGDETVVFPFASLGEVPQDLKFRGERTR
LEIGARNRIREYVTMNPGTEGGGGVTRIGDDGLFMAGSHVAHDCQIGNRVILVNNASVAGHCVLEDDVIVGGLSGVHQFV
RIGRGAMIGAVTMVTADVIPFGLVQGPRGHLDGLNLVGLKRRGASREEIHALRDMLAQLGQGSFRDTARHLAEAENGPMV
REVLDFILGPSDRSFLAPHP

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=246, Percent_Identity=48.3739837398374, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_PARDP (A1B8X9)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_917669.1
- ProteinModelPortal:   A1B8X9
- SMR:   A1B8X9
- STRING:   A1B8X9
- GeneID:   4582458
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_3907
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   A1B8X9
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 27587; Mature: 27456

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETRIHPSAVVDPAAQVGEGCEIGPFCVIGPEVGLGRGVVLKSHVVVAGETLIGDETVV
CCCCCCCCHHHCCCHHHHCCCCCCCCEEEECCCCCCCCCEEEECEEEEECCEEECCCEEE
FPFASLGEVPQDLKFRGERTRLEIGARNRIREYVTMNPGTEGGGGVTRIGDDGLFMAGSH
EECHHHCCCCHHHHCCCCCEEEEECCHHHHHHEEEECCCCCCCCCEEEECCCCEEEECCC
VAHDCQIGNRVILVNNASVAGHCVLEDDVIVGGLSGVHQFVRIGRGAMIGAVTMVTADVI
CCCCCCCCCEEEEEECCCCCEEEEEECCEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHH
PFGLVQGPRGHLDGLNLVGLKRRGASREEIHALRDMLAQLGQGSFRDTARHLAEAENGPM
HHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
VREVLDFILGPSDRSFLAPHP
HHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AETRIHPSAVVDPAAQVGEGCEIGPFCVIGPEVGLGRGVVLKSHVVVAGETLIGDETVV
CCCCCCCHHHCCCHHHHCCCCCCCCEEEECCCCCCCCCEEEECEEEEECCEEECCCEEE
FPFASLGEVPQDLKFRGERTRLEIGARNRIREYVTMNPGTEGGGGVTRIGDDGLFMAGSH
EECHHHCCCCHHHHCCCCCEEEEECCHHHHHHEEEECCCCCCCCCEEEECCCCEEEECCC
VAHDCQIGNRVILVNNASVAGHCVLEDDVIVGGLSGVHQFVRIGRGAMIGAVTMVTADVI
CCCCCCCCCEEEEEECCCCCEEEEEECCEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHH
PFGLVQGPRGHLDGLNLVGLKRRGASREEIHALRDMLAQLGQGSFRDTARHLAEAENGPM
HHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
VREVLDFILGPSDRSFLAPHP
HHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA