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The map label for this gene is meaA [H]

Identifier: 119386582

GI number: 119386582

Start: 1009234

End: 1011300

Strand: Direct

Name: meaA [H]

Synonym: Pden_3875

Alternate gene names: 119386582

Gene position: 1009234-1011300 (Clockwise)

Preceding gene: 119386577

Following gene: 119386585

Centisome position: 58.33

GC content: 66.04

Gene sequence:

>2067_bases
ATGGCGCGCGGCCGTCACCTCGCGGCCTCTCTGCGATGCGGCGAATTGACCGGGCATGATTGTTACGCTATCGGTTTGTC
AGTCGTAATATTGTTGCGAGGACAAATCGTGGCCGAGAAAGACAAACCCTGGCTTTTCCGCACCTATGCGGGCCATTCGA
CCGCCGAGAAATCCAACGCACTTTATCGGGGCAACCTCGCCAAGGGGCAGACCGGCCTGTCGGTGGCCTTCGACCTGCCG
ACCCAGACCGGCTATGACAGCGACCATGTGCTGGCGCGGGGCGAGGTCGGCAAGGTCGGGGTGCCGATCTGCCATCTGGG
CGACATGCGGATGCTCTTCGACCGGATCCCGCTTGAACAGATGAACACCTCGATGACCATCAATGCGACGGCGCCCTGGC
TCTTGTCGCTCTATATCGCCGTGGCCGAGGAGCAGGGGGCCGACATCGCCAGGTTGCAAGGCACGGTGCAGAACGACATC
ATCAAGGAATACCTGTCGCGCGGGACCTATATCTGCCCGCCCAAGCCCTCGCTGCGCATGATCACCGACGTCGCGGCCTA
TACGGCGAAGCATCTGCCGAAGTGGAACCCGATGAACGTCTGCTCCTACCACCTGCAAGAGGCGGGGGCGACGCCCGAGC
AGGAACTGGCCTATGCGCTGGCCACCGGCATCGCGGTGCTGGACGACCTCAAGGACAAGGTCGAGCCACAGGACTTTCCG
GCCATGGTCGGCCGCATCAGCTTCTTCGTGAACGCCGGTATCCGCTTCGTGACCGAGCTGTGCAAGATGCGCGCCTTCAC
TGAGCTGTGGGACGAGATCTGCCGCGAGCGCTACGGAATCGAGGAAGAGAAATTCCGCCGCTTCCGCTATGGCGTGCAGG
TGAACAGCCTGGGCCTGACCGAGCAGCAGCCGGAAAACAACGTCTATCGCATCCTGCTGGAGATGCTGGCGGTCACGCTG
TCCAGGAACGCCCGCGCCCGCGCCGTGCAACTGCCGGCCTGGAACGAGGCCCTGGGCCTGCCGCGGCCCTGGGACCAGCA
ATGGTCGCTGCGCATGCAGCAGATCGTCGCCTACGAGACGGACCTGCTGGAATATGGCGACCTCTTCGACGGCAACCCCG
TCATCGCCGCCAAGGTCGAGGAACTGAAATCCGGGGCCCGAGCGGAACTGGCGACGCTGGACGAGATGGGCGGCGCCATC
GCCGCCATCGAATACATGAAGTCGCGACTGGTCGAATCGAATGCCGAGCGCCTGAATCGCATCGAGGCGAACGAAACGGT
GGTCGTGGGCGTCAACCGCTGGCAGCAGGGCGAGCCCTCGCCGCTGACCGCGGGCGACGGCGGCATCATGGTCGTCGACC
CGGCGGTCGAGCAGGACCAGATCGCCCGGCTGCGCTCTTGGCGCGAGGCGCGCGACGAGGCGGCCGTCGAGGCCGCCCTC
GCCGCGTTGCGCGATGCCGCGCAGGCGGGACGGAACGTGATGCCGCCTTCGATTGCTGCCGCCAAAGCCGGCGCCACCAC
CGGCGAATGGGCGGCGGTGATGCGGCAGGTCCATGGCGAATATCGCGGCCCGACCGGCGTCTCCAGCAGTCCCTCGAACC
GCACAGAGGGCCTGGAGCCGATCCGCGAGGCGGTGGACGCTGTCAGCCGCCGTTTGGGCCGGCGGCTGAAATTCCTGGTC
GGCAAGCCCGGCCTCGACGGCCATTCCAACGGCGCCGAGCAGATCGCCTTCCGCGCCCGTGACTGCGGCATGGACATCAC
CTATGAGGGCATCCGCCTGACCCCCGAGCAGATCGTCGCCCGCGCCGCCGAGGACAATGCCCATGTCGTCGGCCTGTCGA
TCCTCTCGGGCAGCCACCTGCCGCTGATCGAGGAACTGATGGAGCGCATCCGTGCCGCGGGCCTTGCACATGTCCCGGTC
GTGGTCGGCGGCATCATCCCCGACGAGGACGCGGCCAGGCTGCTGAAGATGGGCGTGGCACGCGTCTACACGCCCAAGGA
TTTCGAGCTCAACCGCATCATGATGGACATCGTGGCCCTGGTCGAGCCCGAGGAGGCTGCCGCCTGA

Upstream 100 bases:

>100_bases
TAACATTCGTCCCGCCCTGCGCCAATGCTGCATATGCATTGCCGGGCCTCAGCCGGTCTTTCCCCGGCGGTTCTGCTGGT
TTCCAGGGCATTGCCCATGA

Downstream 100 bases:

>100_bases
TCCGGCGGCAAGGCCGGATGGGTATTTAAGAAACGGAAAGCACCTGGGAGGCGCCCGGTTCTTTCCGTTTTACAAATACC
CCAAGCGCAACCGCGCCGTC

Product: methylmalonyl-CoA mutase, large subunit

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MARGRHLAASLRCGELTGHDCYAIGLSVVILLRGQIVAEKDKPWLFRTYAGHSTAEKSNALYRGNLAKGQTGLSVAFDLP
TQTGYDSDHVLARGEVGKVGVPICHLGDMRMLFDRIPLEQMNTSMTINATAPWLLSLYIAVAEEQGADIARLQGTVQNDI
IKEYLSRGTYICPPKPSLRMITDVAAYTAKHLPKWNPMNVCSYHLQEAGATPEQELAYALATGIAVLDDLKDKVEPQDFP
AMVGRISFFVNAGIRFVTELCKMRAFTELWDEICRERYGIEEEKFRRFRYGVQVNSLGLTEQQPENNVYRILLEMLAVTL
SRNARARAVQLPAWNEALGLPRPWDQQWSLRMQQIVAYETDLLEYGDLFDGNPVIAAKVEELKSGARAELATLDEMGGAI
AAIEYMKSRLVESNAERLNRIEANETVVVGVNRWQQGEPSPLTAGDGGIMVVDPAVEQDQIARLRSWREARDEAAVEAAL
AALRDAAQAGRNVMPPSIAAAKAGATTGEWAAVMRQVHGEYRGPTGVSSSPSNRTEGLEPIREAVDAVSRRLGRRLKFLV
GKPGLDGHSNGAEQIAFRARDCGMDITYEGIRLTPEQIVARAAEDNAHVVGLSILSGSHLPLIEELMERIRAAGLAHVPV
VVGGIIPDEDAARLLKMGVARVYTPKDFELNRIMMDIVALVEPEEAAA

Sequences:

>Translated_688_residues
MARGRHLAASLRCGELTGHDCYAIGLSVVILLRGQIVAEKDKPWLFRTYAGHSTAEKSNALYRGNLAKGQTGLSVAFDLP
TQTGYDSDHVLARGEVGKVGVPICHLGDMRMLFDRIPLEQMNTSMTINATAPWLLSLYIAVAEEQGADIARLQGTVQNDI
IKEYLSRGTYICPPKPSLRMITDVAAYTAKHLPKWNPMNVCSYHLQEAGATPEQELAYALATGIAVLDDLKDKVEPQDFP
AMVGRISFFVNAGIRFVTELCKMRAFTELWDEICRERYGIEEEKFRRFRYGVQVNSLGLTEQQPENNVYRILLEMLAVTL
SRNARARAVQLPAWNEALGLPRPWDQQWSLRMQQIVAYETDLLEYGDLFDGNPVIAAKVEELKSGARAELATLDEMGGAI
AAIEYMKSRLVESNAERLNRIEANETVVVGVNRWQQGEPSPLTAGDGGIMVVDPAVEQDQIARLRSWREARDEAAVEAAL
AALRDAAQAGRNVMPPSIAAAKAGATTGEWAAVMRQVHGEYRGPTGVSSSPSNRTEGLEPIREAVDAVSRRLGRRLKFLV
GKPGLDGHSNGAEQIAFRARDCGMDITYEGIRLTPEQIVARAAEDNAHVVGLSILSGSHLPLIEELMERIRAAGLAHVPV
VVGGIIPDEDAARLLKMGVARVYTPKDFELNRIMMDIVALVEPEEAAA
>Mature_687_residues
ARGRHLAASLRCGELTGHDCYAIGLSVVILLRGQIVAEKDKPWLFRTYAGHSTAEKSNALYRGNLAKGQTGLSVAFDLPT
QTGYDSDHVLARGEVGKVGVPICHLGDMRMLFDRIPLEQMNTSMTINATAPWLLSLYIAVAEEQGADIARLQGTVQNDII
KEYLSRGTYICPPKPSLRMITDVAAYTAKHLPKWNPMNVCSYHLQEAGATPEQELAYALATGIAVLDDLKDKVEPQDFPA
MVGRISFFVNAGIRFVTELCKMRAFTELWDEICRERYGIEEEKFRRFRYGVQVNSLGLTEQQPENNVYRILLEMLAVTLS
RNARARAVQLPAWNEALGLPRPWDQQWSLRMQQIVAYETDLLEYGDLFDGNPVIAAKVEELKSGARAELATLDEMGGAIA
AIEYMKSRLVESNAERLNRIEANETVVVGVNRWQQGEPSPLTAGDGGIMVVDPAVEQDQIARLRSWREARDEAAVEAALA
ALRDAAQAGRNVMPPSIAAAKAGATTGEWAAVMRQVHGEYRGPTGVSSSPSNRTEGLEPIREAVDAVSRRLGRRLKFLVG
KPGLDGHSNGAEQIAFRARDCGMDITYEGIRLTPEQIVARAAEDNAHVVGLSILSGSHLPLIEELMERIRAAGLAHVPVV
VGGIIPDEDAARLLKMGVARVYTPKDFELNRIMMDIVALVEPEEAAA

Specific function: Required for the assimilation of methanol and ethanol [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=634, Percent_Identity=35.3312302839117, Blast_Score=382, Evalue=1e-106,
Organism=Escherichia coli, GI1789284, Length=652, Percent_Identity=38.1901840490798, Blast_Score=391, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI25144500, Length=631, Percent_Identity=35.4992076069731, Blast_Score=385, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 75559; Mature: 75428

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARGRHLAASLRCGELTGHDCYAIGLSVVILLRGQIVAEKDKPWLFRTYAGHSTAEKSNA
CCCCCCCHHHCEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCHHHHCCC
LYRGNLAKGQTGLSVAFDLPTQTGYDSDHVLARGEVGKVGVPICHLGDMRMLFDRIPLEQ
EEECCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCCCCCCCEEECCCHHHHHHHCCHHH
MNTSMTINATAPWLLSLYIAVAEEQGADIARLQGTVQNDIIKEYLSRGTYICPPKPSLRM
CCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHH
ITDVAAYTAKHLPKWNPMNVCSYHLQEAGATPEQELAYALATGIAVLDDLKDKVEPQDFP
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AMVGRISFFVNAGIRFVTELCKMRAFTELWDEICRERYGIEEEKFRRFRYGVQVNSLGLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECCCCC
EQQPENNVYRILLEMLAVTLSRNARARAVQLPAWNEALGLPRPWDQQWSLRMQQIVAYET
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHH
DLLEYGDLFDGNPVIAAKVEELKSGARAELATLDEMGGAIAAIEYMKSRLVESNAERLNR
HHHHHCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IEANETVVVGVNRWQQGEPSPLTAGDGGIMVVDPAVEQDQIARLRSWREARDEAAVEAAL
CCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
AALRDAAQAGRNVMPPSIAAAKAGATTGEWAAVMRQVHGEYRGPTGVSSSPSNRTEGLEP
HHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
IREAVDAVSRRLGRRLKFLVGKPGLDGHSNGAEQIAFRARDCGMDITYEGIRLTPEQIVA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCEECHHHHHH
RAAEDNAHVVGLSILSGSHLPLIEELMERIRAAGLAHVPVVVGGIIPDEDAARLLKMGVA
HHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHEECCCCCHHHHHHHHHHHH
RVYTPKDFELNRIMMDIVALVEPEEAAA
HCCCCCCCHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
ARGRHLAASLRCGELTGHDCYAIGLSVVILLRGQIVAEKDKPWLFRTYAGHSTAEKSNA
CCCCCCHHHCEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCHHHHCCC
LYRGNLAKGQTGLSVAFDLPTQTGYDSDHVLARGEVGKVGVPICHLGDMRMLFDRIPLEQ
EEECCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCCCCCCCEEECCCHHHHHHHCCHHH
MNTSMTINATAPWLLSLYIAVAEEQGADIARLQGTVQNDIIKEYLSRGTYICPPKPSLRM
CCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHH
ITDVAAYTAKHLPKWNPMNVCSYHLQEAGATPEQELAYALATGIAVLDDLKDKVEPQDFP
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AMVGRISFFVNAGIRFVTELCKMRAFTELWDEICRERYGIEEEKFRRFRYGVQVNSLGLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECCCCC
EQQPENNVYRILLEMLAVTLSRNARARAVQLPAWNEALGLPRPWDQQWSLRMQQIVAYET
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHH
DLLEYGDLFDGNPVIAAKVEELKSGARAELATLDEMGGAIAAIEYMKSRLVESNAERLNR
HHHHHCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IEANETVVVGVNRWQQGEPSPLTAGDGGIMVVDPAVEQDQIARLRSWREARDEAAVEAAL
CCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
AALRDAAQAGRNVMPPSIAAAKAGATTGEWAAVMRQVHGEYRGPTGVSSSPSNRTEGLEP
HHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
IREAVDAVSRRLGRRLKFLVGKPGLDGHSNGAEQIAFRARDCGMDITYEGIRLTPEQIVA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCEECHHHHHH
RAAEDNAHVVGLSILSGSHLPLIEELMERIRAAGLAHVPVVVGGIIPDEDAARLLKMGVA
HHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHEECCCCCHHHHHHHHHHHH
RVYTPKDFELNRIMMDIVALVEPEEAAA
HCCCCCCCHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]